p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis.
Robert AH van de Ven,
Jolien S de Groot,
Danielle Park,
Robert van Domselaar,
Danielle de Jong,
Karoly Szuhai,
Elsken van der Wall,
Oscar M Rueda,
H Raza Ali,
Carlos Caldas,
Paul J van Diest,
Martin W Hetzer,
Erik Sahai,
Patrick WB Derksen
Jan 12, 2018
Spatiotemporal activation of RhoA and actomyosin contraction underpins cellular adhesion and division. Loss of cell-cell adhesion and chromosomal instability are cardinal events that drive tumour progression. Here, we show that...