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The Rating of Basketball Players' Competitive Performance Based on RBF-EVA Method
Basketball, as an offensive and defensive game centered around high altitude, has become an international mass competitive sport. Traditional methods cannot comprehensively evaluate the future potential of players, nor can they...
Published by: IGI Global Scientific Publishing
DNA methylation at differentially methylated regions of imprinted genes is resistant to developmental programming by maternal nutrition.
The nutritional environment in which the mammalian fetus or infant develop is recognized as influencing the risk of chronic diseases, such as type 2 diabetes and hypertension, in a phenomenon that has become known as...
Maternal protein restriction affects postnatal growth and the expression of key proteins involved in lifespan regulation in mice.
We previously reported that maternal protein restriction in rodents influenced the rate of growth in early life and ultimately affected longevity. Low birth weight caused by maternal protein restriction followed by catch-up...
Human pluripotent stem cell-based models suggest preadipocyte senescence as a possible cause of metabolic complications of Werner and Bloom Syndromes.
Werner Syndrome (WS) and Bloom Syndrome (BS) are disorders of DNA damage repair caused by biallelic disruption of the WRN or BLM DNA helicases respectively. Both are commonly associated with insulin resistant diabetes, usually...
DNA damage, cellular senescence and organismal ageing
Cellular senescence has long been used as a cellular model for understanding mechanisms underlying the ageing process. Compelling evidence obtained in recent years demonstrate that DNA damage is a common mediator for both...
The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice.
Gerotarget developmental programming immunosenescence lifespan maternal diet thymic involution aging Animal Nutritional Physiological Phenomena Animals Blotting Western Cells Cultured Diet Protein-Restricted Female Flow Cytometry Fluorescent Antibody Technique Immunosenescence Lactation Mice Mice Inbred C57BL RNA Messenger Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction T-Lymphocytes Thymus Gland
Study on Transient Gap Resonance with Consideration of the Motion of Floating Body
In this paper, the transient fluid resonance phenomenon inside a narrow gap between two adjacent boxes excited by the incident focused waves with various spectral peak periods and focused wave amplitudes is simulated by...
Focused waves free-surface amplification Heave motion OpenFOAM transient gap resonance Wave loads /dk/atira/pure/subjectarea/asjc/1900/1910 name=Oceanography /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/2200/2212 name=Ocean Engineering /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Study on Transient Gap Resonance with Consideration of the Motion of Floating Body
In this paper, the transient fluid resonance phenomenon inside a narrow gap between two adjacent boxes excited by the incident focused waves with various spectral peak periods and focused wave amplitudes is simulated by...
Focused waves free-surface amplification Heave motion OpenFOAM transient gap resonance Wave loads /dk/atira/pure/subjectarea/asjc/1900/1910 name=Oceanography /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/2200/2212 name=Ocean Engineering /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Electrostatic force driven helium insertion into ammonia and water crystals under pressure
Yihong Bai, Zhen Liu, Jorge Botana, Dadong Yan, Hai-Qing Lin, Jian Sun, Chris J. Pickard, Richard J. Needs, Mao-Sheng Miao
Sep 01, 2020
Abstract: Helium, ammonia and ice are among the major components of giant gas planets, and predictions of their chemical structures are therefore crucial in predicting planetary dynamics. Here we demonstrate a strong driving...
Monoamine oxidase-A promotes protective autophagy in human SH-SY5Y neuroblastoma cells through Bcl-2 phosphorylation.
Aslihan Ugun-Klusek, Theodosis S Theodosi, Julia C Fitzgerald, Florence Burté, Christoph Ufer, David J Boocock, Patrick Yu-Wai-Man, Lynn Bedford, E Ellen Billett
Dec 07, 2018
Monoamine oxidases (MAOs) are located on the outer mitochondrial membrane and are drug targets for the treatment of neurological disorders. MAOs control the levels of neurotransmitters in the brain via oxidative deamination and...
Autophagy Monoamine Oxidase neurodegeneration Reactive Oxygen Species Autophagy Caspases Cell Line Tumor Cell Survival Fluorescent Antibody Technique Gene Expression Humans Immunohistochemistry Mitochondria Models Biological Monoamine Oxidase Neuroblastoma Oxidation-Reduction Oxidative Stress Phosphorylation Proteome Proteomics Proto-Oncogene Proteins c-bcl-2 Reactive Oxygen Species
Water-stable porous Al24 Archimedean solids for removal of trace iodine.
Ya-Jie Liu, Yi-Fan Sun, Si-Hao Shen, San-Tai Wang, Zhuang-Hua Liu, Wei-Hui Fang, Dominic S Wright, Jian Zhang
Nov 04, 2022
In this paper, we report a unique type of core-shell crystalline material that combines an inorganic zeolitic cage structure with a macrocyclic host arrangement and that can remove trace levels of iodine from water effectively....
Pressure-stabilized divalent ozonide CaO3 and its impact on Earth's oxygen cycles.
Yanchao Wang, Meiling Xu, Liuxiang Yang, Bingmin Yan, Qin Qin, Xuecheng Shao, Yunwei Zhang, Dajian Huang, Xiaohuan Lin, Jian Lv, Dongzhou Zhang, Huiyang Gou, Ho-Kwang Mao, Changfeng Chen, Yanming Ma
Nov 16, 2020
High pressure can drastically alter chemical bonding and produce exotic compounds that defy conventional wisdom. Especially significant are compounds pertaining to oxygen cycles inside Earth, which hold key to understanding...
Determinants of Individual Knowledge Innovation Behavior
With the upsurge of "emotional storm" in the field of organizational behavior, the studies on individual emotions in organizational context are rising. Especially the relationship between emotions and knowledge innovation has...
Published by: IGI Global Scientific Publishing
Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer.
Zhi Hu, Jian-Hua Mao, Christina Curtis, Ge Huang, Shenda Gu, Laura Heiser, Marc E Lenburg, James E Korkola, Nora Bayani, Shamith Samarajiwa, Jose A Seoane, Mark A Dane, Amanda Esch, Heidi S Feiler, Nicholas J Wang, Mary Ann Hardwicke, Sylvie Laquerre, Jeff Jackson, Kenneth W Wood, Barbara Weber, Paul T Spellman, Samuel Aparicio, Richard Wooster, Carlos Caldas, Joe W Gray
Oct 18, 2018
BACKGROUND: High mitotic activity is associated with the genesis and progression of many cancers. Small molecule inhibitors of mitotic apparatus proteins are now being developed and evaluated clinically as anticancer agents....
Breast Cancer Mitotic Index Novel therapeutics Predictive biomarker Aurora Kinases Breast Neoplasms Cell Cycle Proteins Cell Line Tumor Cell Proliferation Chromosomal Proteins Non-Histone Female Gene Amplification Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Regulatory Networks Genome Human Humans Kaplan-Meier Estimate Mitosis Prognosis Protein Serine-Threonine Kinases Proto-Oncogene Proteins RNA Interference Small Molecule Libraries Treatment Outcome
Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats
Jane L Tarry-Adkins, Denise S Fernandez-Twinn, Jian Hua Chen, Iain P Hargreaves, Viruna Neergheen, Catherine E Aiken, Susan E Ozanne
Apr 05, 2018
developmental programming Mitochondria Oxidative Stress Skeletal muscle aging Animals antioxidants Biomarkers DNA Damage Diet Female Growth and Development Inflammation Male Maternal Nutritional Physiological Phenomena Muscle Skeletal NF-kappa B Oxidants Oxidative Stress Phenotype Rats Wistar Telomere Shortening
Monoamine oxidase-dependent endoplasmic reticulum-mitochondria dysfunction and mast cell degranulation lead to adverse cardiac remodeling in diabetes.
Soni Deshwal, Marleen Forkink, Chou-Hui Hu, Guido Buonincontri, Salvatore Antonucci, Moises Di Sante, Michael P Murphy, Nazareno Paolocci, Daria Mochly-Rosen, Thomas Krieg, Fabio Di Lisa, Nina Kaludercic
May 14, 2018
Monoamine oxidase (MAO) inhibitors ameliorate contractile function in diabetic animals, but the mechanisms remain unknown. Equally elusive is the interplay between the cardiomyocyte alterations induced by hyperglycemia and the...
Animals Cell Degranulation Diabetes mellitus Experimental Endoplasmic reticulum stress Glucose Interleukin-1beta Male Mice Mice Inbred C57BL Mitochondria Mitochondrial Membrane Transport Proteins Mitochondrial Permeability Transition Pore Monoamine Oxidase Monoamine Oxidase Inhibitors Muscle Cells Myocardium RNA Interference RNA Small Interfering Rats Reactive Oxygen Species Ventricular Remodeling
A suboptimal maternal diet combined with accelerated postnatal growth results in an altered aging profile in the thymus of male rats.
Jane L Tarry-Adkins, Catherine E Aiken, Thomas J Ashmore, Denise S Fernandez-Twinn, Jian-Hua Chen, Susan E Ozanne
Sep 05, 2018
Reduced fetal nutrition and rapid postnatal growth accelerates the aging phenotype in many organ systems; however, effects on the immune system are unclear. We addressed this by studying the thymus from a rat model of...
Coenzyme Q10 Prevents Insulin Signaling Dysregulation and Inflammation Prior to Development of Insulin Resistance in Male Offspring of a Rat Model of Poor Maternal Nutrition and Accelerated Postnatal Growth.
Jane L Tarry-Adkins, Denise S Fernandez-Twinn, Ralitsa Madsen, Jian-Hua Chen, Asha Carpenter, Iain P Hargreaves, Josie M McConnell, Susan E Ozanne
Aug 03, 2015
Truncation of POC1A associated with short stature and extreme insulin resistance.
Jian-Hua Chen, Maria Segni, Felicity Payne, Isabel Huang-Doran, Alison Sleigh, Claire Adams, UK10K consortium, David B Savage, Stephen O'Rahilly, Robert K Semple, Inês Barroso
Aug 19, 2015
POC1A centriole Centrosome Diabetes dyslipidaemia Insulin Resistance primary cilium short stature skeletal dysplasia Adult Amino Acid Sequence Body Height Cell Cycle Cell Cycle Proteins Centrioles Centrosome Cytoskeletal Proteins Dwarfism Facies Fatty Liver Female Frameshift Mutation Humans Insulin Resistance Mitosis Molecular Sequence Data Protein Isoforms Proteins Sequence Alignment Spindle Apparatus
Evaluation of human dermal fibroblasts directly reprogrammed to adipocyte-like cells as a metabolic disease model.
Jian-Hua Chen, Kim Jee Goh, Nuno Rocha, Matthijs P Groeneveld, Marina Minic, Timothy G Barrett, David Savage, Robert K Semple
May 25, 2018
Adipose tissue is the primary tissue affected in most single gene forms of severe insulin resistance, and growing evidence has implicated it as a site at which many risk alleles for insulin resistance identified in...
microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma.
Julja Burchard, Chunsheng Zhang, Angela M Liu, Ronnie TP Poon, Nikki PY Lee, Kwong-Fai Wong, Pak C Sham, Brian Y Lam, Mark D Ferguson, George Tokiwa, Ryan Smith, Brendan Leeson, Rebecca Beard, John R Lamb, Lee Lim, Mao Mao, Hongyue Dai, John M Luk
Aug 08, 2017
Tumorigenesis involves multistep genetic alterations. To elucidate the microRNA (miRNA)-gene interaction network in carcinogenesis, we examined their genome-wide expression profiles in 96 pairs of tumor/non-tumor tissues from...
Animals Carcinoma Hepatocellular Cell Line Tumor Down-Regulation Energy Metabolism Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Regulatory Networks Genes Mitochondrial Humans Liver Liver Neoplasms Mice Mice Inbred C57BL MicroRNAs Mitochondria RNA Messenger Reproducibility of Results Sequence Homology Nucleic Acid Signal Transduction Survival Analysis Up-Regulation
Water-stable porous Al<sub>24</sub> Archimedean solids for removal of trace iodine.
Ya-Jie Liu, Yi-Fan Sun, Si-Hao Shen, San-Tai Wang, Zhuang-Hua Liu, Wei-Hui Fang, Dominic S Wright, Jian Zhang
Dec 08, 2022
In this paper, we report a unique type of core-shell crystalline material that combines an inorganic zeolitic cage structure with a macrocyclic host arrangement and that can remove trace levels of iodine from water effectively....
Published by: Nature Communications
Exposing the Interplay Between Enzyme Turnover, Protein Dynamics and the Membrane Environment in Monoamine Oxidase B
Hannah B L Jones, Rory M Crean, Anna Mullen, Emanuele Kendrick, Steven D Bull, Stephen A Wells, David Ross Carbery, Fraser MacMillan, Marc W van der Kamp, Christopher Roland Pudney
May 07, 2019
There is an increasing realization that structure-based drug design may show improved success by understanding the ensemble of conformations accessible to an enzyme and how the environment affects this ensemble. Human...
Exposing the Interplay Between Enzyme Turnover, Protein Dynamics and the Membrane Environment in Monoamine Oxidase B
Hannah B L Jones, Rory M Crean, Anna Mullen, Emanuele Kendrick, Steven D Bull, Stephen A Wells, David Ross Carbery, Fraser MacMillan, Marc W van der Kamp, Christopher Roland Pudney
May 07, 2019
There is an increasing realization that structure-based drug design may show improved success by understanding the ensemble of conformations accessible to an enzyme and how the environment affects this ensemble. Human...
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