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Results: 61
At, with and beyond risk
Biomedical research aimed at the development of therapies for chronic and late-onset conditions increasingly concentrates on the early treatment of symptom-less disease. This broad trend is evidenced in prominent shifts in...
Perspectives on Communicating Biomarker-Based Assessments of Alzheimer's Disease to Cognitively Healthy Individuals.
Richard Milne, Eline Bunnik, Ana Diaz, Edo Richard, Shirlene Badger, Dianne Gove, Jean Georges, Karine Fauria, Jose-Luis Molinuevo, Katie Wells, Craig Ritchie, Carol Brayne
Mar 02, 2018
In clinical trials which target pathophysiological mechanisms associated with Alzheimer's disease, research participants who are recruited based on biomarker test results should be informed about their increased risk of...
Prescreening for European Prevention of Alzheimer Dementia (EPAD) trial-ready cohort
Lisa Vermunt, Graciela Muniz-Terrera, Lea ter Meulen, Colin Veal, Kaj Blennow, Archie Campbell, Isabelle Carrié, Julien Delrieu, Karine Fauria, Gema Huesa Rodríguez, Silvia Ingala, Natalie Jenkins, José Luis Molinuevo, Pierre-Jean Ousset, David Porteous, Niels D Prins, Alina Solomon, Brian D Tom, Henrik Zetterberg, Marissa Zwan, Craig W Ritchie, Philip Scheltens, Gerald Luscan, Anthony J Brookes, Pieter Jelle Visser, IMI-EPAD collaborators
Jan 20, 2020
BACKGROUND: Recruitment is often a bottleneck in secondary prevention trials in Alzheimer disease (AD). Furthermore, screen-failure rates in these trials are typically high due to relatively low prevalence of AD pathology in...
Prescreening for European Prevention of Alzheimer Dementia (EPAD) trial-ready cohort
Lisa Vermunt, Graciela Muniz-Terrera, Lea ter Meulen, Colin Veal, Kaj Blennow, Archie Campbell, Isabelle Carrié, Julien Delrieu, Karine Fauria, Gema Huesa Rodríguez, Silvia Ingala, Natalie Jenkins, José Luis Molinuevo, Pierre-Jean Ousset, David Porteous, Niels D Prins, Alina Solomon, Brian D Tom, Henrik Zetterberg, Marissa Zwan, Craig W Ritchie, Philip Scheltens, Gerald Luscan, Anthony J Brookes, Pieter Jelle Visser
Feb 07, 2020
BACKGROUND:Recruitment is often a bottleneck in secondary prevention trials in Alzheimer disease (AD). Furthermore, screen-failure rates in these trials are typically high due to relatively low prevalence of AD pathology in...
Amyloid Recruitment engagement Registries Secondary prevention trials Prescreening Trial-ready cohort
Published by: Alzheimer's research & therapy
Romantic Relationships in Young People with Long-Term Health Conditions
Objective: Forming and maintaining romantic relationships is an important developmental task in adolescence and young adulthood. This scoping review seeks to explore how young people with long-term physical health conditions...
Prescreening for European Prevention of Alzheimer Dementia (EPAD) trial-ready cohort
Lisa Vermunt, Graciela Muniz-Terrera, Lea ter Meulen, Colin Veal, Kaj Blennow, Archie Campbell, Isabelle Carrié, Julien Delrieu, Karine Fauria, Gema Huesa Rodríguez, Silvia Ingala, Natalie Jenkins, José Luis Molinuevo, Pierre-Jean Ousset, David Porteous, Niels D. Prins, Alina Solomon, Brian D. Tom, Henrik Zetterberg, Marissa Zwan, Craig W. Ritchie, Philip Scheltens, Gerald Luscan, Anthony J. Brookes, Pieter Jelle Visser
Jun 06, 2020
Abstract: Background: Recruitment is often a bottleneck in secondary prevention trials in Alzheimer disease (AD). Furthermore, screen-failure rates in these trials are typically high due to relatively low prevalence of AD...
Prescreening for European Prevention of Alzheimer Dementia (EPAD) trial-ready cohort
Lisa Vermunt, Graciela Muniz-Terrera, Lea ter Meulen, Colin Veal, Kaj Blennow, Archie Campbell, Isabelle Carrié, Julien Delrieu, Karine Fauria, Gema Huesa Rodríguez, Silvia Ingala, Natalie Jenkins, José Luis Molinuevo, Pierre-Jean Ousset, David Porteous, Niels D. Prins, Alina Solomon, Brian D. Tom, Henrik Zetterberg, Marissa Zwan, Craig W. Ritchie, Philip Scheltens, Gerald Luscan, Anthony J. Brookes, Pieter Jelle Visser
Jan 05, 2021
Abstract: Background: Recruitment is often a bottleneck in secondary prevention trials in Alzheimer disease (AD). Furthermore, screen-failure rates in these trials are typically high due to relatively low prevalence of AD...
Romantic Relationships in Young People with Long-Term Health Conditions
Objective: Forming and maintaining romantic relationships is an important developmental task in adolescence and young adulthood. This scoping review seeks to explore how young people with long-term physical health conditions...
Effectiveness of protected areas in conserving tropical forest birds.
Victor Cazalis, Karine Princé, Jean-Baptiste Mihoub, Joseph Kelly, Stuart HM Butchart, Ana SL Rodrigues
Sep 14, 2021
Protected areas (PAs) are the cornerstones of global biodiversity conservation efforts, but to fulfil this role they must be effective at conserving the ecosystems and species that occur within their boundaries. Adequate...
Afatinib and radiotherapy, with or without temozolomide, in patients with newly diagnosed glioblastoma
Frank Saran, Liam Welsh, Allan James, Catherine McBain, Rao Gattamaneni, Sarah Jefferies, Fiona Harris, Karine Pemberton, Jennifer Schaible, Shaun Bender, Agnieszka Cseh, Michael Brada
Dec 24, 2021
Transcriptomic analysis of insecticide resistance in the lymphatic filariasis vector Culex quinquefasciatus.
Walter Fabricio Silva Martins, Craig Stephen Wilding, Alison Taylor Isaacs, Emily Joy Rippon, Karine Megy, Martin James Donnelly
Oct 11, 2019
Culex quinquefasciatus plays an important role in transmission of vector-borne diseases of public health importance, including lymphatic filariasis (LF), as well as many arboviral diseases. Currently, efforts to tackle C....
Involving research participants in a pan-European research initiative
S Gregory, EM Bunnik, AB Callado, I Carrie, C De Boer, J Duffus, K Fauria, S Forster, D Gove, I Knezevic, A Laquidain, D Pennetier, S Saunders, S Sparks, J Rice, CW Ritchie, R Milne
Oct 18, 2021
BACKGROUND: Including participants in patient and public involvement activities is increasingly acknowledged as a key pillar of successful research activity. Such activities can influence recruitment and retention, as well as...
The Transcriptomes of Xiphinema index and Longidorus elongatus Suggest Independent Acquisition of Some Plant Parasitism Genes by Horizontal Gene Transfer in Early-Branching Nematodes.
Etienne GJ Danchin, Laetitia Perfus-Barbeoch, Corinne Rancurel, Peter Thorpe, Martine Da Rocha, Simon Bajew, Roy Neilson, Elena Sokolova Guzeeva, Corinne Da Silva, Julie Guy, Karine Labadie, Daniel Esmenjaud, Johannes Helder, John T Jones, Sebastian Eves-van den Akker
Feb 26, 2019
Nematodes have evolved the ability to parasitize plants on at least four independent occasions, with plant parasites present in Clades 1, 2, 10 and 12 of the phylum. In the case of Clades 10 and 12, horizontal gene transfer of...
The Polycomb protein Ezl1 mediates H3K9 and H3K27 methylation to repress transposable elements in Paramecium.
Andrea Frapporti, Caridad Miró Pina, Olivier Arnaiz, Daniel Holoch, Takayuki Kawaguchi, Adeline Humbert, Evangelia Eleftheriou, Bérangère Lombard, Damarys Loew, Linda Sperling, Karine Guitot, Raphaël Margueron, Sandra Duharcourt
Jun 19, 2020
In animals and plants, the H3K9me3 and H3K27me3 chromatin silencing marks are deposited by different protein machineries. H3K9me3 is catalyzed by the SET-domain SU(VAR)3-9 enzymes, while H3K27me3 is catalyzed by the SET-domain...
Effectiveness of protected areas in conserving tropical forest birds
Victor Cazalis, Karine Princé, Jean-Baptiste Mihoub, Joseph Kelly, Stuart H. M. Butchart, Ana S. L. Rodrigues
Sep 15, 2020
Abstract: Protected areas (PAs) are the cornerstones of global biodiversity conservation efforts, but to fulfil this role they must be effective at conserving the ecosystems and species that occur within their boundaries....
Association between genetic obesity susceptibility and mother-reported eating behaviour in children up to 5 years.
Involving research participants in a pan-European research initiative
S. Gregory, E. M. Bunnik, A. B. Callado, I. Carrie, C. De Boer, J. Duffus, K. Fauria, S. Forster, D. Gove, I. Knezevic, A. Laquidain, D. Pennetier, S. Saunders, S. Sparks, J. Rice, C. W. Ritchie, R. Milne
Oct 15, 2020
Abstract: Background: Including participants in patient and public involvement activities is increasingly acknowledged as a key pillar of successful research activity. Such activities can influence recruitment and retention, as...
Comparative performance of lung cancer risk models to define lung screening eligibility in the United Kingdom.
Hilary A Robbins, Karine Alcala, Anthony J Swerdlow, Minouk J Schoemaker, Nick Wareham, Ruth C Travis, Philip AJ Crosbie, Matthew Callister, David R Baldwin, Rebecca Landy, Mattias Johansson
May 03, 2021
BACKGROUND: The National Health Service England (NHS) classifies individuals as eligible for lung cancer screening using two risk prediction models, PLCOm2012 and Liverpool Lung Project-v2 (LLPv2). However, no study has compared...
Transcriptomic analysis of insecticide resistance in the lymphatic filariasis vector Culex quinquefasciatus
Walter Fabricio Silva Martins, Craig Stephen Wilding, Alison Taylor Isaacs, Emily Joy Rippon, Karine Megy, Martin James Donnelly
Aug 05, 2020
Abstract: Culex quinquefasciatus plays an important role in transmission of vector-borne diseases of public health importance, including lymphatic filariasis (LF), as well as many arboviral diseases. Currently, efforts to tackle...
Multilineage Differentiation for Formation of Innervated Skeletal Muscle Fibers from Healthy and Diseased Human Pluripotent Stem Cells.
Kilian Mazaleyrat, Cherif Badja, Natacha Broucqsault, Raphaël Chevalier, Camille Laberthonnière, Camille Dion, Lyla Baldasseroni, Claire El-Yazidi, Morgane Thomas, Richard Bachelier, Alexandre Altié, Karine Nguyen, Nicolas Lévy, Jérôme D Robin, Frédérique Magdinier
Sep 09, 2020
Induced pluripotent stem cells (iPSCs) obtained by reprogramming primary somatic cells have revolutionized the fields of cell biology and disease modeling. However, the number protocols for generating mature muscle fibers with...
Duchenne muscular dystrophy Facio-Scapulo-Humeral Dystrophy Limb girdle muscular dystrophy Myotonic Dystrophy Z-lines contraction DIFFERENTIATION human induced pluripotent cells Motor Neurons Muscular Dystrophy Myoblasts myotubes satellite cells Cell Differentiation Humans Muscle Fibers Skeletal Muscular Dystrophy Duchenne Pluripotent Stem Cells
Comparative performance of lung cancer risk models to define lung screening eligibility in the United Kingdom
Hilary A. Robbins, Karine Alcala, Anthony J. Swerdlow, Minouk J. Schoemaker, Nick Wareham, Ruth C. Travis, Philip A. J. Crosbie, Matthew Callister, David R. Baldwin, Rebecca Landy, Mattias Johansson
Aug 02, 2021
Abstract: Background: The National Health Service England (NHS) classifies individuals as eligible for lung cancer screening using two risk prediction models, PLCOm2012 and Liverpool Lung Project-v2 (LLPv2). However, no study...
The melanocortin pathway and energy homeostasis
Giles SH Yeo, Daniela Herrera Moro Chao, Anna-Maria Siegert, Zoe M Koerperich, Mark D Ericson, Stephanie E Simonds, Courtney M Larson, Serge Luquet, Iain Clarke, Shubh Sharma, Karine Clément, Michael A Cowley, Carrie Haskell-Luevano, Lex Van Der Ploeg, Roger AH Adan
May 24, 2021
BACKGROUND: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in...
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