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Human cytomegalovirus-specific cytotoxic T cells. Relative frequency of stage-specific CTL recognizing the 72-kD immediate early protein and glycoprotein B expressed by recombinant vaccinia viruses.
CTL are held to be an important host defense mechanism in persistent herpes-virus infections. We have therefore studied the nature and specificity of human cytomegalovirus (HCMV)-specific CTL in normal persistently infected...
Effect of the early-life nutritional environment on fecundity and fertility of mammals.
The early-life developmental environment is instrumental in shaping our overall adult health and well-being. Early-life diet and endocrine exposure may independently, or in concert with our genetic constitution, induce a...
Identification of Sex and Aging Differences in C57BL/6-NClr Mice on the Ketogenic Diet
Ken Sprankle
Jan 01, 0001
The ketogenic diet (KD) is a high-fat, low-carbohydrate diet that results in the elevation of serum ketone bodies, known as ketosis. This metabolic consequence has been suggested as a method for treating neurological conditions...
ketogenic diet Mice adipose Motor Cognition Exercise Biology Life Sciences Medicine and Health Sciences Public Health
Published by: Ursinus College
Sex- and Age-Specific Differences in Mice Fed a Ketogenic Diet
Kenyon W. Sprankle, Mya Knappenberger, Erica J. Locke, Jack Thompson, Madison Vinovrski, Kaylin Knapsack, Stephen C. Kolwicz, Jr.
Jan 01, 0001
The ketogenic diet (KD) is a high-fat, low-carbohydrate diet that results in the elevation of serum ketone bodies, known as ketosis. This metabolic consequence has been suggested as a method for treating neurological conditions...
Published by: Ursinus College
King-Devick concussion test performs poorly as a screening tool in elite rugby union players
BACKGROUND: The King-Devick (KD) test is an objective clinical test of eye movements that has been used to screen for concussion. We characterised the accuracy of the KD test and the World Rugby Head Injury Assessment (HIA-1)...
Insights into the Substrate Specificity of Archaeal Entner-Doudoroff Aldolases
Viatcheslav Zaitsev, Ulrike Johnsen, Matthias Reher, Marius Ortjohann, Garry Taylor, Michael Danson, Peter Schönheit, Susan Crennell
Jul 03, 2018
The thermoacidophilic archaea Picrophilus torridus and Sulfolobus solfataricus catabolize glucose via a nonphosphorylative Entner-Doudoroff pathway and a branched Entner-Doudoroff pathway, respectively. Key enzymes for these...
Insights into the Substrate Specificity of Archaeal Entner-Doudoroff Aldolases
Viatcheslav Zaitsev, Ulrike Johnsen, Matthias Reher, Marius Ortjohann, Garry Taylor, Michael Danson, Peter Schönheit, Susan Crennell
Jul 03, 2018
The thermoacidophilic archaea Picrophilus torridus and Sulfolobus solfataricus catabolize glucose via a nonphosphorylative Entner-Doudoroff pathway and a branched Entner-Doudoroff pathway, respectively. Key enzymes for these...
King-Devick concussion test performs poorly as a screening tool in elite rugby union players
BACKGROUND: The King-Devick (KD) test is an objective clinical test of eye movements that has been used to screen for concussion. We characterised the accuracy of the KD test and the World Rugby Head Injury Assessment (HIA-1)...
Diffusion and sorption of trace organic micropollutants in biofilm with varying thickness
Elena Torresi, Fabio Polesel, Kai Bester, Magnus Christensson, Barth F. Smets, Stefan Trapp, Henrik R. Andersen, Benedek Gy. Plosz
Oct 15, 2017
Solid-liquid partitioning is one of the main fate processes determining the removal of micropollutants in wastewater. Little is known on the sorption of micropollutants in biofilms, where molecular diffusion may significantly...
Ketogenic Diets and Exercise Performance
The ketogenic diet (KD) has gained a resurgence in popularity due to its purported reputation for fighting obesity. The KD has also acquired attention as an alternative and/or supplemental method for producing energy in the form...
Ketosis endurance exercise ketone supplements obesity ketone bodies metabolism Dietetics and Clinical Nutrition Exercise Science Medicine and Health Sciences
Published by: Ursinus College
The Effects of Fasting or Ketogenic Diet on Endurance Exercise Performance and Metabolism in Female Mice
The promotion of ketone body (KB) metabolism via ketosis has been suggested as a strategy to increase exercise performance. However, studies in humans and animals have yielded inconsistent results. The purpose of the current...
nutritional ketosis Lipid Metabolism ketone body metabolism Glycogen Triglycerides Exercise Physiology
Published by: Ursinus College
The Contributions of Ketogenic Diet to Behavioral Alterations and Brain Development in C57BL/6-NClr Mice
Mya Knappenberger
Jan 01, 0001
The prevalence of obesity and hyperactivity in children have increased over the last several years. However, research has yet to establish a known association between the development of obesity and behavioral disorders. The...
Published by: Ursinus College
Regulation of human cytomegalovirus transcription in latency
Lytic infection of differentiated cell types with human cytomegalovirus (HCMV) results in the temporal expression of between 170-200 open reading frames (ORFs). A number of studies have demonstrated the temporal regulation of...
Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion.
Mutations in the gene encoding the microtubule (MT)-severing protein spastin are the most common cause of hereditary spastic paraplegia, a genetic condition in which axons of the corticospinal tracts degenerate. We show that not...
Understanding HCMV Latency Using Unbiased Proteomic Analyses
Human cytomegalovirus (HCMV) establishes either a latent (non-productive) or lytic (productive) infection depending upon cell type, cytokine milieu and the differentiation status of the infected cell. Undifferentiated cells...
The Human Cytomegalovirus β2.7 Long Non-Coding RNA Prevents Induction of Reactive Oxygen Species to Maintain Viral Gene Silencing during Latency
Human cytomegalovirus (HCMV) is a significant source of disease for the immunosuppressed and immunonaive. The treatment of HCMV is made more problematic by viral latency, a lifecycle stage in which the virus reduces its...
The intimate relationship between human cytomegalovirus and the dendritic cell lineage.
Primary infection of healthy individuals with human cytomegalovirus (HCMV) is normally asymptomatic but results in the establishment of a lifelong infection of the host. One important cellular reservoir of HCMV latency is the...
Prioritised challenges in the management of acute knee dislocations are stiffness, obesity, treatment delays and associated limb-threatening injuries
Michael Held, Robert C Schenck, Vikas Khanduja, Túlio Vinícius de Oliveira Campos, Sachin Tapasvi, Andy Williams, Wai Pan Yau, Christopher Harner, Authorship group ‘Knee surgery in LRS’
Mar 09, 2021
OBJECTIVES: Heterogeneous patient factors and injury mechanisms result in a great variety of injury patterns encountered in knee dislocations (KD). Attempts to improve outcome can focus on a wide range of challenges. The aim of...
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