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Extracellular Vesicles Isolated from Malignant Mesothelioma Cancer-Associated Fibroblasts Induce Pro-Oncogenic Changes in Healthy Mesothelial Cells.
Tatyana Chernova, Stefano Grosso, Xiao-Ming Sun, Angela Rubio Tenor, Joaquin Zacarias Cabeza, Andrew Craxton, Emily L Self, Apostolos Nakas, Kelvin Cain, Marion MacFarlane, Anne E Willis
Nov 04, 2022
Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf).
Tatyana Chernova, Fiona A Murphy, Sara Galavotti, Xiao-Ming Sun, Ian R Powley, Stefano Grosso, Anja Schinwald, Joaquin Zacarias-Cabeza, Kate M Dudek, David Dinsdale, John Le Quesne, Jonathan Bennett, Apostolos Nakas, Peter Greaves, Craig A Poland, Ken Donaldson, Martin Bushell, Anne E Willis, Marion MacFarlane
Sep 18, 2019
Mesothelioma is a fatal tumor of the pleura and is strongly associated with asbestos exposure. The molecular mechanisms underlying the long latency period of mesothelioma and driving carcinogenesis are unknown. Moreover, late...
CDKN2A asbestos Carbon nanotubes epigenetics hypermethylation Mesothelioma toxicity tumor suppressor genes Aged Animals Asbestos Carcinogenesis Cell Proliferation Cells Cultured Cyclin-Dependent Kinase Inhibitor p16 Cyclin-Dependent Kinase Inhibitor p19 Female Humans Lung Neoplasms Male Mesothelioma Mesothelioma Malignant Methylation Mice Mice Inbred C57BL Middle Aged Nanotubes Carbon
Stratospheric Gravity Waves as a Proxy for Hurricane Intensification
Xue Wu, Lars Hoffmann, Corwin J. Wright, Neil P. Hindley, Silvio Kalisch, M. Joan Alexander, Yinan Wang
Jan 16, 2022
We conducted simulations with a 4-km resolution for Hurricane Joaquin in 2015 using the weather research and forecast (WRF) model. The model data are used to study stratospheric gravity waves (GWs) generated by the hurricane...
Stratospheric Gravity Waves as a Proxy for Hurricane Intensification
Xue Wu, Lars Hoffmann, Corwin J. Wright, Neil P. Hindley, Silvio Kalisch, M. Joan Alexander, Yinan Wang
Jan 16, 2022
We conducted simulations with a 4-km resolution for Hurricane Joaquin in 2015 using the weather research and forecast (WRF) model. The model data are used to study stratospheric gravity waves (GWs) generated by the hurricane...
HPG pore
BACKGROUND: The use of nanopore technologies is expected to spread in the future because they are portable and can sequence long fragments of DNA molecules without prior amplification. The first nanopore sequencer available, the...
Logotherapy and the Empirical Research of Literature
Joaquin Trujillo
Mar 24, 2016
Literature is hermeneutics articulated to entertain and illuminate. It is a meaning-discovery-interpreting process. Literature, the art of thinking and language, creatively discloses the meaning of being human and deepens our...
Published by: Memorial University of Newfoundland
Logotherapy and the Empirical Research of Literature
Joaquin Trujillo
Mar 24, 2016
Literature is hermeneutics articulated to entertain and illuminate. It is a meaning-discovery-interpreting process. Literature, the art of thinking and language, creatively discloses the meaning of being human and deepens our...
Published by: Memorial University of Newfoundland
Advanced Hydroinformatic Techniques for the Simulation and Analysis of Water Supply and Distribution Systems
This document is intended to be a presentation of the Special Issue “Advanced Hydroinformatic Techniques for the Simulation and Analysis of Water Supply and Distribution Systems”. The final aim of this Special Issue is to...
Movement seasonality in a desert-dwelling bat revealed by miniature GPS loggers.
BACKGROUND: Bats are among the most successful desert mammals. Yet, our understanding of their spatio-temporal dynamics in habitat use associated with the seasonal oscillation of resources is still limited. In this study, we...
Elucidating Film Loss and the Role of Hydrogen Bonding of Adsorbed Redox Enzymes by Electrochemical Quartz Crystal Microbalance Analysis.
Vivek M Badiani, Samuel J Cobb, Andreas Wagner, Ana Rita Oliveira, Sónia Zacarias, Inês AC Pereira, Erwin Reisner
Jun 16, 2022
The immobilization of redox enzymes on electrodes enables the efficient and selective electrocatalysis of useful reactions such as the reversible interconversion of dihydrogen (H2) to protons (H+) and formate to carbon dioxide...
Integration of a Hydrogenase in a Lead Halide Perovskite Photoelectrode for Tandem Solar Water Splitting.
Lead halide perovskite solar cells are notoriously moisture-sensitive, but recent encapsulation strategies have demonstrated their potential application as photoelectrodes in aqueous solution. However, perovskite photoelectrodes...
Strategies for Conditional Regulation of Proteins.
Karthik Nadendla, Grant G Simpson, Julie Becher, Toby Journeaux, Mar Cabeza-Cabrerizo, Gonçalo JL Bernardes
Feb 28, 2023
Design of the next-generation of therapeutics, biosensors, and molecular tools for basic research requires that we bring protein activity under control. Each protein has unique properties, and therefore, it is critical to tailor...
Strategies for Conditional Regulation of Proteins.
Karthik Nadendla, Grant G Simpson, Julie Becher, Toby Journeaux, Mar Cabeza-Cabrerizo, Gonçalo J L Bernardes
Apr 05, 2023
Design of the next-generation of therapeutics, biosensors, and molecular tools for basic research requires that we bring protein activity under control. Each protein has unique properties, and therefore, it is critical to tailor...
Published by: JACS Au
Metacognitive Tutoring Systems (MTS)
Intelligent tutoring systems (ITSs) are computational learning support systems based on the use of artificial intelligence. These systems can be used to customize educational content, learning paths, interfaces, and feedback...
Global Information Technology Computer Science and Information Technology Global Information Technology Physical Sciences and Engineering Business and Management
Published by: IGI Global Scientific Publishing
HGVA
Javier Lopez, Jacobo Coll, Matthias Haimel, Swaathi Kandasamy, Joaquin Tarraga, Pedro Furio-Tari, Wasim Bari, Marta Bleda, Antonio Rueda, Stefan Gräf, Augusto Rendon, Joaquin Dopazo, Ignacio Medina
Aug 18, 2017
High-profile genomic variation projects like the 1000 Genomes project or the Exome Aggregation Consortium, are generating a wealth of human genomic variation knowledge which can be used as an essential reference for identifying...
Secondary forest regeneration benefits old-growth specialist bats in a fragmented tropical landscape.
Ricardo Rocha, Otso Ovaskainen, Adrià López-Baucells, Fábio Z Farneda, Erica M Sampaio, Paulo ED Bobrowiec, Mar Cabeza, Jorge M Palmeirim, Christoph FJ Meyer
Oct 03, 2018
Tropical forest loss and fragmentation are due to increase in coming decades. Understanding how matrix dynamics, especially secondary forest regrowth, can lessen fragmentation impacts is key to understanding species persistence...
Advanced Hydroinformatic Techniques for the Simulation and Analysis of Water Supply and Distribution Systems
This document is intended to be a presentation of the Special Issue “Advanced Hydroinformatic Techniques for the Simulation and Analysis of Water Supply and Distribution Systems”. The final aim of this Special Issue is to...
Correlation Analysis of Water Demand and Predictive Variables for Short-Term Forecasting Models
Operational and economic aspects of water distribution make water demand forecasting paramount for water distribution systems (WDSs) management. However, water demand introduces high levels of uncertainty in WDS hydraulic...
Integration of a Hydrogenase in a Lead Halide Perovskite Photoelectrode for Tandem Solar Water Splitting.
Lead halide perovskite solar cells are notoriously moisture-sensitive, but recent encapsulation strategies have demonstrated their potential application as photoelectrodes in aqueous solution. However, perovskite photoelectrodes...
Published by: ACS energy letters
Spatial tracking of individual fluid dispersed particles via Raman spectroscopy.
Benjamin Thomas Hogan, Jennifer O'Dowd, Joaquin Faneca Ruedas, Alexander Baranov, Anna Baldycheva
Sep 01, 2021
We demonstrate a method for the spatial tracking of individual particles, dispersed in a fluid host, via Raman spectroscopy. The effect of moving a particle upon the intensity of different bands within its Raman spectrum is...
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