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Results: 58
Inhibitors of immune checkpoints-PD-1, PD-L1, CTLA-4-new opportunities for cancer patients and a new challenge for internists and general practitioners.
Marek Z Wojtukiewicz, Magdalena M Rek, Kamil Karpowicz, Maria Górska, Barbara Polityńska, Anna M Wojtukiewicz, Marcin Moniuszko, Piotr Radziwon, Stephanie C Tucker, Kenneth V Honn
Oct 29, 2021
The treatment of cancer patients with immune checkpoint inhibitors (ICI) (anti-CTLA-4, anti-PD-1, anti-PD-L1, combined therapy anti-PD-1/PD-L1 with anti-CTLA-4) has without doubt been a significant breakthrough in the field of...
Application of Electron Backscatter Diffraction to Calcite-Twinning Paleopiezometry
Electron backscatter diffraction (EBSD) was used to determine the orientation of mechanically twinned grains in Carrara marble experimentally deformed to a small strain (≤4%) at room temperature and at a moderate confining...
Structure of praseodymium and neodymium gallate glasses
Kamil Wezka, Anita Zeidler, Philip S Salmon, Pinit Kidkhunthod, Adrian C Barnes, Henry E Fischer
Jan 01, 0001
The rare-earth gallate glasses R 4Ga6O15, where R denotes Pr or Nd, were prepared using an aerodynamic levitator and laser heating system. The structure was studied by applying the method of isomorphic substitution in neutron...
Supramolecular encapsulation of redox-active monomers to enable free-radical polymerisation.
Extended polymeric structures based on redox-active species are of great interest in emerging technologies related to energy conversion and storage. However, redox-active monomers tend to inhibit radical polymerisation processes...
Published by: Chemical science
From a Well-Defined Organozinc Precursor to Diverse Luminescent Coordination Polymers Based on Zn(II)-Quinolinate Building Units Interconnected by Mixed Ligand Systems.
Katarzyna Sołtys-Brzostek, Kamil Sokołowski, Iwona Justyniak, Michał K Leszczyński, Natalia Olejnik-Fehér, Janusz Lewiński
Dec 24, 2021
Introduction of photoactive building blocks into mixed-ligand coordination polymers appears to be a promising way to produce new advanced luminescent materials. However, rational design and self-assembly of the multi-component...
Density-driven structural transformations in network forming glasses
Philip Salmon, James Drewitt, Dean Whittaker, Anita Zeidler, Kamil Wezka, Craig L. Bull, Matt G. Tucker, Martin C. Wilding, Malcolm Guthrie, Dario Marrocchelli
Jan 01, 0001
The structure of GeO2 glass was investigated at pressures up to 17.5(5) GPa using in situ time-of-flight neutron diffraction with a Paris–Edinburgh press employing sintered diamond anvils. A new methodology and data correction...
On-Resin Recognition of Aromatic Oligopeptides and Proteins through Host-Enhanced Heterodimerization
Oren Scherman, Jade McCune, Xiaoyi Chen, Zehuan Huang, Kamil Sokolowski, Renata Sala Lang, Alan McLean, Guanglu Wu, Katherine King
Jun 09, 2022
Peptide dimerization is ubiquitous in natural protein conjugates and artificial self-assemblies. A major challenge in artificial systems remains achieving quantitative heterodimerization of peptides, critical for next-generation...
Structure of praseodymium and neodymium gallate glasses
Kamil Wezka, Anita Zeidler, Philip S Salmon, Pinit Kidkhunthod, Adrian C Barnes, Henry E Fischer
Jan 01, 0001
The rare-earth gallate glasses R 4Ga6O15, where R denotes Pr or Nd, were prepared using an aerodynamic levitator and laser heating system. The structure was studied by applying the method of isomorphic substitution in neutron...
Mechanisms of network collapse in GeO(2) glass
Kamil Wezka, Philip S Salmon, Anita Zeidler, Dean A J Whittaker, James W E Drewitt, Stefan Klotz, Henry E Fischer, Dario Marrocchelli
Dec 19, 2012
The structure of the network forming glass GeO(2) is investigated by making the first application of the method of in situ neutron diffraction with isotope substitution at pressures increasing from ambient to 8 GPa. Of the...
Inflammatory Proteins HMGA2 and PRTN3 as Drivers of Vulvar Squamous Cell Carcinoma Progression.
Agnieszka Fatalska, Natalia Rusetska, Elwira Bakuła-Zalewska, Artur Kowalik, Sebastian Zięba, Agnieszka Wroblewska, Kamil Zalewski, Krzysztof Goryca, Dominik Domański, Magdalena Kowalewska
Mar 08, 2021
Current knowledge on the biology of squamous cell vulvar carcinoma (VSCC) is limited. We aimed to identify protein markers of VSCC tumors that would permit to stratify patients by progression risk. Early-stage tumors from...
Acute loss of Cited2 impairs Nanog expression and decreases self-renewal of mouse embryonic stem cells.
OPA1 mutations cause cytochrome c oxidase deficiency due to loss of wild-type mtDNA molecules.
Patrick Yu-Wai-Man, Kamil S Sitarz, David C Samuels, Philip G Griffiths, Amy K Reeve, Laurence A Bindoff, Rita Horvath, Patrick F Chinnery
Mar 07, 2019
Pathogenic OPA1 mutations cause autosomal dominant optic atrophy (DOA), a condition characterized by the preferential loss of retinal ganglion cells and progressive optic nerve degeneration. Approximately 20% of affected...
Density-driven structural transformations in network forming glasses
Philip Salmon, James Drewitt, Dean Whittaker, Anita Zeidler, Kamil Wezka, Craig L. Bull, Matt G. Tucker, Martin C. Wilding, Malcolm Guthrie, Dario Marrocchelli
Jan 01, 0001
The structure of GeO2 glass was investigated at pressures up to 17.5(5) GPa using in situ time-of-flight neutron diffraction with a Paris–Edinburgh press employing sintered diamond anvils. A new methodology and data correction...
Protein-mediated gelation and nano-scale assembly of unfunctionalized hyaluronic acid and chondroitin sulfate.
Anthony Tabet, June Y Park, Jarrod Shilts, Kamil Sokolowski, Vijay K Rana, Marlous Kamp, Nina Warner, Dominique Hoogland, Oren A Scherman
Jul 23, 2019
Background: Hyaluronic acid (HA) is a major component of the extracellular matrix (ECM) in the central nervous system and the only purely supramolecular glycosaminoglycan. Much focus has been given to using this high molecular...
Role of PROPELLER-DWI of the prostate in reducing distortion and artefact from total hip replacement metalwork.
Marcin Czarniecki, Iztok Caglic, James T Grist, Andrew B Gill, Kamil Lorenc, Rhys A Slough, Andrew N Priest, Tristan Barrett
Jun 05, 2018
OBJECTIVE: To compare image quality, artefact, and distortion in standard echo-planar imaging (EPI) with periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) for prostate magnetic resonance...
Diffusion Magnetic Resonance Imaging Magnetic Resonance Imaging Physics Prostate carcinoma artefacts Aged Aged 80 and over Arthroplasty Replacement Hip Artifacts Diffusion Magnetic Resonance Imaging echo-planar imaging hip prosthesis Humans Male Metals Middle Aged Prostatic Neoplasms Retrospective Studies
MFN2 mutations cause compensatory mitochondrial DNA proliferation.
Kamil S Sitarz, Patrick Yu-Wai-Man, Angela Pyle, Joanna D Stewart, Bernd Rautenstrauss, Pavel Seeman, Mary M Reilly, Rita Horvath, Patrick F Chinnery
Mar 07, 2019
Imidazolium-modification enhances photocatalytic CO<sub>2</sub> reduction on ZnSe quantum dots.
Constantin D Sahm, Eric Mates-Torres, Nora Eliasson, Kamil Sokołowski, Andreas Wagner, Kristian E Dalle, Zehuan Huang, Oren A Scherman, Leif Hammarström, Max García-Melchor, Erwin Reisner
Aug 26, 2021
Colloidal photocatalysts can utilize solar light for the conversion of CO2 to carbon-based fuels, but controlling the product selectivity for CO2 reduction remains challenging, in particular in aqueous...
Published by: Chemical science
Detection of dairy products from multiple taxa in Late Neolithic pottery from Poland
Miranda Evans, Jasmine Lundy, Alexandre Lucquin, Richard Hagan, Łukasz Kowalski, Jarosław Wilczyńki, Penny Bickle, Kamil Adamczak, Oliver E Craig, Harry K Robson, Jessica Hendy
Apr 17, 2023
Published by: Royal Society open science
Detection of dairy products from multiple taxa in Late Neolithic pottery from Poland
Miranda Evans, Jasmine Lundy, Alexandre Lucquin, Richard Hagan, Łukasz Kowalski, Jarosław Wilczyńki, Penny Bickle, Kamil Adamczak, Oliver E. Craig, Harry K. Robson, Jessica Hendy
Mar 22, 2023
Earth and environmental science RESEARCH ARTICLES palaeoproteomics Lipids organic residue analysis Funnel Beaker culture Ceramics
Published by: The Royal Society
Detection of dairy products from multiple taxa in Late Neolithic pottery from Poland
Miranda Evans, Jasmine Lundy, Alexandre Lucquin, Richard Hagan, Łukasz Kowalski, Jarosław Wilczyńki, Penny Bickle, Kamil Adamczak, Oliver E Craig, Harry K Robson, Jessica Hendy
Mar 14, 2023
Mechanisms of network collapse in GeO(2) glass
Kamil Wezka, Philip S Salmon, Anita Zeidler, Dean A J Whittaker, James W E Drewitt, Stefan Klotz, Henry E Fischer, Dario Marrocchelli
Dec 19, 2012
The structure of the network forming glass GeO(2) is investigated by making the first application of the method of in situ neutron diffraction with isotope substitution at pressures increasing from ambient to 8 GPa. Of the...
Nanoparticle surfactants for kinetically arrested photoactive assemblies to track light-induced electron transfer.
Kamil Sokołowski, Junyang Huang, Tamás Földes, Jade A McCune, David D Xu, Bart de Nijs, Rohit Chikkaraddy, Sean M Collins, Edina Rosta, Jeremy J Baumberg, Oren A Scherman
Jun 11, 2021
Nature controls the assembly of complex architectures through self-limiting processes; however, few artificial strategies to mimic these processes have been reported to date. Here we demonstrate a system comprising two types of...
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