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Results: 401
BRCA1-like signature in triple negative breast cancer
Tesa M Severson, Justine Peeters, Ian Majewski, Magali Michaut, Astrid Bosma, Philip C Schouten, Suet-Feung Chin, Bernard Pereira, Mae A Goldgraben, Tycho Bismeijer, Roelof JC Kluin, Jettie JF Muris, Karin Jirström, Ron M Kerkhoven, Lodewyk Wessels, Carlos Caldas, René Bernards, Iris M Simon, Sabine Linn
Jul 05, 2018
Triple negative (TN) breast cancers make up some 15% of all breast cancers. Approximately 10-15% are mutant for the tumor suppressor, BRCA1. BRCA1 is required for homologous recombination-mediated DNA repair and deficiency...
BRCA1 Breast Cancer Genomic Instability targeted therapy Triple negative breast cancer Adult Aged Aged 80 and over Comparative Genomic Hybridization DNA Methylation DNA Mutational Analysis Female Gene Expression Profiling Gene Expression Regulation Neoplastic Genes BRCA1 High-Throughput Nucleotide Sequencing Humans Microarray Analysis Middle Aged Molecular Targeted Therapy Promoter Regions Genetic Transcriptome Triple Negative Breast Neoplasms
A brief overview of the tobacco industry in the last 20 years
Since the launch of Tobacco Control 20 years ago, there have been several changes in the tobacco industry worldwide. The goal of this commentary is to present some of the keys changes of the past two decades. This time is marked...
Understanding the emergence of the tobacco industry's use of the term tobacco harm reduction in order to inform public health policy
Objectives: To explore the history of transnational tobacco companies’ use of the term, approach to and perceived benefits of ‘harm reduction’.
Methods: Analysis of internal tobacco industry documents, contemporary...
Methods: Analysis of internal tobacco industry documents, contemporary...
tobacco industry Harm reduction snus public health policy /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production
Ensuring Core Competencies for Cybersecurity Specialists
Within an organization, it is critical that all employees possess a security awareness and thus play a part in the protection of said organization's information assets. Some employees will have key roles and responsibilities and...
Published by: IGI Global Scientific Publishing
Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk.
Karolien Bettens, Nathalie Brouwers, Sebastiaan Engelborghs, Jean-Charles Lambert, Ekaterina Rogaeva, Rik Vandenberghe, Nathalie Le Bastard, Florence Pasquier, Steven Vermeulen, Jasper Van Dongen, Maria Mattheijssens, Karin Peeters, Richard Mayeux, Peter St George-Hyslop, Philippe Amouyel, Peter P De Deyn, Kristel Sleegers, Christine Van Broeckhoven
Mar 07, 2012
Aged Aged 80 and over Alleles Alzheimer Disease Canada Chromosome Mapping Clusterin Cohort Studies Exons Female Gene Frequency genetic variation Genome-Wide Association Study Genotype Humans Male Middle Aged Mutagenesis Insertional Polymorphism Single Nucleotide Risk Factors Sequence Deletion White People
Transnational tobacco company interests in smokeless tobacco in Europe
Background: European Union (EU) legislation bans the sale of snus, a smokeless tobacco (SLT) which is considerably less harmful than smoking, in all EU countries other than Sweden. To inform the current review of this...
Transnational tobacco company interests in smokeless tobacco in Europe
Background: European Union (EU) legislation bans the sale of snus, a smokeless tobacco (SLT) which is considerably less harmful than smoking, in all EU countries other than Sweden. To inform the current review of this...
How online sales and promotion of snus contravenes current European Union legislation
Context: The European Union (EU) Tobacco Products Directive that bans sales of snus (a form of oral tobacco) in EU countries other than Sweden is currently under review. Major tobacco companies favour the ban being...
How online sales and promotion of snus contravenes current European Union legislation
Context: The European Union (EU) Tobacco Products Directive that bans sales of snus (a form of oral tobacco) in EU countries other than Sweden is currently under review. Major tobacco companies favour the ban being...
Understanding the emergence of the tobacco industry's use of the term tobacco harm reduction in order to inform public health policy
Objectives: To explore the history of transnational tobacco companies’ use of the term, approach to and perceived benefits of ‘harm reduction’.
Methods: Analysis of internal tobacco industry documents, contemporary...
Methods: Analysis of internal tobacco industry documents, contemporary...
tobacco industry Harm reduction snus public health policy /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production
A brief overview of the tobacco industry in the last 20 years
Since the launch of Tobacco Control 20 years ago, there have been several changes in the tobacco industry worldwide. The goal of this commentary is to present some of the keys changes of the past two decades. This time is marked...
The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis.
The IkappaB kinase (IKK) complex is composed of three subunits, IKKalpha, IKKbeta, and IKKgamma (NEMO). While IKKalpha and IKKbeta are highly similar catalytic subunits, both capable of IkappaB phosphorylation in vitro, IKKgamma...
Affective Support for Self-Regulation in Mobile-Assisted Language Learning
Mobile-assisted language learning (MALL) research includes examination and development of second language learners' cognitive and metacognitive self-regulated learning skills, but the affective learning component of...
Published by: IGI Global Scientific Publishing
Musicians’ views on the role of reading music in learning, performance, and understanding
Reading music notation is not an easy skill to acquire and can take years of training to master. In addition, it is not strictly necessary to be able to read music to make music. Nevertheless, music teaching and learning in the...
Citizen Adoption in E-Government Systems
Electronic Government (e-Government) refers to a system of information, communication and interaction between government and its citizens. E-Government adoption has been studied for more than a decade with several meta-analytic...
Published by: IGI Global Scientific Publishing
Non-smooth Hopf-type bifurcations arising from impact–friction contact events in rotating machinery
We analyse the novel dynamics arising in a nonlinear rotor dynamic system by investigating the discontinuity-induced bifurcations corresponding to collisions with the rotor housing (touchdown bearing surface interactions). The...
Surveillance recommendations for DICER1 pathogenic variant carriers
Jette J Bakhuizen, Helen Hanson, Karin van der Tuin, Fiona Lalloo, Marc Tischkowitz, Karin Wadt, Marjolijn CJ Jongmans, SIOPE Host Genome Working Group, CanGene-CanVar Clinical Guideline Working Group, Expert Network Members
Oct 01, 2021
DICER1 syndrome is a rare genetic disorder that predisposes to a wide spectrum of tumors. Developing surveillance protocols for this syndrome is challenging because uncertainty exists about the clinical efficacy of surveillance...
Hearing where the eyes see
To reduce sensory uncertainty, humans combine cues from multiple senses. However, in everyday life, many co‐occurring cues are irrelevant to the task at hand. How do humans know which cues to ignore? And does this ability change...
The Effects of Explicit and Implicit Cognitive Factors on the Learning Patterns in the Iowa Gambling Task
The Iowa Gambling Task (IGT) has become a standard tool in the area of decision making, but recent studies have indicated that cognitive factors might distort the implicit learning expected from the original design of the task....
Published by: Digital Commons @ Texas A&M University-San Antonio
High Trait Anxiety Enhances Optimal Integration of Auditory and Visual Threat Cues
Background
Emotion perception is essential to human interaction and relies on effective integration of emotional cues across sensory modalities. Despite initial evidence for anxiety-related biases in multisensory...
Emotion perception is essential to human interaction and relies on effective integration of emotional cues across sensory modalities. Despite initial evidence for anxiety-related biases in multisensory...
Anxiety emotion maximum likelihood estimation Multisensory processing negative bias race model /dk/atira/pure/subjectarea/asjc/3200/3205 name=Experimental and Cognitive Psychology /dk/atira/pure/subjectarea/asjc/1200/1201 name=Arts and Humanities (miscellaneous) /dk/atira/pure/subjectarea/asjc/3200/3203 name=Clinical Psychology /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
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