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A release-and-capture mechanism generates an essential non-centrosomal microtubule array during tube budding
Abstract: Non-centrosomal microtubule arrays serve crucial functions in cells, yet the mechanisms of their generation are poorly understood. During budding of the epithelial tubes of the salivary glands in the Drosophila embryo...
Correct regionalization of a tissue primordium is essential for coordinated morphogenesis.
During organ development, tubular organs often form from flat epithelial primordia. In the placodes of the forming tubes of the salivary glands in the Drosophila embryo, we previously identified spatially defined cell behaviors...
A release-and-capture mechanism generates an essential non-centrosomal microtubule array during tube budding.
Non-centrosomal microtubule arrays serve crucial functions in cells, yet the mechanisms of their generation are poorly understood. During budding of the epithelial tubes of the salivary glands in the Drosophila embryo, we...
Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.
Irina Pleines, Joanne Woods, Stephane Chappaz, Verity Kew, Nicola Foad, José Ballester-Beltrán, Katja Aurbach, Chiara Lincetto, Rachael M Lane, Galina Schevzov, Warren S Alexander, Douglas J Hilton, William J Astle, Kate Downes, Paquita Nurden, Sarah K Westbury, Andrew D Mumford, Samya G Obaji, Peter W Collins, Fabien Delerue, Lars M Ittner, Nicole S Bryce, Mira Holliday, Christine A Lucas, Edna C Hardeman, Willem H Ouwehand, Peter W Gunning, Ernest Turro, Marloes R Tijssen, Benjamin T Kile
Feb 06, 2017
Radially patterned cell behaviours during tube budding from an epithelium.
The budding of tubular organs from flat epithelial sheets is a vital morphogenetic process. Cell behaviours that drive such processes are only starting to be unraveled. Using live-imaging and novel morphometric methods, we show...
D. melanogaster Cell Biology Cell Shape developmental biology Epithelia Morphogenesis Organogenesis quantitative analysis radial polarity Animals Cell Polarity Cell Shape Drosophila melanogaster Embryo Nonmammalian Epithelial Cells Epithelium Fluorescence Imaging Three-Dimensional Morphogenesis Mutation Myosin Type II Salivary Glands Time-Lapse Imaging
Correct regionalization of a tissue primordium is essential for coordinated morphogenesis.
During organ development, tubular organs often form from flat epithelial primordia. In the placodes of the forming tubes of the salivary glands in the Drosophila embryo, we previously identified spatially defined cell behaviors...
Priming and de-priming of neutrophil responses in vitro and in vivo.
Psychological Network Analysis of General Self-Efficacy in High vs. Low Resilient Functioning Healthy Adults.
Katja Schueler, Jessica Fritz, Lena Dorfschmidt, Anne-Laura van Harmelen, Eike Stroemer, Michèle Wessa
Dec 15, 2021
Resilience to stress has gained increasing interest by researchers from the field of mental health and illness and some recent studies have investigated resilience from a network perspective. General self-efficacy constitutes an...
Direct Verbal Suggestibility as a Predictor of Placebo Hypoalgesia Responsiveness
OBJECTIVE: Reliably identifying good placebo responders has pronounced implications for basic research on, and clinical applications of, the placebo response. Multiple studies point to direct verbal suggestibility as a...
Automatic Segmentation of Drosophila Neural Compartments Using GAL4 Expression Data Reveals Novel Visual Pathways.
Karin Panser, Laszlo Tirian, Florian Schulze, Santiago Villalba, Gregory SXE Jefferis, Katja Bühler, Andrew D Straw
Mar 28, 2019
Identifying distinct anatomical structures within the brain and developing genetic tools to target them are fundamental steps for understanding brain function. We hypothesize that enhancer expression patterns can be used to...
Software compensation in particle flow reconstruction.
Huong Lan Tran, Katja Krüger, Felix Sefkow, Steven Green, John Marshall, Mark Thomson, Frank Simon
Jan 31, 2018
The particle flow approach to calorimetry benefits from highly granular calorimeters and sophisticated software algorithms in order to reconstruct and identify individual particles in complex event topologies. The high spatial...
Direct Verbal Suggestibility as a Predictor of Placebo Hypoalgesia Responsiveness
OBJECTIVE: Reliably identifying good placebo responders has pronounced implications for basic research on, and clinical applications of, the placebo response. Multiple studies point to direct verbal suggestibility as a...
Genome-Wide Transcription Factor Binding in Leaves from C3 and C4 Grasses.
Steven J Burgess, Ivan Reyna-Llorens, Sean R Stevenson, Pallavi Singh, Katja Jaeger, Julian M Hibberd
Jul 31, 2019
Brachypodium Deoxyribonuclease I Euchromatin evolution Molecular Gene Expression Regulation Plant Genome Plant Nucleotide Motifs Photosynthesis Photosynthetic Reaction Center Complex Proteins Phylogeny Plant Leaves Plant Proteins Poaceae Promoter Regions Genetic Sequence Analysis DNA Setaria Plant Sorghum Transcription Factors Zea mays
Breast lesion detection and characterization with contrast-enhanced magnetic resonance imaging
Paola Clauser, Thomas H Helbich, Panagiotis Kapetas, Katja Pinker, Maria Bernathova, Ramona Woitek, Andreas Kaneider, Pascal AT Baltzer
Sep 09, 2019
BACKGROUND: Contrast-enhanced magnetic resonance imaging (CE-MRI) of the breast is highly sensitive for breast cancer detection. Multichannel coils and 3T scanners can increase signal, spatial, and temporal resolution. In...
Virtual Touch IQ elastography reduces unnecessary breast biopsies by applying quantitative "rule-in" and "rule-out" threshold values.
Panagiotis Kapetas, Paola Clauser, Ramona Woitek, Katja Pinker, Maria Bernathova, Thomas H Helbich, Pascal A Baltzer
Dec 20, 2018
Our purpose was to evaluate Virtual Touch IQ (VTIQ) elastography and identify quantitative "rule-in" and "rule-out" thresholds for the probability of malignancy, which can help avoid unnecessary breast biopsies. 189 patients...
Academic Medical Centers Austria Biopsy Breast Breast Neoplasms Cross-Sectional Studies Data Accuracy Diagnosis Differential Elasticity Imaging Techniques Feasibility Studies Female Follow-Up Studies Humans ROC Curve Retrospective Studies Sensitivity and Specificity statistics Nonparametric Ultrasonography Mammary
A Simple Ultrasound Based Classification Algorithm Allows Differentiation of Benign from Malignant Breast Lesions by Using Only Quantitative Parameters.
Panagiotis Kapetas, Ramona Woitek, Paola Clauser, Maria Bernathova, Katja Pinker, Thomas H Helbich, Pascal A Baltzer
Dec 20, 2018
PURPOSE: We hypothesized that different quantitative ultrasound (US) parameters may be used as complementary diagnostic criteria and aimed to develop a simple classification algorithm to distinguish benign from malignant breast...
Hippocampus mediates nocebo impairment of opioid analgesia through changes in functional connectivity.
Ulrike Bingel, Katja Wiech, Christoph Ritter, Vishvarani Wanigasekera, Roisin Ní Mhuircheartaigh, Michael C Lee, Markus Ploner, Irene Tracey
Jun 17, 2022
The neural mechanisms underlying placebo analgesia have attracted considerable attention over the recent years. In contrast, little is known about the neural underpinnings of a nocebo-induced increase in pain. We previously...
Endothelial Differentiation G Protein-Coupled Receptor 5 Plays an Important Role in Induction and Maintenance of Pluripotency.
Irina Neganova, Lewis Cotts, Peter Banks, Katja Gassner, Anvar Shukurov, Lyle Armstrong, Graham Ladds, Majlinda Lako
Dec 20, 2018
Direct reprogramming of human somatic cells toward induced pluripotent stem cells holds great promise for regenerative medicine and basic biology. We used a high-throughput small interfering RNA screening assay in the initiation...
Design, development, and validation of a strand-specific RT-qPCR assay for GI and GII human Noroviruses.
Katja Marie Kjara König, Aminu Jahun, Komal Nayak, Lydia N Drumright, Matthias Zibauer, Ian Goodfellow, Myra Hosmillo
Nov 03, 2021
Human noroviruses (HuNoV) are the major cause of viral gastroenteritis worldwide. Similar to other positive-sense single-stranded RNA viruses, norovirus RNA replication requires the formation of a negative strand RNA...
Inter- and intra-observer agreement of BI-RADS-based subjective visual estimation of amount of fibroglandular breast tissue with magnetic resonance imaging
GJ Wengert, TH Helbich, R Woitek, P Kapetas, P Clauser, PA Baltzer, W-D Vogl, M Weber, A Meyer-Baese, Katja Pinker
Dec 20, 2018
PURPOSE: To evaluate the inter-/intra-observer agreement of BI-RADS-based subjective visual estimation of the amount of fibroglandular tissue (FGT) with magnetic resonance imaging (MRI), and to investigate whether FGT assessment...
Design, development, and validation of a strand-specific RT-qPCR assay for GI and GII human Noroviruses.
Katja Marie Kjara König, Aminu S Jahun, Komal Nayak, Lydia N Drumright, Matthias Zibauer, Ian Goodfellow, Myra Hosmillo
Jan 06, 2022
Human noroviruses (HuNoV) are the major cause of viral gastroenteritis worldwide. Similar to other positive-sense single-stranded RNA viruses, norovirus RNA replication requires the formation of a negative strand RNA...
Modulating dream experience
Valdas Noreika, Jennifer M Windt, Markus Kern, Katja Valli, Tiina Salonen, Riitta Parkkola, Antti Revonsuo, Ahmed A Karim, Tonio Ball, Bigna Lenggenhager
Jun 08, 2020
Recently, cortical correlates of specific dream contents have been reported, such as the activation of the sensorimotor cortex during dreamed hand clenching. Yet, despite a close resemblance of such activation patterns to those...
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