Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax.
Jakub Gruszczyk,
Usheer Kanjee,
Li-Jin Chan,
Sébastien Menant,
Benoit Malleret,
Nicholas TY Lim,
Christoph Q Schmidt,
Yee-Foong Mok,
Kai-Min Lin,
Richard D Pearson,
Gabriel Rangel,
Brian J Smith,
Melissa J Call,
Michael P Weekes,
Michael DW Griffin,
James M Murphy,
Jonathan Abraham,
Kanlaya Sriprawat,
Maria J Menezes,
Marcelo U Ferreira,
Bruce Russell,
Laurent Renia,
Manoj T Duraisingh,
Wai-Hong Tham
Jan 29, 2018
Plasmodium vivax shows a strict host tropism for reticulocytes. We identified transferrin receptor 1 (TfR1) as the receptor for P. vivax reticulocyte-binding protein 2b (PvRBP2b). We determined the structure of the N-terminal...