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Results: 39
SOX9 has distinct roles in the formation and progression of different non-small cell lung cancer histotypes.
Jie Bao, Katja Närhi, Ana Teodòsio, Annabrita Hemmes, Nora M Linnavirta, Mikko I Mäyränpää, Kaisa Salmenkivi, John Le Quesne, Emmy W Verschuren
Jun 19, 2021
About That Sex-Related Stiffening.
Aortic stiffness is an important predictor of cardiovascular outcome, adding value to information provided by traditional risk factors, improving risk classification, and predicting all-cause mortality. Mean arterial pressure...
“Shared Online, Made People Envious, Felt Good”
An online survey of 200 participants was conducted on the experiences of sharing material and immaterial artifacts, focusing on interaction with non-media content types. The survey included six categories of sharing: music...
Published by: IGI Global Scientific Publishing
Characterisation of canine KCNIP4
Christopher A Jenkins, Lajos Kalmar, Kaspar Matiasek, Lorenzo Mari, Kaisa Kyöstilä, Hannes Lohi, Ellen C Schofield, Cathryn S Mellersh, Luisa De Risio, Sally L Ricketts
Mar 02, 2020
A form of hereditary cerebellar ataxia has recently been described in the Norwegian Buhund dog breed. This study aimed to identify the genetic cause of the disease. Whole-genome sequencing of two Norwegian Buhund siblings...
The Role of the Autonomic Nervous System in the Regulation of Aortic Stiffness.
Kaisa M Mäki-Petäjä, Sharon ML Barrett, Sarah V Evans, Joseph Cheriyan, Carmel M McEniery, Ian B Wilkinson
Oct 14, 2016
aortic stiffness Autonomic Nervous System blood pressure Healthy Volunteers Heart Rate Hemodynamics Adult Arterial Pressure Autonomic Nervous System Cross-Over Studies Cross-Sectional Studies Double-Blind Method Female Hand Strength Healthy Volunteers Heart Rate Hemodynamics Humans Hypertension Male Pentolinium Tartrate Prognosis Pulse Wave Analysis Role Vascular Stiffness Young Adult
Characterisation of canine KCNIP4
Christopher A. Jenkins, Lajos Kalmar, Kaspar Matiasek, Lorenzo Mari, Kaisa Kyöstilä, Hannes Lohi, Ellen C. Schofield, Cathryn S. Mellersh, Luisa De Risio, Sally L. Ricketts
Feb 11, 2020
A form of hereditary cerebellar ataxia has recently been described in the Norwegian Buhund dog breed. This study aimed to identify the genetic cause of the disease. Whole-genome sequencing of two Norwegian Buhund siblings...
Investigating the lowest threshold of vascular benefits from LDL cholesterol lowering with a PCSK9 mAb inhibitor (alirocumab) in healthy volunteers - a mechanistic physiological study (INTENSITY-LOW)
Michael S Kostapanos, Paul J Cacciottolo, Annette Hubsch, Holly Pavey, James Hurlock, Kaisa Maki-Petaja, Ian B Wilkinson, Joseph Cheriyan
Oct 15, 2019
Objective: Whether reducing low density lipoprotein cholesterol (LDL-C) is associated with cardiovascular benefits in low risk normocholesterolaemic subjects is unknown. The INTENSITY LOW [Investigating the lowest threshold of...
Anticholinergic medication exposure predicts poor physical capability
Kaisa R Yrjana, Victoria L Keevil, Roy L Soiza, Robert N Luben, Nicholas J Wareham, Kay-Tee Khaw, Phyo K Myint
Jul 29, 2020
Evaluation of inert gas rebreathing for determination of cardiac output
Jessica E Middlemiss, Alex Cocks, Kaido Paapstel, Kaisa M Maki-Petaja, Sunita, Ian B Wilkinson, Carmel M McEniery, ACCT Study Investigators
Dec 21, 2018
The aim of this study was to evaluate an inert gas rebreathing method (Innocor) for measurement of cardiac output and related haemodynamic variables and to provide robust normative data describing the influence of age, gender...
Body Size cardiac output Inert gas rebreathing Normative data Adult aging Bicycling Body Size Body Surface Area cardiac output Female Heart Rate Humans Male Middle Aged Noble Gases Posture Reference Values Reproducibility of Results Sex Characteristics Sitting Position Standing Position Stroke Volume Supine Position Young Adult
Effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers
Parag R Gajendragadkar, Annette Hubsch, Kaisa M Mäki-Petäjä, Martin Serg, Ian B Wilkinson, Joseph Cheriyan
Sep 05, 2018
AIMS: The mechanisms by which a 'Mediterranean diet' reduces cardiovascular disease (CVD) burden remain poorly understood. Lycopene is a potent antioxidant found in such diets with evidence suggesting beneficial effects. We...
High-grade ovarian serous carcinoma patients exhibit profound alterations in lipid metabolism.
Elena Ioana Braicu, Silvia Darb-Esfahani, Wolfgang D Schmitt, Kaisa M Koistinen, Laura Heiskanen, Päivi Pöhö, Jan Budczies, Marc Kuhberg, Manfred Dietel, Christian Frezza, Carsten Denkert, Jalid Sehouli, Mika Hilvo
May 31, 2018
Ovarian cancer is a very severe type of disease with poor prognosis. Treatment of ovarian cancer is challenging because of the lack of tests for early detection and effective therapeutic targets. Thus, new biomarkers are needed...
Novel Mechanism for Buffering Dietary Salt in Humans
Viknesh Selvarajah, Kaisa M Mäki-Petäjä, Liliana Pedro, Sylvaine FA Bruggraber, Keith Burling, Anna K Goodhart, Morris J Brown, Carmel M McEniery, Ian B Wilkinson
Jan 24, 2018
High dietary sodium intake triggers increased blood pressure (BP). Animal studies show that dietary salt loading results in dermal Na+ accumulation and lymphangiogenesis mediated by VEGF-C (vascular endothelial growth factor C)...
blood pressure Skin sodium Stroke Volume Vascular Endothelial Growth Factor C Adult blood pressure Diet Sodium-Restricted Double-Blind Method England Female Hemodynamics Humans Hypertension Male Middle Aged Potassium Renal Elimination Sex Factors Skin sodium Sodium Chloride Vascular Endothelial Growth Factor C Water-Electrolyte Balance
Published by: Hypertension
Tetrahydrobiopterin Supplementation Improves Endothelial Function But Does Not Alter Aortic Stiffness in Patients With Rheumatoid Arthritis.
Kaisa M Mäki-Petäjä, Lisa Day, Joseph Cheriyan, Frances C Hall, Andrew JK Östör, Nicholas Shenker, Ian B Wilkinson
Dec 18, 2015
arteriosclerosis endothelial function Inflammation rheumatoid arthritis tetrahydrobiopterin Administration Oral Adult Aged Arthritis Rheumatoid Biomarkers Biopterin Cardiovascular Agents Cross-Over Studies Dietary Supplements Double-Blind Method Drug Administration Schedule Endothelium Vascular England Female Humans Inflammation Mediators Male Middle Aged Nitric Oxide Synthase Type III Pilot Projects Pulse Wave Analysis Time Factors Treatment Outcome Vascular diseases Vascular Stiffness Vasodilation Young Adult
Cytokinin and Auxin Display Distinct but Interconnected Distribution and Signaling Profiles to Stimulate Cambial Activity.
Juha Immanen, Kaisa Nieminen, Olli-Pekka Smolander, Mikiko Kojima, Juan Alonso Serra, Patrik Koskinen, Jing Zhang, Annakaisa Elo, Ari Pekka Mähönen, Nathaniel Street, Rishikesh P Bhalerao, Lars Paulin, Petri Auvinen, Hitoshi Sakakibara, Ykä Helariutta
Jun 23, 2016
Investigating the lowest threshold of vascular benefits from LDL cholesterol lowering with a PCSK9 mAb inhibitor (alirocumab) in healthy volunteers - a mechanistic physiological study (INTENSITY-LOW)
Michael S Kostapanos, Paul J Cacciottolo, Annette Hubsch, Holly Pavey, James Hurlock, Kaisa Maki-Petaja, Ian B Wilkinson, Joseph Cheriyan
Dec 10, 2019
Objective: Whether reducing low density lipoprotein cholesterol (LDL-C) is associated with cardiovascular benefits in low risk normocholesterolaemic subjects is unknown. The INTENSITY LOW [Investigating the lowest threshold of...
The speciation and hybridization history of the genus Salmonella.
Alexis Criscuolo, Sylvie Issenhuth-Jeanjean, Xavier Didelot, Kaisa Thorell, James Hale, Julian Parkhill, Nicholas R Thomson, François-Xavier Weill, Daniel Falush, Sylvain Brisse
Sep 06, 2019
Bacteria and archaea make up most of natural diversity, but the mechanisms that underlie the origin and maintenance of prokaryotic species are poorly understood. We investigated the speciation history of the genus Salmonella, an...
Characterization of cytokinin signaling and homeostasis gene families in two hardwood tree species
Juha Immanen, Kaisa Nieminen, Héctor Duchens Silva, Fernanda Rodríguez Rojas, Lee A Meisel, Herman Silva, Victor A Albert, Torgeir R Hvidsten, Ykä Helariutta
Sep 29, 2018
BACKGROUND: Through the diversity of cytokinin regulated processes, this phytohormone has a profound impact on plant growth and development. Cytokinin signaling is involved in the control of apical and lateral meristem activity...
Baseline anticholinergic burden from medications predicts poorer baseline and long-term health-related quality of life in 16 675 men and women of EPIC-Norfolk prospective population-based cohort study.
Kaisa R Yrjana, Samuel R Neal, Roy L Soiza, Victoria Keevil, Robert N Luben, Nicholas J Wareham, Kay-Tee Khaw, Phyo Kyaw Myint
Nov 20, 2020
PURPOSE: Previous studies investigating the association between anticholinergic burden (ACB) and health-related quality of life (HRQoL) showed conflicting results and focused on older adults or specific patient groups only....
AINTEGUMENTA and the D-type cyclin CYCD3;1 regulate root secondary growth and respond to cytokinins.
Ricardo S Randall, Shunsuke Miyashima, Tiina Blomster, Jing Zhang, Annakaisa Elo, Anna Karlberg, Juha Immanen, Kaisa Nieminen, Ji-Young Lee, Tatsuo Kakimoto, Karolina Blajecka, Charles W Melnyk, Annette Alcasabas, Celine Forzani, Miho Matsumoto-Kitano, Ari Pekka Mähönen, Rishikesh Bhalerao, Walter Dewitte, Ykä Helariutta, James AH Murray
Sep 29, 2018
Higher plant vasculature is characterized by two distinct developmental phases. Initially, a well-defined radial primary pattern is established. In eudicots, this is followed by secondary growth, which involves development of...
Cardiovascular risk prediction using physical performance measures in COPD
Jilles M Fermont, Marie Fisk, Charlotte E Bolton, William MacNee, John R Cockcroft, Jonathan Fuld, Joseph Cheriyan, Divya Mohan, Kaisa M Mäki-Petäjä, Ali B Al-Hadithi, Ruth Tal-Singer, Hana Müllerova, Michael I Polkey, Angela M Wood, Carmel M McEniery, Ian B Wilkinson
Jan 04, 2021
Role of Vascular Adaptation in Determining Systolic Blood Pressure in Young Adults.
Shikai Yu, Jessica E Middlemiss, Chiara Nardin, Stacey S Hickson, Karen L Miles, Yasmin, Kaisa M Maki-Petaja, Barry J McDonnell, John R Cockcroft, Ian B Wilkinson, Carmel M McEniery, Enigma Study Investigators †
Feb 19, 2020
Surrogate Markers of Cardiovascular Risk and Chronic Obstructive Pulmonary Disease
Marie Fisk, Carmel M McEniery, Nichola Gale, Kaisa Mäki-Petäjä, Julia R Forman, Margaret Munnery, Jean Woodcock-Smith, Joseph Cheriyan, Divya Mohan, Jonathan Fuld, Ruth Tal-Singer, Michael I Polkey, John R Cockcroft, Ian B Wilkinson, ERICA Consortium and ACCT Investigators
Feb 06, 2018
Cardiovascular disease is a common comorbidity and cause of mortality in chronic obstructive pulmonary disease. A better understanding of mechanisms of cardiovascular risk in chronic obstructive pulmonary disease patients is...
Cardiovascular Diseases Carotid Intima-Media Thickness Case-Control Studies Pulmonary Disease Chronic Obstructive Pulse Wave Analysis Age Factors Aged Biomarkers Cardiovascular Diseases Carotid Intima-Media Thickness Case-Control Studies Comorbidity Female Hemodynamics Humans Incidence Male Middle Aged Pulmonary Disease Chronic Obstructive Reference Values Respiratory Function Tests Retrospective Studies Risk Assessment Severity of Illness Index Sex Factors Smoking Survival Rate United Kingdom Vascular Stiffness
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