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Derivatives of a PARP inhibitor TIQ-A through synthesis of 8-alkoxythieno[2,3-c]isoquinolin-5(4H)-ones
Mirko Maksimainen, Antti Nurmesjärvi, Reima Terho, Michael Threadgill, Lari Lehtiö, Juha Heiskanen
Jan 01, 0001
Thieno[2,3-c]isoquinolin-5(4H)-one is known for its potential as an anti-ischemic agent through inhibition of poly(ADP-ribose) polymerase 1 (PARP1). However, the compound also inhibits many other enzymes of the PARP family...
Derivatives of a PARP inhibitor TIQ-A through synthesis of 8-alkoxythieno[2,3-c]isoquinolin-5(4H)-ones
Mirko Maksimainen, Antti Nurmesjärvi, Reima Terho, Michael Threadgill, Lari Lehtiö, Juha Heiskanen
Jan 01, 0001
Thieno[2,3-c]isoquinolin-5(4H)-one is known for its potential as an anti-ischemic agent through inhibition of poly(ADP-ribose) polymerase 1 (PARP1). However, the compound also inhibits many other enzymes of the PARP family...
In the Shadow of Genocide
Abstract Internationally regarded as “the crime of crimes” in both legal and moral terms, the concept of genocide has towered over discussions of ethnic conflict and mass violence since the Second...
Jaakko Heiskanen
Oct 08, 2021
Longitudinal regional brain volume loss in schizophrenia
Joyce Y Guo, Sanna Huhtaniska, Jouko Miettunen, Erika Jääskeläinen, Vesa Kiviniemi, Juha Nikkinen, Jani Moilanen, Marianne Haapea, Pirjo Mäki, Peter B Jones, Juha Veijola, Matti Isohanni, Graham K Murray
Jul 14, 2015
Severe mood disorders and schizophrenia in the adult offspring of antenatally depressed mothers in the Northern Finland 1966 Birth Cohort
BACKGROUND: Maternal antenatal depression may alter offspring neurodevelopment, but long follow-up studies are lacking. We studied the risks for mood disorders and schizophrenia in adult offspring of antenatally depressed...
Antenatal Bipolar Disorder Depression Mood Disorders Parental mental disorder Schizophrenia Adolescent Adult Adult Children Child Child of Impaired Parents Cohort Studies Depressive Disorder Female Finland Follow-Up Studies Humans Mood Disorders Mother-Child Relations Mothers Pregnancy Pregnancy Complications Prenatal Diagnosis Schizophrenic Psychology Young Adult
Brain structural deficits and working memory fMRI dysfunction in young adults who were diagnosed with ADHD in adolescence.
Andres Roman-Urrestarazu, Päivi Lindholm, Irma Moilanen, Vesa Kiviniemi, Jouko Miettunen, Erika Jääskeläinen, Pirjo Mäki, Tuula Hurtig, Hanna Ebeling, Jennifer H Barnett, Juha Nikkinen, John Suckling, Peter B Jones, Juha Veijola, Graham K Murray
Jul 28, 2015
High-grade ovarian serous carcinoma patients exhibit profound alterations in lipid metabolism.
Elena Ioana Braicu, Silvia Darb-Esfahani, Wolfgang D Schmitt, Kaisa M Koistinen, Laura Heiskanen, Päivi Pöhö, Jan Budczies, Marc Kuhberg, Manfred Dietel, Christian Frezza, Carsten Denkert, Jalid Sehouli, Mika Hilvo
May 31, 2018
Ovarian cancer is a very severe type of disease with poor prognosis. Treatment of ovarian cancer is challenging because of the lack of tests for early detection and effective therapeutic targets. Thus, new biomarkers are needed...
Understanding the structure and role of DNA-PK in NHEJ
Qian Wu, Shikang Liang, Takashi Ochi, Dimitri Y Chirgadze, Juha T Huiskonen, Tom L Blundell
Apr 15, 2019
DNA double-strand breaks (DSBs), generated by ionizing radiation, reactive oxygen species and DNA replication across nicks, are the most severe DNA damage in eukaryotic cells. Non-Homologous End Joining repairs DNA double-strand...
3D-Printed Soft Lithography for Complex Compartmentalized Microfluidic Neural Devices.
Janko Kajtez, Sebastian Buchmann, Shashank Vasudevan, Marcella Birtele, Stefano Rocchetti, Christian Jonathan Pless, Arto Heiskanen, Roger A Barker, Alberto Martínez-Serrano, Malin Parmar, Johan Ulrik Lind, Jenny Emnéus
Jul 16, 2020
Compartmentalized microfluidic platforms are an invaluable tool in neuroscience research. However, harnessing the full potential of this technology remains hindered by the lack of a simple fabrication approach for the creation...
Associations Between Maternal Prenatal C-Reactive Protein and Risk Factors for Psychosis in Adolescent Offspring
Hugh Ramsay, Heljä-Marja Surcel, Lassi Björnholm, Martta Kerkelä, Golam M Khandaker, Juha Veijola
Sep 24, 2020
Prenatal infection is associated with brain structural and functional abnormalities and may increase the risk for psychosis through a direct effect on neurodevelopment. Various infections may exert their effect through a...
Cryo-EM structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution.
Nejc Kejzar, Elina Laanto, Ilona Rissanen, Vahid Abrishami, Muniyandi Selvaraj, Sylvain Moineau, Janne Ravantti, Lotta-Riina Sundberg, Juha T Huiskonen
Dec 08, 2022
The origin of viruses remains an open question. While lack of detectable sequence similarity hampers the analysis of distantly related viruses, structural biology investigations of conserved capsid protein structures facilitate...
Substantial Fat Loss in Physique Competitors Is Characterized by Increased Levels of Bile Acids, Very-Long Chain Fatty Acids, and Oxylipins.
Heikki V Sarin, Juha J Hulmi, Youwen Qin, Michael Inouye, Scott C Ritchie, Susan Cheng, Jeramie D Watrous, Thien-Tu C Nguyen, Joseph H Lee, Zhezhen Jin, Joseph D Terwilliger, Teemu Niiranen, Aki Havulinna, Veikko Salomaa, Kirsi H Pietiläinen, Ville Isola, Juha P Ahtiainen, Keijo Häkkinen, Mohit Jain, Markus Perola
Oct 06, 2022
Specific adolescent prodromal symptoms associated with onset of psychosis in the Northern Finland Birth Cohort 1986.
Johanna Palomäki, Sebastian Therman, Martta Kerkelä, Marjo-Riitta Järvelin, Peter Jones, Graham K Murray, Tanja Nordström, Markus Heinimaa, Jouko Miettunen, Juha Veijola, Tiina Riekki
Oct 11, 2022
BACKGROUND: Several psychological symptoms in adolescence associate with later development of psychosis. However, it is unclear which symptoms specifically predict psychotic disorders rather than psychiatric disorders in...
Cryo-EM structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution.
Nejc Kejzar, Elina Laanto, Ilona Rissanen, Vahid Abrishami, Muniyandi Selvaraj, Sylvain Moineau, Janne Ravantti, Lotta-Riina Sundberg, Juha T Huiskonen
Jan 04, 2023
The origin of viruses remains an open question. While lack of detectable sequence similarity hampers the analysis of distantly related viruses, structural biology investigations of conserved capsid protein structures facilitate...
Polygenic Risk Score for Schizophrenia and Face-Processing Network in Young Adulthood.
Johannes Lieslehto, Vesa J Kiviniemi, Tanja Nordström, Jennifer H Barnett, Graham K Murray, Peter B Jones, Tomáš Paus, Juha Veijola
Nov 20, 2018
cohort study fMRI face-processing the polygenic risk score for schizophrenia Adult Adverse Childhood Experiences Brain Mapping Cohort Studies Facial Expression Facial Recognition Female Finland Genetic Predisposition to Disease Genome-Wide Association Study Gray Matter Humans Magnetic Resonance Imaging Male Registries risk Schizophrenia Social Perception Young Adult
Substantial Fat Loss in Physique Competitors Is Characterized by Increased Levels of Bile Acids, Very-Long Chain Fatty Acids, and Oxylipins.
Heikki V Sarin, Juha J Hulmi, Youwen Qin, Michael Inouye, Scott C Ritchie, Susan Cheng, Jeramie D Watrous, Thien-Tu C Nguyen, Joseph H Lee, Zhezhen Jin, Joseph D Terwilliger, Teemu Niiranen, Aki Havulinna, Veikko Salomaa, Kirsi H Pietiläinen, Ville Isola, Juha P Ahtiainen, Keijo Häkkinen, Mohit Jain, Markus Perola
Nov 27, 2022
An RGS2 3'UTR polymorphism is associated with preeclampsia in overweight women.
Tiina Karppanen, Tea Kaartokallio, Miira M Klemetti, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Anne Cathrine Staff, Hannele Laivuori
Sep 29, 2016
BACKGROUND: Preeclampsia is a common and heterogeneous vascular syndrome of pregnancy. Its genetic risk profile is yet unknown and may vary between individuals and populations. The rs4606 3' UTR polymorphism of the Regulator of...
Candidate gene study Preeclampsia Pregnancy Regulator of G-protein signaling 2 3' Untranslated Regions Adult Alleles Biomarkers Body Mass Index Case-Control Studies Female Gene Expression Regulation Genetic Association Studies Genetic Predisposition to Disease Genotype Humans Models Biological Odds Ratio Overweight Polymorphism Single Nucleotide pre-eclampsia Pregnancy RGS Proteins Risk Factors
Characterization of cytokinin signaling and homeostasis gene families in two hardwood tree species
Juha Immanen, Kaisa Nieminen, Héctor Duchens Silva, Fernanda Rodríguez Rojas, Lee A Meisel, Herman Silva, Victor A Albert, Torgeir R Hvidsten, Ykä Helariutta
Sep 29, 2018
BACKGROUND: Through the diversity of cytokinin regulated processes, this phytohormone has a profound impact on plant growth and development. Cytokinin signaling is involved in the control of apical and lateral meristem activity...
The progression of disorder-specific brain pattern expression in schizophrenia over 9 years
Johannes Lieslehto, Erika Jääskeläinen, Vesa Kiviniemi, Marianne Haapea, Peter B. Jones, Graham K. Murray, Juha Veijola, Udo Dannlowski, Dominik Grotegerd, Susanne Meinert, Tim Hahn, Anne Ruef, Matti Isohanni, Peter Falkai, Jouko Miettunen, Dominic B. Dwyer, Nikolaos Koutsouleris
Jun 14, 2021
Abstract: Age plays a crucial role in the performance of schizophrenia vs. controls (SZ-HC) neuroimaging-based machine learning (ML) models as the accuracy of identifying first-episode psychosis from controls is poor compared to...
The progression of disorder-specific brain pattern expression in schizophrenia over 9 years.
Johannes Lieslehto, Erika Jääskeläinen, Vesa Kiviniemi, Marianne Haapea, Peter B Jones, Graham K Murray, Juha Veijola, Udo Dannlowski, Dominik Grotegerd, Susanne Meinert, Tim Hahn, Anne Ruef, Matti Isohanni, Peter Falkai, Jouko Miettunen, Dominic B Dwyer, Nikolaos Koutsouleris
Jul 21, 2021
Age plays a crucial role in the performance of schizophrenia vs. controls (SZ-HC) neuroimaging-based machine learning (ML) models as the accuracy of identifying first-episode psychosis from controls is poor compared to chronic...
No association of COMT (Val158Met) genotype with brain structure differences between men and women.
Anna Barnes, Matti Isohanni, Jennifer H Barnett, Olli Pietiläinen, Juha Veijola, Jouko Miettunen, Tiina Paunio, Päivikki Tanskanen, Khanum Ridler, John Suckling, Edward T Bullmore, Graham K Murray, Peter B Jones
May 01, 2018
We examined the effect of the catechol-O-methyltransferase (COMT) Val158Met polymorphism (rs4680), on brain structure in a subset (N = 82) of general population members of the Northern Finland 1966 Birth Cohort, selected through...
Cytokinin and Auxin Display Distinct but Interconnected Distribution and Signaling Profiles to Stimulate Cambial Activity.
Juha Immanen, Kaisa Nieminen, Olli-Pekka Smolander, Mikiko Kojima, Juan Alonso Serra, Patrik Koskinen, Jing Zhang, Annakaisa Elo, Ari Pekka Mähönen, Nathaniel Street, Rishikesh P Bhalerao, Lars Paulin, Petri Auvinen, Hitoshi Sakakibara, Ykä Helariutta
Jun 23, 2016
Association between developmental milestones and age of schizophrenia onset
Jan Stochl, Anjalene Whittier, Adam P Wagner, Juha Veijola, Erika Jääskeläinen, Jouko Miettunen, Golam M Khandaker, Peter B Jones
Feb 22, 2019
We investigated relationships between early developmental milestones, schizophrenia incidence and variability in its age at onset. We hypothesized that the period of risk for schizophrenia would be longer for those with later...
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