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Results: 159
Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis.
Joana Carlevaro-Fita, Andrés Lanzós, Lars Feuerbach, Chen Hong, David Mas-Ponte, Jakob Skou Pedersen, PCAWG Drivers and Functional Interpretation Group, Rory Johnson, PCAWG Consortium
Feb 17, 2021
Long non-coding RNAs (lncRNAs) are a growing focus of cancer genomics studies, creating the need for a resource of lncRNAs with validated cancer roles. Furthermore, it remains debated whether mutated lncRNAs can drive...
Marketing Strategies on Social Media Platforms
Business dynamics are also found in the digital economy, forcing the development of new business models to achieve strategic marketing excellence. It was verified that half of the world's population is present in social media...
Published by: IGI Global Scientific Publishing
Integrating the Internet of Things Into E-Commerce
The emergence of the internet of things (IoT) is changing the behavior of people, companies, and their businesses. The IoT can enhance e-commerce by reducing the gaps between the virtual and physical worlds. Although the...
Published by: IGI Global Scientific Publishing
Eukaryote hybrid genomes.
Interspecific hybridization is the process where closely related species mate and produce offspring with admixed genomes. The genomic revolution has shown that hybridization is common, and that it may represent an important...
Self and Peer E-Assessment
In recent years, universities and other academic institutions have been performing collaborative learning to improve the students' skills, competencies, and learning outcomes. The problem-based learning approach is a learning...
Published by: IGI Global Scientific Publishing
Eukaryote hybrid genomes.
Interspecific hybridization is the process where closely related species mate and produce offspring with admixed genomes. The genomic revolution has shown that hybridization is common, and that it may represent an important...
Sidechain Diversification of Grandifloracin Allows Identification of Analogues with Enhanced Anti-Austerity Activity against Human PANC-1 Pancreatic Cancer Cells
Benjamin E. Alexander, Sijia Sun, Matthew J. Palframan, Gabriele Kociok-Köhn, Dya Fita Dibwe, Shiro Watanabe, Lorenzo Caggiano, Suresh Awale, Simon E. Lewis
Jan 07, 2020
The natural product (+)-grandifloracin is a potent “anti-austerity” agent, able to suppress the ability of various pancreatic cancer cell lines to tolerate conditions of nutrient deprivation. Such anti-austerity agents...
antiproliferation Cancer dearomatization Dimerization nutrient deprivation /dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/subjectarea/asjc/1300/1313 name=Molecular Medicine /dk/atira/pure/subjectarea/asjc/3000/3004 name=Pharmacology /dk/atira/pure/subjectarea/asjc/3000/3002 name=Drug Discovery /dk/atira/pure/subjectarea/asjc/3000 name=Pharmacology, Toxicology and Pharmaceutics(all) /dk/atira/pure/subjectarea/asjc/1600/1605 name=Organic Chemistry /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
BCS-based biowaivers
A BCS-based biowaiver allows extrapolation of drug product bioequivalence (when applicable) based on the BCS class of the drug and in vitro dissolution testing. Drug permeability and solubility considerations for adult BCS might...
Characterizing palliative care needs in people with or at risk of developing diabetic foot ulcers.
Liliane Mendonça, Bárbara Antunes, Joana Rigor, Daniela Martins-Mendes, Matilde Monteiro-Soares
Dec 22, 2022
AIMS: Diabetic foot ulcers (DFUs) have a significant impact on a patient's quality of life and life expectancy, with mortality rates comparable with malignant diseases. However, there is a lack of data regarding palliative care...
Recommended strategies for the oral administration of paediatric medicines with food and drinks in the context of their biopharmaceutical properties
Objectives
This review focuses on the recommended strategies for the oral administration of paediatric medicines with food in the context of their biopharmaceutical properties.
Key findings
Acceptability of...
This review focuses on the recommended strategies for the oral administration of paediatric medicines with food in the context of their biopharmaceutical properties.
Key findings
Acceptability of...
BCS-based biowaivers
A BCS-based biowaiver allows extrapolation of drug product bioequivalence (when applicable) based on the BCS class of the drug and in vitro dissolution testing. Drug permeability and solubility considerations for adult BCS might...
Sidechain Diversification of Grandifloracin Allows Identification of Analogues with Enhanced Anti-Austerity Activity against Human PANC-1 Pancreatic Cancer Cells
Benjamin E. Alexander, Sijia Sun, Matthew J. Palframan, Gabriele Kociok-Köhn, Dya Fita Dibwe, Shiro Watanabe, Lorenzo Caggiano, Suresh Awale, Simon E. Lewis
Jan 07, 2020
The natural product (+)-grandifloracin is a potent “anti-austerity” agent, able to suppress the ability of various pancreatic cancer cell lines to tolerate conditions of nutrient deprivation. Such anti-austerity agents...
antiproliferation Cancer dearomatization Dimerization nutrient deprivation /dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/subjectarea/asjc/1300/1313 name=Molecular Medicine /dk/atira/pure/subjectarea/asjc/3000/3004 name=Pharmacology /dk/atira/pure/subjectarea/asjc/3000/3002 name=Drug Discovery /dk/atira/pure/subjectarea/asjc/3000 name=Pharmacology, Toxicology and Pharmaceutics(all) /dk/atira/pure/subjectarea/asjc/1600/1605 name=Organic Chemistry /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
A Combinatorial View on Speciation and Adaptive Radiation.
Speciation is often thought of as a slow process due to the waiting times for mutations that cause incompatibilities, and permit ecological differentiation or assortative mating. Cases of rapid speciation and particularly cases...
Recommended strategies for the oral administration of paediatric medicines with food and drinks in the context of their biopharmaceutical properties
Objectives
This review focuses on the recommended strategies for the oral administration of paediatric medicines with food in the context of their biopharmaceutical properties.
Key findings
Acceptability of...
This review focuses on the recommended strategies for the oral administration of paediatric medicines with food in the context of their biopharmaceutical properties.
Key findings
Acceptability of...
Characterizing palliative care needs in people with or at risk of developing diabetic foot ulcers.
Liliane Mendonça, Bárbara Antunes, Joana Rigor, Daniela Martins-Mendes, Matilde Monteiro-Soares
Nov 15, 2022
Characterization of glucose-related metabolic pathways in differentiated rat oligodendrocyte lineage cells.
13C acetate Energy Metabolism Glucose Glycolysis Mitochondria Oligodendroglia pyruvate carboxylation Acetates Acetyl Coenzyme A Animals Carbon Radioisotopes Cells Cultured Citric Acid Cycle Cytosol Glucose Lactic Acid Malates Mitochondria Neural Stem Cells Oligodendroglia Oxaloacetic Acid pentose phosphate pathway Phosphoenolpyruvate Pyruvic Acid Radiopharmaceuticals Rats Sprague-Dawley
Rapid generation of ecologically relevant behavioral novelty in experimental cichlid hybrids.
Anna F Feller, Oliver M Selz, Matthew D McGee, Joana I Meier, Salome Mwaiko, Ole Seehausen
Oct 28, 2020
The East African cichlid radiations are characterized by repeated and rapid diversification into many distinct species with different ecological specializations and by a history of hybridization events between nonsister species....
Genomics of Rapid Incipient Speciation in Sympatric Threespine Stickleback.
David A Marques, Kay Lucek, Joana I Meier, Salome Mwaiko, Catherine E Wagner, Laurent Excoffier, Ole Seehausen
Dec 11, 2019
Ecological speciation is the process by which reproductively isolated populations emerge as a consequence of divergent natural or ecologically-mediated sexual selection. Most genomic studies of ecological speciation have...
SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70
Sara Gomes, Bartolomeo Bosco, Joana B Loureiro, Helena Ramos, Liliana Raimundo, Joana Soares, Nair Nazareth, Valentina Barcherini, Lucília Domingues, Carla Oliveira, Alessandra Bisio, Silvano Piazza, Matthias R Bauer, João P Brás, Maria Inês Almeida, Célia Gomes, Flávio Reis, Alan R Fersht, Alberto Inga, Maria MM Santos, Lucília Saraiva
Oct 28, 2019
Half of human cancers harbor TP53 mutations that render p53 inactive as a tumor suppressor. In these cancers, reactivation of mutant p53 (mutp53) through restoration of wild-type-like function constitutes a valuable anticancer...
A Dense Linkage Map of Lake Victoria Cichlids Improved the Pundamilia Genome Assembly and Revealed a Major QTL for Sex-Determination.
Genetic linkage maps are essential for comparative genomics, high quality genome sequence assembly and fine scale quantitative trait locus (QTL) mapping. In the present study we identified and genotyped markers via...
Cichlidae Genetics of Sex RAD XY system amh recombination rate sex chromosome evolution sex determination Synteny Animals Chromosome Mapping Cichlids Databases Genetic evolution Molecular Genetic Linkage Genetic Markers Genomics Genotype High-Throughput Nucleotide Sequencing lakes Quantitative Trait Loci Recombination Genetic Sex Determination Processes Synteny
Multispecies colour polymorphisms associated with contrasting microhabitats in two Mediterranean wrasse radiations.
Sarya N Fark, Steve Gerber, Suzanne H Alonzo, Holly K Kindsvater, Joana I Meier, Ole Seehausen
Mar 19, 2022
Intraspecific colour polymorphisms (CPs) present unique opportunities to study fundamental evolutionary questions, such as the link between ecology and phenotype, mechanisms maintaining genetic diversity and their putative role...
Perceived differences between intensivists and infectious diseases consultants facing antimicrobial resistance
Jordi Rello, Vandana Kalwaje Eshwara, Andrew Conway-Morris, Leonel Lagunes, Joana Alves, Emine Alp, Zhongheng Zhang, Mervyn Mer, TOTEM Study Investigators
Mar 07, 2019
antimicrobials colonization infection control Intensive Care Multidrug-resistant bacteria Prevention Sepsis Anti-Bacterial Agents Carbapenems Cohort Studies Communicable Diseases Critical Care Cross-Sectional Studies Drug Resistance Multiple Bacterial Enterobacteriaceae Global Health Humans infection control Intensive Care Units Microbial Sensitivity Tests Physicians
Transmission of SARS-CoV-2 by children and young people in households and schools
Russell Viner, Claire Waddington, Oliver Mytton, Robert Booy, Joana Cruz, Joseph Ward, Shamez Ladhani, Jasmina Panovska-Griffiths, Chris Bonell, GJ Melendez-Torres
Jan 28, 2022
BACKGROUND: The role of children and young people (CYP) in transmission of SARS-CoV-2 in household and educational settings remains unclear. We undertook a systematic review and meta-analysis of contact-tracing and...
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