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Transcription Factor Levels after Forward Programming of Human Pluripotent Stem Cells with GATA1, FLI1, and TAL1 Determine Megakaryocyte versus Erythroid Cell Fate Decision.
Amanda Dalby, Jose Ballester-Beltrán, Chiara Lincetto, Annett Mueller, Nicola Foad, Amanda Evans, James Baye, Ernest Turro, Thomas Moreau, Marloes R Tijssen, Cedric Ghevaert
Dec 21, 2018
erythroblast Forward programming lineage fate decision megakaryocyte Pluripotent Stem Cells Cell Differentiation Cell Lineage Cells Cultured Cytokines Erythroid Cells Erythropoietin GATA1 Transcription Factor Gene Silencing Humans Megakaryocytes Pluripotent Stem Cells Proto-Oncogene Protein c-fli-1 T-Cell Acute Lymphocytic Leukemia Protein 1 Thrombopoietin Transgenes
The strength of the protein-material interaction determines cell fate.
Cristina González-García, Marco Cantini, José Ballester-Beltrán, George Altankov, Manuel Salmerón-Sánchez
Nov 01, 2018
UNLABELLED: Extracellular matrix (ECM) proteins are key mediators of cell/material interactions. The surface density and conformation of these proteins adsorbed on the material surface influence cell adhesion and the cellular...
Fibronectin adsorption Fibronectin remodeling Protein mobility Protein-material interaction strength 3T3 Cells Acrylic Resins Adsorption Animals Biocompatible Materials Cell Adhesion Cell Differentiation Cell Lineage Cell Survival Extracellular Matrix Fibronectins Humans Mice Microscopy Atomic Force Microscopy Fluorescence Serum Albumin Bovine Surface Properties Vitronectin
Confined Sandwichlike Microenvironments Tune Myogenic Differentiation.
José Ballester-Beltrán, Sara Trujillo, Enateri V Alakpa, Vicente Compañ, Rafael Gavara, Dominic Meek, Christopher C West, Bruno Péault, Matthew J Dalby, Manuel Salmerón-Sánchez
Dec 11, 2017
Sandwichlike (SW) cultures are engineered as a multilayer technology to simultaneously stimulate dorsal and ventral cell receptors, seeking to mimic cell adhesion in three-dimensional (3D) environments in a reductionist manner....
Does a more precise chemical description of protein-ligand complexes lead to more accurate prediction of binding affinity?
Predicting the binding affinities of large sets of diverse molecules against a range of macromolecular targets is an extremely challenging task. The scoring functions that attempt such computational prediction are essential for...
Identification and Validation of Carbonic Anhydrase II as the First Target of the Anti-Inflammatory Drug Actarit.
Background and purpose: Identifying the macromolecular targets of drug molecules is a fundamental aspect of drug discovery and pharmacology. Several drugs remain without known targets (orphan) despite large-scale in silico and...
Hydrodynamic assembly of two-dimensional layered double hydroxide nanostructures.
Formation mechanisms of two-dimensional nanostructures in wet syntheses are poorly understood. Even more enigmatic is the influence of hydrodynamic forces. Here we use liquid flow cell transmission electron microscopy to show...
Electronic Docket Adoption in Rural Police Stations
The adoption of electronic record management systems in rural policing presents significant challenges, impacting case management and service delivery. This study investigates the barriers hindering the implementation of...
Published by: IGI Global Scientific Publishing
Identification and Validation of Carbonic Anhydrase II as the First Target of the Anti-Inflammatory Drug Actarit
Background and purpose: Identifying the macromolecular targets of drug molecules is a fundamental aspect of drug discovery and pharmacology. Several drugs remain without known targets (orphan) despite large-scale in silico and...
Is the Google Book Decision an Unqualified Good?
Mark Y Herring
Jan 01, 0001
Unless you've been living on a deserted island or stranded (or not?) like the pelagic castaway Jose Ivan (http://bit.ly/1fq6JsJ) for over a year, you could not possibly have missed the news thatGoogle's mass digitization...
Published by: Winthrop University
High-Fidelity Sequence-Selective Duplex Formation by Recognition-Encoded Melamine Oligomers.
Melamine oligomers composed of repeating triazine-piperidine units and equipped with phenol and phosphine oxide side-chains form H-bonded duplexes. The melamine backbone provides sufficient rigidity to prevent intramolecular...
Published by: Journal of the American Chemical Society
Regional Indian Movies in Rs.100 Crore Club
Lydia Jose
Jan 01, 2023
The movie industry in India has a distinctive effect on their audience, which is rather unique when compared to the various influencing kinds of messages that are portrayed through different forms of media. Perceptual immediacy...
Published by: IGI Global Scientific Publishing
Shear and Solvent-Mediated Fabrication of Layered Double-Hydroxide Superstructures for High-Rate Supercapacitor Cathodes
The development of sustainable energy economies is blocked by the lack of stable electrical energy sources with high power and energy densities. Next‐generation supercapacitors utilizing 2D layered double hydroxides (LDHs)...
Visible light promoted photocatalytic water oxidation:proton and electron collection
Dominic Walsh, Noelia M. Sanchez-Ballester, Valeska P. Ting, Katsuhiko Ariga, Mark T. Weller
Jun 07, 2016
Visible light promoted photocatalytic water oxidations were conducted using a homogenous cobalt complex as a catalyst that was absorbed onto a silica gel substrate. The porous SiO2 contained Ru(bpy)3...
Experimental assessment of mating opportunities in three shorebird species
Mating opportunities may differ between closely related species, although the evidence for such variation is scant. Here we compare remating opportunities and courtship behaviour between three shorebird species: the Kentish...
Experimental assessment of mating opportunities in three shorebird species
Mating opportunities may differ between closely related species, although the evidence for such variation is scant. Here we compare remating opportunities and courtship behaviour between three shorebird species: the Kentish...
Using Data Science Software to Address Health Disparities
The article assesses data science software to evaluate the usefulness of data science technology in addressing concerns such as health disparities. Data science software was analyzed using KDnuggets data related to analytics...
Published by: IGI Global Scientific Publishing
Analysing the evolution of aerospace ecosystem development.
Aerospace manufacturing industry is predicted to continue growing. Rising demand is triggering the current global aerospace ecosystem to evolve and adapt to challenges never faced before. New players into the aerospace...
Chelate stabilized metal oxides for visible light photocatalyzed water oxidations
Dominic Walsh, Noelia M. Sanchez-Ballester, Katsuhiko Ariga, Akihiro Tanaka, Mark Weller
Feb 01, 2015
Visible light driven photocatalytic water oxidations were undertaken that compared lactate stabilized molecular and nanoparticle cobalt complexes and calcium manganese oxides as simple mimics of the PSII CaMn4O5 catalyst....
Analysing the evolution of aerospace ecosystem development
Aerospace manufacturing industry is predicted to continue growing. Rising demand is triggering the current global aerospace ecosystem to evolve and adapt to challenges never faced before. New players into the aerospace...
Visible light promoted photocatalytic water oxidation
Dominic Walsh, Noelia M. Sanchez-Ballester, Valeska P. Ting, Simon R. Hall, Lui R. Terry, Mark T. Weller
Oct 01, 2015
A range of low cost nanoparticulate mixed transition metal oxides were prepared using a simple methodology and used as catalysts in visible light promoted water oxidations. The effect of catalyst and daylight equivalent light...
Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.
Irina Pleines, Joanne Woods, Stephane Chappaz, Verity Kew, Nicola Foad, José Ballester-Beltrán, Katja Aurbach, Chiara Lincetto, Rachael M Lane, Galina Schevzov, Warren S Alexander, Douglas J Hilton, William J Astle, Kate Downes, Paquita Nurden, Sarah K Westbury, Andrew D Mumford, Samya G Obaji, Peter W Collins, Fabien Delerue, Lars M Ittner, Nicole S Bryce, Mira Holliday, Christine A Lucas, Edna C Hardeman, Willem H Ouwehand, Peter W Gunning, Ernest Turro, Marloes R Tijssen, Benjamin T Kile
Feb 06, 2017
How do weekly obtained task i-deals improve work performance? The role of relational context and structural job resources
Previous research on idiosyncratic deals (i-deals) has treated them as concrete events, arguing that these i-deals shape employment relationships and impact on work performance over long periods of time. However, some types of...
Semi‑continuous pilot‑scale microbial oil production with Metschnikowia pulcherrima on starch hydrolysate
Felix Abeln, Robert H. Hicks, Hadiza Auta, Mauro Moreno-Beltrán, Luca Longanesi, Daniel H. Henk, Christopher J. Chuck
Jul 16, 2020
Background: Heterotrophic microbial oils are potentially a more sustainable alternative to vegetable or fossil oils for food and fuel applications. However, as almost all work in the area is conducted on the laboratory scale...
Bibliometric Analysis of Academic Research in Education for Sustainable Development in the Field of Tourism
An increase is occurring year on year, especially from 2019, in publications related to education for sustainability development (ESD) in the field of tourism. The objective of this paper is to analyse how the concept of...
Published by: IGI Global Scientific Publishing
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