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Interview with Mary Kate Brearley Glasser
Mary Kate Brearley Glasser
Jan 01, 0001
Interview with Mary Kate Brearley Glasser, 2008 South Carolina Mother of the Year.
Published by: Winthrop University
Play ''Kiss Me Kate'' is Challenging Production for Department
Winthrop University
Jan 01, 0001
"Kiss Me Kate" is based on a book by Sam and Bella Spewack, with Broadway composer Cole Porter providing music and lyrics. The play was first presented at Winthrop in 1963 when it was directed by Chris Reynolds.
Published by: Winthrop University
Cambridge Women and the Law
Abstract In this article Kate Faulkner writes about the significant moments in the journey of women as they entered into the legal profession taking a perspective from the University of Cambridge....
Kate Faulkner
Apr 05, 2019
Usage and User Experience in an Academic Law Library
Abstract This article, written by Josephine Bailey and Kate Faulkner, discusses the collection of library usage data at the Squire Law Library, an academic law library embedded in the Faculty of...
Review of: Projects in Linguistics: A Practical Research Guide to Researching Language, by Alison Wray, Kate Trott and Aileen Bloomer. London
Robert Fink
Jul 18, 2013
Review of: Projects in Linguistics: A Practical Research Guide to Researching Language, by Alison Wray, Kate Trott and Aileen Bloomer. London: Arnold, 1998. Pp xv, 303. Can $38.50.
Published by: Atlantic Provinces Linguistic Association
Review of: Projects in Linguistics: A Practical Research Guide to Researching Language, by Alison Wray, Kate Trott and Aileen Bloomer. London
Robert Fink
Jul 18, 2013
Review of: Projects in Linguistics: A Practical Research Guide to Researching Language, by Alison Wray, Kate Trott and Aileen Bloomer. London: Arnold, 1998. Pp xv, 303. Can $38.50.
Published by: Atlantic Provinces Linguistic Association
Thrombomodulin in patients with mild to moderate bleeding tendency.
Dino Mehic, Alexander Tolios, Stefanie Hofer, Cihan Ay, Helmuth Haslacher, Kate Downes, Matthias Haimel, Ingrid Pabinger, Johanna Gebhart
Oct 10, 2021
INTRODUCTION: A massive increase of soluble thrombomodulin (sTM) due to variants in the thrombomodulin gene (THBD) has recently been identified as a novel bleeding disorder. AIM: To investigate sTM levels and underlying genetic...
How common are single gene mutations as a cause for lacunar stroke? A targeted gene panel study.
Rhea YY Tan, Matthew Traylor, Karyn Megy, Daniel Duarte, Sri VV Deevi, Olga Shamardina, Rutendo P Mapeta, NIHR BioResource: Rare Diseases Consortium, Willem H Ouwehand, Stefan Gräf, Kate Downes, Hugh S Markus
May 30, 2019
TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-κB pathway.
Jun Wang, Ricardo Ferreira, Wanhua Lu, Samatha Farrow, Kate Downes, Lutz Jermutus, Ralph Minter, Rafia S Al-Lamki, Jordan S Pober, John R Bradley
Sep 08, 2018
Human T regulatory cells (T regs) express high levels of TNF receptor 2 (TNFR2). Ligation of TNFR2 with TNF, which can recognise both TNFR1 and TNFR2, or with a TNFR2-selective binding molecule, DARPin 18 (D18) activates...
Cell Nucleus Cell Proliferation Cells Cultured Gene Expression Regulation Healthy Volunteers Humans Interleukin-2 NF-KappaB Inhibitor alpha NF-kappa B p52 Subunit Primary Cell Culture Proteolysis Receptors Tumor Necrosis Factor Type II Recombinant Fusion Proteins Signal Transduction T-Lymphocytes Regulatory Transcription Factor RelB
Effectiveness and costs of a stepwise versus an all-in-one approach to diagnose mild bleeding disorders.
Floor CJI Heubel-Moenen, Loes EM Ansems, Paul WM Verhezen, Rick JH Wetzels, Rene GM van Oerle, Ron JMHE Straat, Karyn Megy, Kate Downes, Yvonne MC Henskens, Erik AM Beckers, Manuela A Joore
Nov 29, 2022
The diagnostic work-up of patients referred to the haematologist for bleeding evaluation is performed in a stepwise way: bleeding history and results of screening laboratory tests guide further diagnostic evaluation. This can be...
The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes.
Jason D Cooper, Deborah J Smyth, Rebecca Bailey, Felicity Payne, Kate Downes, Lisa M Godfrey, Jennifer Masters, Lauren R Zeitels, Adrian Vella, Neil M Walker, John A Todd
Jun 16, 2011
Antigens CD Apoptosis Regulatory Proteins Case-Control Studies Diabetes mellitus Type 1 Genetic Markers Genetic Predisposition to Disease Genotype Humans Intercellular Adhesion Molecule-1 Interleukin-6 Logistic Models Polymorphism Single Nucleotide Programmed Cell Death 1 Receptor T Cell Transcription Factor 1 TATA-Binding Protein Associated Factors Transcription Factor TFIID
Platelet surface receptor glycoprotein VI-dimer is overexpressed in stroke
Isuru Induruwa, Harriet McKinney, Carly Kempster, Patrick Thomas, Joana Batista, Jean-Daniel Malcor, Arkadiusz Bonna, Joanne McGee, Elaine Bumanlag-Amis, Karola Rehnstrom, Sophie Ashford, Kenji Soejima, Willem Ouwehand, Richard Farndale, Kate Downes, Elizabeth Warburton, Masaaki Moroi, Stephanie Jung
Feb 18, 2022
Multiparameter platelet function analysis of bleeding patients with a prolonged platelet function analyser closure time.
Floor CJI Heubel-Moenen, Sanne LN Brouns, Linda Herfs, Lara S Boerenkamp, Natalie J Jooss, Rick JH Wetzels, Paul WM Verhezen, Patric Machiels, Karyn Megy, Kate Downes, Johan WM Heemskerk, Erik AM Beckers, Yvonne MC Henskens
Jan 10, 2022
Patients referred for evaluation of bleeding symptoms occasionally have a prolonged platelet function analyser (PFA) closure time, without evidence for von Willebrand disease or impaired platelet aggregation. The aim of this...
Paired rRNA-depleted and polyA-selected RNA sequencing data and supporting multi-omics data from human T cells.
Li Chen, Ruirui Yang, Tony Kwan, Chao Tang, Stephen Watt, Yiming Zhang, Guillaume Bourque, Bing Ge, Kate Downes, Mattia Frontini, Willem H Ouwehand, Jing-Wen Lin, Nicole Soranzo, Tomi Pastinen, Lu Chen
Nov 09, 2020
Personalised Risk Prediction in Hereditary Breast and Ovarian Cancer
Stephanie Archer, Nichola Fennell, Ellen Colvin, Rozelle Laquindanum, Meredith Mills, Romy Dennis, Francisca Stutzin Donoso, Rochelle Gold, Alice Fan, Kate Downes, James Ford, Antonis C Antoniou, Allison W Kurian, D Gareth Evans, Marc Tischkowitz
Jul 10, 2022
Women who test positive for an inherited pathogenic/likely pathogenic gene variant in BRCA1, BRCA2, PALB2, CHEK2 and ATM are at an increased risk of developing certain types of cancer-specifically breast (all) and epithelial...
Platelet surface receptor glycoprotein VI-dimer is overexpressed in stroke
Isuru Induruwa, Harriet McKinney, Carly Kempster, Patrick Thomas, Joana Batista, Jean-Daniel Malcor, Arkadiusz Bonna, Joanne McGee, Elaine Bumanlag-Amis, Karola Rehnstrom, Sophie Ashford, Kenji Soejima, Willem Ouwehand, Richard Farndale, Kate Downes, Liz Warburton, Masaaki Moroi, Stephanie Jung
Jan 28, 2022
Transcriptional characterization of human megakaryocyte polyploidization and lineage commitment
Fizzah A. Choudry, Frederik O. Bagger, Iain C. Macaulay, Samantha Farrow, Frances Burden, Carly Kempster, Harriet McKinney, Lars R. Olsen, Ni Huang, Kate Downes, Thierry Voet, Rakesh Uppal, John F. Martin, Anthony Mathur, Willem H. Ouwehand, Elisa Laurenti, Sarah A. Teichmann, Mattia Frontini
Apr 20, 2021
Original Article Thrombosis Megakaryocytes Hematopoietic Stem Cells platelets single cell RNA‐seq Thrombosis
Published by: Journal of Thrombosis and Haemostasis
Transcriptional characterization of human megakaryocyte polyploidization and lineage commitment.
Fizzah A Choudry, Frederik O Bagger, Iain C Macaulay, Samantha Farrow, Frances Burden, Carly Kempster, Harriet McKinney, Lars R Olsen, Ni Huang, Kate Downes, Thierry Voet, Rakesh Uppal, John F Martin, Anthony Mathur, Willem H Ouwehand, Elisa Laurenti, Sarah A Teichmann, Mattia Frontini
Mar 15, 2021
BACKGROUND: Megakaryocytes (MKs) originate from cells immuno-phenotypically indistinguishable from hematopoietic stem cells (HSCs), bypassing intermediate progenitors. They mature within the adult bone marrow and release...
Curated disease-causing genes for bleeding, thrombotic, and platelet disorders
Karyn Megy, Kate Downes, Ilenia Simeoni, Loredana Bury, Joannella Morales, Rutendo Mapeta, Daniel B Bellissimo, Paul F Bray, Anne C Goodeve, Paolo Gresele, Michele Lambert, Pieter Reitsma, Willem H Ouwehand, Kathleen Freson, Subcommittee on Genomics in Thrombosis and Hemostasis
Jun 27, 2019
Distinct Trends of DNA Methylation Patterning in the Innate and Adaptive Immune Systems.
Ronald P Schuyler, Angelika Merkel, Emanuele Raineri, Lucia Altucci, Edo Vellenga, Joost HA Martens, Farzin Pourfarzad, Taco W Kuijpers, Frances Burden, Samantha Farrow, Kate Downes, Willem H Ouwehand, Laura Clarke, Avik Datta, Ernesto Lowy, Paul Flicek, Mattia Frontini, Hendrik G Stunnenberg, José I Martín-Subero, Ivo Gut, Simon Heath
Oct 10, 2018
DNA methylation and the localization and post-translational modification of nucleosomes are interdependent factors that contribute to the generation of distinct phenotypes from genetically identical cells. With 112 whole-genome...
Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients.
Kate Downes, M Loredana Marcovecchio, Pamela Clarke, Jason D Cooper, Ricardo C Ferreira, Joanna MM Howson, Jennifer Jolley, Sarah Nutland, Helen E Stevens, Neil M Walker, Chris Wallace, David B Dunger, John A Todd
Feb 21, 2020
AIMS/HYPOTHESIS: Type 1 diabetes is a common autoimmune disease that has genetic and environmental determinants. Variations within the IL2 and IL2RA (also known as CD25) gene regions are associated with disease risk, and...
High-throughput elucidation of thrombus formation reveals sources of platelet function variability.
Johanna P van Geffen, Sanne LN Brouns, Joana Batista, Harriet McKinney, Carly Kempster, Magdolna Nagy, Suthesh Sivapalaratnam, Constance CFMJ Baaten, Nikki Bourry, Mattia Frontini, Kerstin Jurk, Manuela Krause, Daniele Pillitteri, Frauke Swieringa, Remco Verdoold, Rachel Cavill, Marijke JE Kuijpers, Willem H Ouwehand, Kate Downes, Johan WM Heemskerk
Oct 31, 2019
In combination with microspotting, whole-blood microfluidics can provide high-throughput information on multiple platelet functions in thrombus formation. Based on assessment of the inter- and intra-subject variability in...
Phenotype description and response to thrombopoietin receptor agonist in DIAPH1-related disorder.
Sarah K Westbury, Kate Downes, Claire Burney, Maria L Lozano, Samya G Obaji, Cheng Hock Toh, Teresa Sevivas, Neil V Morgan, Wendy N Erber, Carly Kempster, Samantha F Moore, Chantal Thys, Sofia Papadia, Willem H Ouwehand, NIHR BioResource–Rare Diseases, Michael A Laffan, Keith Gomez, Kathleen Freson, Jose Rivera, Andrew D Mumford
Nov 22, 2018
DIAPH1-related disorder has a bilineage hematological phenotype of macrothrombocytopenia and neutropenia associated with hearing loss. Eltrombopag increased proplatelet formation from cultured DIAPH1-related disorder...
An update on long-acting therapies in chronic sight-threatening eye diseases of the posterior segment
Faruque Ghanchi, Rupert Bourne, Susan M Downes, Richard Gale, Christina Rennie, Ian Tapply, Sobha Sivaprasad
Jun 07, 2022
Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage.
Amir-Babak Sioofy-Khojine, Sarah J Richardson, Jonathan M Locke, Sami Oikarinen, Noora Nurminen, Antti-Pekka Laine, Kate Downes, Johanna Lempainen, John A Todd, Riitta Veijola, Jorma Ilonen, Mikael Knip, Noel G Morgan, Heikki Hyöty, Mark Peakman, Martin Eichmann
Sep 15, 2022
Autoimmunity Enterovirus genetic risk IFIH-1 Interferon induced with helicase C domain 1 MDA5 Melanoma differentiation-associated protein 5 Pancreatic islets type 1 diabetes rs1990760 Adult Alleles Autoantibodies Child DEAD-box RNA Helicases Diabetes mellitus Type 1 Enterovirus Enterovirus Infections Genetic Predisposition to Disease Humans Insulins Interferon-Induced Helicase IFIH1 Leukocytes Mononuclear RNA
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