Search
Results: 1164
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Jan 22, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.
Sympathetic neurons depend on NGF binding to TrkA for their survival during vertebrate development. NGF deprivation initiates a transcription-dependent apoptotic response, which is suggested to require activation of the...
Animals Apoptosis Base Sequence Brain-Derived Neurotrophic Factor Cells Cultured Cycloheximide Gene Expression Regulation Developmental Genetic Vectors Green Fluorescent Proteins Immunohistochemistry Indicators and Reagents Integrases Luminescent Proteins Mice Mice Knockout Mutation Nerve Growth Factor Neurons Protein Synthesis Inhibitors Proto-Oncogene Proteins c-jun Receptor Nerve Growth Factor Superior Cervical Ganglion Transfection Viral Proteins
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun.
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Mar 15, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Self-rated walking pace and all-cause, cardiovascular disease and cancer mortality
Emmanuel Stamatakis, Paul Kelly, Tessa Strain, Elaine M Murtagh, Ding Ding, Marie H Murphy
May 14, 2018
BACKGROUND/OBJECTIVES: Walking pace is associated with risk of premature mortality. However, whether this relationship is independent of total volume of physical activity and highest physical activity intensity remains unclear....
Targeted fluorescence imaging enhanced by 2D materials
Donghao Xie, Ding Kun Ji, Yue Zhang, Jun Cao, Hu Zheng, Lin Liu, Yi Zang, Jia Li, Guo Rong Chen, Tony D. James, Xiao Peng He
Aug 04, 2016
Here we demonstrate that 2D MoS2 can enhance the receptor-targeting and imaging ability of a fluorophore-labelled ligand. The 2D MoS2 has an enhanced working concentration range when compared with...
Prenatal and birth predictors of objectively measured physical activity and sedentary time in three population-based birth cohorts in Brazil.
Ding Ding, Gregore I Mielke, Inacio Crochemore M Silva, Fernando C Wehrmeister, Bernardo L Horta, Soren Brage, Pedro C Hallal, Ulf Ekelund
Feb 22, 2020
Physical inactivity is a global pandemic with no signs of improvement. Prolonged sitting time is an emerging risk factor that exacerbates the health consequences of physical inactivity. Both behaviours are influenced by various...
Published by: Scientific reports
Twisting of a Pristine α-Fe Nanowire
The torsion of pristine α-Fe nanowires was studied by molecular dynamics simulations. Torsion-induced plastic deformation in pristine nanowires is divided into two regimes. Under weak torsion, plastic deformation leads to...
On hydrodynamic characteristics of gap resonance between two fixed bodies in close proximity
The resonant water motion inside a narrow gap between two identical fixed boxes that are in side-by-side configuration is investigated using a two-dimensional (2D) numerical wave tank based on OpenFOAM®, an open...
Twisting of a Pristine α-Fe Nanowire
The torsion of pristine α-Fe nanowires was studied by molecular dynamics simulations. Torsion-induced plastic deformation in pristine nanowires is divided into two regimes. Under weak torsion, plastic deformation leads to...
Current vortices and magnetic fields driven by moving polar twin boundaries in ferroelastic materials
Abstract: Ferroelastic twin boundaries often have properties that do not exist in bulk, such as superconductivity, polarity etc. Designing and optimizing domain walls can hence functionalize ferroelastic materials. Using...
Ferroelectric switching in ferroelastic materials with rough surfaces
Abstract: Electric switching of non-polar bulk crystals is shown to occur when domain walls are polar in ferroelastic materials and when rough surfaces with steps on an atomic scale promote domain switching. All domains emerging...
Twisting of a Pristine α-Fe Nanowire
The torsion of pristine α-Fe nanowires was studied by molecular dynamics simulations. Torsion-induced plastic deformation in pristine nanowires is divided into two regimes. Under weak torsion, plastic deformation leads to...
Topographic effects on wave resonance in the narrow gap between fixed box and vertical wall
Multiple coastal and offshore structures deployed side by side with narrow gap may be subject to large-amplitude free surface resonance, which can lead to green water on the deck and cause rapid increase of hydrodynamic loading...
Numerical investigations of wave loads on fixed box in front of vertical wall with a narrow gap under wave actions
Violent fluid oscillations may appear inside the narrow gap between multiple structures in close proximity and cause severe damage to such structures and safe operations. Here, based on the OpenFOAM® package, this paper...
Data Informed Model Test Design With Machine Learning – An Example in Nonlinear Wave Load on a Vertical Cylinder
Tianning Tang, Haoyu Ding, Saishuai Dai, Xi Chen, Paul H. Taylor, Jun Zang, Thomas A.A. Adcock
Apr 01, 2024
Model testing is common in coastal and offshore engineering. The design of such model tests is important such that the maximal information of the underlying physics can be extrapolated with a limited amount of test cases. The...
Numerical study of harbor oscillations induced by water surface disturbances within harbors of constant depth
Oscillations within an enclosed rectangular harbor and a set of partially opened rectangular harbors with various widths and locations of entrance induced by cubic water surface disturbances with different initial heights and...
Exploring practice characteristics and research priorities of practitioners of traditional acupuncture in China and the EU-A survey
ETHNOPHARMACOLOGICAL RELEVANCE: Acupuncture practice is based on the theoretical, historical and philosophical principles, which are part of Chinese medicine. Traditional acupuncture practitioners assess their patients'...
Exploring practice characteristics and research priorities of practitioners of traditional acupuncture in China and the EU-A survey
ETHNOPHARMACOLOGICAL RELEVANCE: Acupuncture practice is based on the theoretical, historical and philosophical principles, which are part of Chinese medicine. Traditional acupuncture practitioners assess their patients'...
|
|< |
< |
1 |