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Effectiveness of CoQ10 in Attenuating Parkinsonian Symptoms Caused by Overexpression of the LRRK2 Gene Modeled in Caenorhabditis elegans
Brennan W. McFarland
Jan 01, 0001
Reactive oxygen species (ROS) are reactive molecules that contain oxygen. ROS are naturally formed as a byproduct of cellular processes that metabolize oxygen. These products continue to react with and damage DNA, proteins, and...
CoQ10 Parkinson's Disease Lrrk2 Caenorhabditis elegans neurodegeneration Oxidative Stress Biology Genetics and Genomics Life Sciences Molecular genetics
Published by: Ursinus College
The Ursinus Weekly, March 1, 1915
Freshman contest unusually good Interest keen in baseball activities Representative of Ursinus selected Some points about Southern colleges for women Varsity wins and loses Literary societies Group notes Modern language...
Ursinus College Collegeville Pennsylvania newspaper Frank Glendenning Basketball baseball George H. Hodges YMCA YWCA Zwinglian literary society Schaff literary society cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Analysis of Fluorogenic Probes for the Detection of Chlorite in Drinking Water
Morgan McFarland
Jan 01, 0001
Chlorite is a common water contaminant that results from the chlorination and purification of drinking water. The overconsumption of chlorite is associated with numerous birth defects and abnormal changes in red blood cells and...
Published by: Ursinus College
Present in love
IA McFarland
Oct 24, 2016
While Karl Barth's identification of love and freedom (in that order) as the fundamental divine perfections was intended to eliminate any gap between God as revealed and God's eternal being, Barth's equation of divine freedom...
The Problem with Evil
IA McFarland
Aug 03, 2017
This essay contends that there are significant theological problems connected with the use of the term “evil” to label states of affairs, such that the “problem with evil” is that we are too quick to presume to know what evil...
The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro
Inaba, K., Witmer-Pack, M., Inaba, M., Sakuta, H., Hathcock, K.S., Azuma, M., Yagita, H., Okumura, K., Linsley, P.S., Ikehara, S., Muramatsu, S., Hodes, R.J., and Steinman, R.M. The tissue distribution of the B7-2 costimulator...
Published by: The Rockefeller University Press
The Ursinus Weekly, March 17, 1913
Charles Otto Reinhold
Jan 01, 0001
Successful Glee Club concerts Society notes Baseball season opening Oratorical contest at Swarthmore Lebanon High 48, fresh 25 Kell to enter oratorical contest Zwinglian anniversary New Weekly staff elected Christian...
Ursinus College Collegeville Pennsylvania newspaper baseball Benjamin Kell YMCA YWCA Zwinglian literary society Schaff literary society cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Librarians Receive Baseball Research Award for Book on Fans' Deaths
Winthrop University
Jan 01, 0001
The awards are given annually to recognize outstanding baseball research published in the previous calendar year in areas other than history and biography. Robert M. Gorman and David Weeks won for "Death at the Ballpark: A...
Published by: Winthrop University
Retired Education Professor Authors Book About Cherokee Myths and Legends
Winthrop University
Jan 01, 0001
Written by Terry L. Norton '81 and recently released by McFarland Publishers, the 232-page book contains some of the essential folklore of the Eastern Cherokees of western North Carolina. From 1981-2008, Norton worked as a...
Published by: Winthrop University
Initial development and validation of a mitochondrial disease quality of life scale.
JL Elson, M Cadogan, S Apabhai, RG Whittaker, A Phillips, MI Trennell, R Horvath, RW Taylor, R McFarland, E McColl, DM Turnbull, GS Gorman
Sep 03, 2020
Mitochondrial diseases are a clinically diverse group of genetic disorders that often present to neurologists. Health related quality of life (HRQOL) is increasingly recognised as a fundamental patient based outcome measure in...
Role of bioenergy, biorefinery and bioeconomy in sustainable development
Jhuma Sadhukhan, Elias Martinez-Hernandez, Richard J. Murphy, Denny K.s. Ng, Mimi H. Hassim, Kok Siew Ng, Wan Yoke Kin, Ida Fahani Md Jaye, Melissa Y. Leung Pah Hang, Viknesh Andiappan
Jan 01, 2018
Malaysia has a plethora of biomass that can be utilized in a sustainable manner to produce bio-products for circular green economy. At the 15th Conference of Parties in Copenhagen, Malaysia stated to voluntarily reduce its...
Adaptation and resilience circular economy Climate Change Mitigation Lignocellulosic biorefinery Malaysia development plan Resource recovery from waste (RRfW) sustainable development goals /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/sustainabledevelopmentgoals/zero_hunger name=SDG 2 - Zero Hunger /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy /dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action
Role of bioenergy, biorefinery and bioeconomy in sustainable development
Jhuma Sadhukhan, Elias Martinez-Hernandez, Richard J. Murphy, Denny K.s. Ng, Mimi H. Hassim, Kok Siew Ng, Wan Yoke Kin, Ida Fahani Md Jaye, Melissa Y. Leung Pah Hang, Viknesh Andiappan
Jan 01, 2018
Malaysia has a plethora of biomass that can be utilized in a sustainable manner to produce bio-products for circular green economy. At the 15th Conference of Parties in Copenhagen, Malaysia stated to voluntarily reduce its...
Adaptation and resilience circular economy Climate Change Mitigation Lignocellulosic biorefinery Malaysia development plan Resource recovery from waste (RRfW) sustainable development goals /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/sustainabledevelopmentgoals/zero_hunger name=SDG 2 - Zero Hunger /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy /dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action
Both mitochondrial DNA and mitonuclear gene mutations cause hearing loss through cochlear dysfunction.
Hooking Up: Pluralistic Ignorance, Sociosexual Orientation, and Self-Concept Clarity
Marisa Waite
Jan 01, 0001
Pluralistic ignorance occurs when most individuals believe their attitudes are discrepant from the majority group's attitude. Previous studies have demonstrated this effect in various situations such as alcohol use (Miller &...
pluralistic ignorance hook up sociosexual orienation CLARITY Psychology Social and Behavioral Sciences
Published by: Ursinus College
The Ursinus Weekly, June 25, 1945
Bond drive tops goal to enable purchase of two Army ambulances Board of Directors appoint new instructors to faculty Ursinus presents degrees to fifty-five at seventy-fifth annual commencement Rev. Bomberger gives sermon at...
Ursinus College Collegeville Pennsylvania newspaper war bond drive student government Joseph McFarland commencement John H. A. Bomberger student housing Rosicrucians Navy Norman E. McClure John Lentz softball baseball tennis Physical Education Club Who's who cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation.
Liang Wei Wang, Hongying Shen, Luis Nobre, Ina Ersing, Joao A Paulo, Stephen Trudeau, Zhonghao Wang, Nicholas A Smith, Yijie Ma, Bryn Reinstadler, Jason Nomburg, Thomas Sommermann, Ellen Cahir-McFarland, Steven P Gygi, Vamsi K Mootha, Michael P Weekes, Benjamin E Gewurz
Jun 05, 2019
Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B cell lymphomas. How EBV remodels metabolic pathways to support rapid B cell outgrowth remains largely unknown. To gain insights, primary human B cells were...
B-cell activation de novo serine synthesis folate isotope tracing metabolic remodeling mitochondrial one-carbon metabolism quantitative proteomics tandem mass tag tumor virus virus oncoprotein Aminohydrolases B-Lymphocytes Cell Transformation Viral Epstein-Barr Virus Infections Epstein-Barr Virus Nuclear Antigens Female Folic Acid Glycolysis HEK293 Cells Herpesvirus 4 Human Humans Lymphocyte Activation Methylenetetrahydrofolate Dehydrogenase (NADP) Mitochondria Multifunctional Enzymes NADP Oxidation-Reduction Proteome Proto-Oncogene Proteins c-myc Serine
Nuclear factors involved in mitochondrial translation cause a subgroup of combined respiratory chain deficiency.
John P Kemp, Paul M Smith, Angela Pyle, Vivienne CM Neeve, Helen AL Tuppen, Ulrike Schara, Beril Talim, Haluk Topaloglu, Elke Holinski-Feder, Angela Abicht, Birgit Czermin, Hanns Lochmüller, Robert McFarland, Patrick F Chinnery, Zofia MA Chrzanowska-Lightowlers, Robert N Lightowlers, Robert W Taylor, Rita Horvath
Mar 07, 2019
Mutations in several mitochondrial DNA and nuclear genes involved in mitochondrial protein synthesis have recently been reported in combined respiratory chain deficiency, indicating a generalized defect in mitochondrial...
Consensus-based statements for the management of mitochondrial stroke-like episodes.
Yi Shiau Ng, Laurence A Bindoff, Gráinne S Gorman, Rita Horvath, Thomas Klopstock, Michelangelo Mancuso, Mika H Martikainen, Robert McFarland, Victoria Nesbitt, Robert DS Pitceathly, Andrew M Schaefer, Doug M Turnbull
Mar 02, 2020
Background: Focal-onset seizures and encephalopathy are prominent features of a stroke-like episode, which is a severe neurological manifestation associated with subtypes of mitochondrial disease. Despite more than 30 years of...
Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease.
Gráinne S Gorman, Andrew M Schaefer, Yi Ng, Nicholas Gomez, Emma L Blakely, Charlotte L Alston, Catherine Feeney, Rita Horvath, Patrick Yu-Wai-Man, Patrick F Chinnery, Robert W Taylor, Douglass M Turnbull, Robert McFarland
Mar 07, 2019
OBJECTIVE: The prevalence of mitochondrial disease has proven difficult to establish, predominantly as a result of clinical and genetic heterogeneity. The phenotypic spectrum of mitochondrial disease has expanded significantly...
Epilepsy in adults with mitochondrial disease
Roger G Whittaker, Helen E Devine, Grainne S Gorman, Andrew M Schaefer, Rita Horvath, Yi Ng, Victoria Nesbitt, Nichola Z Lax, Robert McFarland, Mark O Cunningham, Robert W Taylor, Douglass M Turnbull
Mar 07, 2019
OBJECTIVE: The aim of this work was to determine the prevalence and progression of epilepsy in adult patients with mitochondrial disease. METHODS: We prospectively recruited a cohort of 182 consecutive adult patients attending a...
Hook-up Culture and Attitude Shifts: The Role of Self-Concept Clarity and Sociosexual Orientation
Marisa Waite
Jan 01, 0001
Pluralistic ignorance occurs when most individuals believe their attitudes are discrepant from the majority group's attitude. Previous studies have demonstrated this effect in various situations such as alcohol use (Miller &...
Published by: Ursinus College
Congenital myasthenic syndrome with mild intellectual disability caused by a recurrent SLC25A1 variant.
Sunitha Balaraju, Ana Töpf, Grace McMacken, Veeramani Preethish Kumar, Astrid Pechmann, Helen Roper, Seena Vengalil, Kiran Polavarapu, Saraswati Nashi, Niranjan Prakash Mahajan, Ines A Barbosa, Charu Deshpande, Robert W Taylor, Judith Cossins, David Beeson, Steven Laurie, Janbernd Kirschner, Rita Horvath, Robert McFarland, Nalini Atchayaram, Hanns Lochmüller
Oct 15, 2019
MicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor gene.
Yu Wei Phua, Akira Nguyen, Daniel L Roden, Benjamin Elsworth, Niantao Deng, Iva Nikolic, Jessica Yang, Andrea McFarland, Roslin Russell, Warren Kaplan, Mark J Cowley, Radhika Nair, Elena Zotenko, Sandra O'Toole, Shi-Xiong Tan, David E James, Susan J Clark, Hosein Kouros-Mehr, Alexander Swarbrick
May 07, 2019
INTRODUCTION: The study of mammalian development has offered many insights into the molecular aetiology of cancer. We previously used analysis of mammary morphogenesis to discover a critical role for GATA-3 in mammary...
Animals Breast Neoplasms Cell Line Tumor Cell Proliferation Cell Transformation Neoplastic Cluster Analysis Epigenesis Genetic Female Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Silencing Genes Tumor Suppressor Humans Mammary Glands Animal Mice MicroRNAs Neoplasm Metastasis Prognosis Proto-Oncogene Proteins c-akt RNA Interference Sexual Maturation TOR Serine-Threonine Kinases
Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB.
Holly Holliday, Daniel Roden, Simon Junankar, Sunny Z Wu, Laura A Baker, Christoph Krisp, Chia-Ling Chan, Andrea McFarland, Joanna N Skhinas, Thomas R Cox, Bhupinder Pal, Nicholas D Huntington, Christopher J Ormandy, Jason S Carroll, Jane Visvader, Mark P Molloy, Alexander Swarbrick
Jan 28, 2021
Inhibitor of differentiation (ID) proteins dimerize with basic HLH (bHLH) transcription factors, repressing transcription of lineage-specification genes across diverse cellular lineages. ID4 is a key regulator of mammary stem...
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