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Results: 99
The MITRE trial protocol
Nicola A Thompson, Grant Stewart, Sarah Welsh, Gary Doherty, Matthew J Robinson, B Anne Neville, Kevin Vervier, Simon R Harris, David J Adams, Katy Dalchau, David Bruce, Nikolaos Demiris, Trevor D Lawley, Pippa G Corrie
Jan 28, 2022
BACKGROUND: The gut microbiome is implicated as a marker of response to immune checkpoint inhibitors (ICI) based on preclinical mouse models and preliminary observations in limited patient series. Furthermore, early studies...
The MITRE trial protocol
Nicola A Thompson, Grant D Stewart, Sarah J Welsh, Gary J Doherty, Matthew J Robinson, B Anne Neville, Kevin Vervier, Simon R Harris, David J Adams, Katy Dalchau, David Bruce, Nikolaos Demiris, Trevor D Lawley, Pippa G Corrie
Feb 25, 2022
BACKGROUND: The gut microbiome is implicated as a marker of response to immune checkpoint inhibitors (ICI) based on preclinical mouse models and preliminary observations in limited patient series. Furthermore, early studies...
biomarker EFFICACY Immune checkpoint inhibitor Immunotherapy Melanoma Microbiome Non-Small Cell Lung Cancer renal cancer toxicity Antibodies Viral Antigens Viral Carcinoma Non-Small-Cell Lung Disease Progression Feces Gastrointestinal Microbiome Humans Immune Checkpoint Inhibitors Kidney Neoplasms Lung Neoplasms Melanoma Microbial Consortia Neoplasms Progression-Free Survival Prospective Studies SARS-CoV-2 Skin Neoplasms
Stochastic pulsing of gene expression enables the generation of spatial patterns in Bacillus subtilis biofilms
Abstract: Stochastic pulsing of gene expression can generate phenotypic diversity in a genetically identical population of cells, but it is unclear whether it has a role in the development of multicellular systems. Here, we show...
When Eurosceptics become Europhiles
Katy Brown
Dec 31, 2020
Turkey’s involvement in the European Union has long provoked controversy among Europe’s elites. Recently, in the context of the so-called ‘migrant crisis’, coupled with the mainstreaming of Islamophobia and rising...
Disease and disaster
Epidemics of water-borne infections often follow natural disasters and extreme weather events that disrupt water management processes. The impact of such epidemics may be reduced by deployment of transmission control facilities...
Stochastic pulsing of gene expression enables the generation of spatial patterns in Bacillus subtilis biofilms.
Stochastic pulsing of gene expression can generate phenotypic diversity in a genetically identical population of cells, but it is unclear whether it has a role in the development of multicellular systems. Here, we show how...
Stochastic pulsing of gene expression enables the generation of spatial patterns in Bacillus subtilis biofilms.
Stochastic pulsing of gene expression can generate phenotypic diversity in a genetically identical population of cells, but it is unclear whether it has a role in the development of multicellular systems. Here, we show how...
Published by: Nature Communications
When Eurosceptics become Europhiles
Katy Brown
Dec 31, 2020
Turkey’s involvement in the European Union has long provoked controversy among Europe’s elites. Recently, in the context of the so-called ‘migrant crisis’, coupled with the mainstreaming of Islamophobia and rising...
Teaching Medical Students About Attention Deficit Hyperactivity Disorder (ADHD)
In this paper, we describe how an e-learning resource on Attention Deficit Hyperactivity Disorder (ADHD) for medical students was designed and developed. The aim of the resource was to provide students with essential knowledge...
Disease and disaster
Epidemics of water-borne infections often follow natural disasters and extreme weather events that disrupt water management processes. The impact of such epidemics may be reduced by deployment of transmission control facilities...
Platforms and Institutions in the Post-Pandemic University
In this paper we argue that digital platforms play an important role within higher education, not least of all when Covid-19 has made remote working the norm. An increasingly rich field of theoretical and empirical work has...
Self-reported motivations for offending by autistic sexual offenders
Autism spectrum disorder is a neurodevelopmental disorder estimated to have elevated prevalence in forensic populations (approximately 4.5%). It has been suggested that offenders with autism spectrum disorder engage more...
Characterization of Intrinsic Properties of Promoters.
Timothy J Rudge, James R Brown, Fernan Federici, Neil Dalchau, Andrew Phillips, James W Ajioka, Jim Haseloff
Dec 08, 2015
Epigallocatechin Gallate Modulates Microglia Phenotype to Suppress Pro-Inflammatory Signalling Cues and Inhibit Phagocytosis
Microglia are crucial players in the pathogenesis of late-onset Alzheimer’s disease (AD), with evidence for both deleterious and beneficial effects. Identifying interventions to modulate microglial responsiveness, promote...
EdTech for Ugandan girls
MOTIVATION: This article discusses the use of educational technology (EdTech) in girls' education at PEAS (Promoting Education in African Schools) schools in rural Uganda during the Covid-19-related school closures. PURPOSE...
Self-reported motivations for offending by autistic sexual offenders
Autism spectrum disorder is a neurodevelopmental disorder estimated to have elevated prevalence in forensic populations (approximately 4.5%). It has been suggested that offenders with autism spectrum disorder engage more...
Orthogonal intercellular signaling for programmed spatial behavior.
Paul K Grant, Neil Dalchau, James R Brown, Fernan Federici, Timothy J Rudge, Boyan Yordanov, Om Patange, Andrew Phillips, Jim Haseloff
Nov 13, 2017
Epigallocatechin Gallate Modulates Microglia Phenotype to Suppress Pro-Inflammatory Signalling Cues and Inhibit Phagocytosis
Microglia are crucial players in the pathogenesis of late-onset Alzheimer’s disease (AD), with evidence for both deleterious and beneficial effects. Identifying interventions to modulate microglial responsiveness, promote...
Decentralizing Cell-Free RNA Sensing With the Use of Low-Cost Cell Extracts.
Anibal Arce, Fernando Guzman Chavez, Chiara Gandini, Juan Puig, Tamara Matute, Jim Haseloff, Neil Dalchau, Jenny Molloy, Keith Pardee, Fernán Federici
Oct 28, 2021
Cell-free gene expression systems have emerged as a promising platform for field-deployed biosensing and diagnostics. When combined with programmable toehold switch-based RNA sensors, these systems can be used to detect...
Communicating the move to individualized donor selection policy
Eamonn Ferguson, Sarah Bowen, Claire Lawrence, Chris Starmer, Abigail Barr, Katy Davison, Claire Reynolds, Susan R Brailsford
Nov 09, 2022
Genome-wide assessment of DNA methylation alterations induced by superovulation, sexual immaturity and in vitro follicle growth in mouse blastocysts.
Laura Saucedo-Cuevas, Elena Ivanova, Anamaria-Cristina Herta, Felix Krueger, Katy Billooye, Johan Smitz, Gavin Kelsey, Ellen Anckaert
Feb 17, 2023
BACKGROUND: In their attempt to fulfill the wish of having children, women who suffer from fertility issues often undergo assisted reproductive technologies such as ovarian stimulation, which has been associated with adverse...
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