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Results: 98
Severe mood disorders and schizophrenia in the adult offspring of antenatally depressed mothers in the Northern Finland 1966 Birth Cohort
BACKGROUND: Maternal antenatal depression may alter offspring neurodevelopment, but long follow-up studies are lacking. We studied the risks for mood disorders and schizophrenia in adult offspring of antenatally depressed...
Antenatal Bipolar Disorder Depression Mood Disorders Parental mental disorder Schizophrenia Adolescent Adult Adult Children Child Child of Impaired Parents Cohort Studies Depressive Disorder Female Finland Follow-Up Studies Humans Mood Disorders Mother-Child Relations Mothers Pregnancy Pregnancy Complications Prenatal Diagnosis Schizophrenic Psychology Young Adult
Brain structural deficits and working memory fMRI dysfunction in young adults who were diagnosed with ADHD in adolescence.
Derivatives of a PARP inhibitor TIQ-A through synthesis of 8-alkoxythieno[2,3-c]isoquinolin-5(4H)-ones
Mirko Maksimainen, Antti Nurmesjärvi, Reima Terho, Michael Threadgill, Lari Lehtiö, Juha Heiskanen
Jan 01, 0001
Thieno[2,3-c]isoquinolin-5(4H)-one is known for its potential as an anti-ischemic agent through inhibition of poly(ADP-ribose) polymerase 1 (PARP1). However, the compound also inhibits many other enzymes of the PARP family...
Understanding the structure and role of DNA-PK in NHEJ
Qian Wu, Shikang Liang, Takashi Ochi, Dimitri Y Chirgadze, Juha T Huiskonen, Tom L Blundell
Apr 15, 2019
DNA double-strand breaks (DSBs), generated by ionizing radiation, reactive oxygen species and DNA replication across nicks, are the most severe DNA damage in eukaryotic cells. Non-Homologous End Joining repairs DNA double-strand...
Derivatives of a PARP inhibitor TIQ-A through synthesis of 8-alkoxythieno[2,3-c]isoquinolin-5(4H)-ones
Mirko Maksimainen, Antti Nurmesjärvi, Reima Terho, Michael Threadgill, Lari Lehtiö, Juha Heiskanen
Jan 01, 0001
Thieno[2,3-c]isoquinolin-5(4H)-one is known for its potential as an anti-ischemic agent through inhibition of poly(ADP-ribose) polymerase 1 (PARP1). However, the compound also inhibits many other enzymes of the PARP family...
Associations Between Maternal Prenatal C-Reactive Protein and Risk Factors for Psychosis in Adolescent Offspring
Hugh Ramsay, Heljä-Marja Surcel, Lassi Björnholm, Martta Kerkelä, Golam M Khandaker, Juha Veijola
Sep 24, 2020
Prenatal infection is associated with brain structural and functional abnormalities and may increase the risk for psychosis through a direct effect on neurodevelopment. Various infections may exert their effect through a...
Genetic analyses identify widespread sex-differential participation bias.
Nicola Pirastu, Mattia Cordioli, Priyanka Nandakumar, Gianmarco Mignogna, Abdel Abdellaoui, Benjamin Hollis, Masahiro Kanai, Veera M Rajagopal, Pietro Della Briotta Parolo, Nikolas Baya, Caitlin E Carey, Juha Karjalainen, Thomas D Als, Matthijs D Van der Zee, Felix R Day, Ken K Ong, FinnGen study, 23andMe Research Team, iPSYCH Consortium, Takayuki Morisaki, Eco de Geus, Rino Bellocco, Yukinori Okada, Anders D Børglum, Peter Joshi, Adam Auton, David Hinds, Benjamin M Neale, Raymond K Walters, Michel G Nivard, John RB Perry, Andrea Ganna
Jul 23, 2021
Cryo-EM structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution.
Nejc Kejzar, Elina Laanto, Ilona Rissanen, Vahid Abrishami, Muniyandi Selvaraj, Sylvain Moineau, Janne Ravantti, Lotta-Riina Sundberg, Juha T Huiskonen
Dec 08, 2022
The origin of viruses remains an open question. While lack of detectable sequence similarity hampers the analysis of distantly related viruses, structural biology investigations of conserved capsid protein structures facilitate...
Learn to Train Like You Fight
This qualitative study includes nine semi-structured interviews with cybersecurity experts from different security-related organizations who are familiar with cybersecurity exercises. Its contribution to cybersecurity workforce...
Published by: IGI Global Scientific Publishing
Substantial Fat Loss in Physique Competitors Is Characterized by Increased Levels of Bile Acids, Very-Long Chain Fatty Acids, and Oxylipins.
Heikki V Sarin, Juha J Hulmi, Youwen Qin, Michael Inouye, Scott C Ritchie, Susan Cheng, Jeramie D Watrous, Thien-Tu C Nguyen, Joseph H Lee, Zhezhen Jin, Joseph D Terwilliger, Teemu Niiranen, Aki Havulinna, Veikko Salomaa, Kirsi H Pietiläinen, Ville Isola, Juha P Ahtiainen, Keijo Häkkinen, Mohit Jain, Markus Perola
Oct 06, 2022
Comparison of high versus low frequency cerebral physiology for cerebrovascular reactivity assessment in traumatic brain injury
Eric P. Thelin, Rahul Raj, Bo-Michael Bellander, David Nelson, Anna Piippo-Karjalainen, Jari Siironen, Päivi Tanskanen, Gregory Hawryluk, Mohammed Hasen, Bertram Unger, Frederick A. Zeiler
Sep 30, 2020
Abstract: Current accepted cerebrovascular reactivity indices suffer from the need of high frequency data capture and export for post-acquisition processing. The role for minute-by-minute data in cerebrovascular reactivity...
Specific adolescent prodromal symptoms associated with onset of psychosis in the Northern Finland Birth Cohort 1986.
Johanna Palomäki, Sebastian Therman, Martta Kerkelä, Marjo-Riitta Järvelin, Peter Jones, Graham K Murray, Tanja Nordström, Markus Heinimaa, Jouko Miettunen, Juha Veijola, Tiina Riekki
Oct 11, 2022
BACKGROUND: Several psychological symptoms in adolescence associate with later development of psychosis. However, it is unclear which symptoms specifically predict psychotic disorders rather than psychiatric disorders in...
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease
Connor A. Emdin, Mary E. Haas, Amit V. Khera, Krishna Aragam, Mark Chaffin, Derek Klarin, George Hindy, Lan Jiang, Wei-Qi Wei, Qiping Feng, Juha Karjalainen, Aki Havulinna, Tuomo Kiiskinen, Alexander Bick, Diego Ardissino, James G. Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J. Bown, Nilesh J. Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Danish Saleheen, Kyong-Mi Chang, Marijana Vujkovic, Ben Voight, Scott Damrauer, Julie Lynch, David Kaplan, Marina Serper, Philip Tsao, Million Veteran Program, Josep Mercader, Craig Hanis, Mark Daly, Joshua Denny, Stacey Gabriel, Sekar Kathiresan
May 05, 2020
Analyzing 12,361 all-cause cirrhosis cases and 790,095 controls from eight cohorts, we identify a common missense variant in the Mitochondrial Amidoxime Reducing Component 1 gene (MARC1 p.A165T) that associates with protection...
Cryo-EM structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution.
Nejc Kejzar, Elina Laanto, Ilona Rissanen, Vahid Abrishami, Muniyandi Selvaraj, Sylvain Moineau, Janne Ravantti, Lotta-Riina Sundberg, Juha T Huiskonen
Jan 04, 2023
The origin of viruses remains an open question. While lack of detectable sequence similarity hampers the analysis of distantly related viruses, structural biology investigations of conserved capsid protein structures facilitate...
Polygenic Risk Score for Schizophrenia and Face-Processing Network in Young Adulthood.
Johannes Lieslehto, Vesa J Kiviniemi, Tanja Nordström, Jennifer H Barnett, Graham K Murray, Peter B Jones, Tomáš Paus, Juha Veijola
Nov 20, 2018
cohort study fMRI face-processing the polygenic risk score for schizophrenia Adult Adverse Childhood Experiences Brain Mapping Cohort Studies Facial Expression Facial Recognition Female Finland Genetic Predisposition to Disease Genome-Wide Association Study Gray Matter Humans Magnetic Resonance Imaging Male Registries risk Schizophrenia Social Perception Young Adult
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease.
Connor A Emdin, Mary E Haas, Amit V Khera, Krishna Aragam, Mark Chaffin, Derek Klarin, George Hindy, Lan Jiang, Wei-Qi Wei, Qiping Feng, Juha Karjalainen, Aki Havulinna, Tuomo Kiiskinen, Alexander Bick, Diego Ardissino, James G Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J Bown, Nilesh J Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Danish Saleheen, Kyong-Mi Chang, Marijana Vujkovic, Ben Voight, Scott Damrauer, Julie Lynch, David Kaplan, Marina Serper, Philip Tsao, Million Veteran Program, Josep Mercader, Craig Hanis, Mark Daly, Joshua Denny, Stacey Gabriel, Sekar Kathiresan
May 16, 2020
Analyzing 12,361 all-cause cirrhosis cases and 790,095 controls from eight cohorts, we identify a common missense variant in the Mitochondrial Amidoxime Reducing Component 1 gene (MARC1 p.A165T) that associates with protection...
Substantial Fat Loss in Physique Competitors Is Characterized by Increased Levels of Bile Acids, Very-Long Chain Fatty Acids, and Oxylipins.
Heikki V Sarin, Juha J Hulmi, Youwen Qin, Michael Inouye, Scott C Ritchie, Susan Cheng, Jeramie D Watrous, Thien-Tu C Nguyen, Joseph H Lee, Zhezhen Jin, Joseph D Terwilliger, Teemu Niiranen, Aki Havulinna, Veikko Salomaa, Kirsi H Pietiläinen, Ville Isola, Juha P Ahtiainen, Keijo Häkkinen, Mohit Jain, Markus Perola
Nov 27, 2022
Comparison of high versus low frequency cerebral physiology for cerebrovascular reactivity assessment in traumatic brain injury
Eric P Thelin, Rahul Raj, Bo-Michael Bellander, David Nelson, Anna Piippo-Karjalainen, Jari Siironen, Päivi Tanskanen, Gregory Hawryluk, Mohammed Hasen, Bertram Unger, Frederick A Zeiler
Sep 25, 2019
Current accepted cerebrovascular reactivity indices suffer from the need of high frequency data capture and export for post-acquisition processing. The role for minute-by-minute data in cerebrovascular reactivity monitoring...
An RGS2 3'UTR polymorphism is associated with preeclampsia in overweight women.
Tiina Karppanen, Tea Kaartokallio, Miira M Klemetti, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Anne Cathrine Staff, Hannele Laivuori
Sep 29, 2016
BACKGROUND: Preeclampsia is a common and heterogeneous vascular syndrome of pregnancy. Its genetic risk profile is yet unknown and may vary between individuals and populations. The rs4606 3' UTR polymorphism of the Regulator of...
Candidate gene study Preeclampsia Pregnancy Regulator of G-protein signaling 2 3' Untranslated Regions Adult Alleles Biomarkers Body Mass Index Case-Control Studies Female Gene Expression Regulation Genetic Association Studies Genetic Predisposition to Disease Genotype Humans Models Biological Odds Ratio Overweight Polymorphism Single Nucleotide pre-eclampsia Pregnancy RGS Proteins Risk Factors
Characterization of cytokinin signaling and homeostasis gene families in two hardwood tree species
Juha Immanen, Kaisa Nieminen, Héctor Duchens Silva, Fernanda Rodríguez Rojas, Lee A Meisel, Herman Silva, Victor A Albert, Torgeir R Hvidsten, Ykä Helariutta
Sep 29, 2018
BACKGROUND: Through the diversity of cytokinin regulated processes, this phytohormone has a profound impact on plant growth and development. Cytokinin signaling is involved in the control of apical and lateral meristem activity...
The progression of disorder-specific brain pattern expression in schizophrenia over 9 years
Johannes Lieslehto, Erika Jääskeläinen, Vesa Kiviniemi, Marianne Haapea, Peter B. Jones, Graham K. Murray, Juha Veijola, Udo Dannlowski, Dominik Grotegerd, Susanne Meinert, Tim Hahn, Anne Ruef, Matti Isohanni, Peter Falkai, Jouko Miettunen, Dominic B. Dwyer, Nikolaos Koutsouleris
Jun 14, 2021
Abstract: Age plays a crucial role in the performance of schizophrenia vs. controls (SZ-HC) neuroimaging-based machine learning (ML) models as the accuracy of identifying first-episode psychosis from controls is poor compared to...
The progression of disorder-specific brain pattern expression in schizophrenia over 9 years.
Johannes Lieslehto, Erika Jääskeläinen, Vesa Kiviniemi, Marianne Haapea, Peter B Jones, Graham K Murray, Juha Veijola, Udo Dannlowski, Dominik Grotegerd, Susanne Meinert, Tim Hahn, Anne Ruef, Matti Isohanni, Peter Falkai, Jouko Miettunen, Dominic B Dwyer, Nikolaos Koutsouleris
Jul 21, 2021
Age plays a crucial role in the performance of schizophrenia vs. controls (SZ-HC) neuroimaging-based machine learning (ML) models as the accuracy of identifying first-episode psychosis from controls is poor compared to chronic...
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