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[18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia
WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, YT Hong, TD Fryer, R Arnold, KSJ Allinson, JP Coles, FI Aigbirhio, K Patterson, JT O'Brien, JB Rowe
Oct 02, 2017
[18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia
A case report of metastatic renal cell carcinoma causing corticobasal syndrome.
We present a case report of a patient with a history of renal cell carcinoma in which corticobasal syndrome had been diagnosed ante-mortem. However, distinguishing features of corticobasal degeneration pathology were absent at...
Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity.
Sanne Simone Kaalund, Luca Passamonti, Kieren SJ Allinson, Alexander G Murley, Trevor W Robbins, Maria Grazia Spillantini, James B Rowe
Feb 04, 2020
Neuroinflammation and protein pathology in Parkinson’s disease dementia
Abstract: Parkinson’s disease dementia is neuropathologically characterized by aggregates of α-synuclein (Lewy bodies) in limbic and neocortical areas of the brain with additional involvement of Alzheimer’s disease-type...
Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity.
Sanne Simone Kaalund, Luca Passamonti, Kieren S J Allinson, Alexander G Murley, Trevor W Robbins, Maria Grazia Spillantini, James B Rowe
Mar 10, 2020
The locus coeruleus is the major source of noradrenaline to the brain and contributes to a wide range of physiological and cognitive functions including arousal, attention, autonomic control, and adaptive behaviour....
Locus Coeruleus Tau neurodegeneration frontotemporal dementia progressive supranuclear palsy Noradrenalin
Published by: Acta neuropathologica communications
Clinicopathological co-occurrence of Fahr’s disease and dementia with Lewy bodies
Melanie P Jensen, Olivera Spasic-Boskovic, James B Rowe, Clare Galton, Kieren SJ Allinson
Apr 15, 2020
We present the clinicopathological findings of a case of combined Fahr’s disease (FD) and dementia with Lewy bodies (DLB), associated with a novel pathogenic mutation. The patient presented with visual hallucinations...
Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity
Sanne Simone Kaalund, Luca Passamonti, Kieren S. J. Allinson, Alexander G. Murley, Trevor W. Robbins, Maria Grazia Spillantini, James B. Rowe
Feb 03, 2021
Abstract: The locus coeruleus is the major source of noradrenaline to the brain and contributes to a wide range of physiological and cognitive functions including arousal, attention, autonomic control, and adaptive behaviour....
Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity
Sanne Simone Kaalund, Luca Passamonti, Kieren S. J. Allinson, Alexander G. Murley, Trevor W. Robbins, Maria Grazia Spillantini, James B. Rowe
Jun 06, 2020
Abstract: The locus coeruleus is the major source of noradrenaline to the brain and contributes to a wide range of physiological and cognitive functions including arousal, attention, autonomic control, and adaptive behaviour....
Neuroinflammation and protein pathology in Parkinson's disease dementia.
Parkinson's disease dementia is neuropathologically characterized by aggregates of α-synuclein (Lewy bodies) in limbic and neocortical areas of the brain with additional involvement of Alzheimer's disease-type pathology. Whilst...
Infiltrating lymphocytes Microglia Neuroinflammation neuropathology Parkinson’s disease dementia Pro-inflammatory cytokines Toll-Like Receptors Aged Aged 80 and over Amygdala Amyloid beta-Peptides Astrocytes Brain Cytokines Dementia Female Frontal Lobe gliosis Hippocampus Humans Inflammation Male Microglia Parkinson Disease Substantia Nigra Synucleinopathies T-Lymphocytes Toll-Like Receptor 2 Toll-Like Receptor 4 ALPHA-SYNUCLEIN tau Proteins
Less Invasive Phenotype Found in Isocitrate Dehydrogenase-mutated Glioblastomas than in Isocitrate Dehydrogenase Wild-Type Glioblastomas
A rare case of bone marrow infiltration by medulloblastoma in a child.
Anna Santarsieri, Emmy Dickens, C Elizabeth Hook, Kieren Allinson, Tomasz Matys, Matthew J Murray
May 03, 2019
A seven-year-old boy was previously treated for the primarya posterior fossa tumour, medulloblastoma, with extensive central nervous system metastases including leptomeningeal and intrathecal spinal disease; methylation...
Heteroplasmic mitochondrial DNA mutations in frontotemporal lobar degeneration.
Frontotemporal lobar degeneration (FTLD) is a common cause of young onset dementia and is characterised by focal neuropathology. The reasons for the regional neuronal vulnerability are not known. Mitochondrial mechanisms have...
Heteroplasmic mitochondrial DNA mutations in frontotemporal lobar degeneration.
Yu Nie, Alexander Murley, Zoe Golder, James B Rowe, Kieren Allinson, Patrick F Chinnery
Jun 07, 2022
Frontotemporal lobar degeneration (FTLD) is a common cause of young onset dementia and is characterised by focal neuropathology. The reasons for the regional neuronal vulnerability are not known. Mitochondrial mechanisms have...
An Evaluation of the Tolerability and Feasibility of Combining 5-Amino-Levulinic Acid (5-ALA) with BCNU Wafers in the Surgical Management of Primary Glioblastoma.
Colin Watts, Keyoumars Ashkan, Michael D Jenkinson, Stephen J Price, Thomas Santarius, Tomasz Matys, Ting Ting Zhang, Alina Finch, Peter Collins, Kieren Allinson, Sarah J Jefferies, Daniel J Scoffings, Athanasios Zisakis, Mark Phillips, Katharina Wanek, Paul Smith, Laura Clifton-Hadley, Nicholas Counsell
Sep 05, 2021
Background Glioblastoma (GBM) is the commonest primary malignant brain tumour in adults and effective treatment options are limited. Combining local chemotherapy with enhanced surgical resection using 5-aminolevulinic acid...
Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia.
Ruma Raha-Chowdhury, Animesh Alexander Raha, James Henderson, Seyedeh Deniz Ghaffari, Monika Grigorova, Jessica Beresford-Webb, Kieren Allinson, Subhojit Chakraborty, Anthony Holland, Shahid H Zaman
Sep 20, 2021
Down syndrome (DS) subjects are more likely to develop the clinical features of Alzheimer's disease (AD) very early in the disease process due to the additional impact of neuroinflammation and because of activation of innate...
Neoplasia in Three Aye-Ayes (Daubentonia madagascariensis).
Tumours diagnosed in three aged captive aye-ayes (Daubentonia madagascariensis), held in two different institutions, are described. A cerebral glioblastoma was diagnosed based on histological and immunohistochemical findings in...
[18F]fluoroethyltyrosine-induced Cerenkov Luminescence Improves Image-Guided Surgical Resection of Glioma.
David Y Lewis, Richard Mair, Alan Wright, Kieren Allinson, Scott K Lyons, Tom Booth, Julia Jones, Robert Bielik, Dmitry Soloviev, Kevin M Brindle
Sep 08, 2018
Localisation of an occult thyrotropinoma with $^{11}$C-methionine PET-CT before and after somatostatin analogue therapy
O Koulouri, AC Hoole, P English, K Allinson, N Antoun, H Cheow, NG Burnet, N Donnelly, RJ Mannion, M Gurnell
Dec 21, 2016
A 75-year-old woman presented to her local endocrine service with tiredness, palpitations, and enlargement of a longstanding goitre. Unexpectedly, her thyrotropin (thyroid-stimulating hormone [TSH]) concentration was not...
Investigating the relationship between diffusion kurtosis tensor imaging (DKTI) and histology within the normal human brain.
Ahmed Maiter, Frank Riemer, Kieren Allinson, Fulvio Zaccagna, Mireia Crispin-Ortuzar, Marcel Gehrung, Mary A McLean, Andrew N Priest, James Grist, Tomasz Matys, Martin J Graves, Ferdia A Gallagher
Mar 29, 2021
Measurements of water diffusion with MRI have been used as a biomarker of tissue microstructure and heterogeneity. In this study, diffusion kurtosis tensor imaging (DKTI) of the brain was undertaken in 10 healthy volunteers at a...
Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia.
Ruma Raha-Chowdhury, Animesh Alexander Raha, James Henderson, Seyedeh Deniz Ghaffari, Monika Grigorova, Jessica Beresford-Webb, Kieren Allinson, Subhojit Chakraborty, Anthony Holland, Shahid H Zaman
Aug 02, 2021
Down syndrome (DS) subjects are more likely to develop the clinical features of Alzheimer's disease (AD) very early in the disease process due to the additional impact of neuroinflammation and because of activation of innate...
Iron ferritin Alzheimer’s disease Hepcidin iron homeostasis Choroid Plexus trisomy 21 Olig2 RUNX1 S100β accelerating ageing down syndrome dementia erythroid-megakaryocyte
Published by: Journal of clinical medicine
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