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Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Jan 22, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.
Sympathetic neurons depend on NGF binding to TrkA for their survival during vertebrate development. NGF deprivation initiates a transcription-dependent apoptotic response, which is suggested to require activation of the...
Animals Apoptosis Base Sequence Brain-Derived Neurotrophic Factor Cells Cultured Cycloheximide Gene Expression Regulation Developmental Genetic Vectors Green Fluorescent Proteins Immunohistochemistry Indicators and Reagents Integrases Luminescent Proteins Mice Mice Knockout Mutation Nerve Growth Factor Neurons Protein Synthesis Inhibitors Proto-Oncogene Proteins c-jun Receptor Nerve Growth Factor Superior Cervical Ganglion Transfection Viral Proteins
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun.
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Mar 15, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Genomic risk scores for juvenile idiopathic arthritis and its subtypes
Rodrigo Cánovas, Joanna Cobb, Marta Brozynska, John Bowes, Yun R Li, Samantha Louise Smith, Hakon Hakonarson, Wendy Thomson, Justine A Ellis, Gad Abraham, Jane E Munro, Michael Inouye
Sep 09, 2020
Objectives: Juvenile idiopathic arthritis (JIA) is an autoimmune disease and a common cause of chronic disability in children. Diagnosis of JIA is based purely on clinical symptoms, which can be variable, leading to diagnosis...
90K immunostimulatory glycoprotein in children with juvenile idiopathic arthritis.
Cristina Cecamore, Manuela Marsili, Roberta Salvatore, Roberto Troiani, Maurizia D'Egidio, Nicola Tinari, Piernicola Pelliccia, Francesco Chiarelli, M Loredana Marcovecchio, Luciana Breda
Nov 23, 2018
OBJECTIVES: To assess whether circulating levels of 90K glycoprotein are increased in children with juvenile idiopathic arthritis (JIA) at different stages of the disease, compared to healthy controls and to evaluate potential...
Numerical investigation of wave propagation and transformation over a submerged reef
In this paper, wave transformation over a submerged reef has been numerically studied based on the OpenFOAM model. This numerical model solves the Reynolds-Averaged Navier-Stokes equations for two-phase flow, and employs the...
Numerical investigation of wave propagation and transformation over a submerged reef
In this paper, wave transformation over a submerged reef has been numerically studied based on the OpenFOAM model. This numerical model solves the Reynolds-Averaged Navier-Stokes equations for two-phase flow, and employs the...
Supporting primary school children with Juvenile Idiopathic Arthritis
Background: Juvenile Idiopathic Arthritis (JIA) has a deleterious impact on numerous areas of children’s lives including school functioning. This study moves beyond eliciting child reports of school functioning to examine...
Supporting primary school children with Juvenile Idiopathic Arthritis
Background: Juvenile Idiopathic Arthritis (JIA) has a deleterious impact on numerous areas of children’s lives including school functioning. This study moves beyond eliciting child reports of school functioning to examine...
Exploring practice characteristics and research priorities of practitioners of traditional acupuncture in China and the EU-A survey
ETHNOPHARMACOLOGICAL RELEVANCE: Acupuncture practice is based on the theoretical, historical and philosophical principles, which are part of Chinese medicine. Traditional acupuncture practitioners assess their patients'...
Accommodation-Free Head Mounted Display with Comfortable 3D Perception and an Enlarged Eye-box.
Pawan K Shrestha, Matt J Pryn, Jia Jia, Jhen-Si Chen, Hector Navarro Fructuoso, Atanas Boev, Qing Zhang, Daping Chu
Mar 13, 2020
An accommodation-free displays, also known as Maxwellian displays, keep the displayed image sharp regardless of the viewer's focal distance. However, they typically suffer from a small eye-box and limited effective field of view...
Exploring practice characteristics and research priorities of practitioners of traditional acupuncture in China and the EU-A survey
ETHNOPHARMACOLOGICAL RELEVANCE: Acupuncture practice is based on the theoretical, historical and philosophical principles, which are part of Chinese medicine. Traditional acupuncture practitioners assess their patients'...
ID proteins promote the survival and primed-to-naive transition of human embryonic stem cells through TCF3-mediated transcription.
Haibin Jiang, Mingxia Du, Yaning Li, Tengfei Zhou, Jia Lei, Hongqing Liang, Zhen Zhong, Rafia S Al-Lamki, Ming Jiang, Jun Yang
Jul 15, 2022
Inhibition of DNA binding proteins 1 and 3 (ID1 and ID3) are important downstream targets of BMP signalling that are necessary for embryonic development. However, their specific roles in regulating the pluripotency of human...
Accommodation-Free Head Mounted Display with Comfortable 3D Perception and an Enlarged Eye-box.
Pawan K Shrestha, Matt J Pryn, Jia Jia, Jhen-Si Chen, Hector Navarro Fructuoso, Atanas Boev, Qing Zhang, Daping Chu
Feb 17, 2020
An accommodation-free displays, also known as Maxwellian displays, keep the displayed image sharp regardless of the viewer's focal distance. However, they typically suffer from a small eye-box and limited effective field of view...
Targeted fluorescence imaging enhanced by 2D materials
Donghao Xie, Ding Kun Ji, Yue Zhang, Jun Cao, Hu Zheng, Lin Liu, Yi Zang, Jia Li, Guo Rong Chen, Tony D. James, Xiao Peng He
Aug 04, 2016
Here we demonstrate that 2D MoS2 can enhance the receptor-targeting and imaging ability of a fluorophore-labelled ligand. The 2D MoS2 has an enhanced working concentration range when compared with...
/dk/atira/pure/subjectarea/asjc/1500/1503 name=Catalysis /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/2500/2503 name=Ceramics and Composites /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2500/2508 name=Surfaces, Coatings and Films /dk/atira/pure/subjectarea/asjc/2500/2506 name=Metals and Alloys /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
Facilitating the Deprotonation of OH to O through Fe4+ -Induced States in Perovskite LaNiO3 Enables a Fast Oxygen Evolution Reaction.
A Study on Pollution in Livestock and Poultry Breeding in Shiyan City
With the investigation and research of agricultural ecology situation, the pollution characteristics of livestock manure were indicated by the statistical analysis of data as well as the effect of livestock and poultry breeding...
BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.
Rahul Roychoudhuri, David Clever, Peng Li, Yoshiyuki Wakabayashi, Kylie M Quinn, Christopher A Klebanoff, Yun Ji, Madhusudhanan Sukumar, Robert L Eil, Zhiya Yu, Rosanne Spolski, Douglas C Palmer, Jenny H Pan, Shashank J Patel, Derek C Macallan, Giulia Fabozzi, Han-Yu Shih, Yuka Kanno, Akihiko Muto, Jun Zhu, Luca Gattinoni, John J O'Shea, Klaus Okkenhaug, Kazuhiko Igarashi, Warren J Leonard, Nicholas P Restifo
Jun 27, 2018
T cell antigen receptor (TCR) signaling drives distinct responses depending on the differentiation state and context of CD8(+) T cells. We hypothesized that access of signal-dependent transcription factors (TFs) to enhancers is...
Adaptive Immunity Animals Basic-Leucine Zipper Transcription Factors CD8-Positive T-Lymphocytes Cell Differentiation Cells Cultured Enhancer Elements Genetic Gene Expression Regulation Immunologic Memory Lymphocyte Activation Mice Mice Inbred C57BL Mice Knockout Oncogene Protein p65(gag-jun) Signal Transduction Transcription Factor AP-1 Vaccinia vaccinia virus
Targeted fluorescence imaging enhanced by 2D materials
Donghao Xie, Ding Kun Ji, Yue Zhang, Jun Cao, Hu Zheng, Lin Liu, Yi Zang, Jia Li, Guo Rong Chen, Tony D. James, Xiao Peng He
Aug 04, 2016
Here we demonstrate that 2D MoS2 can enhance the receptor-targeting and imaging ability of a fluorophore-labelled ligand. The 2D MoS2 has an enhanced working concentration range when compared with...
/dk/atira/pure/subjectarea/asjc/1500/1503 name=Catalysis /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/2500/2503 name=Ceramics and Composites /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2500/2508 name=Surfaces, Coatings and Films /dk/atira/pure/subjectarea/asjc/2500/2506 name=Metals and Alloys /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair.
Sergio Velasco-Aviles, Nikiben Patel, Angeles Casillas-Bajo, Laura Frutos-Rincón, Enrique Velasco-Serna, Juana Gallar, Peter Arthur-Farraj, Jose A Gomez-Sanchez, Hugo Cabedo
Feb 17, 2022
The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express Hdac4, 5 and 7 but not Hdac9. Here we show that a transcription factor regulated...
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