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Results: 100
Calling on a million minds for community annotation in WikiProteins.
Barend Mons, Michael Ashburner, Christine Chichester, Erik van Mulligen, Marc Weeber, Johan den Dunnen, Gert-Jan van Ommen, Mark Musen, Matthew Cockerill, Henning Hermjakob, Albert Mons, Abel Packer, Roberto Pacheco, Suzanna Lewis, Alfred Berkeley, William Melton, Nickolas Barris, Jimmy Wales, Gerard Meijssen, Erik Moeller, Peter Jan Roes, Katy Borner, Amos Bairoch
Jun 17, 2011
When Eurosceptics become Europhiles
Katy Brown
Dec 31, 2020
Turkey’s involvement in the European Union has long provoked controversy among Europe’s elites. Recently, in the context of the so-called ‘migrant crisis’, coupled with the mainstreaming of Islamophobia and rising...
Disease and disaster
Epidemics of water-borne infections often follow natural disasters and extreme weather events that disrupt water management processes. The impact of such epidemics may be reduced by deployment of transmission control facilities...
When Eurosceptics become Europhiles
Katy Brown
Dec 31, 2020
Turkey’s involvement in the European Union has long provoked controversy among Europe’s elites. Recently, in the context of the so-called ‘migrant crisis’, coupled with the mainstreaming of Islamophobia and rising...
Teaching Medical Students About Attention Deficit Hyperactivity Disorder (ADHD)
In this paper, we describe how an e-learning resource on Attention Deficit Hyperactivity Disorder (ADHD) for medical students was designed and developed. The aim of the resource was to provide students with essential knowledge...
Disease and disaster
Epidemics of water-borne infections often follow natural disasters and extreme weather events that disrupt water management processes. The impact of such epidemics may be reduced by deployment of transmission control facilities...
Platforms and Institutions in the Post-Pandemic University
In this paper we argue that digital platforms play an important role within higher education, not least of all when Covid-19 has made remote working the norm. An increasingly rich field of theoretical and empirical work has...
Self-reported motivations for offending by autistic sexual offenders
Autism spectrum disorder is a neurodevelopmental disorder estimated to have elevated prevalence in forensic populations (approximately 4.5%). It has been suggested that offenders with autism spectrum disorder engage more...
Jennifer Hirst, James R Edgar, Georg HH Borner, Sam Li, Daniela A Sahlender, Robin Antrobus, Margaret S Robinson
Sep 08, 2015
Fractionation profiling
Georg HH Borner, Marco Y Hein, Jennifer Hirst, James R Edgar, Matthias Mann, Margaret S Robinson
Feb 13, 2019
We developed "fractionation profiling," a method for rapid proteomic analysis of membrane vesicles and protein particles. The approach combines quantitative proteomics with subcellular fractionation to generate signature protein...
Epigallocatechin Gallate Modulates Microglia Phenotype to Suppress Pro-Inflammatory Signalling Cues and Inhibit Phagocytosis
Microglia are crucial players in the pathogenesis of late-onset Alzheimer’s disease (AD), with evidence for both deleterious and beneficial effects. Identifying interventions to modulate microglial responsiveness, promote...
EdTech for Ugandan girls
MOTIVATION: This article discusses the use of educational technology (EdTech) in girls' education at PEAS (Promoting Education in African Schools) schools in rural Uganda during the Covid-19-related school closures. PURPOSE...
Self-reported motivations for offending by autistic sexual offenders
Autism spectrum disorder is a neurodevelopmental disorder estimated to have elevated prevalence in forensic populations (approximately 4.5%). It has been suggested that offenders with autism spectrum disorder engage more...
AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A.
Alexandra K Davies, Daniel N Itzhak, James R Edgar, Tara L Archuleta, Jennifer Hirst, Lauren P Jackson, Margaret S Robinson, Georg HH Borner
Dec 13, 2018
Adaptor protein 4 (AP-4) is an ancient membrane trafficking complex, whose function has largely remained elusive. In humans, AP-4 deficiency causes a severe neurological disorder of unknown aetiology. We apply unbiased proteomic...
Clathrin heavy chain 22 contributes to the control of neuropeptide degradation and secretion during neuronal development.
Michael S Nahorski, Georg HH Borner, Samiha S Shaikh, Alexandra K Davies, Lihadh Al-Gazali, Robin Antrobus, C Geoffrey Woods
Mar 14, 2018
The repertoire of cell types in the human nervous system arises through a highly orchestrated process, the complexity of which is still being discovered. Here, we present evidence that CHC22 has a non-redundant role in an early...
Role of clathrin in dense core vesicle biogenesis
BS Sahu, PT Manna, JR Edgar, R Antrobus, SK Mahata, A Bartolomucci, GHH Borner, MS Robinson
Oct 05, 2017
Epigallocatechin Gallate Modulates Microglia Phenotype to Suppress Pro-Inflammatory Signalling Cues and Inhibit Phagocytosis
Microglia are crucial players in the pathogenesis of late-onset Alzheimer’s disease (AD), with evidence for both deleterious and beneficial effects. Identifying interventions to modulate microglial responsiveness, promote...
Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles.
Georg HH Borner, Robin Antrobus, Jennifer Hirst, Gary S Bhumbra, Patrycja Kozik, Lauren P Jackson, Daniela A Sahlender, Margaret S Robinson
Jan 24, 2018
Despite recent advances in mass spectrometry, proteomic characterization of transport vesicles remains challenging. Here, we describe a multivariate proteomics approach to analyzing clathrin-coated vesicles (CCVs) from HeLa...
Communicating the move to individualized donor selection policy
Eamonn Ferguson, Sarah Bowen, Claire Lawrence, Chris Starmer, Abigail Barr, Katy Davison, Claire Reynolds, Susan R Brailsford
Nov 09, 2022
Genome-wide assessment of DNA methylation alterations induced by superovulation, sexual immaturity and in vitro follicle growth in mouse blastocysts.
Laura Saucedo-Cuevas, Elena Ivanova, Anamaria-Cristina Herta, Felix Krueger, Katy Billooye, Johan Smitz, Gavin Kelsey, Ellen Anckaert
Feb 17, 2023
BACKGROUND: In their attempt to fulfill the wish of having children, women who suffer from fertility issues often undergo assisted reproductive technologies such as ovarian stimulation, which has been associated with adverse...
Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15.
Jennifer Hirst, Georg HH Borner, James Edgar, Marco Y Hein, Matthias Mann, Frank Buchholz, Robin Antrobus, Margaret S Robinson
Feb 13, 2019
The AP-5 complex is a recently identified but evolutionarily ancient member of the family of heterotetrameric adaptor proteins (AP complexes). It is associated with two proteins that are mutated in patients with hereditary...
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