Search
Results: 75
Myeloproliferative neoplasms
Substantial progress has been made in our understanding of the pathogenetic basis of myeloproliferative neoplasms. The discovery of mutations in JAK2 over a decade ago heralded a new age for patient care as a consequence of...
Clonal approaches to understanding the impact of mutations on hematologic disease development.
Interrogation of hematopoietic tissue at the clonal level has a rich history spanning over 50 years, and has provided critical insights into both normal and malignant hematopoiesis. Characterization of chromosomes identified...
Edwin Chen, Jong Sook Ahn, David B Sykes, Lawrence J Breyfogle, Anna L Godfrey, Jyoti Nangalia, Amy Ko, Daniel J DeAngelo, Anthony R Green, Ann Mullally
Oct 28, 2015
Animals Apoptosis Cell Line Tumor Cell Survival DNA Breaks Double-Stranded DNA Replication Furans Gene Knock-In Techniques Genomic Instability Humans Hydroxyurea Janus Kinase 2 Mice Mice Inbred C57BL Mutagenesis Site-Directed Neoplasms Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Pyridines Pyrimidines RNA Interference RNA Small Interfering RecQ Helicases Signal Transduction
Methylation age as a correlate for allele burden, disease status, and clinical response in myeloproliferative neoplasm patients treated with vorinostat.
Suzanne McPherson, Graeme Greenfield, Christen Andersen, Jacob Grinfeld, Hans C Hasselbalch, Jyoti Nangalia, Ken I Mills, Mary F McMullin
Oct 04, 2019
The myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal neoplastic disorders. Driver mutations in JAK2, CALR, and MPL genes have been identified in the majority of cases. Alongside these, an increasing number...
Clonal hematopoiesis and therapy-related myeloid neoplasms following neuroblastoma treatment.
Tim HH Coorens, Grace Collord, Wanhua Lu, Emily Mitchell, Jannat Ijaz, Thomas Roberts, Thomas RW Oliver, GA Amos Burke, Michael Gattens, Emmy Dickens, Jyoti Nangalia, Marc Tischkowitz, John Anderson, Adam Shlien, Anna L Godfrey, Matthew J Murray, Sam Behjati
Feb 05, 2021
Therapy-related myeloid neoplasms (TMN) constitute one of the most challengingcomplications of cancer treatment.1 Whilst understanding of TMN pathogenesis remains fragmentary, genomic studies in adults have thus far refuted the...
Longitudinal Cytokine Profiling Identifies GRO-α and EGF as Potential Biomarkers of Disease Progression in Essential Thrombocythemia.
Lineage tracing of human development through somatic mutations.
Michael Spencer Chapman, Anna Maria Ranzoni, Brynelle Myers, Nicholas Williams, Tim HH Coorens, Emily Mitchell, Timothy Butler, Kevin J Dawson, Yvette Hooks, Luiza Moore, Jyoti Nangalia, Philip S Robinson, Kenichi Yoshida, Elizabeth Hook, Peter J Campbell, Ana Cvejic
Apr 19, 2021
The ontogeny of the human haematopoietic system during fetal development has previously been characterized mainly through careful microscopic observations1. Here we reconstruct a phylogenetic tree of blood development using...
The longitudinal dynamics and natural history of clonal haematopoiesis.
Margarete A Fabre, José Guilherme de Almeida, Edoardo Fiorillo, Emily Mitchell, Aristi Damaskou, Justyna Rak, Valeria Orrù, Michele Marongiu, Michael Spencer Chapman, MS Vijayabaskar, Joanna Baxter, Claire Hardy, Federico Abascal, Nicholas Williams, Jyoti Nangalia, Iñigo Martincorena, Peter J Campbell, Eoin F McKinney, Francesco Cucca, Moritz Gerstung, George S Vassiliou
Jul 02, 2022
Building and Bridging Security and Privacy-Related Technical Knowledge Amongst HR Professionals
An ever-increasing range of smart, connected internet of things (IoT) devices poses entirely novel security and privacy challenges. Business models that wish to rely on smart product adoption will need to ensure the capability...
Published by: IGI Global Scientific Publishing
The longitudinal dynamics and natural history of clonal haematopoiesis.
Margarete A Fabre, José Guilherme de Almeida, Edoardo Fiorillo, Emily Mitchell, Aristi Damaskou, Justyna Rak, Valeria Orrù, Michele Marongiu, Michael Spencer Chapman, MS Vijayabaskar, Joanna Baxter, Claire Hardy, Federico Abascal, Nicholas Williams, Jyoti Nangalia, Iñigo Martincorena, Peter J Campbell, Eoin F McKinney, Francesco Cucca, Moritz Gerstung, George Vassiliou
Jun 09, 2022
Clonal expansions driven by somatic mutations become pervasive across human tissues with age, including in the haematopoietic system, where the phenomenon is termed clonal haematopoiesis1-4. The understanding of how and when...
Myeloproliferative neoplasms – from origins to outcomes
The longitudinal dynamics and natural history of clonal haematopoiesis.
Margarete A Fabre, José Guilherme de Almeida, Edoardo Fiorillo, Emily Mitchell, Aristi Damaskou, Justyna Rak, Valeria Orrù, Michele Marongiu, Michael Spencer Chapman, MS Vijayabaskar, Joanna Baxter, Claire Hardy, Federico Abascal, Nicholas Williams, Jyoti Nangalia, Iñigo Martincorena, Peter J Campbell, Eoin F McKinney, Francesco Cucca, Moritz Gerstung, George Vassiliou
Jun 08, 2022
Clonal expansions driven by somatic mutations become pervasive across human tissues with age, including in the haematopoietic system, where the phenomenon is termed clonal haematopoiesis1-4. The understanding of how and when...
Self-Learning and Self-Satisfaction
The awareness towards organizational advantage through knowledge sharing among individuals has gained its significance globally. Numerous illustrations in the field of knowledge sharing behaviour indicate that in order to...
Published by: IGI Global Scientific Publishing
Neuromuscular blocking characteristics of rocuronium bromide mixed with sodium bicarbonate
Intravenous rocuronium produces intense discomfort at the site of injection hence leading to limb movements. Strategies to reduce or prevent pain on injection, along with the effect of adjuvant on the onset and duration of...
Published by: IJHS Medical Association
Pathogenesis of Myeloproliferative Disorders.
Myeloproliferative neoplasms (MPNs) are a set of chronic hematopoietic neoplasms with overlapping clinical and molecular features. Recent years have witnessed considerable advances in our understanding of their pathogenetic...
Replacement of Human Labour With Integration of Machines Into a Self-Governing System
Advanced manufacturing runs with highly innovative technology and accommodates quality production without excessive capital investment. So, there are three main corners named. Efficient production, intelligent production, and...
Published by: IGI Global Scientific Publishing
Molecular determinants of pathogenesis and clinical phenotype in myeloproliferative neoplasms
The myeloproliferative neoplasms are a heterogeneous group of clonal disorders characterized by the overproduction of mature cells in the peripheral blood, together with an increased risk of thrombosis and progression to acute...
Clonal dynamics of haematopoiesis across the human lifespan.
Emily Mitchell, Michael Spencer Chapman, Nicholas Williams, Kevin J Dawson, Nicole Mende, Emily F Calderbank, Hyunchul Jung, Thomas Mitchell, Tim HH Coorens, David H Spencer, Heather Machado, Henry Lee-Six, Megan Davies, Daniel Hayler, Margarete A Fabre, Krishnaa Mahbubani, Federico Abascal, Alex Cagan, George S Vassiliou, Joanna Baxter, Inigo Martincorena, Michael R Stratton, David G Kent, Krishna Chatterjee, Kourosh Saeb Parsy, Anthony R Green, Jyoti Nangalia, Elisa Laurenti, Peter J Campbell
Jul 02, 2022
Classification and Personalized Prognosis in Myeloproliferative Neoplasms.
Jacob Grinfeld, Jyoti Nangalia, E Joanna Baxter, David C Wedge, Nicos Angelopoulos, Robert Cantrill, Anna L Godfrey, Elli Papaemmanuil, Gunes Gundem, Cathy MacLean, Julia Cook, Laura O'Neil, Sarah O'Meara, Jon W Teague, Adam P Butler, Charlie E Massie, Nicholas Williams, Francesca L Nice, Christen L Andersen, Hans C Hasselbalch, Paola Guglielmelli, Mary F McMullin, Alessandro M Vannucchi, Claire N Harrison, Moritz Gerstung, Anthony R Green, Peter J Campbell
Oct 03, 2018
Neuromuscular blocking characteristics of rocuronium bromide mixed with sodium bicarbonate
Intravenous rocuronium produces intense discomfort at the site of injection hence leading to limb movements. Strategies to reduce or prevent pain on injection, along with the effect of adjuvant on the onset and duration of...
Published by: IJHS Medical Association
Assessing Marketing Capabilities and Re-Patronage Intentions Relationship Through the Lens of Technological Advancement
This study examines the relationship between marketing capabilities and re-patronage intentions in the retail sector. Building upon dynamic capability theory, expectation-confirmation theory, and social exchange theory, it also...
Published by: IGI Global Scientific Publishing
Terzyme
Published by: Plant methods
Clonal dynamics of haematopoiesis across the human lifespan.
Emily Mitchell, Michael Spencer Chapman, Nicholas Williams, Kevin J Dawson, Nicole Mende, Emily Calderbank, Hyunchul Jung, Thomas Mitchell, Tim HH Coorens, David H Spencer, Heather Machado, Henry Lee-Six, Megan Davies, Daniel Hayler, Margarete A Fabre, Krishnaa Mahbubani, Federico Abascal, Alex Cagan, George Vassiliou, Joanna Baxter, Inigo Martincorena, Michael R Stratton, David G Kent, Krishna Chatterjee, Kourosh Saeb Parsy, Tony Green, Jyoti Nangalia, Elisa Laurenti, Peter J Campbell
Jun 09, 2022
Age-related change in human haematopoiesis causes reduced regenerative capacity1, cytopenias2, immune dysfunction3 and increased risk of blood cancer4-6, but the reason for such abrupt functional decline after 70 years of age...
Perceived Career Success and Career Advancement of Women
Ever since there have been a lot of challenges that a woman has to go through to make her career a success. The study focuses on the challenges that women face as a resultant of organizational and family barriers. The current...
Published by: IGI Global Scientific Publishing
|
|< |
< |
1 |