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Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Jan 22, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.
Sympathetic neurons depend on NGF binding to TrkA for their survival during vertebrate development. NGF deprivation initiates a transcription-dependent apoptotic response, which is suggested to require activation of the...
Animals Apoptosis Base Sequence Brain-Derived Neurotrophic Factor Cells Cultured Cycloheximide Gene Expression Regulation Developmental Genetic Vectors Green Fluorescent Proteins Immunohistochemistry Indicators and Reagents Integrases Luminescent Proteins Mice Mice Knockout Mutation Nerve Growth Factor Neurons Protein Synthesis Inhibitors Proto-Oncogene Proteins c-jun Receptor Nerve Growth Factor Superior Cervical Ganglion Transfection Viral Proteins
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun.
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Mar 15, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Behaviorally consequential astrocytic regulation of neural circuits.
Jun Nagai, Xinzhu Yu, Thomas Papouin, Eunji Cheong, Marc R Freeman, Kelly R Monk, Michael H Hastings, Philip G Haydon, David Rowitch, Shai Shaham, Baljit S Khakh
Jan 21, 2021
Astrocytes are a large and diverse population of morphologically complex cells that exist throughout nervous systems of multiple species. Progress over the last two decades has shown that astrocytes mediate developmental...
BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.
Rahul Roychoudhuri, David Clever, Peng Li, Yoshiyuki Wakabayashi, Kylie M Quinn, Christopher A Klebanoff, Yun Ji, Madhusudhanan Sukumar, Robert L Eil, Zhiya Yu, Rosanne Spolski, Douglas C Palmer, Jenny H Pan, Shashank J Patel, Derek C Macallan, Giulia Fabozzi, Han-Yu Shih, Yuka Kanno, Akihiko Muto, Jun Zhu, Luca Gattinoni, John J O'Shea, Klaus Okkenhaug, Kazuhiko Igarashi, Warren J Leonard, Nicholas P Restifo
Jun 27, 2018
T cell antigen receptor (TCR) signaling drives distinct responses depending on the differentiation state and context of CD8(+) T cells. We hypothesized that access of signal-dependent transcription factors (TFs) to enhancers is...
Adaptive Immunity Animals Basic-Leucine Zipper Transcription Factors CD8-Positive T-Lymphocytes Cell Differentiation Cells Cultured Enhancer Elements Genetic Gene Expression Regulation Immunologic Memory Lymphocyte Activation Mice Mice Inbred C57BL Mice Knockout Oncogene Protein p65(gag-jun) Signal Transduction Transcription Factor AP-1 Vaccinia vaccinia virus
A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair.
Sergio Velasco-Aviles, Nikiben Patel, Angeles Casillas-Bajo, Laura Frutos-Rincón, Enrique Velasco-Serna, Juana Gallar, Peter Arthur-Farraj, Jose A Gomez-Sanchez, Hugo Cabedo
Feb 17, 2022
The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express Hdac4, 5 and 7 but not Hdac9. Here we show that a transcription factor regulated...
An M-Learning Model in the Context of the Blended Synchronous Learning Environment
Mobile learning provides more flexibility and holds considerable promise for improving the learning process and promoting lifelong learning. In order to reduce the sense of isolation felt by the learners, this research...
Published by: IGI Global Scientific Publishing
Dispersion retrieval from multi-level ultra-deep reactive-ion-etched microstructures for terahertz slow-wave circuits
Risk Assessment Modeling of Urban Railway Investment and Financing Based on Improved SVM Model for Advanced Intelligent Systems
A risk assessment method for urban railway investment and financing based on an improved SVM model under big data is proposed. First, the inner product in the traditional SVM is replaced by a kernel function to obtain a more...
Published by: IGI Global Scientific Publishing
Engineering Crystal Packing in RNA-Protein Complexes II
Adelaine Kwun-Wai Leung, Yasushi Kondo, Daniel A Pomeranz Krummel, Jade Li, Stephen R Price, Anne-Marie M van Roon
Aug 17, 2021
Cryo-electron microscopy has greatly advanced our understanding of how the spliceosome cycles through different conformational states to conduct the chemical reactions that remove introns from pre-mRNA transcripts. The Cryo-EM...
A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair
Sergio Velasco-Aviles, Nikiben Patel, Angeles Casillas-Bajo, Laura Frutos-Rincón, Enrique Velasco-Serna, Juana Gallar Gallar, Peter Arthur-Farraj, Jose Gomez-Sanchez, Hugo Cabedo
Feb 25, 2022
The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express Hdac4, 5 and 7 but not Hdac9. Here we show that a transcription factor regulated...
Generalized Ordered Weighted Simplified Neutrosophic Cosine Similarity Measure for Multiple Attribute Group Decision Making
Jun Ye
Jan 01, 2020
The paper proposes a generalized ordered weighted simplified neutrosophic cosine similarity (GOWSNCS) measure by combining the cosine similarity measure of simplified neutrosophic sets (SNSs) with the generalized ordered...
Published by: IGI Global Scientific Publishing
The Source of the Current of Injury
Jacques Loeb and Reinhard Beutner. The source of the current of injury
Reprinted from Science, 1912, Jun 21, 35(912):970-971
Published by: Rockefeller University
MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models.
Zheng Xue, Daniel J Vis, Alejandra Bruna, Tonci Sustic, Sake van Wageningen, Ankita Sati Batra, Oscar M Rueda, Evert Bosdriesz, Carlos Caldas, Lodewyk FA Wessels, René Bernards
Apr 29, 2019
Activation of the mitogen-activated protein kinase (MAPK) pathway is frequent in cancer. Drug development efforts have been focused on kinases in this pathway, most notably on RAF and MEK. We show here that MEK inhibition...
Animals Benzimidazoles Breast Neoplasms Cell Line Tumor Colonic Neoplasms Drug Resistance Neoplasm Female Heterografts Humans Loss of Function Mutation MAP Kinase Kinase 4 MAP Kinase Kinase Kinase 1 MAP Kinase Signaling System Male Mice Inbred BALB C Mice Nude Mitogen-Activated Protein Kinase Kinases Prostatic Neoplasms Protein Kinase Inhibitors
Personal Information Protection in Government Data Openness Using Decision Tree Model
To address the issues of personal privacy and information security in the current digital age, this study first collects and analyzes relevant government data openness policies and personal information protection laws and...
Published by: IGI Global Scientific Publishing
The Johnsonian Summer Edition Jun. 14, 1995
Winthrop University
Jan 01, 0001
The Johnsonian is the weekly student newspaper of Winthrop University. It is published during fall and spring semesters with the exception of university holidays and exam periods. We have proudly served the Winthrop and Rock...
Published by: Winthrop University
Does the Technological Diversification and R&D Internationalization of eMNCs Promote Enterprise Innovation?
Under the background of digital economy, technological diversification and R&D internationalization are important strategic choices for eMNCs, represented by China, to seek advanced technological resources and create competitive...
Published by: IGI Global Scientific Publishing
Learning Sparrow Algorithm With Non-Uniform Search for Global Optimization
Sparrow Algorithm as a New Swarm Intelligence Search Algorithm, the sparrow algorithm has good optimization ability, but in complex environments, it still has certain limitations, such as weak learning ability. Therefore, this...
Published by: IGI Global Scientific Publishing
Research and Analysis of an Enterprise E-Commerce Marketing System Under the Big Data Environment
As an emerging online shopping method, e-commerce has been widely popular since the popularization of the Internet. Online sales and online shopping have become the trend of modern business development. However, the...
Published by: IGI Global Scientific Publishing
Contrastive Representation Learning With Mixture-of-Instance-and-Pixel
Contrastive learning has remarkable transfer learning capabilities. But many current methods are pretrained based on instance-level or pixel-level pretext tasks, resulting in representations lacking local or global information....
Published by: IGI Global Scientific Publishing
A Novel Task-Scheduling Algorithm of Cloud Computing Based on Particle Swarm Optimization
With the characteristics of low cost, high availability, and scalability, cloud computing has become a high demand platform in the field of information technology. Due to the dynamic and diversity of cloud computing system, the...
Published by: IGI Global Scientific Publishing
Recommendations for Crowdsourcing Services Based on Mobile Scenarios and User Trajectory Awareness
With the rapid development of the mobile internet and the rapid popularization of smart terminal devices, types and content of services are changing with each passing day, these bring serious mobile information overload problems...
Published by: IGI Global Scientific Publishing
Semantic Trajectory Frequent Pattern Mining Model
A method for mining frequent patterns of individual user trajectories is proposed based on location semantics. The semantic trajectory is obtained by inverse geocoding and preprocessed to obtain the Top-k candidate frequent...
Published by: IGI Global Scientific Publishing
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