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Glucose in the hypothalamic paraventricular nucleus regulates GLP-1 release.
Yue Ma, Risheka Ratnasabapathy, Ivan De Backer, Chioma Izzi-Engbeaya, Marie-Sophie Nguyen-Tu, Joyceline Cuenco, Ben Jones, Christopher D John, Brian YH Lam, Guy A Rutter, Giles SH Yeo, Waljit S Dhillo, James Gardiner
Jun 15, 2020
Glucokinase (GK) is highly expressed in the hypothalamic paraventricular nucleus (PVN); however, its role is currently unknown. We found that GK in the PVN acts as part of a glucose-sensing mechanism within the PVN that...