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Results: 59
Oxidative stress and life histories
John R Speakman, Jonathan D Blount, Anne M Bronikowski, Rochelle Buffenstein, Caroline Isaksson, Tom BL Kirkwood, Pat Monaghan, Susan E Ozanne, Michaël Beaulieu, Michael Briga, Sarah K Carr, Louise L Christensen, Helena M Cochemé, Dominic L Cram, Ben Dantzer, Jim M Harper, Diana Jurk, Annette King, Jose C Noguera, Karine Salin, Elin Sild, Mirre JP Simons, Shona Smith, Antoine Stier, Michael Tobler, Emma Vitikainen, Malcolm Peaker, Colin Selman
Aug 12, 2020
Life-history theory concerns the trade-offs that mold the patterns of investment by animals between reproduction, growth, and survival. It is widely recognized that physiology plays a role in the mediation of life-history...
Romantic Relationships in Young People with Long-Term Health Conditions
Objective: Forming and maintaining romantic relationships is an important developmental task in adolescence and young adulthood. This scoping review seeks to explore how young people with long-term physical health conditions...
Romantic Relationships in Young People with Long-Term Health Conditions
Objective: Forming and maintaining romantic relationships is an important developmental task in adolescence and young adulthood. This scoping review seeks to explore how young people with long-term physical health conditions...
At, with and beyond risk
Biomedical research aimed at the development of therapies for chronic and late-onset conditions increasingly concentrates on the early treatment of symptom-less disease. This broad trend is evidenced in prominent shifts in...
Solving the conundrum of intra-specific variation in metabolic rate: A multidisciplinary conceptual and methodological toolkit: New technical developments are opening the door to an understanding of why metabolic rate varies among individual animals of a species
Neil B Metcalfe, Jakob Bellman, Pierre Bize, Pierre U Blier, Amélie Crespel, Neal J Dawson, Ruth E Dunn, Lewis G Halsey, Wendy R Hood, Mark Hopkins, Shaun S Killen, Darryl McLennan, Lauren E Nadler, Julie JH Nati, Matthew J Noakes, Tommy Norin, Susan E Ozanne, Malcolm Peaker, Amanda K Pettersen, Anna Przybylska-Piech, Alann Rathery, Charlotte Récapet, Enrique Rodríguez, Karine Salin, Antoine Stier, Elisa Thoral, Klaas R Westerterp, Margriet S Westerterp-Plantenga, Michał S Wojciechowski, Pat Monaghan
Apr 12, 2023
Researchers from diverse disciplines, including organismal and cellular physiology, sports science, human nutrition, evolution and ecology, have sought to understand the causes and consequences of the surprising variation in...
Effectiveness of protected areas in conserving tropical forest birds.
Victor Cazalis, Karine Princé, Jean-Baptiste Mihoub, Joseph Kelly, Stuart HM Butchart, Ana SL Rodrigues
Sep 14, 2021
Protected areas (PAs) are the cornerstones of global biodiversity conservation efforts, but to fulfil this role they must be effective at conserving the ecosystems and species that occur within their boundaries. Adequate...
Afatinib and radiotherapy, with or without temozolomide, in patients with newly diagnosed glioblastoma
Frank Saran, Liam Welsh, Allan James, Catherine McBain, Rao Gattamaneni, Sarah Jefferies, Fiona Harris, Karine Pemberton, Jennifer Schaible, Shaun Bender, Agnieszka Cseh, Michael Brada
Dec 24, 2021
Perspectives on Communicating Biomarker-Based Assessments of Alzheimer's Disease to Cognitively Healthy Individuals.
Richard Milne, Eline Bunnik, Ana Diaz, Edo Richard, Shirlene Badger, Dianne Gove, Jean Georges, Karine Fauria, Jose-Luis Molinuevo, Katie Wells, Craig Ritchie, Carol Brayne
Mar 02, 2018
In clinical trials which target pathophysiological mechanisms associated with Alzheimer's disease, research participants who are recruited based on biomarker test results should be informed about their increased risk of...
Transcriptomic analysis of insecticide resistance in the lymphatic filariasis vector Culex quinquefasciatus.
Walter Fabricio Silva Martins, Craig Stephen Wilding, Alison Taylor Isaacs, Emily Joy Rippon, Karine Megy, Martin James Donnelly
Oct 11, 2019
Culex quinquefasciatus plays an important role in transmission of vector-borne diseases of public health importance, including lymphatic filariasis (LF), as well as many arboviral diseases. Currently, efforts to tackle C....
The Transcriptomes of Xiphinema index and Longidorus elongatus Suggest Independent Acquisition of Some Plant Parasitism Genes by Horizontal Gene Transfer in Early-Branching Nematodes.
Etienne GJ Danchin, Laetitia Perfus-Barbeoch, Corinne Rancurel, Peter Thorpe, Martine Da Rocha, Simon Bajew, Roy Neilson, Elena Sokolova Guzeeva, Corinne Da Silva, Julie Guy, Karine Labadie, Daniel Esmenjaud, Johannes Helder, John T Jones, Sebastian Eves-van den Akker
Feb 26, 2019
Nematodes have evolved the ability to parasitize plants on at least four independent occasions, with plant parasites present in Clades 1, 2, 10 and 12 of the phylum. In the case of Clades 10 and 12, horizontal gene transfer of...
The Polycomb protein Ezl1 mediates H3K9 and H3K27 methylation to repress transposable elements in Paramecium.
Andrea Frapporti, Caridad Miró Pina, Olivier Arnaiz, Daniel Holoch, Takayuki Kawaguchi, Adeline Humbert, Evangelia Eleftheriou, Bérangère Lombard, Damarys Loew, Linda Sperling, Karine Guitot, Raphaël Margueron, Sandra Duharcourt
Jun 19, 2020
In animals and plants, the H3K9me3 and H3K27me3 chromatin silencing marks are deposited by different protein machineries. H3K9me3 is catalyzed by the SET-domain SU(VAR)3-9 enzymes, while H3K27me3 is catalyzed by the SET-domain...
Effectiveness of protected areas in conserving tropical forest birds
Victor Cazalis, Karine Princé, Jean-Baptiste Mihoub, Joseph Kelly, Stuart H. M. Butchart, Ana S. L. Rodrigues
Sep 15, 2020
Abstract: Protected areas (PAs) are the cornerstones of global biodiversity conservation efforts, but to fulfil this role they must be effective at conserving the ecosystems and species that occur within their boundaries....
Association between genetic obesity susceptibility and mother-reported eating behaviour in children up to 5 years.
Comparative performance of lung cancer risk models to define lung screening eligibility in the United Kingdom.
Hilary A Robbins, Karine Alcala, Anthony J Swerdlow, Minouk J Schoemaker, Nick Wareham, Ruth C Travis, Philip AJ Crosbie, Matthew Callister, David R Baldwin, Rebecca Landy, Mattias Johansson
May 03, 2021
BACKGROUND: The National Health Service England (NHS) classifies individuals as eligible for lung cancer screening using two risk prediction models, PLCOm2012 and Liverpool Lung Project-v2 (LLPv2). However, no study has compared...
Transcriptomic analysis of insecticide resistance in the lymphatic filariasis vector Culex quinquefasciatus
Walter Fabricio Silva Martins, Craig Stephen Wilding, Alison Taylor Isaacs, Emily Joy Rippon, Karine Megy, Martin James Donnelly
Aug 05, 2020
Abstract: Culex quinquefasciatus plays an important role in transmission of vector-borne diseases of public health importance, including lymphatic filariasis (LF), as well as many arboviral diseases. Currently, efforts to tackle...
Multilineage Differentiation for Formation of Innervated Skeletal Muscle Fibers from Healthy and Diseased Human Pluripotent Stem Cells.
Kilian Mazaleyrat, Cherif Badja, Natacha Broucqsault, Raphaël Chevalier, Camille Laberthonnière, Camille Dion, Lyla Baldasseroni, Claire El-Yazidi, Morgane Thomas, Richard Bachelier, Alexandre Altié, Karine Nguyen, Nicolas Lévy, Jérôme D Robin, Frédérique Magdinier
Sep 09, 2020
Induced pluripotent stem cells (iPSCs) obtained by reprogramming primary somatic cells have revolutionized the fields of cell biology and disease modeling. However, the number protocols for generating mature muscle fibers with...
Duchenne muscular dystrophy Facio-Scapulo-Humeral Dystrophy Limb girdle muscular dystrophy Myotonic Dystrophy Z-lines contraction DIFFERENTIATION human induced pluripotent cells Motor Neurons Muscular Dystrophy Myoblasts myotubes satellite cells Cell Differentiation Humans Muscle Fibers Skeletal Muscular Dystrophy Duchenne Pluripotent Stem Cells
Identification of amino acid substitutions supporting antigenic change of influenza A(H1N1)pdm09 viruses.
Björn F Koel, Ramona Mögling, Salin Chutinimitkul, Pieter L Fraaij, David F Burke, Stefan van der Vliet, Emmie de Wit, Theo M Bestebroer, Guus F Rimmelzwaan, Albert DME Osterhaus, Derek J Smith, Ron AM Fouchier, Miranda de Graaf
May 28, 2015
Comparative performance of lung cancer risk models to define lung screening eligibility in the United Kingdom
Hilary A. Robbins, Karine Alcala, Anthony J. Swerdlow, Minouk J. Schoemaker, Nick Wareham, Ruth C. Travis, Philip A. J. Crosbie, Matthew Callister, David R. Baldwin, Rebecca Landy, Mattias Johansson
Aug 02, 2021
Abstract: Background: The National Health Service England (NHS) classifies individuals as eligible for lung cancer screening using two risk prediction models, PLCOm2012 and Liverpool Lung Project-v2 (LLPv2). However, no study...
Simultaneous estimation of global background synaptic inhibition and excitation from membrane potential fluctuations in layer III layer III neurons of the rat entorhinal cortex <i>in vitro</i>
It is becoming clear that the detection and integration of synaptic input and its conversion into an output signal in cortical neurones is strongly influenced by background synaptic activity or “noise”. The majority of this...
Simultaneous estimation of global background synaptic inhibition and excitation from membrane potential fluctuations in layer III layer III neurons of the rat entorhinal cortex <i>in vitro</i>
It is becoming clear that the detection and integration of synaptic input and its conversion into an output signal in cortical neurones is strongly influenced by background synaptic activity or “noise”. The majority of this...
The melanocortin pathway and energy homeostasis
Giles SH Yeo, Daniela Herrera Moro Chao, Anna-Maria Siegert, Zoe M Koerperich, Mark D Ericson, Stephanie E Simonds, Courtney M Larson, Serge Luquet, Iain Clarke, Shubh Sharma, Karine Clément, Michael A Cowley, Carrie Haskell-Luevano, Lex Van Der Ploeg, Roger AH Adan
May 24, 2021
BACKGROUND: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in...
Comparative performance of lung cancer risk models to define lung screening eligibility in the United Kingdom
Hilary A. Robbins, Karine Alcala, Anthony J. Swerdlow, Minouk J. Schoemaker, Nick Wareham, Ruth C. Travis, Philip A. J. Crosbie, Matthew Callister, David R. Baldwin, Rebecca Landy, Mattias Johansson
Jun 08, 2021
Abstract: Background: The National Health Service England (NHS) classifies individuals as eligible for lung cancer screening using two risk prediction models, PLCOm2012 and Liverpool Lung Project-v2 (LLPv2). However, no study...
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