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Results: 52
Variation in dermcidin expression in a range of primary human tumours and in hypoxic/oxidatively stressed human cell lines.
GD Stewart, RJE Skipworth, CJ Pennington, AG Lowrie, DAC Deans, DR Edwards, FK Habib, ACP Riddick, KCH Fearon, JA Ross
May 14, 2020
Dermcidin acts as a survival factor in a variety of cancer cell lines under hypoxia or oxidative stress. The aim of this study was to evaluate dermcidin expression in cell lines following simulation of tumour microenvironmental...
mRNA profiling of the cancer degradome in oesophago-gastric adenocarcinoma.
JP Baren, GD Stewart, A Stokes, K Gray, CJ Pennington, R O'Neill, DAC Deans, S Paterson-Brown, ACP Riddick, DR Edwards, KCH Fearon, JA Ross, RJE Skipworth
May 14, 2020
BACKGROUND: Degradation of the extracellular matrix is fundamental to tumour development, invasion and metastasis. Several protease families have been implicated in the development of a broad range of tumour types, including...
Pitfalls of Using Data Portals as Sources for Psychological Research
Increasingly, data portals allow researchers to download data-sets generated by others for futher analyses. Open-access data have many benefits. However, researchers should be aware of the need to carefully assess the data...
The longitudinal development of emotion regulation capacities in children at risk for externalizing disorders
Sarah L. Halligan, Peter J. Cooper, Pasco Fearon, Sarah L. Wheeler, Michelle Crosby, Lynne Murray
May 01, 2013
The development of emotional regulation capacities in children at high versus low risk for externalizing disorder was examined in a longitudinal study investigating: (a) whether disturbances in emotion regulation precede and...
Experiences of face mask use during the COVID‐19 pandemic
Esmée Hanna, Graham Martin, Anne Campbell, Paris Connolly, Kriss Fearon, Steven Markham
Sep 02, 2022
Abstract: The use of face masks and coverings has been a central component of efforts to mitigate the impact of the COVID‐19 pandemic and has been legally mandated in some countries. Most academic studies to date, however, have...
The impacts and implications of the community face mask use during the Covid-19 pandemic
INTRODUCTION: A range of nonpharmaceutical public health interventions has been introduced in many countries following the rapid spread of Covid-19 since 2020, including recommendations or mandates for the use of face masks or...
Maternal postnatal depression predicts altered offspring biological stress reactivity in adulthood
Tom J. Barry, Lynne Murray, R. M Pasco Fearon, Christina Moutsiana, Peter Cooper, Ian M. Goodyer, Joe Herbert, Sarah L. Halligan
Feb 01, 2015
The offspring of depressed parents have been found to show elevated basal levels of the stress hormone cortisol. Whether heightened cortisol stress reactivity is also present in this group has yet to be clearly demonstrated....
Maternal postnatal depression predicts altered offspring biological stress reactivity in adulthood
Tom J. Barry, Lynne Murray, R. M Pasco Fearon, Christina Moutsiana, Peter Cooper, Ian M. Goodyer, Joe Herbert, Sarah L. Halligan
Feb 01, 2015
The offspring of depressed parents have been found to show elevated basal levels of the stress hormone cortisol. Whether heightened cortisol stress reactivity is also present in this group has yet to be clearly demonstrated....
Amygdala volume and hypothalamic-pituitary-adrenal axis reactivity to social stress
Tom J. Barry, Lynne Murray, Pasco Fearon, Christina Moutsiana, Tom Johnstone, Sarah L. Halligan
Nov 01, 2017
The amygdala plays a central role in emotional processing and has an activating influence on the hypothalamic-pituitary-adrenal (HPA) axis. Structural changes in the amygdala have been associated with early adversity and, in...
Amygdala Cortisol Depression hypothalamic-pituitary-adrenal axis Stress sensitivity /dk/atira/pure/subjectarea/asjc/2700/2712 name=Endocrinology, Diabetes and Metabolism /dk/atira/pure/subjectarea/asjc/1300/1310 name=Endocrinology /dk/atira/pure/subjectarea/asjc/2800/2807 name=Endocrine and Autonomic Systems /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/subjectarea/asjc/2800/2803 name=Biological Psychiatry /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
PTSD symptoms and cortisol stress reactivity in adolescence
Annie Zimmerman, Sarah Halligan, Sarah Skeen, Barak Morgan, Abigail Fraser, Pasco Fearon, Mark Tomlinson
Nov 30, 2020
Background: Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is implicated in the pathophysiology of post-traumatic stress disorder (PTSD). However, there has been little study of HPA stress reactivity in...
ADOLESCENTS Cortisol reactivity Low and middle income country PTSD Stress trauma /dk/atira/pure/subjectarea/asjc/2700/2712 name=Endocrinology, Diabetes and Metabolism /dk/atira/pure/subjectarea/asjc/1300/1310 name=Endocrinology /dk/atira/pure/subjectarea/asjc/2800/2807 name=Endocrine and Autonomic Systems /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/subjectarea/asjc/2800/2803 name=Biological Psychiatry /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
The longitudinal development of emotion regulation capacities in children at risk for externalizing disorders
Sarah L. Halligan, Peter J. Cooper, Pasco Fearon, Sarah L. Wheeler, Michelle Crosby, Lynne Murray
May 01, 2013
The development of emotional regulation capacities in children at high versus low risk for externalizing disorder was examined in a longitudinal study investigating: (a) whether disturbances in emotion regulation precede and...
Amygdala volume and hypothalamic-pituitary-adrenal axis reactivity to social stress
Tom J. Barry, Lynne Murray, Pasco Fearon, Christina Moutsiana, Tom Johnstone, Sarah L. Halligan
Nov 01, 2017
The amygdala plays a central role in emotional processing and has an activating influence on the hypothalamic-pituitary-adrenal (HPA) axis. Structural changes in the amygdala have been associated with early adversity and, in...
Amygdala Cortisol Depression hypothalamic-pituitary-adrenal axis Stress sensitivity /dk/atira/pure/subjectarea/asjc/2700/2712 name=Endocrinology, Diabetes and Metabolism /dk/atira/pure/subjectarea/asjc/1300/1310 name=Endocrinology /dk/atira/pure/subjectarea/asjc/2800/2807 name=Endocrine and Autonomic Systems /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/subjectarea/asjc/2800/2803 name=Biological Psychiatry /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
PTSD symptoms and cortisol stress reactivity in adolescence
Annie Zimmerman, Sarah Halligan, Sarah Skeen, Barak Morgan, Abigail Fraser, Pasco Fearon, Mark Tomlinson
Nov 30, 2020
Background: Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is implicated in the pathophysiology of post-traumatic stress disorder (PTSD). However, there has been little study of HPA stress reactivity in...
ADOLESCENTS Cortisol reactivity Low and middle income country PTSD Stress trauma /dk/atira/pure/subjectarea/asjc/2700/2712 name=Endocrinology, Diabetes and Metabolism /dk/atira/pure/subjectarea/asjc/1300/1310 name=Endocrinology /dk/atira/pure/subjectarea/asjc/2800/2807 name=Endocrine and Autonomic Systems /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/subjectarea/asjc/2800/2803 name=Biological Psychiatry /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity
TR Flint, T Janowitz, CM Connell, EW Roberts, AE Denton, AP Coll, DI Jodrell, DT Fearon
Dec 20, 2016
Cancer immunotherapy trial registrations increase exponentially but chronic immunosuppressive glucocorticoid therapy may compromise outcomes
This work was supported by the Wellcome Trust Translational Medicine and Therapeutics Programme [RJAG/076 to TJ], Cancer Research UK and the Cambridge Translational Medicine and Therapeutics Academic Clinical Fellowship...
Ethnicity and long-term course and outcome of psychotic disorders in a UK sample
C Morgan, P Fearon, J Lappin, M Heslin, K Donoghue, B Lomas, U Reininghaus, A Onyejiaka, T Croudace, PB Jones, RM Murray, GA Doody, P Dazzan
Jul 18, 2017
Frailty and cerebrovascular disease
Nicholas R Evans, Oliver M Todd, Jatinder S Minhas, Patricia Fearon, George W Harston, Jonathan Mant, Gillian Mead, Jonathan Hewitt, Terence J Quinn, Elizabeth A Warburton
Feb 23, 2022
Frailty is a distinctive health state in which the ability of older people to cope with acute stressors is compromised by an increased vulnerability brought by age-associated declines in physiological reserve and function across...
Frailty and cerebrovascular disease
Nicholas Evans, Oliver M Todd, Jatinder S Minhas, Patricia Fearon, George W Harston, Jonathan Mant, Gillian Mead, Jonathan Hewitt, Terence J Quinn, Liz Warburton
Aug 02, 2021
Frailty is a distinctive health state in which the ability of older people to cope with acute stressors is compromised by an increased vulnerability brought by age-associated declines in physiological reserve and function across...
Symptom remission at 12-weeks strongly predicts long-term recovery from the first episode of psychosis.
Paola Dazzan, Julia M Lappin, Margaret Heslin, Kim Donoghue, Ben Lomas, Uli Reininghaus, Adanna Onyejiaka, Tim Croudace, Peter B Jones, Robin M Murray, Paul Fearon, Gillian A Doody, Craig Morgan
Nov 22, 2019
clinical outcome Functional outcome Psychosis Remission Schizophrenia Activities of Daily Living Adult Bipolar Disorder Female Follow-Up Studies Humans Logistic Models Male Outcome Assessment Health Care Psychiatric Status Rating Scales Psychotic Disorders Remission Induction Schizophrenia Schizophrenic Psychology United Kingdom Young Adult
Adapting and testing a brief intervention to reduce maternal anxiety during pregnancy (ACORN)
Esther L. Wilkinson, Heather A. O'Mahen, Pasco Fearon, Sarah Halligan, Dorothy X. King, Geva Greenfield, Jacqueline Dunkley-Bent, Jennifer Ericksen, Jeannette Milgrom, Paul G. Ramchandani
Mar 22, 2016
Background
National guidelines in the UK, United States of America, Canada, and Australia have recently stressed the importance of identifying and treating antenatal anxiety and depression. However, there is little research...
National guidelines in the UK, United States of America, Canada, and Australia have recently stressed the importance of identifying and treating antenatal anxiety and depression. However, there is little research...
Adapting and testing a brief intervention to reduce maternal anxiety during pregnancy (ACORN)
Heather A O'Mahen, Paul Ramchandani, Dorothy X King, Leonie Lee-Carbon, Esther L Wilkinson, Chloe Thompson-Booth, Jennifer Ericksen, Jeannette Milgrom, Jacqueline Dunkley-Bent, Sarah L Halligan, Pasco Fearon
Feb 17, 2022
BACKGROUND: We investigated the acceptability and feasibility of a new brief intervention for maternal prenatal anxiety within maternity services in London and Exeter, UK. METHODS: One hundred fourteen pregnant individuals...
Carcinomas assemble a filamentous CXCL12-keratin-19 coating that suppresses T cell-mediated immune attack.
Zhikai Wang, Philip Moresco, Ran Yan, Jiayun Li, Ya Gao, Daniele Biasci, Min Yao, Jordan Pearson, Jaclyn F Hechtman, Tobias Janowitz, Raza M Zaidi, Matthew J Weiss, Douglas T Fearon
Feb 20, 2022
Cancer immunotherapy frequently fails because most carcinomas have few T cells, suggesting that cancers can suppress T cell infiltration. Here, we show that cancer cells of human pancreatic ductal adenocarcinoma (PDA)...
Adapting and testing a brief intervention to reduce maternal anxiety during pregnancy (ACORN)
Esther L Wilkinson, Heather A O'Mahen, Pasco Fearon, Sarah Halligan, Dorothy X King, Geva Greenfield, Jacqueline Dunkley-Bent, Jennifer Ericksen, Jeannette Milgrom, Paul G Ramchandani
Jan 08, 2019
BACKGROUND: National guidelines in the UK, United States of America, Canada, and Australia have recently stressed the importance of identifying and treating antenatal anxiety and depression. However, there is little research...
Antenatal Anxiety Cognitive behavioural therapy Feasibility Group intervention Anxiety Body Temperature Regulation Clinical Protocols Cognitive Behavioral Therapy England Feasibility Studies Female Humans Infant Newborn Midwifery Mother-Child Relations Pilot Projects Pregnancy Pregnancy Complications Prenatal Care Psychiatric Status Rating Scales Psychotherapy Brief Psychotherapy Group Quality of life Research Design Sleep Time Factors Treatment Outcome
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