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Multifaceted Cellular Reprogramming at the Crossroads Between Plant Development and Biotic Interactions.
One of the striking features of multicellular plants is their developmental plasticity in response to environmental change. For example, flowering plants can transform the vegetative meristem into a reproductive meristem for...
Enteroendocrine cell lineages that differentially control feeding and gut motility.
Marito Hayashi, Judith A Kaye, Ella R Douglas, Narendra R Joshi, Fiona M Gribble, Frank Reimann, Stephen D Liberles
Mar 24, 2023
NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.
Kazuhiro Murakami, Ufuk Günesdogan, Jan J Zylicz, Walfred WC Tang, Roopsha Sengupta, Toshihiro Kobayashi, Shinseog Kim, Richard Butler, Sabine Dietmann, M Azim Surani
Dec 09, 2015
Activins Animals Bone Morphogenetic Protein 4 Cell Differentiation Chromatin DNA-Binding Proteins Enhancer Elements Genetic Epigenesis Genetic Female Fibroblast Growth Factor 2 Gene Expression Regulation Developmental Genome Germ Cells Germ Layers Homeodomain Proteins Male Mice Mouse embryonic stem cells Nanog Homeobox Protein Pluripotent Stem Cells Positive Regulatory Domain I-Binding Factor 1 Protein Binding RNA-Binding Proteins SOXB1 Transcription Factors Transcription Factor AP-2 Transcription Factors
The modeling of Alzheimer's disease by the overexpression of mutant Presenilin 1 in human embryonic stem cells.
Makoto Honda, Itsunari Minami, Norie Tooi, Nobuhiro Morone, Hisae Nishioka, Kengo Uemura, Ayae Kinoshita, John E Heuser, Norio Nakatsuji, Kazuhiro Aiba
May 28, 2019
Cellular disease models are useful tools for Alzheimer's disease (AD) research. Pluripotent stem cells, including human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), are promising materials for...
Building primary care in Japan
Daisuke Kato, Hikohaku Ryu, Tomoki Matsumoto, Kazuhiro Abe, Makoto Kaneko, Mezhen Ko, Greg Irving, Robin Ramsay, Masatoshi Kondo
Feb 24, 2020
Japan's health system is well known for achieving one of the world's highest life expectancy with universal health coverage. However, the country now faces challenges of a rapidly aging population and changes in patterns and...
Statistical Correlation between the Distribution of Lyα Emitters and Intergalactic Medium Hi at z∼2.2 Mapped by the Subaru/Hyper Suprime-Cam
Yongming Liang, Nobunari Kashikawa, Zheng Cai, Xiaohui Fan, J. Xavier Prochaska, Kazuhiro Shimasaku, Masayuki Tanaka, Hisakazu Uchiyama, Kei Ito, Rhythm Shimakawa, Kentaro Nagamine, Ikkoh Shimizu, Masafusa Onoue, Jun Toshikawa
Jan 19, 2021
The correlation between neutral hydrogen (H I) in the intergalactic medium (IGM) and galaxies attracts great interest. We select four fields that include several coherently strong Lyα absorption systems at z ∼ 2.2 detected...
2D coherent charge transport in highly ordered conducting polymers doped by solid state diffusion.
Keehoon Kang, Shun Watanabe, Katharina Broch, Alessandro Sepe, Adam Brown, Iyad Nasrallah, Mark Nikolka, Zhuping Fei, Martin Heeney, Daisuke Matsumoto, Kazuhiro Marumoto, Hisaaki Tanaka, Shin-Ichi Kuroda, Henning Sirringhaus
Apr 13, 2016
The “Edutab Box”
Tatsuro Furuya, Kazutaka Mizukoshi, Yoshiaki Mizuochi, Yuto Omae, Takayuki Oshima, Norihisa Sakakibara, Hirotaka Takahashi, Kazuhiro Yatsushiro
Dec 27, 2019
Collaborative/active learning is a notably effective educational method. Since tablet terminals are now being widely used in the educational field, it is being possible to use tablet terminals for collaborative/active learning....
Published by: IGI Global Scientific Publishing
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.
Alisa F Zyryanova, Kazuhiro Kashiwagi, Claudia Rato, Heather P Harding, Ana Crespillo-Casado, Luke A Perera, Ayako Sakamoto, Madoka Nishimoto, Mayumi Yonemochi, Mikako Shirouzu, Takuhiro Ito, David Ron
Oct 26, 2020
The small molecule ISRIB antagonizes the activation of the integrated stress response (ISR) by phosphorylated translation initiation factor 2, eIF2(αP). ISRIB and eIF2(αP) bind distinct sites in their common target, eIF2B, a...
CRISPR/Cas9-homologous recombination cell stress drug action Eukaryotic Initiation Factor-2B mRNA translation Phosphorylation Protein Binding protein biosynthesis/drug effects Protein Conformation Acetamides Allosteric Regulation Animals Binding Sites CHO Cells Cricetulus Cryoelectron Microscopy Cyclohexylamines Eukaryotic Initiation Factor-2 Eukaryotic Initiation Factor-2B HeLa Cells Humans Phosphorylation
Statistical Correlation between the Distribution of Lyα Emitters and Intergalactic Medium Hi at z∼2.2 Mapped by the Subaru/Hyper Suprime-Cam
Yongming Liang, Nobunari Kashikawa, Zheng Cai, Xiaohui Fan, J. Xavier Prochaska, Kazuhiro Shimasaku, Masayuki Tanaka, Hisakazu Uchiyama, Kei Ito, Rhythm Shimakawa, Kentaro Nagamine, Ikkoh Shimizu, Masafusa Onoue, Jun Toshikawa
Jan 19, 2021
The correlation between neutral hydrogen (H I) in the intergalactic medium (IGM) and galaxies attracts great interest. We select four fields that include several coherently strong Lyα absorption systems at z ∼ 2.2 detected...
A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions.
Itsunari Minami, Kohei Yamada, Tomomi G Otsuji, Takuya Yamamoto, Yan Shen, Shinya Otsuka, Shin Kadota, Nobuhiro Morone, Maneesha Barve, Yasuyuki Asai, Tatyana Tenkova-Heuser, John E Heuser, Motonari Uesugi, Kazuhiro Aiba, Norio Nakatsuji
May 28, 2019
Human pluripotent stem cells (hPSCs), including embryonic stem cells and induced pluripotent stem cells, are potentially useful in regenerative therapies for heart disease. For medical applications, clinical-grade cardiac cells...
MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis.
Katsuhiko Hayashi, Susana M Chuva de Sousa Lopes, Masahiro Kaneda, Fuchou Tang, Petra Hajkova, Kaiqin Lao, Donal O'Carroll, Partha P Das, Alexander Tarakhovsky, Eric A Miska, M Azim Surani
Feb 15, 2021
BACKGROUND: MicroRNAs (miRNAs) are critical regulators of transcriptional and post-transcriptional gene silencing, which are involved in multiple developmental processes in many organisms. Apart from miRNAs, mouse germ cells...
Animals Argonaute Proteins Cell Differentiation Cell Proliferation Cells Cultured DEAD-box RNA Helicases DNA Methylation Endoribonucleases Eukaryotic Initiation Factor-2 Female Gene Expression Regulation Germ Cells Inhibitor of Apoptosis Proteins Integrases Long Interspersed Nucleotide Elements Male Mice Mice Knockout MicroRNAs RNA Small Interfering Ribonuclease III Spermatogenesis Testis Ubiquitin-Protein Ligases
Human artificial chromosome with a conditional centromere for gene delivery and gene expression.
Yuichi Iida, Jung-Hyun Kim, Yasuhiro Kazuki, Hidetoshi Hoshiya, Masato Takiguchi, Masahiro Hayashi, Indri Erliandri, Hee-Sheung Lee, Alex Samoshkin, Hiroshi Masumoto, William C Earnshaw, Natalay Kouprina, Vladimir Larionov, Mitsuo Oshimura
Dec 18, 2020
Human artificial chromosomes (HACs), which carry a fully functional centromere and are maintained as a single-copy episome, are not associated with random mutagenesis and offer greater control over expression of ectopic genes on...
Animals CHO Cells Cell Line Centromere Chickens Chromosomes Artificial Human Cricetinae Cricetulus Gene Expression Gene Targeting Gene Transfer Techniques Genetic Therapy Genetic Vectors Green Fluorescent Proteins Humans In Situ Hybridization Fluorescence Operator Regions Genetic Plasmids Polymerase Chain Reaction Recombination Genetic Tetracyclines Transgenes
Ursinus College Alumni Journal, September 1951
J. Harold Brownback, Muriel B. Pancoast, Calvin D. Yost, Louis A. Krug, Paul Levengood, Raymond V. Gurzynski, Norman E. McClure
Jan 01, 0001
President's page Dr. Harry Cochran addresses graduating class Newcomen Society honors Ursinus Robert Herber awarded Fulbright scholarship Dr. Prentis to speak on Founders Day Faculty changes 1951-52 New stack level houses...
Ursinus College Collegeville Pennsylvania alumni Deaths Marriages commencement Henry Herber Robert C. Herber Newcomen Society Henning Webb Prentis Alumni Memorial Library Karl Heinz Munsinger David Laucks Hain Charles H. Noss Kermit Black Walter R. Douthett Richard C. Wentzel Bunny Harshaw Vosters Teru Hayashi John L. Roth Ray S. Detwiler Harry W. Snyder Don Young Nancy Vadner lacrosse softball Football tennis track team baseball Higher Education Social History United States History
Published by: Ursinus College
The 3rd DBCLS BioHackathon
Toshiaki Katayama, Mark D Wilkinson, Gos Micklem, Shuichi Kawashima, Atsuko Yamaguchi, Mitsuteru Nakao, Yasunori Yamamoto, Shinobu Okamoto, Kenta Oouchida, Hong-Woo Chun, Jan Aerts, Hammad Afzal, Erick Antezana, Kazuharu Arakawa, Bruno Aranda, Francois Belleau, Jerven Bolleman, Raoul Jp Bonnal, Brad Chapman, Peter Ja Cock, Tore Eriksson, Paul Mk Gordon, Naohisa Goto, Kazuhiro Hayashi, Heiko Horn, Ryosuke Ishiwata, Eli Kaminuma, Arek Kasprzyk, Hideya Kawaji, Nobuhiro Kido, Young Joo Kim, Akira R Kinjo, Fumikazu Konishi, Kyung-Hoon Kwon, Alberto Labarga, Anna-Lena Lamprecht, Yu Lin, Pierre Lindenbaum, Luke McCarthy, Hideyuki Morita, Katsuhiko Murakami, Koji Nagao, Kozo Nishida, Kunihiro Nishimura, Tatsuya Nishizawa, Soichi Ogishima, Keiichiro Ono, Kazuki Oshita, Keun-Joon Park, Pjotr Prins, Taro L Saito, Matthias Samwald, Venkata P Satagopam, Yasumasa Shigemoto, Richard Smith, Andrea Splendiani, Hideaki Sugawara, James Taylor, Rutger A Vos, David Withers, Chisato Yamasaki, Christian M Zmasek, Shoko Kawamoto, Kosaku Okubo, Kiyoshi Asai, Toshihisa Takagi
Mar 06, 2013
Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium.
Tsuyoshi Fukushima, Yosuke Tanaka, Fiona K Hamey, Chih-Hsiang Chang, Toshihiko Oki, Shuhei Asada, Yasutaka Hayashi, Takeshi Fujino, Taishi Yonezawa, Reina Takeda, Kimihito Cojin Kawabata, Tomofusa Fukuyama, Terumasa Umemoto, Keiyo Takubo, Hitoshi Takizawa, Susumu Goyama, Yasushi Ishihama, Hiroaki Honda, Berthold Göttgens, Toshio Kitamura
Dec 16, 2019
Quiescent hematopoietic stem cells (HSCs) are typically dormant, and only a few quiescent HSCs are active. The relationship between "dormant" and "active" HSCs remains unresolved. Here we generate a G0 marker (G0M) mouse line...
CDK G(0) phase HSC Calcium Cell Cycle dormancy Hematopoietic stem cell p27 Animals Biomarkers Calcium Cell Proliferation Cell Self Renewal Cytoplasm Female Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks Hematopoietic Stem Cells Male Mice Mice Inbred C57BL Resting Phase Cell Cycle Single-Cell Analysis
Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer.
Gouji Toyokawa, Ken Masuda, Yataro Daigo, Hyun-Soo Cho, Masanori Yoshimatsu, Masashi Takawa, Shinya Hayami, Kazuhiro Maejima, Makoto Chino, Helen I Field, David E Neal, Eiju Tsuchiya, Bruce AJ Ponder, Yoshihiko Maehara, Yusuke Nakamura, Ryuji Hamamoto
Jun 28, 2011
Biomarkers Tumor Carcinoma Non-Small-Cell Lung Cell Cycle Proteins Cell Line Tumor Cell Proliferation DNA-Binding Proteins Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Silencing HCT116 Cells HEK293 Cells HeLa Cells Hep G2 Cells Humans Lung Neoplasms Minichromosome Maintenance Complex Component 7 Neoplasms Nuclear Proteins Prognosis Protein Binding Protein-Arginine N-Methyltransferases RNA Small Interfering
The Ursinus Weekly, March 7, 1938
Editorship of 1939 Ruby goes to Gene Hile Harmony between races urged by Hill "Mr. Pim passes by" is junior play St. Patrick's Day motif for soph hop York County alumni convene, elect new officers Pre-meds to hear Behney...
Ursinus College Collegeville Pennsylvania newspaper Physical Education Club W. Austen Bishop Color Day Leslie Hill Fred Weiland Charles A. Behney French Club Curtain Club Basketball baseball wrestling Whorten A. Kline Clarence Kline debate team cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
The Ursinus Weekly, March 14, 1938
Founders' Day program and dinner Wednesday: Address of day is 'function of leadership' Ursinus to be at Saturday peace conference MSC begins work on fund for chapel speakers It's the hormones in you, but 40% don't have them ...
Ursinus College Collegeville Pennsylvania newspaper Founders Day Frank Graves E. Kermit Harbaugh International Relations Club YMCA YWCA Physical Education Club debate team Charles A. Behney wrestling Basketball Intramural Sports John Lentz cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
The Ursinus Weekly, March 15, 1937
Ditzel is chosen 1938 Ruby editor Vernon D. Groff elected Weekly editor at annual board meeting Interracial fellowship to present play on Wednesday Editor announces formal Ruby to appear on campus in May Class Day committee...
Ursinus College Collegeville Pennsylvania newspaper YMCA YWCA wrestling International Relations Club Forensic Society baseball Basketball Warren K. Hess cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Rotating Starburst Cores in Massive Galaxies at z = 2.5
Ken-ichi Tadaki, Tadayuki Kodama, Erica J. Nelson, Sirio Belli, Natascha M Förster Schreiber, Reinhard Genzel, Masao Hayashi, Rodrigo Herrera-camus, Yusei Koyama, Philipp Lang, Dieter Lutz, Rhythm Shimakawa, Linda J. Tacconi, Hannah Ubler, Emily Wisnioski, Stijn Wuyts, Bunyo Hatsukade, Magdalena Lippa, Kouichiro Nakanishi, Soh Ikarashi, Kotaro Kohno, Tomoko L. Suzuki, Yoichi Tamura, Ichi Tanaka
May 26, 2017
We present spatially resolved ALMA observations of the CO J = 3 - 2 emission line in two massive galaxies at z = 2.5 on the star-forming main sequence. Both galaxies have compact dusty star-forming cores with effective radii...
SXDF-ALMA 1.5 arcmin$^2$ Deep Survey
K.-i. Tadaki, K. Kohno, T. Kodama, S. Ikarashi, I. Aretxaga, S. Berta, K.~I. Caputi, J.~S. Dunlop, B. Hatsukade, M. Hayashi, D.~H. Hughes, R. Ivison, T. Izumi, Y. Koyama, D. Lutz, R. Makiya, Y. Matsuda, K. Nakanishi, W. Rujopakarn, Y. Tamura, H. Umehata, G.~W. Wilson, S. Wuyts, Y. Yamaguchi, M.~S. Yun
Sep 20, 2015
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