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Modular reorganization of the global network of gene regulatory interactions during perinatal human brain development
Background
During early development of the nervous system, gene expression patterns are known to vary widely depending on the specific developmental trajectories of different structures. Observable changes in gene expression...
During early development of the nervous system, gene expression patterns are known to vary widely depending on the specific developmental trajectories of different structures. Observable changes in gene expression...
Modular reorganization of the global network of gene regulatory interactions during perinatal human brain development
Background
During early development of the nervous system, gene expression patterns are known to vary widely depending on the specific developmental trajectories of different structures. Observable changes in gene expression...
During early development of the nervous system, gene expression patterns are known to vary widely depending on the specific developmental trajectories of different structures. Observable changes in gene expression...
Increased brain size in mammals is associated with size variations in gene families with cell signalling, chemotaxis and immune-related functions
Genomic determinants underlying increased encephalization across mammalian lineages are unknown. Whole genome comparisons have revealed large and frequent changes in the size of gene families, and it has been proposed that these...
Increased brain size in mammals is associated with size variations in gene families with cell signalling, chemotaxis and immune-related functions
Genomic determinants underlying increased encephalization across mammalian lineages are unknown. Whole genome comparisons have revealed large and frequent changes in the size of gene families, and it has been proposed that these...
Transcriptional, behavioural and biochemical profiling in the 3xTg-AD mouse model reveals a specific signature of amyloid deposition and functional decline in Alzheimer’s disease
Wencheng Yin, Navei Cerda Hernandez, Atahualpa Castillo Morales, Mayra Ruiz Tejada Segura, Jimena Monzón Sandoval, Perla Moreno Castillo, Rodrigo Perez Ortega, Federico Bermudez Rattoni, Araxi Urrutia, Humberto Gutierrez
Dec 15, 2020
Alzheimer’s disease (AD)-related degenerative decline is associated to the presence of amyloid beta (Aβ) plaque lesions and neuro fibrillary tangles (NFT). However, the precise molecular mechanisms linking Aβ deposition and...
Transcriptional, behavioural and biochemical profiling in the 3xTg-AD mouse model reveals a specific signature of amyloid deposition and functional decline in Alzheimer’s disease
Wencheng Yin, Navei Cerda Hernandez, Atahualpa Castillo Morales, Mayra Ruiz Tejada Segura, Jimena Monzón Sandoval, Perla Moreno Castillo, Rodrigo Perez Ortega, Federico Bermudez Rattoni, Araxi Urrutia, Humberto Gutierrez
Dec 15, 2020
Alzheimer’s disease (AD)-related degenerative decline is associated to the presence of amyloid beta (Aβ) plaque lesions and neuro fibrillary tangles (NFT). However, the precise molecular mechanisms linking Aβ deposition and...
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Renzo Mancuso, Gemma Fryatt, Madeleine Cleal, Juliane Obst, Elena Pipi, Jimena Monzón-Sandoval, Elena Ribe, Laura Winchester, Caleb Webber, Alejo Nevado, Tom Jacobs, Nigel Austin, Clara Theunis, Karolien Grauwen, Eva Daniela Ruiz, Amrit Mudher, Marta Vicente-Rodriguez, Christine A Parker, Camilla Simmons, Diana Cash, Jill Richardson, NIMA Consortium, Declan NC Jones, Simon Lovestone, Diego Gómez-Nicola, V Hugh Perry
Dec 05, 2019
Guidelines for Data Collection to Measure SDG 4.7.4 and 4.7.5
In an effort to promote robust and comparable measurements of SDG 4 in this Decade of Action as nations strive to meet education targets, the UIS has spearheaded a methodological program on learning outcomes. Drawing from the...
SDGs global citizenship sustainability ICCS ILSA TIMSS measurement /dk/atira/pure/sustainabledevelopmentgoals/quality_education name=SDG 4 - Quality Education
Published by: UNESCO Institute for Statistics
Guidelines for Data Collection to Measure SDG 4.7.4 and 4.7.5
In an effort to promote robust and comparable measurements of SDG 4 in this Decade of Action as nations strive to meet education targets, the UIS has spearheaded a methodological program on learning outcomes. Drawing from the...
SDGs global citizenship sustainability ICCS ILSA TIMSS measurement /dk/atira/pure/sustainabledevelopmentgoals/quality_education name=SDG 4 - Quality Education
Published by: UNESCO Institute for Statistics
Genetic dissection of a regionally differentiated network for exploratory behavior in Drosophila larvae.
Jimena Berni
May 21, 2015
Protein amino acid composition
Large brains relative to body size represent an evolutionarily costly adaptation as they are metabolically expensive and demand substantial amounts of time to reach structural and functional maturity thereby exacerbating...
Polypyrimidine tract-binding proteins are essential for B cell development.
Elisa Monzón-Casanova, Louise S Matheson, Kristina Tabbada, Kathi Zarnack, Christopher WJ Smith, Martin Turner
May 11, 2020
Polypyrimidine tract-binding protein 1 (PTBP1) is a RNA-binding protein (RBP) expressed throughout B cell development. Deletion of Ptbp1 in mouse pro-B cells results in upregulation of PTBP2 and normal B cell development. We...
B Cell Development RNA-Binding Proteins Alternative Splicing Cell Cycle Chromosomes Gene Expression immunology Inflammation MOUSE Animals B-Lymphocytes Cell Cycle Cell Differentiation Cell Proliferation Female Flow Cytometry Gene Expression Regulation Heterogeneous-Nuclear Ribonucleoproteins Male Mice Nerve Tissue Proteins Polypyrimidine Tract-Binding Protein RNA-Binding Proteins
The transcription factor SoxD controls neuronal guidance in the Drosophila visual system.
Esteban G Contreras, Tomás Palominos, Álvaro Glavic, Andrea H Brand, Jimena Sierralta, Carlos Oliva
Nov 13, 2018
Precise control of neurite guidance during development is essential to ensure proper formation of neuronal networks and correct function of the central nervous system (CNS). How neuronal projections find their targets to...
Optimal searching behaviour generated intrinsically by the central pattern generator for locomotion.
Efficient searching for resources such as food by animals is key to their survival. It has been proposed that diverse animals from insects to sharks and humans adopt searching patterns that resemble a simple Lévy random walk...
D. melanogaster central pattern generator Ecology Exploration levy walk Locomotion neuroscience Animals Apoptosis Appetitive Behavior Brain Central pattern generators Cues Drosophila Proteins Drosophila melanogaster Dynamins Exploratory Behavior Feeding Behavior Larva Locomotion Probability Temperature
Protein amino acid composition
Large brains relative to body size represent an evolutionarily costly adaptation as they are metabolically expensive and demand substantial amounts of time to reach structural and functional maturity thereby exacerbating...
Polypyrimidine tract-binding proteins are essential for B cell development
Elisa Monzón-Casanova, Louise S Matheson, Kristina Tabbada, Kathi Zarnack, Christopher WJ Smith, Martin Turner
Mar 06, 2020
Polypyrimidine tract-binding protein 1 (PTBP1) is a RNA-binding protein (RBP) expressed throughout B cell development. Deletion of Ptbp1 in mouse pro-B cells results in upregulation of PTBP2 and normal B cell development. We...
The Serine Protease Homolog, Scarface, Is Sensitive to Nutrient Availability and Modulates the Development of the Drosophila Blood-Brain Barrier.
Essential requirement for polypyrimidine tract binding proteins 1 and 3 in the maturation and maintenance of mature B cells in mice.
The maturation of immature B cells and the survival of mature B cells is stringently controlled to maintain a diverse repertoire of antibody specificities while avoiding self-reactivity. At the molecular level this is regulated...
PTBP1 PTBP3 RNA binding proteins mature B cells posttranscriptional gene expression regulation 3' Untranslated Regions Alternative Splicing Animals B-Lymphocytes Gene Expression Regulation Heterogeneous-Nuclear Ribonucleoproteins Mice Mice Inbred C57BL Mice Knockout Polypyrimidine Tract-Binding Protein Signal Transduction Transcriptome
Drosophila para bss Flies as a Screening Model for Traditional Medicine
Samuel S. Dare, Emiliano Merlo, Jesus Rodriguez Curt, Peter E. Ekanem, Nan Hu, Jimena Berni
Jan 27, 2021
Epilepsy is among the most common serious neurological disorders and affects around 50 million people worldwide, 80% of which live in developing countries. Despite the introduction of several new Anti-Epileptic Drugs (AEDs) in...
The Serine Protease Homolog, Scarface, Is Sensitive to Nutrient Availability and Modulates the Development of the <i>Drosophila</i> Blood-Brain Barrier.
The adaptable transcriptional response to changes in food availability not only ensures animal survival but also lets embryonic development progress. Interestingly, the CNS is preferentially protected from periods of...
Polypyrimidine tract-binding proteins are essential for B cell development.
Elisa Monzón-Casanova, Louise S Matheson, Kristina Tabbada, Kathi Zarnack, Christopher WJ Smith, Martin Turner
Mar 25, 2020
Polypyrimidine tract-binding protein 1 (PTBP1) is a RNA-binding protein (RBP) expressed throughout B cell development. Deletion of Ptbp1 in mouse pro-B cells results in upregulation of PTBP2 and normal B cell development. We...
Cell Cycle MOUSE Alternative Splicing Inflammation Chromosomes immunology Gene Expression RNA-Binding Proteins B Cell Development
Published by: eLife
Drosophila para bss Flies as a Screening Model for Traditional Medicine
Samuel S Dare, Emiliano Merlo, Jesus Rodriguez Curt, Peter E Ekanem, Nan Hu, Jimena Berni
Mar 01, 2021
Epilepsy is among the most common serious neurological disorders and affects around 50 million people worldwide, 80% of which live in developing countries. Despite the introduction of several new Anti-Epileptic Drugs (AEDs) in...
The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers.
Elisa Monzón-Casanova, Michael Screen, Manuel D Díaz-Muñoz, Richard Mr Coulson, Sarah E Bell, Greta Lamers, Michele Solimena, Christopher WJ Smith, Martin Turner
Aug 30, 2018
Antibody affinity maturation occurs in germinal centers (GCs), where B cells cycle between the light zone (LZ) and the dark zone. In the LZ, GC B cells bearing immunoglobulins with the highest affinity for antigen receive...
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