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Results: 104

Lignocellulose degradation mechanisms across the Tree of Life.

Simon M Cragg, Gregg T Beckham, Neil C Bruce, Timothy DH Bugg, Daniel L Distel, Paul Dupree, Amaia Green Etxabe, Barry S Goodell, Jody Jellison, John E McGeehan, Simon J McQueen-Mason, Kirk Schnorr, Paul H Walton, Joy EM Watts, Martin Zimmer

Dec 04, 2015

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Couple Establishes Endowed Scholarship for Political Science, Business Majors

Winthrop University

Jan 01, 0001

The Jody Guy Gaulin and Gary V. Gaulin Endowed Scholarship will support political science or business majors. The couple, who lives in Seneca, South Carolina, met at Winthrop.

Published by: Winthrop University

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A POWER TO INTRIGUE? EXPLORING THE ‘TIMELESS’ QUALITIES OF THE SO‐CALLED ‘GROTESQUE’ IRON AGE TORC FROM SNETTISHAM, NORFOLK

Jody Joy

Sep 23, 2019

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Intracellular application of an asparaginyl endopeptidase for producing recombinant head-to-tail cyclic proteins

Simon Tang, Jody Mason

Dec 25, 2023

Peptide backbone cyclization is commonly observed in nature and is increasingly applied to proteins and peptides to improve thermal and chemical stability and resistance to proteolytic enzymes and enhance biological activity....

OaAEP1 RiPPs asparaginyl endopeptidases cyclic peptides peptide ligation ribosomally synthesized and post-translationally modified peptides /dk/atira/pure/subjectarea/asjc/1600/1602 name=Analytical Chemistry /dk/atira/pure/subjectarea/asjc/1600/1601 name=Chemistry (miscellaneous) /dk/atira/pure/subjectarea/asjc/1600/1606 name=Physical and Theoretical Chemistry /dk/atira/pure/subjectarea/asjc/1600/1605 name=Organic Chemistry

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Coupling Computational and Intracellular Screening and Selection Toward Co-compatible cJun and cFos Antagonists

Alex Lathbridge, Anna Michalowska, Jody Mason

Feb 04, 2020

Basic leucine-zipper (bZIP) proteins represent difficult yet compelling oncogenic targets, since numerous cell-signalling cascades converge upon them where they function to modulate transcription of specific gene targets. bZIPs...

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Uncertainty evaluation method for axi-symmetric measurement machines

Jody Emlyn Muelaner, Patrick S. Keogh

Jan 01, 0001

This paper describes a method of uncertainty evaluation for axi-symmetric measurement machines. Specialized measuring machines for the inspection of axisymmetric components enable the measurement of properties such as roundness...

Axi-Symmetric Measurement runout axial runout radial runout

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‘Fire Burn and Cauldron Bubble’

Jody Joy

Nov 06, 2014

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Combining Constrained Heptapeptide Cassettes With Computational Design to Create Coiled-coil Targeting Helical Peptides

Alexander Lathbridge, Jody Mason

Jun 21, 2019

A total of 32 heptapeptides have been synthesized and characterized to establish the effect of K → D (i → i + 4) lactamization upon their ability to adopt a helical conformation. Because most parallel and dimeric coiled-coil...

/dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/subjectarea/asjc/1300/1313 name=Molecular Medicine

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Toward peptide-based inhibitors as therapies for Parkinson's disease

Jody M. Mason, David P. Fairlie

Jan 01, 0001

ALPHA-SYNUCLEIN mimetics Drug Design Peptides Parkinson's Disease Amyloid

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Uncertainty of measurement for large product verification

Jody Muelaner, Zheng Wang, Patrick Keogh, John Brownell, David Fisher

Sep 22, 2016

Understanding the uncertainty of dimensional measurements for large products such as aircraft, spacecraft and wind turbines is fundamental to improving efficiency in these products. Much work has been done to ascertain the...

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Intracellular application of an asparaginyl endopeptidase for producing recombinant head-to-tail cyclic proteins

Simon Tang, Jody Mason

Dec 25, 2023

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Computational Competitive and Negative Design to Derive a Specific cJun Antagonist

Alexander Lathbridge, Jody Mason

Oct 23, 2018

Basic leucine zipper (bZIP) proteins reside at the end of cell-signaling cascades and function to modulate transcription of specific gene targets. bZIPs are recognized as important regulators of cellular processes such as...

/dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being

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Class matters in the interview setting?

Jody Mellor, Nicola Ingram, Jessie Abrahams, Phoebe Beedell

Feb 01, 2014

In this article we argue that despite methodological and analytical advancements in the field of social class research, these developments have not led to a wholehearted discussion about class positionality and situatedness in...

Methodology social class interviews

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Insights Into Peptide Inhibition of Alpha-Synuclein Aggregation

James Torpey, Richard Meade, Ravina Mistry, Jody Mason, Jillian Madine

Oct 15, 2020

α-Synuclein (aSyn) aggregation is an attractive target for therapeutic development fora range of neurodegenerative conditions, collectively termed synucleinopathies. Here,we probe the mechanism of action of a peptide 4554W...

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A series of helical α-synuclein fibril polymorphs are populated in the presence of lipid vesicles

Richard Meade, Robert J Williams, Jody Mason

Aug 19, 2020

α-Synuclein (αS) deposition is a defining characteristic of Parkinson’s disease (PD) pathology, and other synucleinopathies. αS aggregates in disease, leading to the generation of neuronal inclusions known as Lewy bodies....

/dk/atira/pure/subjectarea/asjc/2800/2808 name=Neurology /dk/atira/pure/subjectarea/asjc/2700/2728 name=Clinical Neurology /dk/atira/pure/subjectarea/asjc/2800/2804 name=Cellular and Molecular Neuroscience

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Verification of the indoor GPS system, by comparison with calibrated coordinates and by angular reference

Jody E Muelaner, Zheng Wang, Oliver Martin, Jafar Jamshidi, Paul G Maropoulos

Dec 01, 2012

This paper details work carried out to verify the dimensional measurement performance of the Indoor GPS (iGPS) system; a network of Rotary-Laser Automatic Theodolites (R-LATs). Initially tests were carried out to determine the...

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Intracellular selection of peptide inhibitors that target disulphide-bridged Aβ<sub>42 </sub> oligomers

Nicola Acerra, Neil. M. Kad, Harish Cheruvara, Jody M. Mason

Sep 01, 2014

The β-amyloid (Aβ) peptide aggregates into a number of soluble and insoluble forms, with soluble oligomers thought to be the primary factor implicated in Alzheimer's disease pathology. As a result, a wide range of potential...

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Intracellular screening of a peptide library to derive a potent peptide inhibitor of α-synuclein aggregation

Harish Cheruvara, Victoria L. Allen-Baume, Neil M. Kad, Jody M. Mason

Mar 20, 2015

Aggregation of α-synuclein (α-syn) into toxic fibrils is a pathogenic hallmark of Parkinson's disease (PD). Studies have largely focused on residues 71-82, yet most early onset mutations are located between residues 46-53. A...

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Computational Competitive and Negative Design to Derive a Specific cJun Antagonist

Alexander Lathbridge, Jody Mason

Oct 23, 2018

/dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being

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Combining Constrained Heptapeptide Cassettes With Computational Design to Create Coiled-coil Targeting Helical Peptides

Alexander Lathbridge, Jody Mason

Jun 21, 2019

/dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/subjectarea/asjc/1300/1313 name=Molecular Medicine

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The Library Derived 4554W Peptide Inhibits Primary Nucleation of α-Synuclein

Richard Meade, Kimberley Morris, Kathryn Watt, Robert J Williams, Jody Mason

Dec 05, 2020

Aggregation of alpha-Synuclein (aS) is widely regarded as a key factor in neuronal cell death, leading to a wide range of synucleinopathies that includes Parkinson’s Disease. Development of therapeutics has therefore focused on...

ALPHA-SYNUCLEIN Peptide Amyloid AGGREGATION primary nucleation Lipid vesicles Parkinson's Disease

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Toward peptide-based inhibitors as therapies for Parkinson's disease

Jody M. Mason, David P. Fairlie

Jan 01, 0001

ALPHA-SYNUCLEIN mimetics Drug Design Peptides Parkinson's Disease Amyloid

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Computational prediction and design for creating iteratively larger heterospecific coiled coil sets

Richard Crooks, Alexander Lathbridge, Anna Panek, Jody Mason

Mar 21, 2017

A major biochemical goal is the ability to mimic nature in engineering highly specific protein-protein interactions. We previously devised a computational interactome screen to identify eight peptides that form four...

protein-protein interactions coiled coils library screening Computational Biology interactome screen heterospecific proteins De novo design

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Coupling Computational and Intracellular Screening and Selection Toward Co-compatible cJun and cFos Antagonists

Alex Lathbridge, Anna Michalowska, Jody Mason

Feb 04, 2020

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Combined Computational and Intracellular Peptide Library Screening

Miao Yu, Lila Ghamsari, Jim Rotolo, Barry Kappel, Jody Mason

Apr 01, 2021

To date, most research into the inhibition of oncogenic transcriptional regulator, Activator Protein 1 (AP-1), has focused on heterodimers of cJun and cFos. However, the Fra1 homologue remains an important cancer target. Here we...

Coiled coil activator protein-1 fos related antigen-1 Transcription factor Computational design peptide libraries protein-protein interactions protein-fragment complementation assay /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being

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