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Results: 160
Features of effective staff training programmes within school-based interventions targeting student activity behaviour
Mairead Ryan, Olivia Alliott, Erika Ikeda, Jian'an Luan, Riikka Hofmann, Esther van Sluijs
Oct 25, 2022
Prepubertal Dietary and Plasma Phospholipid Fatty Acids Related to Puberty Timing
Tuck Seng Cheng, Felix R Day, John RB Perry, Jian'an Luan, Claudia Langenberg, Nita G Forouhi, Nicholas J Wareham, Ken K Ong
May 31, 2021
Genome-wide association study of adipocyte lipolysis in the GENetics of adipocyte lipolysis (GENiAL) cohort.
Agné Kulyté, Veroniqa Lundbäck, Cecilia M Lindgren, Jian'an Luan, Luca A Lotta, Claudia Langenberg, Peter Arner, Rona J Strawbridge, Ingrid Dahlman
Apr 17, 2020
OBJECTIVES:Lipolysis, hydrolysis of triglycerides to fatty acids in adipocytes, is tightly regulated, poorly understood, and, if perturbed, can lead to metabolic diseases including obesity and type 2 diabetes. The goal of this...
Published by: Molecular metabolism
Genome-wide association study of adipocyte lipolysis in the GENetics of adipocyte lipolysis (GENiAL) cohort.
Agné Kulyté, Veroniqa Lundbäck, Cecilia M Lindgren, Jian'an Luan, Luca A Lotta, Claudia Langenberg, Peter Arner, Rona J Strawbridge, Ingrid Dahlman
Apr 01, 2020
OBJECTIVES: Lipolysis, hydrolysis of triglycerides to fatty acids in adipocytes, is tightly regulated, poorly understood, and, if perturbed, can lead to metabolic diseases including obesity and type 2 diabetes. The goal of this...
Synergistic insights into human health from aptamer- and antibody-based proteomic profiling.
Maik Pietzner, Eleanor Wheeler, Julia Carrasco-Zanini, Nicola D Kerrison, Erin Oerton, Mine Koprulu, Jian'an Luan, Aroon D Hingorani, Steve A Williams, Nicholas J Wareham, Claudia Langenberg
Jan 07, 2022
Genome-wide Association Study for Vitamin D Levels Reveals 69 Independent Loci.
Despoina Manousaki, Ruth Mitchell, Tom Dudding, Simon Haworth, Adil Harroud, Vincenzo Forgetta, Rupal L Shah, Jian'an Luan, Claudia Langenberg, Nicholas J Timpson, J Brent Richards
Jan 14, 2021
We aimed to increase our understanding of the genetic determinants of vitamin D levels by undertaking a large-scale genome-wide association study (GWAS) of serum 25 hydroxyvitamin D (25OHD). To do so, we used imputed genotypes...
Regional fat depot masses are influenced by protein-coding gene variants.
Matt J Neville, Laura BL Wittemans, Katherine E Pinnick, Marijana Todorčević, Risto Kaksonen, Kirsi H Pietiläinen, Jian'an Luan, Robert A Scott, Nicholas J Wareham, Claudia Langenberg, Fredrik Karpe
Jun 24, 2019
Waist-to-hip ratio (WHR) is a prominent cardiometabolic risk factor that increases cardio-metabolic disease risk independently of BMI and for which multiple genetic loci have been identified. However, WHR is a relatively crude...
Meta-analysis investigating the role of interleukin-6 mediated inflammation in type 2 diabetes.
Nicholas Bowker, Rupal L Shah, Stephen J Sharp, Jian'an Luan, Isobel D Stewart, Eleanor Wheeler, Manuel AR Ferreira, Aris Baras, Nicholas J Wareham, Claudia Langenberg, Luca A Lotta
Oct 07, 2020
Genetic Interleukin-6 Trans-ethnic Type 2 diabetes Adiposity Biomarkers Blood Glucose Body Weights and Measures Cytokines Diabetes mellitus Type 2 Disease Susceptibility Genetic Predisposition to Disease Humans Inflammation Inflammation Mediators Interleukin-6 Odds Ratio Receptors Interleukin-6 Risk Factors Signal Transduction
Association of Genetically Enhanced Lipoprotein Lipase-Mediated Lipolysis and Low-Density Lipoprotein Cholesterol-Lowering Alleles With Risk of Coronary Disease and Type 2 Diabetes.
Luca A Lotta, Isobel D Stewart, Stephen J Sharp, Felix R Day, Stephen Burgess, Jian'an Luan, Nicholas Bowker, Lina Cai, Chen Li, Laura BL Wittemans, Nicola D Kerrison, Kay-Tee Khaw, Mark I McCarthy, Stephen O'Rahilly, Robert A Scott, David B Savage, John RB Perry, Claudia Langenberg, Nicholas J Wareham
Nov 05, 2018
Aged Angiopoietin-Like Protein 4 Cholesterol LDL Coronary Artery Disease Diabetes mellitus Type 2 Female Genetic Association Studies Genetic Predisposition to Disease Humans Hydroxymethylglutaryl CoA Reductases Lipolysis Lipoprotein Lipase Male Membrane Proteins Membrane Transport Proteins Middle Aged Odds Ratio Proprotein Convertase 9
Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations
Bram P Prins, Karoline B Kuchenbaecker, Yanchun Bao, Melissa Smart, Delilah Zabaneh, Ghazaleh Fatemifar, Jian'an Luan, Nick J Wareham, Robert A Scott, John RB Perry, Claudia Langenberg, Michaela Benzeval, Meena Kumari, Eleftheria Zeggini
Dec 12, 2017
Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene.
Katherine A Kentistou, Jian'an Luan, Laura BL Wittemans, Catherine Hambly, Lucija Klaric, Zoltán Kutalik, John R Speakman, Nicholas J Wareham, Timothy J Kendall, Claudia Langenberg, James F Wilson, Peter K Joshi, Nicholas M Morton
Feb 19, 2023
Obesity remains an unmet global health burden. Detrimental anatomical distribution of body fat is a major driver of obesity-mediated mortality risk and is demonstrably heritable. However, our understanding of the full genetic...
Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene.
Katherine A Kentistou, Jian'an Luan, Laura BL Wittemans, Catherine Hambly, Lucija Klaric, Zoltán Kutalik, John R Speakman, Nicholas J Wareham, Timothy J Kendall, Claudia Langenberg, James F Wilson, Peter K Joshi, Nicholas M Morton
Jan 19, 2023
Obesity remains an unmet global health burden. Detrimental anatomical distribution of body fat is a major driver of obesity-mediated mortality risk and is demonstrably heritable. However, our understanding of the full genetic...
Liver Function and Risk of Type 2 Diabetes
N Maneka G De Silva, Maria Carolina Borges, Aroon D Hingorani, Jorgen Engmann, Tina Shah, Xiaoshuai Zhang, Jian'an Luan, Claudia Langenberg, Andrew Wong, Diana Kuh, John C Chambers, Weihua Zhang, Marjo-Ritta Jarvelin, Sylvain Sebert, Juha Auvinen, UCLEB Consortium, Tom R Gaunt, Deborah A Lawlor
May 15, 2019
Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity.
Luca A Lotta, Jacek Mokrosiński, Edson Mendes de Oliveira, Chen Li, Stephen J Sharp, Jian'an Luan, Bas Brouwers, Vikram Ayinampudi, Nicholas Bowker, Nicola Kerrison, Vasileios Kaimakis, Diana Hoult, Isobel D Stewart, Eleanor Wheeler, Felix R Day, John RB Perry, Claudia Langenberg, Nicholas J Wareham, I Sadaf Farooqi
Apr 12, 2019
The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor whose disruption causes obesity. We functionally characterized 61 MC4R variants identified in 0.5 million people from UK Biobank and examined their associations...
GPCRs MC4R UK Biobank biased signaling Genetics melanocortin obesity β-Arrestin Adult Aged Body Mass Index Coronary Artery Disease Cyclic AMP Databases Factual Diabetes mellitus Type 2 Female GTP-Binding Protein alpha Subunits Gs Gain of Function Mutation Genetic Predisposition to Disease Genotype Humans Male Middle Aged obesity Polymorphism Single Nucleotide Receptor Melanocortin Type 4 Signal Transduction beta-Arrestins
Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors.
Luca A Lotta, Laura BL Wittemans, Verena Zuber, Isobel D Stewart, Stephen J Sharp, Jian'an Luan, Felix R Day, Chen Li, Nicholas Bowker, Lina Cai, Emanuella De Lucia Rolfe, Kay-Tee Khaw, John RB Perry, Stephen O'Rahilly, Robert A Scott, David B Savage, Stephen Burgess, Nicholas J Wareham, Claudia Langenberg
Jan 07, 2019
Mapping the proteo-genomic convergence of human diseases.
Maik Pietzner, Eleanor Wheeler, Julia Carrasco-Zanini, Adrian Cortes, Mine Koprulu, Maria A Wörheide, Erin Oerton, James Cook, Isobel D Stewart, Nicola D Kerrison, Jian'an Luan, Johannes Raffler, Matthias Arnold, Wiebke Arlt, Stephen O'Rahilly, Gabi Kastenmüller, Eric R Gamazon, Aroon D Hingorani, Robert A Scott, Nicholas J Wareham, Claudia Langenberg
Oct 07, 2021
aging Alternative Splicing Blood Proteins covid-19 Connective Tissue Diseases Disease Drug development Female Gallstones Genetic Association Studies genetic variation Genome Human Genome-Wide Association Study Genomics Humans Internet Male Phenotype Proteins Proteome Quantitative Trait Loci Sex Characteristics
An integrative model of new product evaluation
The literature on perceived novelty and product evaluation has diverged into two disparate streams of research. The first stream builds on theories of curiosity and argues that the perceived novelty of a new product benefits...
An integrative model of new product evaluation
The literature on perceived novelty and product evaluation has diverged into two disparate streams of research. The first stream builds on theories of curiosity and argues that the perceived novelty of a new product benefits...
Risk Prediction of the Development of the Digital Economy Industry Based on a Machine Learning Model in the Context of Rural Revitalization
In today's society, rural areas face challenges such as complex terrain and uneven population distribution, and infrastructure construction is exceptionally difficult. At the same time, poor information transmission and low...
Published by: IGI Global Scientific Publishing
The Spatial Influence on Vocabulary Acquisition in an Immersive Virtual Reality-Mediated Learning Environment
This study aims to investigate whether VR-assisted language learning facilitates EFL learners' vocabulary learning and memory retention. One hundred seventy-seven Chinese undergraduate EFL learners were divided into VRG...
Published by: IGI Global Scientific Publishing
Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults.
Tibor V Varga, Azra Kurbasic, Mattias Aine, Pontus Eriksson, Ashfaq Ali, George Hindy, Stefan Gustafsson, Jian'an Luan, Dmitry Shungin, Yan Chen, Christina-Alexandra Schulz, Peter M Nilsson, Göran Hallmans, Inês Barroso, Panos Deloukas, Claudia Langenberg, Robert A Scott, Nicholas J Wareham, Lars Lind, Erik Ingelsson, Olle Melander, Marju Orho-Melander, Frida Renström, Paul W Franks
Aug 15, 2017
BACKGROUND: Cross-sectional genome-wide association studies have identified hundreds of loci associated with blood lipids and related cardiovascular traits, but few genetic association studies have focused on long-term changes...
Prospective cohort study Genetic epidemiology longitudinal analysis Morbidity single nucleotide polymorphism Total cholesterol Triglycerides Adult Aged Coronary Artery Disease Cross-Sectional Studies Female Genetic Loci Genome-Wide Association Study Genotype Humans Lipids Male Meta-Analysis as Topic Middle Aged Polymorphism Single Nucleotide Prospective Studies Sweden White People
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