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Results: 534
Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation.
Kellie J Hall, Matthew T Harper, Karen Gilio, Judith M Cosemans, Johan WM Heemskerk, Alastair W Poole
May 28, 2020
BACKGROUND: PKCtheta is a novel protein kinase C isozyme, predominately expressed in T cells and platelets. PKCtheta(-/-) T cells exhibit reduced activation and PKCtheta(-/-) mice are resistant to autoimmune disease, making...
Multiparameter platelet function analysis of bleeding patients with a prolonged platelet function analyser closure time.
Floor CJI Heubel-Moenen, Sanne LN Brouns, Linda Herfs, Lara S Boerenkamp, Natalie J Jooss, Rick JH Wetzels, Paul WM Verhezen, Patric Machiels, Karyn Megy, Kate Downes, Johan WM Heemskerk, Erik AM Beckers, Yvonne MC Henskens
Jan 10, 2022
Patients referred for evaluation of bleeding symptoms occasionally have a prolonged platelet function analyser (PFA) closure time, without evidence for von Willebrand disease or impaired platelet aggregation. The aim of this...
Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces.
Natalie J Jooss, Ilaria De Simone, Isabella Provenzale, Delia I Fernández, Sanne LN Brouns, Richard W Farndale, Yvonne MC Henskens, Marijke JE Kuijpers, Hugo Ten Cate, Paola EJ van der Meijden, Rachel Cavill, Johan WM Heemskerk
Sep 11, 2019
Platelet interaction with collagens, via von Willebrand factor, is a potent trigger of shear-dependent thrombus formation mediated by subsequent engagement of the signaling collagen receptor glycoprotein (GP)VI, enforced by...
Assessment of a complete and classified platelet proteome from genome-wide transcripts of human platelets and megakaryocytes covering platelet functions.
Jingnan Huang, Frauke Swieringa, Fiorella A Solari, Isabella Provenzale, Luigi Grassi, Ilaria De Simone, Constance CFMJ Baaten, Rachel Cavill, Albert Sickmann, Mattia Frontini, Johan WM Heemskerk
Jun 11, 2021
Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis.
Mitchell J Geer, Johanna P van Geffen, Piraveen Gopalasingam, Timo Vögtle, Christopher W Smith, Silke Heising, Marijke JE Kuijpers, Bibian ME Tullemans, Gavin E Jarvis, Johannes A Eble, Mark Jeeves, Michael Overduin, Johan WM Heemskerk, Alexandra Mazharian, Yotis A Senis
Oct 10, 2018
The immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptor G6b-B has emerged as a key regulator of platelet homeostasis. However, it remains unclear how it mediates its effects. Tyrosine phosphorylation of...
Animals Binding Sites Blood Platelets Homeostasis Mice Mice Inbred C57BL Mice Transgenic Models Molecular Phosphorylation Point Mutation Protein Interaction Maps Protein Tyrosine Phosphatase Non-Receptor Type 11 Protein Tyrosine Phosphatase Non-Receptor Type 6 Receptors Immunologic Signal Transduction Thrombocytopenia src Homology Domains
Identification of platelet function defects by multi-parameter assessment of thrombus formation.
Susanne M de Witt, Frauke Swieringa, Rachel Cavill, Moniek ME Lamers, Roger van Kruchten, Tom Mastenbroek, Constance Baaten, Susan Coort, Nicholas Pugh, Ansgar Schulz, Inge Scharrer, Kerstin Jurk, Barbara Zieger, Kenneth J Clemetson, Richard W Farndale, Johan WM Heemskerk, Judith MEM Cosemans
Jul 10, 2014
Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome.
Johanna P van Geffen, Frauke Swieringa, Kim van Kuijk, Bibian ME Tullemans, Fiorella A Solari, Bing Peng, Kenneth J Clemetson, Richard W Farndale, Ludwig J Dubois, Albert Sickmann, René P Zahedi, Robert Ahrends, Erik AL Biessen, Judith C Sluimer, Johan WM Heemskerk, Marijke JE Kuijpers
Feb 12, 2021
Hyperlipidemia is a well-established risk factor for cardiovascular diseases. Millions of people worldwide display mildly elevated levels of plasma lipids and cholesterol linked to diet and life-style. While the prothrombotic...
High-throughput elucidation of thrombus formation reveals sources of platelet function variability.
Johanna P van Geffen, Sanne LN Brouns, Joana Batista, Harriet McKinney, Carly Kempster, Magdolna Nagy, Suthesh Sivapalaratnam, Constance CFMJ Baaten, Nikki Bourry, Mattia Frontini, Kerstin Jurk, Manuela Krause, Daniele Pillitteri, Frauke Swieringa, Remco Verdoold, Rachel Cavill, Marijke JE Kuijpers, Willem H Ouwehand, Kate Downes, Johan WM Heemskerk
Oct 31, 2019
In combination with microspotting, whole-blood microfluidics can provide high-throughput information on multiple platelet functions in thrombus formation. Based on assessment of the inter- and intra-subject variability in...
Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation.
Sanne LN Brouns, Johanna P van Geffen, Elena Campello, Frauke Swieringa, Luca Spiezia, René van Oerle, Isabella Provenzale, Remco Verdoold, Richard W Farndale, Kenneth J Clemetson, Henri MH Spronk, Paola EJ van der Meijden, Rachel Cavill, Marijke JE Kuijpers, Elisabetta Castoldi, Paolo Simioni, Johan WM Heemskerk
Sep 09, 2020
In haemostasis and thrombosis, platelet, coagulation and anticoagulation pathways act together to produce fibrin-containing thrombi. We developed a microspot-based technique, in which we assessed platelet adhesion, platelet...
Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148.
Jun Mori, Zoltan Nagy, Giada Di Nunzio, Christopher W Smith, Mitchell J Geer, Rashid Al Ghaithi, Johanna P van Geffen, Silke Heising, Luke Boothman, Bibian ME Tullemans, Joao N Correia, Louise Tee, Marijke JE Kuijpers, Paul Harrison, Johan WM Heemskerk, Gavin E Jarvis, Alexander Tarakhovsky, Arthur Weiss, Alexandra Mazharian, Yotis A Senis
Mar 16, 2018
Src family kinases (SFKs) coordinate the initiating and propagating activation signals in platelets, but it remains unclear how they are regulated. Here, we show that ablation of C-terminal Src kinase (Csk) and receptor-like...
Amino Acid Motifs Animals Blood Platelets CSK Tyrosine-Protein Kinase Homeostasis Mice Mice Knockout Platelet Membrane Glycoproteins Protein Tyrosine Phosphatase Non-Receptor Type 11 Protein Tyrosine Phosphatase Non-Receptor Type 6 Receptor-Like Protein Tyrosine Phosphatases Class 3 Thrombosis src-Family Kinases
Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice.
Inga Hofmann, Mitchell J Geer, Timo Vögtle, Andrew Crispin, Dean R Campagna, Alastair Barr, Monica L Calicchio, Silke Heising, Johanna P van Geffen, Marijke JE Kuijpers, Johan WM Heemskerk, Johannes A Eble, Klaus Schmitz-Abe, Esther A Obeng, Michael Douglas, Kathleen Freson, Corinne Pondarré, Rémi Favier, Gavin E Jarvis, Kyriacos Markianos, Ernest Turro, Willem H Ouwehand, Alexandra Mazharian, Mark D Fleming, Yotis A Senis
Oct 10, 2018
Unlike primary myelofibrosis (PMF) in adults, myelofibrosis in children is rare. Congenital (inherited) forms of myelofibrosis (cMF) have been described, but the underlying genetic mechanisms remain elusive. Here we describe 4...
The underlying structure of visuospatial working memory in children with mathematical learning disability.
This study examined visual, spatial-sequential, and spatial-simultaneous working memory (WM) performance in children with mathematical learning disability (MLD) and low mathematics achievement (LMA) compared with typically...
Automatic prioritization of self-referential stimuli in working memory
People preferentially attend to external stimuli that are related to themselves compared with others. Whether a similar self-reference bias applies to internal representations, such as those maintained in working memory (WM), is...
A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding.
Constance CFMJ Baaten, Stuart Meacham, Susanne M de Witt, Marion AH Feijge, David J Adams, Jan-Willem N Akkerman, Judith MEM Cosemans, Luigi Grassi, Steve Jupe, Myrto Kostadima, Nadine JA Mattheij, Martin H Prins, Ramiro Ramirez-Solis, Oliver Soehnlein, Frauke Swieringa, Christian Weber, Jacqueline K White, Willem H Ouwehand, Johan WM Heemskerk
Nov 22, 2018
Antithrombotic therapies reduce cardiovascular diseases by preventing arterial thrombosis and thromboembolism, but at expense of increased bleeding risks. Arterial thrombosis studies using genetically modified mice have been...
Interventions targeting working memory in 4-11 year olds within their everyday contexts
It has been suggested that diverse interventions applied within children's everyday contexts have the potential to improve working memory (WM) and produce transfer to real-world skills but little is known about the effectiveness...
U.S. Disc Golf Championship Returns Oct. 5-8 to Winthrop's Gold Course
Winthrop University
Jan 01, 0001
Top players to watch during the week on the course around the Winthrop Coliseum are: defending champion Paul McBeth, Ricky Wysocki, Ken Climo, Barry Schultz and Karl Johan Nybo. More than 90 participants are expected to compete.
Published by: Winthrop University
Precise Topology of Adjacent Domain-General and Sensory-Biased Regions in the Human Brain.
Recent functional MRI studies identified sensory-biased regions across much of the association cortices and cerebellum. However, their anatomical relationship to multiple-demand (MD) regions, characterized as domain-general due...
A systematic review examining the characteristics of users of NHS patient medicines helpline services, and the types of enquiries they make
Background and objective: Patient medicines helpline services (PMHS) are available from some National Health Service Trusts in the United Kingdom to support patients following discharge. The aim of this systematic review was to...
Cerebral Microbleeds and Structural White Matter Integrity in Patients With Traumatic Brain Injury-A Diffusion Tensor Imaging Study.
Juho Dahl, Olli Tenovuo, Jussi P Posti, Jussi Hirvonen, Ari J Katila, Janek Frantzén, Henna-Riikka Maanpää, Riikka Takala, Eliisa Löyttyniemi, Jussi Tallus, Virginia Newcombe, David K Menon, Peter J Hutchinson, Mehrbod Mohammadian
Jul 18, 2022
Diffuse axonal injury (DAI) is a common neuropathological manifestation of traumatic brain injury (TBI), presenting as traumatic alterations in the cerebral white matter (WM) microstructure and often leading to long-term...
Automatic prioritization of self-referential stimuli in working memory
People preferentially attend to external stimuli that are related to themselves compared with others. Whether a similar self-reference bias applies to internal representations, such as those maintained in working memory (WM), is...
White and gray matter damage in primary progressive MS
Benedetta Bodini, Declan Chard, Daniel R Altmann, Daniel Tozer, David H Miller, Alan J Thompson, Claudia Wheeler-Kingshott, Olga Ciccarelli
Jun 22, 2018
OBJECTIVE: The temporal relationship between white matter (WM) and gray matter (GM) damage in vivo in early primary progressive multiple sclerosis (PPMS) was investigated testing 2 hypotheses: (1) WM tract abnormalities predict...
Sensitivity of Diffusion MRI to White Matter Pathology
Evgenios N Kornaropoulos, Stefan Winzeck, Theodor Rumetshofer, Anna Wikstrom, Linda Knutsson, Marta M Correia, Pia C Sundgren, Markus Nilsson
Jun 13, 2022
There are many ways to acquire and process diffusion MRI (dMRI) data for group studies, but it is unknown which maximizes the sensitivity to white matter (WM) pathology. Inspired by this question, we analyzed data acquired for...
Cerebral Microbleeds and Structural White Matter Integrity in Patients With Traumatic Brain Injury-A Diffusion Tensor Imaging Study.
Juho Dahl, Olli Tenovuo, Jussi P Posti, Jussi Hirvonen, Ari J Katila, Janek Frantzén, Henna-Riikka Maanpää, Riikka Takala, Eliisa Löyttyniemi, Jussi Tallus, Virginia Newcombe, David K Menon, Peter Hutchinson, Mehrbod Mohammadian
Jun 14, 2022
Diffuse axonal injury (DAI) is a common neuropathological manifestation of traumatic brain injury (TBI), presenting as traumatic alterations in the cerebral white matter (WM) microstructure and often leading to long-term...
Feature coding dataset for trained and untrained working memory tasks in randomized controlled trials of working memory training.
The data presented in this article are produced as part of the original research article entitled "Working memory training involves learning new skills" (Gathercole, Dunning, Holmes & Norris, in press). This article presents a...
Predictors of mathematics in primary school
We determined the relative importance of the so-called approximate number system (ANS), symbolic number comparison (SNC) and verbal and spatial short-term and working memory (WM) capacity for mathematics achievement in 1,254...
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