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Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Jan 22, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.
Sympathetic neurons depend on NGF binding to TrkA for their survival during vertebrate development. NGF deprivation initiates a transcription-dependent apoptotic response, which is suggested to require activation of the...
Animals Apoptosis Base Sequence Brain-Derived Neurotrophic Factor Cells Cultured Cycloheximide Gene Expression Regulation Developmental Genetic Vectors Green Fluorescent Proteins Immunohistochemistry Indicators and Reagents Integrases Luminescent Proteins Mice Mice Knockout Mutation Nerve Growth Factor Neurons Protein Synthesis Inhibitors Proto-Oncogene Proteins c-jun Receptor Nerve Growth Factor Superior Cervical Ganglion Transfection Viral Proteins
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun.
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Mar 15, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
S-Box Construction Method Based on the Combination of Quantum Chaos and PWLCM Chaotic Map
For a security system built on symmetric-key cryptography algorithms, the substitution box (S-box) plays a crucial role to resist cryptanalysis. In this article, we incorporate quantum chaos and PWLCM chaotic map into a new...
Published by: IGI Global Scientific Publishing
BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.
Rahul Roychoudhuri, David Clever, Peng Li, Yoshiyuki Wakabayashi, Kylie M Quinn, Christopher A Klebanoff, Yun Ji, Madhusudhanan Sukumar, Robert L Eil, Zhiya Yu, Rosanne Spolski, Douglas C Palmer, Jenny H Pan, Shashank J Patel, Derek C Macallan, Giulia Fabozzi, Han-Yu Shih, Yuka Kanno, Akihiko Muto, Jun Zhu, Luca Gattinoni, John J O'Shea, Klaus Okkenhaug, Kazuhiko Igarashi, Warren J Leonard, Nicholas P Restifo
Jun 27, 2018
T cell antigen receptor (TCR) signaling drives distinct responses depending on the differentiation state and context of CD8(+) T cells. We hypothesized that access of signal-dependent transcription factors (TFs) to enhancers is...
Adaptive Immunity Animals Basic-Leucine Zipper Transcription Factors CD8-Positive T-Lymphocytes Cell Differentiation Cells Cultured Enhancer Elements Genetic Gene Expression Regulation Immunologic Memory Lymphocyte Activation Mice Mice Inbred C57BL Mice Knockout Oncogene Protein p65(gag-jun) Signal Transduction Transcription Factor AP-1 Vaccinia vaccinia virus
Visualizing the landscape and evolution of capacitive deionization by scientometric analysis
Capacitive deionization (CDI) as an emerging desalination technology attracts increasing attention due to its advantages such as low cost, environmental friendliness, simple operation, and large water recovery. This study...
Biblioshiny Capacitive deionization CiteSpace Desalination Scientometric analysis VOSviewer /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/2300/2312 name=Water Science and Technology /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering
The Application of Multimedia Information Fusion Technology in the Construction of University Intelligent Libraries
Nan Pang
Jan 01, 2024
Multimedia information fusion technology is currently a popular technology for data processing. The advanced productivity it brings is dozens of times that of traditional data information processing. The collected and processed...
Published by: IGI Global Scientific Publishing
A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair.
Sergio Velasco-Aviles, Nikiben Patel, Angeles Casillas-Bajo, Laura Frutos-Rincón, Enrique Velasco-Serna, Juana Gallar, Peter Arthur-Farraj, Jose A Gomez-Sanchez, Hugo Cabedo
Feb 17, 2022
The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express Hdac4, 5 and 7 but not Hdac9. Here we show that a transcription factor regulated...
An M-Learning Model in the Context of the Blended Synchronous Learning Environment
Mobile learning provides more flexibility and holds considerable promise for improving the learning process and promoting lifelong learning. In order to reduce the sense of isolation felt by the learners, this research...
Published by: IGI Global Scientific Publishing
The Association between Fatalistic Beliefs and Late Stage at Diagnosis of Lung and Colorectal Cancer.
Georgios Lyratzopoulos, Michael Pang-Hsiang Liu, Gary A Abel, Jane Wardle, Nancy L Keating
Apr 21, 2015
Dispersion retrieval from multi-level ultra-deep reactive-ion-etched microstructures for terahertz slow-wave circuits
Exotic massive 3D gravity
The linearized equations of “New Massive Gravity” propagate a parity doublet of massive spin-2 modes in 3D Minkowski spacetime, but a different non-linear extension is made possible by “third-way” consistency. There is a...
Visualizing the landscape and evolution of capacitive deionization by scientometric analysis
Capacitive deionization (CDI) as an emerging desalination technology attracts increasing attention due to its advantages such as low cost, environmental friendliness, simple operation, and large water recovery. This study...
Biblioshiny Capacitive deionization CiteSpace Desalination Scientometric analysis VOSviewer /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/2300/2312 name=Water Science and Technology /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering
Removal of fluoride from water using activated carbon fibres modified with zirconium by a drop-coating method
Metal-modified carbon materials have been widely used for fluoride removal, but the traditional impregnation by soaking method suffers from low loading of metals and substantial use of chemicals. This study proposed a new...
Activated carbon fibre Adsorption Drop-coating fluoride zirconium /dk/atira/pure/subjectarea/asjc/2300/2305 name=Environmental Engineering /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2310 name=Pollution /dk/atira/pure/subjectarea/asjc/2300/2307 name=Health, Toxicology and Mutagenesis
The Isothermal Oxidation of a New Polycrystalline Turbine Disk Ni-Based Superalloy at 800 °C and Its Modification with Pre-oxidation
Ni-based superalloys with enhanced oxidation resistance at high temperatures are crucial for next-generation gas turbine engines. A new polycrystalline Ni-based superalloy (C19) that combines improved microstructural stability...
Risk Assessment Modeling of Urban Railway Investment and Financing Based on Improved SVM Model for Advanced Intelligent Systems
A risk assessment method for urban railway investment and financing based on an improved SVM model under big data is proposed. First, the inner product in the traditional SVM is replaced by a kernel function to obtain a more...
Published by: IGI Global Scientific Publishing
Performance incentives and competition in healthcare markets
Our paper investigates the effects of introducing performance-based incentives in a competitive healthcare market. We consider a market in which a payer applies a performance-based compensation contract to two competing...
A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair
Sergio Velasco-Aviles, Nikiben Patel, Angeles Casillas-Bajo, Laura Frutos-Rincón, Enrique Velasco-Serna, Juana Gallar Gallar, Peter Arthur-Farraj, Jose Gomez-Sanchez, Hugo Cabedo
Feb 25, 2022
The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express Hdac4, 5 and 7 but not Hdac9. Here we show that a transcription factor regulated...
Generalized Ordered Weighted Simplified Neutrosophic Cosine Similarity Measure for Multiple Attribute Group Decision Making
Jun Ye
Jan 01, 2020
The paper proposes a generalized ordered weighted simplified neutrosophic cosine similarity (GOWSNCS) measure by combining the cosine similarity measure of simplified neutrosophic sets (SNSs) with the generalized ordered...
Published by: IGI Global Scientific Publishing
Removal of fluoride from water using activated carbon fibres modified with zirconium by a drop-coating method
Metal-modified carbon materials have been widely used for fluoride removal, but the traditional impregnation by soaking method suffers from low loading of metals and substantial use of chemicals. This study proposed a new...
Activated carbon fibre Adsorption Drop-coating fluoride zirconium /dk/atira/pure/subjectarea/asjc/2300/2305 name=Environmental Engineering /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2310 name=Pollution /dk/atira/pure/subjectarea/asjc/2300/2307 name=Health, Toxicology and Mutagenesis
The Source of the Current of Injury
Jacques Loeb and Reinhard Beutner. The source of the current of injury
Reprinted from Science, 1912, Jun 21, 35(912):970-971
Published by: Rockefeller University
MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models.
Zheng Xue, Daniel J Vis, Alejandra Bruna, Tonci Sustic, Sake van Wageningen, Ankita Sati Batra, Oscar M Rueda, Evert Bosdriesz, Carlos Caldas, Lodewyk FA Wessels, René Bernards
Apr 29, 2019
Activation of the mitogen-activated protein kinase (MAPK) pathway is frequent in cancer. Drug development efforts have been focused on kinases in this pathway, most notably on RAF and MEK. We show here that MEK inhibition...
Animals Benzimidazoles Breast Neoplasms Cell Line Tumor Colonic Neoplasms Drug Resistance Neoplasm Female Heterografts Humans Loss of Function Mutation MAP Kinase Kinase 4 MAP Kinase Kinase Kinase 1 MAP Kinase Signaling System Male Mice Inbred BALB C Mice Nude Mitogen-Activated Protein Kinase Kinases Prostatic Neoplasms Protein Kinase Inhibitors
Personal Information Protection in Government Data Openness Using Decision Tree Model
To address the issues of personal privacy and information security in the current digital age, this study first collects and analyzes relevant government data openness policies and personal information protection laws and...
Published by: IGI Global Scientific Publishing
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