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A Systematic Review of Neurosurgical Care in Low-Income Countries.
Hannah K Weiss, Roxanna M Garcia, Jesutofunmi A Omiye, Dominique Vervoort, Robert Riestenberg, Ketan Yerneni, Nikhil Murthy, Annie B Wescott, Peter Hutchinson, Gail Rosseau
Feb 19, 2020
Objective:More than 5 billion individuals lack access to essential surgical care. Neurosurgical care is especially limited in low-income countries (LICs). Studies describing neurosurgical care in LICs are critical for...
Research Traumatic brain injury Hydrocephalus Literature review Global Health Low-income Countries TBI Traumatic Brain Injury Global neurosurgery Lcogs Lancet Commission On Global Surgery Lic Low-income Country
Published by: World neurosurgery: X
A Systematic Review of Neurosurgical Care in Low-Income Countries.
Hannah K Weiss, Roxanna M Garcia, Jesutofunmi A Omiye, Dominique Vervoort, Robert Riestenberg, Ketan Yerneni, Nikhil Murthy, Annie B Wescott, Peter Hutchinson, Gail Rosseau
Feb 24, 2020
OBJECTIVE: More than 5 billion individuals lack access to essential surgical care. Neurosurgical care is especially limited in low-income countries (LICs). Studies describing neurosurgical care in LICs are critical for...
Flavonoids and Their Metabolites
The occurrence of atherosclerosis and diabetes is expanding rapidly worldwide. These two metabolic disorders often co-occur, and are part of what is often referred to as the metabolic syndrome. In order to determine future...
Amino acid dependent formaldehyde metabolism in mammals
Matthias Pietzke, Guillermo Burgos-Barragan, Niek Wit, Jacqueline Tait-Mulder, David Sumpton, Gillian M. Mackay, Ketan J. Patel, Alexei Vazquez
Feb 18, 2021
Abstract: Aldehyde dehydrogenase class 3, encoded by ADH5 in humans, catalyzes the glutathione dependent detoxification of formaldehyde. Here we show that ADH5 deficient cells turn over formaldehyde using alternative pathways...
Amino acid dependent formaldehyde metabolism in mammals.
Matthias Pietzke, Guillermo Burgos-Barragan, Niek Wit, Jacqueline Tait-Mulder, David Sumpton, Gillian M Mackay, Ketan J Patel, Alexei Vazquez
Jun 17, 2021
Aldehyde dehydrogenase class 3, encoded by ADH5 in humans, catalyzes the glutathione dependent detoxification of formaldehyde. Here we show that ADH5 deficient cells turn over formaldehyde using alternative pathways starting...
Amino acid dependent formaldehyde metabolism in mammals
Matthias Pietzke, Guillermo Burgos-Barragan, Niek Wit, Jacqueline Tait-Mulder, David Sumpton, Gillian M. Mackay, Ketan J. Patel, Alexei Vazquez
Jun 16, 2020
Abstract: Aldehyde dehydrogenase class 3, encoded by ADH5 in humans, catalyzes the glutathione dependent detoxification of formaldehyde. Here we show that ADH5 deficient cells turn over formaldehyde using alternative pathways...
Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury.
Andrea Paolini, Saleh Omairi, Robert Mitchell, Danielle Vaughan, Antonios Matsakas, Sakthivel Vaiyapuri, Thomas Ricketts, David C Rubinsztein, Ketan Patel
Sep 27, 2018
Autophagy has been implicated as a major factor in the development of a number of diseases of skeletal muscle. However, its role in skeletal muscle homeostasis is still evolving. We examined skeletal muscle architecture in a...
Impacts of Commonly Used Edible Plants on the Modulation of Platelet Function.
Dina AI Albadawi, Divyashree Ravishankar, Thomas M Vallance, Ketan Patel, Helen MI Osborn, Sakthivel Vaiyapuri
Jan 10, 2022
Cardiovascular diseases (CVDs) are a primary cause of deaths worldwide. Thrombotic diseases, specifically stroke and coronary heart diseases, account for around 85% of CVDs-induced deaths. Platelets (small circulating blood...
Activity of Antioxidants from Crocus sativus L. Petals
Keti Zeka, Pasquale Marrazzo, Matteo Micucci, Ketan C Ruparelia, Randolph RJ Arroo, Guido Macchiarelli, Stefania Annarita Nottola, Maria Adelaide Continenza, Alberto Chiarini, Cristina Angeloni, Silvana Hrelia, Roberta Budriesi
Feb 01, 2021
The petals of the saffron crocus (Crocus sativus L.) are considered a waste material in saffron production, but may be a sustainable source of natural biologically active substances of nutraceutical interest. The aim of this...
Activity of Antioxidants from Crocus sativus L. Petals
Keti Zeka, Pasquale Marrazzo, Matteo Micucci, Ketan C. Ruparelia, Randolph R. J. Arroo, Guido Macchiarelli, Stefania Annarita Nottola, Maria Adelaide Continenza, Alberto Chiarini, Cristina Angeloni, Silvana Hrelia, Roberta Budriesi
Nov 10, 2020
The petals of the saffron crocus (Crocus sativus L.) are considered a waste material in saffron production, but may be a sustainable source of natural biologically active substances of nutraceutical interest. The aim of this...
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.
Felix A Dingler, Meng Wang, Anfeng Mu, Christopher L Millington, Nina Oberbeck, Sam Watcham, Lucas B Pontel, Ashley N Kamimae-Lanning, Frederic Langevin, Camille Nadler, Rebecca L Cordell, Paul S Monks, Rui Yu, Nicola K Wilson, Asuka Hira, Kenichi Yoshida, Minako Mori, Yusuke Okamoto, Yusuke Okuno, Hideki Muramatsu, Yuichi Shiraishi, Masayuki Kobayashi, Toshinori Moriguchi, Tomoo Osumi, Motohiro Kato, Satoru Miyano, Etsuro Ito, Seiji Kojima, Hiromasa Yabe, Miharu Yabe, Keitaro Matsuo, Seishi Ogawa, Berthold Göttgens, Michael RG Hodskinson, Minoru Takata, Ketan J Patel
Nov 06, 2020
Reactive aldehydes arise as by-products of metabolism and are normally cleared by multiple families of enzymes. We find that mice lacking two aldehyde detoxifying enzymes, mitochondrial ALDH2 and cytoplasmic ADH5, have greatly...
DNA Damage Ageing bone marrow failure Cancer Formaldehyde Hematopoiesis Hematopoietic Stem Cells immunodeficiency Mutagenesis oncometabolite Adolescent Alcohol Dehydrogenase Aldehyde Dehydrogenase Mitochondrial Aldehydes Animals Child Child Preschool DNA Adducts DNA Damage DNA Repair Female Formaldehyde Hematopoiesis Hematopoietic Stem Cells Humans Infant Leukemia Male Mice Mutation Substrate Specificity