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Results: 1168
Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing.
Lourdes Ortiz-Fernández, Elio G Carmona, Martin Kerick, Paul Lyons, Francisco David Carmona, Raquel López Mejías, Chiea Chuen Khor, Peter C Grayson, Enrico Tombetti, Lindi Jiang, Haner Direskeneli, Guher Saruhan-Direskeneli, José-Luis Callejas-Rubio, Augusto Vaglio, Carlo Salvarani, Jose Hernández-Rodríguez, Maria Cinta Cid, Ann W Morgan, Peter A Merkel, David Burgner, Kenneth GC Smith, Miguel Angel Gonzalez-Gay, Amr H Sawalha, Javier Martin, Ana Marquez
Feb 21, 2023
Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice.
Frank Reimann, C Rubio, , Marta Puerto, Juan J García-Rodríquez, Van B Lu, Irma García-Martínez, Rosa Alén, , Patricia Sanmartín-Salinas, M Val Toledo-Lobo, Jorge Saiz, Javier Ruperez, Coral Barbas, Luis Menchén, Fiona M Gribble, Luis G Guijarro, Jose M Carrascosa, Angela M Valverde
Jan 31, 2020
GLP-1 GLP-2 Gut microbiota Inflammation NASH PTP1B Animals Choline Deficiency Diet Disease Models Animal Gastrointestinal Microbiome Gene Expression Gene Knockout Techniques Glucagon-Like Peptide 1 Inflammation Intestinal Mucosa Liver Male Methionine Mice Mice Inbred C57BL Mice Knockout non-alcoholic fatty liver disease Permeability Protein Tyrosine Phosphatase Non-Receptor Type 1 RAW 264.7 Cells
Natural history of hypertrophic cardiomyopathy in cats from rehoming centers
Erasmian Didacticism and Political Advice in Luis Zapata’s <i>Carlo famoso</i>
Jessica Hagley
Nov 09, 2020
The presence of Erasmian discourse in Luis Zapata’s Carlo famoso (1566) has been both neglected and misinterpreted in literary scholarship. Previously understood as an expression of insubordination against the reign of Philip...
Running demands and heart rate response in rugby union referees
Luis Suarez-Arrones, Luis J. Portillo, Jose M. García, Africa Calvo-Lluch, Simon P. Roberts, Alberto Mendez-Villanueva
Nov 01, 2013
The aim of this study was to examine the match physical demands and exercise intensity associated with men rugby union refereeing using global positioning system technology. Ten male rugby union referees (age, 37.1 ± 5.9 years;...
Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice.
Carmen Rubio, Marta Puerto, Juan J García-Rodríquez, Van B Lu, Irma García-Martínez, Rosa Alén, Patricia Sanmartín-Salinas, M Val Toledo-Lobo, Jorge Saiz, Javier Ruperez, Coral Barbas, Luis Menchén, Fiona M Gribble, Frank Reimann, Luis G Guijarro, Jose M Carrascosa, Ángela M Valverde
May 05, 2020
OBJECTIVE:Non-alcoholic steatohepatitis (NASH) is characterized by a robust pro-inflammatory component at both hepatic and systemic levels together with a disease-specific gut microbiome signature. Protein tyrosine phosphatase...
Published by: Molecular metabolism
Online Interval Type-2 Fuzzy Extreme Learning Machine Applied to 3D Path Following for Remotely Operated Underwater Vehicles
Adrian Rubio-Solis, Uriel Martinez Hernandez, Luciano Nava-Balanzar, Luis Garcia-Valdovinos, Noe Rodriguez-Olivares, Juan Orozco-Muniz, Tomas Salgado-Jimenez
Jan 31, 2022
In marine missions that involve 3D path following tasks, the overall goal of Underwater Vehicles (UVs) is the successful completion of a path previously specified by the operator. This implies that the path must be followed...
Biomarker changes with systolic anterior motion of the mitral valve in cats with hypertrophic cardiomyopathy.
Joonbum Seo, Jessie Rosie Payne, Jose Novo Matos, Wesley Wynne Fong, David J Connolly, Virginia Luis Fuentes
Sep 23, 2021
BACKGROUND: N-terminal pro B-type natriuretic peptide (NT-proBNP) and cardiac troponin-I (cTnI) are biomarkers commonly evaluated in cats with suspected heart disease. Many cats with hypertrophic cardiomyopathy (HCM) have...
Online Interval Type-2 Fuzzy Extreme Learning Machine Applied to 3D Path Following for Remotely Operated Underwater Vehicles
Adrian Rubio-Solis, Uriel Martinez Hernandez, Luciano Nava-Balanzar, Luis Garcia-Valdovinos, Noe Rodriguez-Olivares, Juan Orozco-Muniz, Tomas Salgado-Jimenez
Jan 31, 2022
In marine missions that involve 3D path following tasks, the overall goal of Underwater Vehicles (UVs) is the successful completion of a path previously specified by the operator. This implies that the path must be followed...
Regional parent flood frequency distributions in Europe – Part 2
This study aims to better understand the effect of catchment scale and climate on the statistical properties of regional flood frequency distributions. A database of L-moment ratios of annual maximum series (AMS) of peak...
Regional parent flood frequency distributions in Europe – Part 2
This study aims to better understand the effect of catchment scale and climate on the statistical properties of regional flood frequency distributions. A database of L-moment ratios of annual maximum series (AMS) of peak...
Running demands and heart rate response in rugby union referees
Luis Suarez-Arrones, Luis J. Portillo, Jose M. García, Africa Calvo-Lluch, Simon P. Roberts, Alberto Mendez-Villanueva
Nov 01, 2013
The aim of this study was to examine the match physical demands and exercise intensity associated with men rugby union refereeing using global positioning system technology. Ten male rugby union referees (age, 37.1 ± 5.9 years;...
Development and External Validation of the STRATified CANcer Surveillance (STRATCANS) Multivariable Model for Predicting Progression in Men with Newly Diagnosed Prostate Cancer Starting Active Surveillance.
Alexander Light, Artitaya Lophatananon, Alexandra Keates, Vineetha Thankappannair, Tristan Barrett, Jose Dominguez-Escrig, Jose Rubio-Briones, Toufik Benheddi, Jonathan Olivier, Arnauld Villers, Kirthana Babureddy, Haitham Abdelmoteleb, Vincent J Gnanapragasam
Feb 09, 2023
For men with newly diagnosed prostate cancer, we aimed to develop and validate a model to predict the risk of progression on active surveillance (AS), which could inform more personalised AS strategies. In total, 883 men from 3...
Routine care provided by specialists to children and adolescents in the United States (2002-2006).
Jose M Valderas, Barbara Starfield, Christopher B Forrest, Luis Rajmil, Martin Roland, Bonnie Sibbald
Jun 16, 2011
Micro-computed tomography (micro-CT) for the assessment of myocardial disarray, fibrosis and ventricular mass in a feline model of hypertrophic cardiomyopathy.
Jose Novo Matos, Patricia Garcia-Canadilla, Ian C Simcock, J Ciaran Hutchinson, Melanie Dobromylskyj, Anna Guy, Owen J Arthurs, Andrew C Cook, Virginia Luis Fuentes
Dec 14, 2020
Micro-computed tomography (micro-CT) is a high-resolution imaging modality that provides accurate tissue characterization. Hypertrophic cardiomyopathy (HCM) occurs as a spontaneous disease in cats, and is characterized by...
Using prognosis to guide inclusion criteria, define standardised endpoints and stratify follow-up in active surveillance for prostate cancer.
Vincent J Gnanapragasam, Tristan Barrett, Vineetha Thankapannair, David Thurtle, Jose Rubio-Briones, Jose Domínguez-Escrig, Ola Bratt, Par Statin, Kenneth Muir, Artitaya Lophatananon
May 10, 2019
OBJECTIVES: To test whether using disease prognosis can inform a rational approach to active surveillance (AS) for early prostate cancer. PATIENTS AND METHODS: We previously developed the Cambridge Prognostics Groups (CPG)...
Development and External Validation of the STRATified CANcer Surveillance (STRATCANS) Multivariable Model for Predicting Progression in Men with Newly Diagnosed Prostate Cancer Starting Active Surveillance.
Alexander Light, Artitaya Lophatananon, Alexandra Keates, Vineetha Thankappannair, Tristan Barrett, Jose Dominguez-Escrig, Jose Rubio-Briones, Toufik Benheddi, Jonathan Olivier, Arnauld Villers, Kirthana Babureddy, Haitham Abdelmoteleb, Vincent J Gnanapragasam
Jan 24, 2023
Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or Inflammation.
Alejandro Carrillo-Jimenez, Mar Puigdellívol, Anna Vilalta, Jose Luis Venero, Guy Charles Brown, Peter StGeorge-Hyslop, Miguel Angel Burguillos
Nov 22, 2018
Microglia, the resident immune cells of the brain, have multiple functions in physiological and pathological conditions, including Alzheimer's disease (AD). The use of primary microglial cell cultures has proved to be a valuable...
Micro-computed tomography (micro-CT) for the assessment of myocardial disarray, fibrosis and ventricular mass in a feline model of hypertrophic cardiomyopathy
Jose Novo Matos, Patricia Garcia-Canadilla, Ian C. Simcock, J. Ciaran Hutchinson, Melanie Dobromylskyj, Anna Guy, Owen J. Arthurs, Andrew C. Cook, Virginia Luis Fuentes
Nov 19, 2020
Abstract: Micro-computed tomography (micro-CT) is a high-resolution imaging modality that provides accurate tissue characterization. Hypertrophic cardiomyopathy (HCM) occurs as a spontaneous disease in cats, and is characterized...
A Multilayer Interval Type-2 Fuzzy Extreme Learning Machine for the Recognition of Walking Activities and Gait Events using Wearable Sensors
In this paper, a novel Multilayer Interval Type-2 Fuzzy Extreme Learning Machine (ML-IT2-FELM) for the recognition of walking activities and Gait events is presented. The ML-IT2-FELM uses a hierarchical learning scheme that...
The New Capital of Spanish Language Literature
This translation was originally published as:
“The New Capital of Spanish Language Literature: The Best Seller.” New Spain New Literatures, by Maarten Steenmeijer. Eds. Luis Martín Estudillo and Nicholas Spadaccini. Vanderbilt...
Published by: Digital Commons @ Texas A&M University-San Antonio
A Multilayer Interval Type-2 Fuzzy Extreme Learning Machine for the Recognition of Walking Activities and Gait Events using Wearable Sensors
In this paper, a novel Multilayer Interval Type-2 Fuzzy Extreme Learning Machine (ML-IT2-FELM) for the recognition of walking activities and Gait events is presented. The ML-IT2-FELM uses a hierarchical learning scheme that...
The New Capital of Spanish Language Literature
This translation was originally published as:
“The New Capital of Spanish Language Literature: The Best Seller.” New Spain New Literatures, by Maarten Steenmeijer. Eds. Luis Martín Estudillo and Nicholas Spadaccini. Vanderbilt...
Published by: Digital Commons @ Texas A&M University-San Antonio
Pivotal Roles for pH, Lactate, and Lactate-Utilizing Bacteria in the Stability of a Human Colonic Microbial Ecosystem.
Shui Ping Wang, Luis A Rubio, Sylvia H Duncan, Gillian E Donachie, Grietje Holtrop, Galiana Lo, Freda M Farquharson, Josef Wagner, Julian Parkhill, Petra Louis, Alan W Walker, Harry J Flint
Dec 18, 2020
Lactate can be produced by many gut bacteria, but in adults its accumulation in the colon is often an indicator of microbiota perturbation. Using continuous culture anaerobic fermentor systems, we found that lactate...
FGFR1 amplification or overexpression and hormonal resistance in luminal breast cancer
Silvana Mouron, Luis Manso, Eduardo Caleiras, Jose L. Rodriguez-Peralto, Oscar M. Rueda, Carlos Caldas, Ramon Colomer, Miguel Quintela-Fandino, Maria J. Bueno
Feb 13, 2021
Abstract: Background: FGFR1 amplification, but not overexpression, has been related to adverse prognosis in hormone-positive breast cancer (HRPBC). Whether FGFR1 overexpression and amplification are correlated, what is their...
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