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OPA1 Modulates Mitochondrial Ca2+ Uptake Through ER-Mitochondria Coupling.
Benjamín Cartes-Saavedra, Josefa Macuada, Daniel Lagos, Duxan Arancibia, María E Andrés, Patrick Yu-Wai-Man, György Hajnóczky, Verónica Eisner
Jan 28, 2022
Autosomal Dominant Optic Atrophy (ADOA), a disease that causes blindness and other neurological disorders, is linked to OPA1 mutations. OPA1, dependent on its GTPase and GED domains, governs inner mitochondrial membrane (IMM)...
Phosphoinositide 3-kinase beta controls replication factor C assembly and function.
Javier Redondo-Muñoz, María Josefa Rodríguez, Virginia Silió, Vicente Pérez-García, José María Valpuesta, Ana C Carrera
Apr 16, 2019
Genomic integrity is preserved by the action of protein complexes that control DNA homeostasis. These include the sliding clamps, trimeric protein rings that are arranged around DNA by clamp loaders. Replication factor C (RFC)...
A novel mechanism causing imbalance of mitochondrial fusion and fission in human myopathies.
Marina Bartsakoulia, Angela Pyle, Diego Troncoso-Chandía, Josefa Vial-Brizzi, Marysol V Paz-Fiblas, Jennifer Duff, Helen Griffin, Veronika Boczonadi, Hanns Lochmüller, Stephanie Kleinle, Patrick F Chinnery, Sarah Grünert, Janbernd Kirschner, Verónica Eisner, Rita Horvath
Mar 20, 2018
Mitochondrial dynamics play an important role in cellular homeostasis and a variety of human diseases are linked to its dysregulated function. Here, we describe a 15-year-old boy with a novel disease caused by altered...
Broad geographic sampling reveals the shared basis and environmental correlates of seasonal adaptation in Drosophila
Heather E Machado, Alan O Bergland, Ryan Taylor, Susanne Tilk, Emily Behrman, Kelly Dyer, Daniel K Fabian, Thomas Flatt, Josefa González, Talia L Karasov, Bernard Kim, Iryna Kozeretska, Brian P Lazzaro, Thomas Js Merritt, John E Pool, Katherine O'Brien, Subhash Rajpurohit, Paula R Roy, Stephen W Schaeffer, Svitlana Serga, Paul Schmidt, Dmitri A Petrov
Jul 02, 2021
To advance our understanding of adaptation to temporally varying selection pressures, we identified signatures of seasonal adaptation occurring in parallel among Drosophila melanogaster populations. Specifically, we estimated...
Broad geographic sampling reveals the shared basis and environmental correlates of seasonal adaptation in Drosophila.
Heather E Machado, Alan O Bergland, Ryan Taylor, Susanne Tilk, Emily Behrman, Kelly Dyer, Daniel K Fabian, Thomas Flatt, Josefa González, Talia L Karasov, Bernard Kim, Iryna Kozeretska, Brian P Lazzaro, Thomas Js Merritt, John E Pool, Katherine O'Brien, Subhash Rajpurohit, Paula R Roy, Stephen W Schaeffer, Svitlana Serga, Paul Schmidt, Dmitri A Petrov
Jul 28, 2021
To advance our understanding of adaptation to temporally varying selection pressures, we identified signatures of seasonal adaptation occurring in parallel among Drosophila melanogaster populations. Specifically, we estimated...
D. melanogaster Ecology evolution evolutionary biology fluctuating selection Genomics population genetics seasonal adaptation selection Adaptation Biological Animals Austria Chromosome Inversion Drosophila melanogaster Gene Frequency Male Ontario Polymorphism Genetic Seasons selection Genetic Spain Ukraine United States