Search

Results: 587
Target Enzyme-Activated Two-Photon Fluorescent Probes

The rapid development of fluorescent probes for monitoring target enzymes is still a great challenge owing to the lack of efficient ways to optimize a specific fluorophore. Herein, a practical two-dimensional strategy was...

Target Enzyme-Activated Two-Photon Fluorescent Probes

The rapid development of fluorescent probes for monitoring target enzymes is still a great challenge owing to the lack of efficient ways to optimize a specific fluorophore. Herein, a practical two-dimensional strategy was...

Molecular Design Strategy to Construct the Near-Infrared Fluorescent Probe for Selectively Sensing Human Cytochrome P450 2J2

Cytochrome P450 2J2 (CYP2J2), a key enzyme responsible for oxidative metabolism of various xenobiotics and endogenous compounds, participates in a diverse array of physiological and pathological processes in humans. Its...

Molecular Design Strategy to Construct the Near-Infrared Fluorescent Probe for Selectively Sensing Human Cytochrome P450 2J2

Cytochrome P450 2J2 (CYP2J2), a key enzyme responsible for oxidative metabolism of various xenobiotics and endogenous compounds, participates in a diverse array of physiological and pathological processes in humans. Its...

Rational Design of a Two-Photon Fluorescent Probe for Human Cytochrome P450 3A and the Visualization of Mechanism-Based Inactivation

Mechanism-based inactivation (MBI) can mediate adverse reactions and hepatotoxicity from drugs, which is a result of their conversion into highly reactive metabolites catalyzed by enzymes such as cytochrome P450 3A (CYP3A)....

Empathy, Theory of Mind, and Prosocial Behaviors in Autistic Children.
BACKGROUND: Previous research has suggested that children with autism spectrum disorder (ASD) display fewer prosocial behaviors, and the role of empathy or Theory of Mind (ToM) in prosocial behaviors of autistic children remains...
Rational Design of a Two-Photon Fluorescent Probe for Human Cytochrome P450 3A and the Visualization of Mechanism-Based Inactivation

Mechanism-based inactivation (MBI) can mediate adverse reactions and hepatotoxicity from drugs, which is a result of their conversion into highly reactive metabolites catalyzed by enzymes such as cytochrome P450 3A (CYP3A)....

Behavior Recognition of College Students Based on Improved Deep Learning Algorithm
Xiaoke Ning
Feb 23, 2023
With the vigorous development of intelligent campus construction, great changes have taken place in the development of information technology in colleges and universities from the previous digital to intelligent development. In...
Sex-linked genetic diversity originates from persistent sociocultural processes at microgeographic scales.
Population genetics has been successful at identifying the relationships between human groups and their interconnected histories. However, the link between genetic demography inferred at large scales and the individual human...
The influence of oral vocabulary knowledge on individual differences in a computational model of reading.
Ya-Ning Chang
Jan 30, 2023
Studies have demonstrated systematic individual differences in the degree of semantic reliance (SR) when reading aloud exception words in adult skilled readers. However, the origins of individual differences in reading remain...
Semantic ambiguity effects on traditional Chinese character naming
Words are considered semantically ambiguous if they have more than one meaning and can be used in multiple contexts. A number of recent studies have provided objective ambiguity measures by using a corpus-based approach and have...
Can You Help Me Stay Fit?
En Mao, Jing Zhang
Jan 01, 2022
The main purpose of this study is to reveal the impact of consumer satisfaction on continuance intention to use wearable fitness devices. Building upon the IS Continuance Intention Model, the authors explored the effects of...
Activation mechanism of the class D fungal GPCR dimer Ste2.
The fungal class D1 G-protein-coupled receptor (GPCR) Ste2 has a different arrangement of transmembrane helices compared with mammalian GPCRs and a distinct mode of coupling to the heterotrimeric G protein Gpa1-Ste2-Ste181. In...
Power System Relay Protection Based on Faster R-CNN Algorithm
The technology of relay protection in China's power system has gradually changed from the traditional operation mode to the development direction of informatization, intelligence, and automation. As a result, the role of relay...
Personal Health and Illness Management and the Future Vision of Biomedical Clothing Based on WSN
Ge Zhang, Zubin Ning
Jan 01, 2023
It is essential to have a fast, reliable, and energy-efficient connection between wireless sensor networks (WSNs). Control specifications, networking layers, media access control, and physical layers should be optimised or...
Experimental and numerical study of hot-rolled duplex stainless steel CHS columns

Stainless steel circular hollow section (CHS) members have been widely used in building structures because of their comparable strength to structural carbon steels, attractive appearance and excellent corrosion resistance....

A 3D parallel Particle-In-Cell solver for extreme wave interaction with floating bodies
Floating structures are widely used for vessels, offshore platforms, and recently considered for deep water floating offshore wind system and wave energy devices. However, modelling complex wave interactions with floating...
Genomic evolution of cancer metastasis under therapeutic pressure
Abstract: In the era of precision medicine, the selection of cancer treatment relies increasingly on the identification of genomic alterations; however, it is not yet clear how frequently genomic profiling should be performed...
Did firm age, experience, and access to finance count? SME performance after the global financial crisis

This paper examines the relationships between firm age and entrepreneurs experience on SME performance after the 2008/09 global financial crisis. We find that in general the crisis had a long-lasting scarring effect on the...

Coping with multiple institutional logics
An increasing body of research has applied an institutional perspective to understand actors’ responses to conflicting institutional logics and the creation process of new organizational forms. Although China provides a natural...
Innovation of the Teaching Mode of History Courses in Colleges and Universities Based on Digital Technology
There are some problems in the teaching reform of history majors in some colleges. Not only are there deviations in teaching level and teaching methods, but there are also limitations in the implementation of reform methods that...
Blended English Teaching Model in Higher Education School Environment AR Constructive Technology
Jing Yang, Lei Bu
Jan 01, 2023
China's education modernization requirements clearly suggest exploring new teaching methods to improve teaching effectiveness. Based on this, this article investigates AR construction technology as a blended English teaching...
Activation mechanism of the class D fungal GPCR dimer Ste2.
The fungal class D1 G-protein-coupled receptor (GPCR) Ste2 has a different arrangement of transmembrane helices compared with mammalian GPCRs and a distinct mode of coupling to the heterotrimeric G protein Gpa1-Ste2-Ste181. In...

|<

<

1

2

3

4

5

>

>|