Search
Results: 302
Kinetic Uncertainty Relations for the Control of Stochastic Reaction Networks.
Nonequilibrium stochastic reaction networks are commonly found in both biological and nonbiological systems, but have remained hard to analyze because small differences in rate functions or topology can change the dynamics...
Quantification of very low-abundant proteins in bacteria using the HaloTag and epi-fluorescence microscopy.
Alessia Lepore, Hannah Taylor, Dirk Landgraf, Burak Okumus, Sebastián Jaramillo-Riveri, Lorna McLaren, Somenath Bakshi, Johan Paulsson, M El Karoui
Aug 19, 2019
Cell biology is increasingly dependent on quantitative methods resulting in the need for microscopic labelling technologies that are highly sensitive and specific. Whilst the use of fluorescent proteins has led to major...
Bacterial persisters are a stochastically formed subpopulation of low-energy cells.
Sylvie Manuse, Yue Shan, Silvia J Canas-Duarte, Somenath Bakshi, Wei-Sheng Sun, Hirotada Mori, Johan Paulsson, Kim Lewis
Jun 14, 2021
Persisters represent a small subpopulation of non- or slow-growing bacterial cells that are tolerant to killing by antibiotics. Despite their prominent role in the recalcitrance of chronic infections to antibiotic therapy, the...
Mechanical slowing-down of cytoplasmic diffusion allows in vivo counting of proteins in individual cells.
Burak Okumus, Dirk Landgraf, Ghee Chuan Lai, Somenath Bakshi, Juan Carlos Arias-Castro, Sadik Yildiz, Dann Huh, Raul Fernandez-Lopez, Celeste N Peterson, Erdal Toprak, Meriem El Karoui, Johan Paulsson
Jan 31, 2020
Many key regulatory proteins in bacteria are present in too low numbers to be detected with conventional methods, which poses a particular challenge for single-cell analyses because such proteins can contribute greatly to...
Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator
David T. Riglar, David L. Richmond, Laurent Potvin-Trottier, Andrew A. Verdegaal, Alexander D. Naydich, Somenath Bakshi, Emanuele Leoncini, Lorena G. Lyon, Johan Paulsson, Pamela A. Silver
Oct 10, 2020
Abstract: Synthetic gene oscillators have the potential to control timed functions and periodic gene expression in engineered cells. Such oscillators have been refined in bacteria in vitro, however, these systems have lacked the...
Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator.
David T Riglar, David L Richmond, Laurent Potvin-Trottier, Andrew A Verdegaal, Alexander D Naydich, Somenath Bakshi, Emanuele Leoncini, Lorena G Lyon, Johan Paulsson, Pamela A Silver
Dec 11, 2019
Synthetic gene oscillators have the potential to control timed functions and periodic gene expression in engineered cells. Such oscillators have been refined in bacteria in vitro, however, these systems have lacked the...
U.S. Disc Golf Championship Returns Oct. 5-8 to Winthrop's Gold Course
Winthrop University
Jan 01, 0001
Top players to watch during the week on the course around the Winthrop Coliseum are: defending champion Paul McBeth, Ricky Wysocki, Ken Climo, Barry Schultz and Karl Johan Nybo. More than 90 participants are expected to compete.
Published by: Winthrop University
A lifting method for analyzing distributed synchronization on the unit sphere
This paper introduces a new lifting method for analyzing convergence of continuous-time distributed synchronization/consensus systems on the unit sphere. Points on the d-dimensional unit sphere are lifted to the (d +...
Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia.
Minjun Yang, Mattias Vesterlund, Ioannis Siavelis, Larissa H Moura-Castro, Anders Castor, Thoas Fioretos, Rozbeh Jafari, Henrik Lilljebjörn, Duncan T Odom, Linda Olsson, Naveen Ravi, Eleanor L Woodward, Louise Harewood, Janne Lehtiö, Kajsa Paulsson
Jun 20, 2019
Hyperdiploidy, i.e. gain of whole chromosomes, is one of the most common genetic features of childhood acute lymphoblastic leukemia (ALL), but its pathogenetic impact is poorly understood. Here, we report a proteogenomic...
Adolescent Aneuploidy CCCTC-Binding Factor Cell Cycle Proteins Child Child Preschool Chromatin Chromosomal Proteins Non-Histone Chromosome Aberrations Core Binding Factor Alpha 2 Subunit Female Gene Dosage Gene Expression Profiling Gene Expression Regulation Leukemic Genome Human Genome-Wide Association Study Humans Infant Infant Newborn Male Precursor Cell Lymphoblastic Leukemia-Lymphoma Proteogenomics Proteome Proto-Oncogene Proteins c-ets Repressor Proteins Sequence Analysis RNA Transcription Genetic
Towards powerful educational knowledge?
This paper introduces a special issue which aims to address the challenges facing the ‘deliberative’ educational knowledge traditions of educational foundations, curriculum theory and Didaktik as a consequence of the rising tide...
Seeing and Treating the Out-group Like Family
Transference effects occur when our impressions are guided by our mental representations of significant others. For instance, if a target resembles an individual’s significant other, then that person’s feelings toward their...
Entrepreneurship and psychological disorders
Amidst predominant focus on positive traits for entrepreneurship, this paper explores how disorders such as ADHD influence the decision to engage in entrepreneurial action and the success of entrepreneurial action. Based on a...
Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
Dominik Glodzik, Ana Bosch, Johan Hartman, Mattias Aine, Johan Vallon-Christersson, Christel Reuterswärd, Anna Karlsson, Shamik Mitra, Emma Niméus, Karolina Holm, Jari Häkkinen, Cecilia Hegardt, Lao H. Saal, Christer Larsson, Martin Malmberg, Lisa Rydén, Anna Ehinger, Niklas Loman, Anders Kvist, Hans Ehrencrona, Serena Nik-Zainal, Åke Borg, Johan Staaf
Jul 28, 2021
Development of a tilt control method for a narrow-track three-wheeled vehicle
The space and weight savings provided by narrow tilting vehicles could make them a solution to the pollution and congestion problems seen in urban environments. The success of this new type of vehicle relies heavily on the...
Lateral dynamics simulation of a three-wheeled tilting vehicle
A novel tilting three-wheeled vehicle was developed at the University of Bath as part of a project funded by the European Union. The space and weight savings provided by this type of vehicle could be a solution to the pollution...
Lateral dynamics simulation of a three-wheeled tilting vehicle
A novel tilting three-wheeled vehicle was developed at the University of Bath as part of a project funded by the European Union. The space and weight savings provided by this type of vehicle could be a solution to the pollution...
A computational method for sharp interface advection.
We devise a numerical method for passive advection of a surface, such as the interface between two incompressible fluids, across a computational mesh. The method is called isoAdvector, and is developed for general meshes...
Non-linear control of a hydraulic piezo-valve using a generalized Prandtl-Ishlinskii hysteresis model
Frederik Stefanski, Bartosz Minorowicz, Johan Persson, Andrew Plummer, Christopher Bowen
Jan 01, 2017
The potential to actuate proportional flow control valves using piezoelectric ceramics or other smart materials has been investigated for a number of years. Although performance advantages compared to electromagnetic actuation...
Towards powerful educational knowledge?
This paper introduces a special issue which aims to address the challenges facing the ‘deliberative’ educational knowledge traditions of educational foundations, curriculum theory and Didaktik as a consequence of the rising tide...
|
|< |
< |
1 |