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Results: 40
Myopia disease mouse models
Katarzyna I Szczerkowska, Silvia Petrezselyova, Jiri Lindovsky, Marcela Palkova, Jan Dvorak, Peter Makovicky, Mingyan Fang, Chongyi Jiang, Lingyan Chen, Mingming Shi, Xiao Liu, Jianguo Zhang, Agnieszka Kubik-Zahorodna, Bjoern Schuster, Inken M Beck, Vendula Novosadova, Jan Prochazka, Radislav Sedlacek
Feb 24, 2020
Zinc finger 644 (Zfp644 in mouse, ZNF644 in human) gene is a transcription factor whose mutation S672G is considered a potential genetic factor of inherited high myopia. ZNF644 interacts with G9a/GLP complex, which functions as...
MD simulations reveal the basis for dynamic assembly of Hfq-RNA complexes.
The conserved protein Hfq is a key factor in the RNA-mediated control of gene expression in most known bacteria. The transient intermediates Hfq forms with RNA support intricate and robust regulatory networks. In Pseudomonas...
ARN repeats Crc protein Hfq protein RNA metabolism RNA-binding protein dynamic recognition Molecular dynamics protein–nucleic acid interaction Binding Sites Gene Expression Regulation Bacterial Host Factor 1 Protein Nucleic Acid Conformation Nucleotide Motifs Protein Binding Protein Conformation Pseudomonas aeruginosa RNA Bacterial
FliI 6 -FliJ molecular motor assists with unfolding in the type III secretion export apparatus
Abstract: The role of rotational molecular motors of the ATP synthase class is integral to the metabolism of cells. Yet the function of FliI6-FliJ complex, a homolog of the F1 ATPase motor, within the flagellar export apparatus...
Biogeographic implication of temperature-induced plant cell wall lignification.
More than 200 years after von Humboldt's pioneering work on the treeline, our understanding of the cold distribution limit of upright plant growth is still incomplete. Here, we use wood anatomical techniques to estimate the...
Biogeographic implication of temperature-induced plant cell wall lignification.
More than 200 years after von Humboldt's pioneering work on the treeline, our understanding of the cold distribution limit of upright plant growth is still incomplete. Here, we use wood anatomical techniques to estimate the...
Perineuronal nets affect memory and learning after synapse withdrawal.
Jiri Ruzicka, Marketa Dalecka, Kristyna Safrankova, Diego Peretti, Pavla Jendelova, Jessica CF Kwok, James W Fawcett
Nov 15, 2022
Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have effects on memory formation, retention and extinction in a variety of animal models....
Perineuronal nets affect memory and learning after synapse withdrawal.
Jiri Ruzicka, Marketa Dalecka, Kristyna Safrankova, Diego Peretti, Pavla Jendelova, Jessica CF Kwok, James W Fawcett
Dec 16, 2022
Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have effects on memory formation, retention and extinction in a variety of animal models....
Predictors of intracranial hemorrhage in adult patients on extracorporeal membrane oxygenation
Alexander Fletcher-Sandersjöö, Jiri Bartek, Eric Peter Thelin, Anders Eriksson, Adrian Elmi-Terander, Mikael Broman, Bo-Michael Bellander
Dec 04, 2017
BACKGROUND: Intracranial hemorrhage (ICH) is a recognized complication of adults treated with extracorporeal membrane oxygenation (ECMO) and is associated with increased morbidity and mortality. However, the predictors of ICH in...
Learnings from user feedback of a novel digital mental health assessment.
Erin Lucy Funnell, Benedetta Spadaro, Jiri Benacek, Nayra A Martin-Key, Tim Metcalfe, Tony Olmert, Giles Barton-Owen, Sabine Bahn
Nov 03, 2022
Controlled Oil/Water Partitioning of Hydrophobic Substrates Extending the Bioanalytical Applications of Droplet-Based Microfluidics.
Tomas Buryska, Michal Vasina, Fabrice Gielen, Pavel Vanacek, Liisa van Vliet, Jan Jezek, Zdenek Pilat, Pavel Zemanek, Jiri Damborsky, Florian Hollfelder, Zbynek Prokop
Jun 27, 2019
A state-of-the-art review of micron-scale spatially resolved residual stress analysis by FIB-DIC ring-core milling and other techniques
Alexander J.G. Lunt, Nikolaos Baimpas, Enrico Salvati, Igor P. Dolbnya, Tan Sui, Siqi Ying, Hongjia Zhang, Annette K. Kleppe, Jiri Dluhoš, Alexander M. Korsunsky
Oct 01, 2015
Quantification of residual stress gradients can provide great improvements in understanding the complex interactions between microstructure, mechanical state, mode(s) of failure and structural integrity. Highly focused local...
Digital image correlation Focused ion beam micro-scale Residual stress Ring-core X-Ray Diffraction /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/2200/2211 name=Mechanics of Materials /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics
Engineering the protein dynamics of an ancestral luciferase.
Andrea Schenkmayerova, Gaspar P Pinto, Martin Toul, Martin Marek, Lenka Hernychova, Joan Planas-Iglesias, Veronika Daniel Liskova, Daniel Pluskal, Michal Vasina, Stephane Emond, Mark Dörr, Radka Chaloupkova, David Bednar, Zbynek Prokop, Florian Hollfelder, Uwe T Bornscheuer, Jiri Damborsky
Jul 28, 2021
Protein dynamics are often invoked in explanations of enzyme catalysis, but their design has proven elusive. Here we track the role of dynamics in evolution, starting from the evolvable and thermostable ancestral protein...
NIH 3T3 Cells Animals Mammals Mice Luciferases Luciferases Renilla Protein Engineering Enzyme Stability Temperature Mutagenesis Binding Sites Protein Conformation Kinetics Mutation Catalysis Molecular Dynamics Simulation
Published by: Nature Communications
Robust, universal biomarker assay to detect senescent cells in biological specimens.
Konstantinos Evangelou, Nikolaos Lougiakis, Sophia V Rizou, Athanassios Kotsinas, Dimitris Kletsas, Daniel Muñoz-Espín, Nikolaos G Kastrinakis, Nicole Pouli, Panagiotis Marakos, Paul Townsend, Manuel Serrano, Jiri Bartek, Vassilis G Gorgoulis
Apr 16, 2019
Cellular senescence contributes to organismal development, aging, and diverse pathologies, yet available assays to detect senescent cells remain unsatisfactory. Here, we designed and synthesized a lipophilic, biotin-linked Sudan...
Engineering the protein dynamics of an ancestral luciferase.
Andrea Schenkmayerova, Gaspar P Pinto, Martin Toul, Martin Marek, Lenka Hernychova, Joan Planas-Iglesias, Veronika Daniel Liskova, Daniel Pluskal, Michal Vasina, Stephane Emond, Mark Dörr, Radka Chaloupkova, David Bednar, Zbynek Prokop, Florian Hollfelder, Uwe T Bornscheuer, Jiri Damborsky
Jul 05, 2021
A state-of-the-art review of micron-scale spatially resolved residual stress analysis by FIB-DIC ring-core milling and other techniques
Alexander J.G. Lunt, Nikolaos Baimpas, Enrico Salvati, Igor P. Dolbnya, Tan Sui, Siqi Ying, Hongjia Zhang, Annette K. Kleppe, Jiri Dluhoš, Alexander M. Korsunsky
Oct 01, 2015
Quantification of residual stress gradients can provide great improvements in understanding the complex interactions between microstructure, mechanical state, mode(s) of failure and structural integrity. Highly focused local...
Digital image correlation Focused ion beam micro-scale Residual stress Ring-core X-Ray Diffraction /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/2200/2211 name=Mechanics of Materials /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics
In situ correlation between metastable phase-transformation mechanism and kinetics in a metallic glass
Jiri Orava, Shanoob Balachandran, Xiaoliang Han, Olga Shuleshova, Ebrahim Nurouzi, Ivan Soldatov, Steffen Oswald, Olof Gutowski, Oleh Ivashko, Ann-Christin Dippel, Martin v. Zimmermann, Yurii P. Ivanov, A. Lindsay Greer, Dierk Raabe, Michael Herbig, Ivan Kaban
May 20, 2021
In situ correlation between metastable phase-transformation mechanism and kinetics in a metallic glass.
Jiri Orava, Shanoob Balachandran, Xiaoliang Han, Olga Shuleshova, Ebrahim Nurouzi, Ivan Soldatov, Steffen Oswald, Olof Gutowski, Oleh Ivashko, Ann-Christin Dippel, Martin V Zimmermann, Yurii P Ivanov, A Lindsay Greer, Dierk Raabe, Michael Herbig, Ivan Kaban
Jun 17, 2021
Published by: Nature Communications
In situ correlation between metastable phase-transformation mechanism and kinetics in a metallic glass.
Jiri Orava, Shanoob Balachandran, Xiaoliang Han, Olga Shuleshova, Ebrahim Nurouzi, Ivan Soldatov, Steffen Oswald, Olof Gutowski, Oleh Ivashko, Ann-Christin Dippel, Martin V Zimmermann, Yurii P Ivanov, A Lindsay Greer, Dierk Raabe, Michael Herbig, Ivan Kaban
Jun 25, 2021
A combination of complementary high-energy X-ray diffraction, containerless solidification during electromagnetic levitation and transmission electron microscopy is used to map in situ the phase evolution in a prototype Cu-Zr-Al...
Engineering the protein dynamics of an ancestral luciferase
Andrea Schenkmayerova, Gaspar P. Pinto, Martin Toul, Martin Marek, Lenka Hernychova, Joan Planas-Iglesias, Veronika Daniel Liskova, Daniel Pluskal, Michal Vasina, Stephane Emond, Mark Dörr, Radka Chaloupkova, David Bednar, Zbynek Prokop, Florian Hollfelder, Uwe T. Bornscheuer, Jiri Damborsky
Jun 14, 2021
Abstract: Protein dynamics are often invoked in explanations of enzyme catalysis, but their design has proven elusive. Here we track the role of dynamics in evolution, starting from the evolvable and thermostable ancestral...
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