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Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet.
Adiponectin Animals Blood Glucose Caloric Restriction Delta-5 Fatty Acid Desaturase Diet High-Fat Dietary Fats Docosahexaenoic Acids Eicosapentaenoic Acid Fatty Acid Desaturases Insulin Leptin Linoleic Acid Lipogenesis Liver Male obesity Rats Rats Sprague-Dawley Stearoyl-CoA Desaturase Subcutaneous Fat Triglycerides Weight Gain alpha-Linolenic Acid
Altered motor, anxiety-related and attentional task performance at baseline associate with multiple gene copies of the vesicular acetylcholine transporter and related protein overexpression in ChAT:
Craig P. Mantanona, Johan Alsiö, Joanna L. Elson, Beth M. Fisher, Jeffrey W. Dalley, Timothy Bussey, Ilse S. Pienaar
Sep 09, 2020
Abstract: Transgenic rodents expressing Cre recombinase cell specifically are used for exploring mechanisms regulating behavior, including those mediated by cholinergic signaling. However, it was recently reported that...
Altered motor, anxiety-related and attentional task performance at baseline associate with multiple gene copies of the vesicular acetylcholine transporter and related protein overexpression in ChAT:
Craig P Mantanona, Johan Alsiö, Joanna L Elson, Beth M Fisher, Jeffrey W Dalley, Timothy Bussey, Ilse S Pienaar
Oct 01, 2019
Transgenic rodents expressing Cre recombinase cell specifically are used for exploring mechanisms regulating behavior, including those mediated by cholinergic signaling. However, it was recently reported that transgenic mice...
5-CSRTT ChAT::Cre rats Cre-recombinase HPA endocrine axis Touchscreen-based behavioral testing Vesicular acetylcholine transporter Animals Anxiety Attention Brain Conditioning Classical Fear Gene Dosage Hypothalamo-Hypophyseal System Male Mice Inbred C57BL Mice Transgenic Motor Activity Rats Long-Evans Rats Transgenic Vesicular Acetylcholine Transport Proteins
Serotonergic Innervations of the Orbitofrontal and Medial-prefrontal Cortices are Differentially Involved in Visual Discrimination and Reversal Learning in Rats.
Johan Alsiö, Olivia Lehmann, Colin McKenzie, David E Theobald, Lydia Searle, Jing Xia, Jeffrey W Dalley, Trevor W Robbins
Sep 02, 2020
Cognitive flexibility medial prefrontal cortex orbitofrontal cortex Serotonin translational neuroscience 5 6-Dihydroxytryptamine Animals Creatinine Discrimination Learning Infusions Intraventricular Male Photic Stimulation Prefrontal Cortex Rats Reversal Learning Serotonergic Neurons Serotonin Visual Perception
Markers of serotonergic function in the orbitofrontal cortex and dorsal raphé nucleus predict individual variation in spatial-discrimination serial reversal learning.
Rebecca L Barlow, Johan Alsiö, Bianca Jupp, Rebecca Rabinovich, Saurav Shrestha, Angela C Roberts, Trevor W Robbins, Jeffrey W Dalley
Mar 04, 2015
Animals Citalopram Conditioning Operant discrimination Psychological Dorsal Raphe Nucleus Dose-Response Relationship Drug Gene Expression Male Monoamine Oxidase Piperazines Prefrontal Cortex Protein Binding RNA Messenger Rats Reinforcement psychology Reversal Learning Serotonin Selective Serotonin Reuptake Inhibitors Space Perception Tryptophan Hydroxylase
Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice.
Benjamin U Phillips, Sigma Dewan, Simon RO Nilsson, Trevor W Robbins, Christopher J Heath, Lisa M Saksida, Timothy J Bussey, Johan Alsiö
Jul 13, 2018
RATIONALE: Dysregulation of the serotonin (5-HT) system is a pathophysiological component in major depressive disorder (MDD), a condition closely associated with abnormal emotional responsivity to positive and negative feedback....
5-HT2C receptor SB 242084 WAY 163909 Aminopyridines Animals Azepines Depressive Disorder Major Discrimination Learning Indoles Male Mice Probability Learning Receptor Serotonin 5-HT2C Reinforcement psychology Reversal Learning Serotonin 5-HT2 Receptor Agonists Serotonin 5-HT2 Receptor Antagonists Task Performance and Analysis Visual Perception
Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat
Johan Alsiö, Benjamin U Phillips, Júlia Sala-Bayo, Simon RO Nilsson, Teresa C Calafat-Pla, Arazo Rizwand, Jessica M Plumbridge, Laura López-Cruz, Jeffrey W Dalley, Rudolf N Cardinal, Adam C Mar, Trevor W Robbins
Jun 17, 2019
Cognition Cognitive flexibility Computational modelling Dopamine Dopamine D1 receptor Dopamine D2 receptor Hierarchical Bayesian analysis rat reinforcement learning Reversal Learning Animals Dopamine Dopamine Agonists Dopamine Antagonists Dopamine D2 Receptor Antagonists Feedback Physiological Male Photic Stimulation Rats Receptors Dopamine D1 Receptors Dopamine D2 Reversal Learning Space Perception Visual Perception
Dorsal and ventral striatal dopamine D1 and D2 receptors differentially modulate distinct phases of serial visual reversal learning.
Júlia Sala-Bayo, Leanne Fiddian, Simon RO Nilsson, Mona E Hervig, Colin McKenzie, Alexis Mareschi, Maria Boulos, Peter Zhukovsky, Janet Nicholson, Jeffrey W Dalley, Johan Alsiö, Trevor W Robbins
Jan 03, 2020
Impaired cognitive flexibility in visual reversal-learning tasks has been observed in a wide range of neurological and neuropsychiatric disorders. Although both human and animal studies have implicated striatal D2-like and...
Dorsal and ventral striatal dopamine D1 and D2 receptors differentially modulate distinct phases of serial visual reversal learning
Withdrawal from escalated cocaine self-administration impairs reversal learning by disrupting the effects of negative feedback on reward exploitation
Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat
Johan Alsiö, Benjamin U. Phillips, Júlia Sala-Bayo, Simon R. O. Nilsson, Teresa C. Calafat-Pla, Arazo Rizwand, Jessica M. Plumbridge, Laura López-Cruz, Jeffrey W. Dalley, Rudolf N. Cardinal, Adam C. Mar, Trevor W. Robbins
Jun 18, 2020
Abstract: Rationale: Dopamine D2-like receptors (D2R) are important drug targets in schizophrenia and Parkinson’s disease, but D2R ligands also cause cognitive inflexibility such as poor reversal learning. The specific role of...
U.S. Disc Golf Championship Returns Oct. 5-8 to Winthrop's Gold Course
Winthrop University
Jan 01, 0001
Top players to watch during the week on the course around the Winthrop Coliseum are: defending champion Paul McBeth, Ricky Wysocki, Ken Climo, Barry Schultz and Karl Johan Nybo. More than 90 participants are expected to compete.
Published by: Winthrop University
A lifting method for analyzing distributed synchronization on the unit sphere
This paper introduces a new lifting method for analyzing convergence of continuous-time distributed synchronization/consensus systems on the unit sphere. Points on the d-dimensional unit sphere are lifted to the (d +...
The NEWMEDS rodent touchscreen test battery for cognition relevant to schizophrenia.
M Hvoslef-Eide, AC Mar, SRO Nilsson, J Alsiö, CJ Heath, LM Saksida, TW Robbins, TJ Bussey
Jul 07, 2015
Attention Cognitive flexibility Drug Discovery Executive Function Long-term memory MOUSE Neuropsychiatric disease rat Response inhibition Working memory Animals Antipsychotic Agents Cognition Cognition Disorders Conditioning Operant Mice Psychomotor Performance Rats Schizophrenia Schizophrenic Psychology
Towards powerful educational knowledge?
This paper introduces a special issue which aims to address the challenges facing the ‘deliberative’ educational knowledge traditions of educational foundations, curriculum theory and Didaktik as a consequence of the rising tide...
Seeing and Treating the Out-group Like Family
Transference effects occur when our impressions are guided by our mental representations of significant others. For instance, if a target resembles an individual’s significant other, then that person’s feelings toward their...
Entrepreneurship and psychological disorders
Amidst predominant focus on positive traits for entrepreneurship, this paper explores how disorders such as ADHD influence the decision to engage in entrepreneurial action and the success of entrepreneurial action. Based on a...
Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
Dominik Glodzik, Ana Bosch, Johan Hartman, Mattias Aine, Johan Vallon-Christersson, Christel Reuterswärd, Anna Karlsson, Shamik Mitra, Emma Niméus, Karolina Holm, Jari Häkkinen, Cecilia Hegardt, Lao H. Saal, Christer Larsson, Martin Malmberg, Lisa Rydén, Anna Ehinger, Niklas Loman, Anders Kvist, Hans Ehrencrona, Serena Nik-Zainal, Åke Borg, Johan Staaf
Jul 28, 2021
Development of a tilt control method for a narrow-track three-wheeled vehicle
The space and weight savings provided by narrow tilting vehicles could make them a solution to the pollution and congestion problems seen in urban environments. The success of this new type of vehicle relies heavily on the...
Lateral dynamics simulation of a three-wheeled tilting vehicle
A novel tilting three-wheeled vehicle was developed at the University of Bath as part of a project funded by the European Union. The space and weight savings provided by this type of vehicle could be a solution to the pollution...
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