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The Translators' Take on Three Possible Typos in Jorge L. Borges' Story “Tlön, Uqbar, Orbis Tertius”
Marcelo Sanchez
Jan 01, 2023
This article examines how translators tackled the problem given by three possible typos in Jorge Luis Borges' short story “Tlön, Uqbar, Orbis Tertius.” Translations to all major Western languages are considered. The translators'...
Published by: IGI Global Scientific Publishing
Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells.
Superoxide generation by mitochondria respiratory complexes is a major source of reactive oxygen species (ROS) which are capable of initiating redox signaling and oxidative damage. Current understanding of the role of...
Huntington's disease MitoParaquat Mitochondria Parkinson's Disease Superoxide Zebrafish Animals antioxidants Brain Humans Huntingtin Protein Huntington Disease Mitochondria Oxidation-Reduction Oxidative Stress Paraquat Parkinson Disease Phenotype protein aggregation Pathological Reactive Oxygen Species Rotenone Superoxides Tyrosine 3-Monooxygenase Zebrafish
Genomic profile of advanced breast cancer in circulating tumour DNA.
Belinda Kingston, Rosalind J Cutts, Hannah Bye, Matthew Beaney, Giselle Walsh-Crestani, Sarah Hrebien, Claire Swift, Lucy S Kilburn, Sarah Kernaghan, Laura Moretti, Katie Wilkinson, Andrew M Wardley, Iain R Macpherson, Richard D Baird, Rebecca Roylance, Jorge S Reis-Filho, Michael Hubank, Iris Faull, Kimberly C Banks, Richard B Lanman, Isaac Garcia-Murillas, Judith M Bliss, Alistair Ring, Nicholas C Turner
May 03, 2021
The genomics of advanced breast cancer (ABC) has been described through tumour tissue biopsy sequencing, although these approaches are limited by geographical and temporal heterogeneity. Here we use plasma circulating tumour DNA...
The Landscape of Somatic Genetic Alterations in Breast Cancers From ATM Germline Mutation Carriers.
Britta Weigelt, Rui Bi, Rahul Kumar, Pedro Blecua, Diana L Mandelker, Felipe C Geyer, Fresia Pareja, Paul A James, kConFab Investigators, Fergus J Couch, Diana M Eccles, Fiona Blows, Paul Pharoah, Anqi Li, Pier Selenica, Raymond S Lim, Gowtham Jayakumaran, Nic Waddell, Ronglai Shen, Larry Norton, Hannah Y Wen, Simon N Powell, Nadeem Riaz, Mark E Robson, Jorge S Reis-Filho, Georgia Chenevix-Trench
Jul 26, 2018
Alleles Phenotype Mutation ataxia-telangiectasia hormone receptors brcal protein DNA DNA Damage Genes brcal gene tp53 gene Germ-Line Mutation Loss of Heterozygosity protein p53 Recombination Genetic Genetics Neoplasms Breast Cancer Somatic mutation biopharmaceutics classification system infiltrates cell cycle checkpoint Exome datasets
Unraveling tumor-immune heterogeneity in advanced ovarian cancer uncovers immunogenic effect of chemotherapy.
Alejandro Jiménez-Sánchez, Paulina Cybulska, Katherine LaVigne Mager, Simon Koplev, Oliver Cast, Dominique-Laurent Couturier, Danish Memon, Pier Selenica, Ines Nikolovski, Yousef Mazaheri, Yonina Bykov, Felipe C Geyer, Geoff Macintyre, Lena Morrill Gavarró, Ruben M Drews, Michael B Gill, Anastasios D Papanastasiou, Ramon E Sosa, Robert A Soslow, Tyler Walther, Ronglai Shen, Dennis S Chi, Kay J Park, Travis Hollmann, Jorge S Reis-Filho, Florian Markowetz, Pedro Beltrao, Hebert Alberto Vargas, Dmitriy Zamarin, James D Brenton, Alexandra Snyder, Britta Weigelt, Evis Sala, Martin L Miller
May 20, 2020
In metastatic cancer, the degree of heterogeneity of the tumor microenvironment (TME) and its molecular underpinnings remain largely unstudied. To characterize the tumor-immune interface at baseline and during neoadjuvant...
Animals cisplatin Cohort Studies Cystadenocarcinoma Serous DNA Copy Number Variations Female Gene Expression Profiling Gene Expression Regulation Neoplastic Genes myc Humans Killer Cells Natural Lymphocytes Tumor-Infiltrating Mice Mutation Ovarian Neoplasms principal component analysis Tumor Microenvironment Wnt Signaling Pathway
Compromised BRCA1-PALB2 interaction is associated with breast cancer risk.
TK Foo, M Tischkowitz, S Simhadri, T Boshari, N Zayed, KA Burke, SH Berman, P Blecua, N Riaz, Y Huo, YC Ding, SL Neuhausen, B Weigelt, JS Reis-Filho, WD Foulkes, B Xia
Dec 07, 2020
The major breast cancer suppressor proteins BRCA1 and BRCA2 play essential roles in homologous recombination (HR)-mediated DNA repair, which is thought to be critical for tumor suppression. The two BRCA proteins are linked by a...
Fine-scale computations for adaptive processing in the human brain
Elisa Zamboni, Valentin G Kemper, Nuno Reis Goncalves, Ke Jia, Vasilis M Karlaftis, Samuel J Bell, Joseph Giorgio, Reuben Rideaux, Rainer Goebel, Zoe Kourtzi
Nov 26, 2020
Adapting to the environment statistics by reducing brain responses to repetitive sensory information is key for efficient information processing. Yet, the fine-scale computations that support this adaptive processing in the...
Rethinking Technology-Based Services to Promote Citizen Participation in Urban Mobility
Cities are complex and dynamic systems in which a network of actors interact, creating value through different activities. Cities can, therefore, be viewed as service ecosystems. Municipalities take advantage of digitalization...
Published by: IGI Global Scientific Publishing
From JWH-018 to OXIZIDS
With new synthetic cannabinoids (SCs) appearing on the European drug market every year, early warning systems are key to detect, monitor, and respond to threats posed by them. The European Union Early Warning System (EU EWS)...
OKR Methodology
In a changing world, dominated by fierce competition, it is imperative that companies have the necessary agility to adapt to the market constraints where they operate, investing in frameworks that promote the achievement of...
Published by: IGI Global Scientific Publishing
Gaining a Competitive Advantage Through Benefits Management
To gain competitive advantage, organizations need to have something that the competitors do not have and cannot achieve in the short-term. In the past, organizations invested large amounts of financial resources to the finest...
Published by: IGI Global Scientific Publishing
Immunocapture of <i>Escherichia coli</i> in a fluoropolymer microcapillary array
This study presents novel experimental insights into the direct quantitation and immunocapture of bacteria cells in a fluoropolymer microcapillary array, using Escherichia coli as work model, a pathogen responsible for around...
Microfluidic smartphone quantitation of <i>Escherichia coli</i> in synthetic urine
In spite of the clinical need, there is a major gap in rapid diagnostics for identification and quantitation of E. coli and other pathogens, also regarded as the biggest bottleneck in the fight against the spread of...
Defining Business Objectives Supported by Organizational Maturity and Benefits Management
Organizations today need to provide better products and services. The issues they face require integrated approaches and effective management of their resources. Maturity models help integrate traditionally separate...
Global Information Technology Computer Science and Information Technology Global Information Technology Physical Sciences and Engineering Business and Management
Published by: IGI Global Scientific Publishing
Homologous recombination DNA repair defects in PALB2-associated breast cancers.
Anqi Li, Felipe C Geyer, Pedro Blecua, Ju Youn Lee, Pier Selenica, David N Brown, Fresia Pareja, Simon SK Lee, Rahul Kumar, Barbara Rivera, Rui Bi, Salvatore Piscuoglio, Hannah Y Wen, John R Lozada, Rodrigo Gularte-Mérida, Luca Cavallone, kConFab Investigators, Zoulikha Rezoug, Tu Nguyen-Dumont, Paolo Peterlongo, Carlo Tondini, Thorkild Terkelsen, Karina Rønlund, Susanne E Boonen, Arto Mannerma, Robert Winqvist, Marketa Janatova, Pathmanathan Rajadurai, Bing Xia, Larry Norton, Mark E Robson, Pei-Sze Ng, Lai-Meng Looi, Melissa C Southey, Britta Weigelt, Teo Soo-Hwang, Marc Tischkowitz, William D Foulkes, Jorge S Reis-Filho
Jun 11, 2019
Processed pseudogenes acquired somatically during cancer development.
Susanna L Cooke, Adam Shlien, John Marshall, Christodoulos P Pipinikas, Inigo Martincorena, Jose MC Tubio, Yilong Li, Andrew Menzies, Laura Mudie, Manasa Ramakrishna, Lucy Yates, Helen Davies, Niccolo Bolli, Graham R Bignell, Patrick S Tarpey, Sam Behjati, Serena Nik-Zainal, Elli Papaemmanuil, Vitor H Teixeira, Keiran Raine, Sarah O'Meara, Maryam S Dodoran, Jon W Teague, Adam P Butler, Christine Iacobuzio-Donahue, Thomas Santarius, Richard G Grundy, David Malkin, Mel Greaves, Nikhil Munshi, Adrienne M Flanagan, David Bowtell, Sancha Martin, Denis Larsimont, Jorge S Reis-Filho, Alex Boussioutas, Jack A Taylor, Neil D Hayes, Sam M Janes, P Andrew Futreal, Michael R Stratton, Ultan McDermott, Peter J Campbell, ICGC Breast Cancer Group
Nov 01, 2018
Cancer evolves by mutation, with somatic reactivation of retrotransposons being one such mutational process. Germline retrotransposition can cause processed pseudogenes, but whether this occurs somatically has not been...
A high-throughput multi-microfluidic crystal generator (MMicroCryGen) platform for facile screening of polymorphism and crystal morphology for pharmaceutical compounds
In this work, a novel multi-microfluidic crystallization platform called MMicroCryGen is presented, offering a facile methodology for generating individual crystals for fast and easy screening of the polymorphism and crystal...
Immunocapture of <i>Escherichia coli</i> in a fluoropolymer microcapillary array
This study presents novel experimental insights into the direct quantitation and immunocapture of bacteria cells in a fluoropolymer microcapillary array, using Escherichia coli as work model, a pathogen responsible for around...
Rethinking the Postwar Period in Spain
Jorge Marco
Jul 31, 2020
There is a consensus among scholars regarding the slow transformation of ‘hot-blooded terror’ into ‘cold-blooded terror’ during the Civil War and the Post-war period in Spain. This article challenges this framework in two ways....
Recurrent Processing Drives Perceptual Plasticity.
Ke Jia, Elisa Zamboni, Valentin Kemper, Catarina Rua, Nuno Reis Goncalves, Adrian Ka Tsun Ng, Christopher T Rodgers, Guy Williams, Rainer Goebel, Zoe Kourtzi
Aug 10, 2020
Learning and experience are critical for translating ambiguous sensory information from our environments to perceptual decisions. Yet evidence on how training molds the adult human brain remains controversial, as fMRI at...
experience-dependent plasticity layer-to-layer functional connectivity learning perceptual decisions ultra-high-field brain imaging Visual Cortex Adult Female Humans Magnetic Resonance Imaging Male Neuronal Plasticity Orientation Spatial Photic Stimulation Spatial Learning Visual Cortex Visual Perception Young Adult
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