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Results: 3588
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Jan 22, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.
Sympathetic neurons depend on NGF binding to TrkA for their survival during vertebrate development. NGF deprivation initiates a transcription-dependent apoptotic response, which is suggested to require activation of the...
Animals Apoptosis Base Sequence Brain-Derived Neurotrophic Factor Cells Cultured Cycloheximide Gene Expression Regulation Developmental Genetic Vectors Green Fluorescent Proteins Immunohistochemistry Indicators and Reagents Integrases Luminescent Proteins Mice Mice Knockout Mutation Nerve Growth Factor Neurons Protein Synthesis Inhibitors Proto-Oncogene Proteins c-jun Receptor Nerve Growth Factor Superior Cervical Ganglion Transfection Viral Proteins
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun.
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Mar 15, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Performing Locality and Identity
Lijun Zhang
Sep 21, 2016
The paper examines the fusion of narratives, time, space, and personal identity through ethnographic study of rickshaw driver’s performance in the context of “Hutong tour” as a form of urban tourism in Beijing, a cosmopolitan...
Published by: Association of Cambridge Studies
Research and Analysis of an Enterprise E-Commerce Marketing System Under the Big Data Environment
As an emerging online shopping method, e-commerce has been widely popular since the popularization of the Internet. Online sales and online shopping have become the trend of modern business development. However, the...
Published by: IGI Global Scientific Publishing
Learning Sparrow Algorithm With Non-Uniform Search for Global Optimization
Sparrow Algorithm as a New Swarm Intelligence Search Algorithm, the sparrow algorithm has good optimization ability, but in complex environments, it still has certain limitations, such as weak learning ability. Therefore, this...
Published by: IGI Global Scientific Publishing
Identification of high risk clinical and imaging features for intracranial artery dissection using high-resolution cardiovascular magnetic resonance.
Zhang Shi, Xia Tian, Bing Tian, Zakaria Meddings, Xuefeng Zhang, Jing Li, David Saloner, Qi Liu, Zhongzhao Teng, Jianping Lu
Jul 28, 2021
Background
Intracranial artery dissection (IAD) often causes headache and cerebral vascular ischemic events. The imaging characteristics of IAD remain unclear. This study aims to characterize the appearance of culprit...
Identification of high risk clinical and imaging features for intracranial artery dissection using high-resolution cardiovascular magnetic resonance
Zhang Shi, Xia Tian, Bing Tian, Zakaria Meddings, Xuefeng Zhang, Jing Li, David Saloner, Qi Liu, Zhongzhao Teng, Jianping Lu
Jun 14, 2021
Abstract: Background: Intracranial artery dissection (IAD) often causes headache and cerebral vascular ischemic events. The imaging characteristics of IAD remain unclear. This study aims to characterize the appearance of culprit...
Identification of high risk clinical and imaging features for intracranial artery dissection using high-resolution cardiovascular magnetic resonance.
Zhang Shi, Xia Tian, Bing Tian, Zakaria Meddings, Xuefeng Zhang, Jing Li, David Saloner, Qi Liu, Zhongzhao Teng, Jianping Lu
Jul 21, 2021
BACKGROUND: Intracranial artery dissection (IAD) often causes headache and cerebral vascular ischemic events. The imaging characteristics of IAD remain unclear. This study aims to characterize the appearance of culprit and...
Hydrodynamic performance of a floating breakwater as an oscillating-buoy type wave energy converter
Combined floating breakwater and wave energy converter systems have the potential to provide a cost-effective solution to offshore power supply and coastal protection. This will make wave energy economically competitive and...
Experimental investigations of secondary load cycle formation in wave force on a circular cylinder under steep regular waves
When a large wave interacts with a marine structure, it would lead to a high-frequency structure response, and impose great threats to marine structures. In this paper, wave forces on a vertical cylinder in regular waves with...
Study on Transient Gap Resonance with Consideration of the Motion of Floating Body
In this paper, the transient fluid resonance phenomenon inside a narrow gap between two adjacent boxes excited by the incident focused waves with various spectral peak periods and focused wave amplitudes is simulated by...
A coupled Particle-In-Cell (PIC)-Discrete Element Method (DEM) solver for fluid-solid mixture flow simulations
In this paper, a coupled Particle-In-Cell (PIC)-Discrete Element Method (DEM) model is developed for numerical simulations of complex fluid–solid mixture flows. The fluid–solid interaction part is solved using the hybrid...
Systematic characterization of mutations altering protein degradation in human cancers.
Collin Tokheim, Xiaoqing Wang, Richard T Timms, Boning Zhang, Elijah L Mena, Binbin Wang, Cynthia Chen, Jun Ge, Jun Chu, Wubing Zhang, Stephen J Elledge, Myles Brown, X Shirley Liu
Feb 11, 2021
The ubiquitin-proteasome system (UPS) is the primary route for selective protein degradation in human cells. The UPS is an attractive target for novel cancer therapies, but the precise UPS genes and substrates important for...
Design and Characteristic Study of a Novel Internal Cooling High Temperature Superconducting Composite Cable with REBCO for Energy Storage Applications
Jiahui Zhu, Panpan Chen, Hongjie Zhang, Ming Qiu, Huiming Zhang, Jun Gong, Yuanyuan He, Min Zhang
Apr 01, 2018
High temperature superconducting magnetic energy storage systems (HTS SMES) have attracted significant attention for fast response and ensure a reliable power supply. However, the current carrying capacity of single...
Study on Transient Gap Resonance with Consideration of the Motion of Floating Body
In this paper, the transient fluid resonance phenomenon inside a narrow gap between two adjacent boxes excited by the incident focused waves with various spectral peak periods and focused wave amplitudes is simulated by...
Hydrodynamic performance of a floating breakwater as an oscillating-buoy type wave energy converter
Combined floating breakwater and wave energy converter systems have the potential to provide a cost-effective solution to offshore power supply and coastal protection. This will make wave energy economically competitive and...
Advanced opportunities and insights on the influence of nitrogen incorporation on the physico-/electro-chemical properties of robust electrocatalysts for electrocatalytic energy conversion
Sundaram Chandrasekaran, Chenle Zhang, Yiqing Shu, Huide Wang, Sanming Chen, Thomas Nesakumar Jebakumar Immanuel Edison, Yongping Liu, Namachivayam Karthik, R. D.K. Misra, Libo Deng, Peng Yin, Yanqi Ge, Omar A. Al-Hartomy, Ahmed Al-Ghamdi, Swelm Wageh, Peixin Zhang, Chris Bowen, Zhang Han
Dec 15, 2021
The use of a wide range of methods for incorporating nitrogen atoms on robust catalysts has given rise to fundamental advances in the field of energy conversion and storage. Recently, nitrogen incorporation has proven to be...
Online Learning Resource Management System Utilization and College Students' Engagement at Zhongshan University
The study aimed to assess the extent of utilization of the Learning Resource Management System (LRMS) and its impact on student' engagement among 218 college students at ZhongShan College. Utilizing a descriptive correlational...
Published by: IGI Global Scientific Publishing
An Enhanced Cascading Model for E-Commerce Consumer Credit Default Prediction
As an important global policy guide to promote economic transformation and upgrading, the upsurge of E-Commerce has been continuously upgraded with continuous breakthroughs in information technology. In recent years, China’s...
Published by: IGI Global Scientific Publishing
A coupled Particle-In-Cell (PIC)-Discrete Element Method (DEM) solver for fluid-solid mixture flow simulations
In this paper, a coupled Particle-In-Cell (PIC)-Discrete Element Method (DEM) model is developed for numerical simulations of complex fluid–solid mixture flows. The fluid–solid interaction part is solved using the hybrid...
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