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Interview with D. H. Mellor (2001)
This article is the text of an interview with D. H. Mellor conducted in Cambridge on 30 May 2001 by Anna-Sofia Maurin and Johannes Persson for the philosophical journal Theoria.
Published by: Theoria
Targeted long-read sequencing identifies missing pathogenic variants in unsolved Werner syndrome cases.
Danny E Miller, Lin Lee, Miranda Galey, Renuka Kandhaya-Pillai, Marc Tischkowitz, Deepak Amalnath, Avadh Vithlani, Koutaro Yokote, Hisaya Kato, Yoshiro Maezawa, Aki Takada-Watanabe, Minoru Takemoto, George M Martin, Evan E Eichler, Fuki M Hisama, Junko Oshima
May 11, 2022
BACKGROUND: Werner syndrome (WS) is an autosomal recessive progeroid syndrome caused by variants in WRN. The International Registry of Werner Syndrome has identified biallelic pathogenic variants in 179/188 cases of classical...
Human pluripotent stem cell-based models suggest preadipocyte senescence as a possible cause of metabolic complications of Werner and Bloom Syndromes.
Werner Syndrome (WS) and Bloom Syndrome (BS) are disorders of DNA damage repair caused by biallelic disruption of the WRN or BLM DNA helicases respectively. Both are commonly associated with insulin resistant diabetes, usually...
Quantifying the shifts in physicochemical property space introduced by the metabolism of small organic molecules
Johannes Kirchmair, Andrew Howlett, Julio Peironcely, Daniel S Murrell, Mark Williamson, Samuel E Adams, Thomas Hankemeier, Leo van Buren, Guus Duchateau, Werner Klaffke, Robert C Glen
Mar 22, 2013
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display...
Monographs of the RIMR. Vol. 13, 1920
The Rockefeller University
Jan 01, 0001
The Early Stages of Tabanidae (Horse-flies) by Werner Marchand
Published by: The Rockefeller Institute for Medical Research
Asymptotically cylindrical Calabi-Yau manifolds
Let M be a complete Ricci-flat Kähler manifold with one end and assume that this end converges at an exponential rate to [0, ∞) x X for some compact connected Ricci-flat manifold X. We begin by proving general structure...
Asymptotically cylindrical Calabi-Yau manifolds
Let M be a complete Ricci-flat Kähler manifold with one end and assume that this end converges at an exponential rate to [0, ∞) x X for some compact connected Ricci-flat manifold X. We begin by proving general structure...
Efficient Adaptive Designs for Clinical Trials of Interventions for COVID-19.
Nigel Stallard, Lisa Hampson, Norbert Benda, Werner Brannath, Thomas Burnett, Tim Friede, Peter K Kimani, Franz Koenig, Johannes Krisam, Pavel Mozgunov, Martin Posch, James Wason, Gernot Wassmer, John Whitehead, S Faye Williamson, Sarah Zohar, Thomas Jaki
Aug 02, 2021
The COVID-19 pandemic has led to an unprecedented response in terms of clinical research activity. An important part of this research has been focused on randomized controlled clinical trials to evaluate potential therapies for...
Pandemic research Adaptive trial SARS-CoV-2 group sequential design Platform trial Multi-arm multi-stage
Published by: Statistics in biopharmaceutical research
Efficient Adaptive Designs for Clinical Trials of Interventions for COVID-19.
Nigel Stallard, Lisa Hampson, Norbert Benda, Werner Brannath, Thomas Burnett, Tim Friede, Peter K Kimani, Franz Koenig, Johannes Krisam, Pavel Mozgunov, Martin Posch, James Wason, Gernot Wassmer, John Whitehead, S Faye Williamson, Sarah Zohar, Thomas Jaki
Jul 07, 2020
The COVID-19 pandemic has led to an unprecedented response in terms of clinical research activity. An important part of this research has been focused on randomized controlled clinical trials to evaluate potential therapies for...
Area Archeologist Talks about Finds at Darlington County Site
Winthrop University
Jan 01, 0001
As part of S.C. Archeology Month, Winthrop University will host a lecture entitled "Fifteen Years of Archeology and Education at the Johannes Kolb Site" on Thursday, Oct. 14, at 5:30 p.m. in Kinard Auditorium. Chris Judge, an...
Published by: Winthrop University
Engaging the Crowd
In this article, the challenges of realising e-participatory projects in urban planning are described. A participatory case study in Singapore serves as the basis for their presented conclusions. The researchers used a map-based...
Published by: IGI Global Scientific Publishing
Time Propagation and Spectroscopy of Fermionic Systems Using a Stochastic Technique.
We present a stochastic method for solving the time-dependent Schrödinger equation, generalizing a ground state full configuration interaction quantum Monte Carlo method. By performing the time integration in the complex plane...
A hidden Markov model for describing turbostratic disorder applied to carbon blacks and graphene
A mathematical framework is presented to represent turbostratic disorder in materials like carbon blacks, smectites and twisted n-layer graphene. In particular, the set of all possible disordered layers, including rotated...
Carbon blacks hidden Markov model Scattering cross sections Turbostratic disorder /dk/atira/pure/subjectarea/asjc/1300/1315 name=Structural Biology /dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/1600/1606 name=Physical and Theoretical Chemistry /dk/atira/pure/subjectarea/asjc/1600/1604 name=Inorganic Chemistry
A hidden Markov model for describing turbostratic disorder applied to carbon blacks and graphene
A mathematical framework is presented to represent turbostratic disorder in materials like carbon blacks, smectites and twisted n-layer graphene. In particular, the set of all possible disordered layers, including rotated...
Carbon blacks hidden Markov model Scattering cross sections Turbostratic disorder /dk/atira/pure/subjectarea/asjc/1300/1315 name=Structural Biology /dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/1600/1606 name=Physical and Theoretical Chemistry /dk/atira/pure/subjectarea/asjc/1600/1604 name=Inorganic Chemistry
Resolution of Low-Energy States in Spin-Exchange Transition-Metal Clusters
Polynuclear transition-metal (PNTM) clusters owe their catalytic activity to numerous energetically low-lying spin states and stable oxidation states. The characterization of their electronic structure represents one of the...
Linguistic Distances in Dialectometric Intensity Estimation
Dialectometric intensity estimation as introduced in Rumpf etal. (2009) and Pickl and Rumpf (2011, 2012) is a method for the unsupervised generation of maps visualizing geolinguistic data on the level of linguistic...
Sustainable Consumerism via Context-Aware Shopping
Johannes Klinglmayr, Bernhard Bergmair, Maria Klaffenböck, LeanderB. Hörmann, Evangelos Pournaras
Oct 01, 2017
We are living in a world of vast information. The means of the Internet allow access to diverse sources of information, with social media and Internet of Things technologies significantly expanding the informational ecosystem....
Grid & High Performance Computing Computer Science and Information Technology High Performance Computing
Published by: IGI Global Scientific Publishing
Hareth Al-Janabi, Job Van Exel, Werner Brouwer, Caroline Trotter, Linda Glennie, Laurie Hannigan, Joanna Coast
Sep 21, 2015
Connection probabilities for conformal loop ensembles
The goal of the present paper is to explain, based on properties of the conformal loop ensembles $\CLE_\kappa$ (both with simple and non-simple loops, i.e., for the whole range $\kappa \in (8/3, 8)$) how to derive the connection...
Preferential binding of unsaturated hydrocarbons in aryl-bisimidazolium·cucurbit[8]uril complexes furbishes evidence for small-molecule π-π interactions.
Whilst cucurbit[n]urils (CBn) have been utilized in gas encapsulation, only the smaller CBn (n = 5 and 6) have utility given their small cavity size. In this work, we demonstrate that the large cavity of CB8 can be tailored for...
Published by: Chemical science
Novel Single-Site Device for Conjoined Glucose Sensing and Insulin Infusion
Mathias Tschaikner, Kevin Powell, Miro Jungklaus, Martin Fritz, Martin Ellmerer, Roman Hovorka, Steve Lane, Thomas R Pieber, Werner Regittnig
Jul 01, 2019
OBJECTIVE: This study evaluated a novel diabetes treatment device that combines commercially available continuous glucose monitoring and insulin infusion technology in such a way as to perform insulin delivery and glucose...
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