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Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation.
Allyson M Freedy, Maria J Matos, Omar Boutureira, Francisco Corzana, Ana Guerreiro, Padma Akkapeddi, Víctor J Somovilla, Tiago Rodrigues, Karl Nicholls, Bangwen Xie, Gonzalo Jiménez-Osés, Kevin M Brindle, André A Neves, Gonçalo JL Bernardes
Feb 07, 2018
Chemical modification of proteins is essential for a variety of important diagnostic and therapeutic applications. Many strategies developed to date lack chemo- and regioselectivity as well as result in non-native linkages that...
Michael Heidelberger, 1933
The Rockefeller University
Jan 01, 0001
Dr. Michael Heidelberger. Contributions of Chemistry of the Knowledge of Immune Processes
Lecture delivered March 17th, 1933
Posted with permission
Published by: The William & Wilkins Company
Remembering Michael Shute
Dedication to Michael Shute.
Published by: Memorial University of Newfoundland
JEFFREY RAVETCH AND MICHAEL YOUNG
The Rockefeller University
Jan 01, 0001
Congratulations to Jeffrey Ravetch and Michael Young, recipients of the 2012 Canada Gairdner International Award
Published by: The Rockefeller University
Remembering Michael Shute
Dedication to Michael Shute.
Published by: Memorial University of Newfoundland
Sound human, steer clear of jargon, and be prepared.
Kevin McConway and David Spiegelhalter offer tips to statisticians communicating through the media, especially in the time of Covid-19.
New approaches for imaging tumour responses to treatment.
Kevin Brindle
Jun 16, 2011
Animals Clinical Trials as Topic Diagnostic Imaging Fluorodeoxyglucose F18 Glycolysis Humans Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Neoplasms Neovascularization Pathologic Positron-Emission Tomography Tomography Emission-Computed Single-Photon Tomography X-Ray Computed Ultrasonography
Rigid analytic quantum groups and quantum Arens-Michael envelopes
Nicolas Dupré
Aug 19, 2019
We introduce a rigid analytification of the quantized coordinate algebra of a semisimple algebraic group and a quantized Arens-Michael envelope of the enveloping algebra of the corresponding Lie algebra, working over a...
Organocatalytic Enantioselective Sulfa-Michael Additions to α,β-Unsaturated Diazoketones
Patricia B Momo, Eduardo F Mizobuchi, Radell Echemendía, Isabel Baddeley, Matthew N Grayson, Antonio C B Burtoloso
Mar 04, 2022
Enantioselective sulfa-Michael additions to α,β unsaturated diazocarbonyl compounds have been developed. Quinine-derived squaramide was found to be the best catalyst to promote C-S bond formation in a highly stereoselective...
Written in White
Nathan Lyons
Jan 16, 2017
The poem ‘Colloquies’ by Australian poet Kevin Hart can be read as a literary elaboration of Rabbi Isaac the Blind’s theory of divine white writing. ‘Colloquies’ finds white writing in the pages of God s three books—scripture...
Organocatalytic Enantioselective Sulfa-Michael Additions to α,β-Unsaturated Diazoketones
Patricia B Momo, Eduardo F Mizobuchi, Radell Echemendía, Isabel Baddeley, Matthew N Grayson, Antonio C B Burtoloso
Mar 04, 2022
Enantioselective sulfa-Michael additions to α,β unsaturated diazocarbonyl compounds have been developed. Quinine-derived squaramide was found to be the best catalyst to promote C-S bond formation in a highly stereoselective...
A multi spin echo pulse sequence with optimized excitation pulses and a 3D cone readout for hyperpolarized 13 C imaging.
PURPOSE: Imaging tumor metabolism in vivo using hyperpolarized [1-13 C]pyruvate is a promising technique for detecting disease, monitoring disease progression, and assessing treatment response. However, the transient nature of...
Hyperpolarized 13 C spectroscopic imaging using single-shot 3D sequences with unpaired adiabatic refocusing pulses.
Lectins in Cervical Screening.
Anita WW Lim, André A Neves, Sarah Lam Shang Leen, Pierre Lao-Sirieix, Elizabeth Bird-Lieberman, Naveena Singh, Michael Sheaff, Tony Hollingworth, Kevin Brindle, Peter Sasieni
Aug 10, 2020
Cervical screening in low-resource settings remains an unmet need. Lectins are naturally occurring sugar-binding glycoproteins whose binding patterns change as cancer develops. Lectins discriminate between dysplasia and normal...
Density Functional Theory Transition-State Modeling for the Prediction of Ames Mutagenicity in 1,4 Michael Acceptors
Assessing the safety of new chemicals, without introducing the need for animal testing, is a task of great importance. The Ames test, a widely used bioassay to assess mutagenicity, can be an expensive, wasteful process with...
Density Functional Theory Transition-State Modeling for the Prediction of Ames Mutagenicity in 1,4 Michael Acceptors
Assessing the safety of new chemicals, without introducing the need for animal testing, is a task of great importance. The Ames test, a widely used bioassay to assess mutagenicity, can be an expensive, wasteful process with...
Increasing the sensitivity of hyperpolarized [15 N2 ]urea detection by serial transfer of polarization to spin-coupled protons.
PURPOSE: Hyperpolarized 15 N-labeled molecules have been proposed as imaging agents for investigating tissue perfusion and pH. However, the sensitivity of direct 15 N detection is limited by the isotope's low gyromagnetic ratio....
Expanding Theranostic Radiopharmaceuticals for Tumor Diagnosis and Therapy.
Cristina Barca, Christoph M Griessinger, Andreas Faust, Dominic Depke, Markus Essler, Albert D Windhorst, Nick Devoogdt, Kevin M Brindle, Michael Schäfers, Bastian Zinnhardt, Andreas H Jacobs
Feb 21, 2022
Radioligand theranostics (RT) in oncology use cancer-type specific biomarkers and molecular imaging (MI), including positron emission tomography (PET), single-photon emission computed tomography (SPECT) and planar scintigraphy...
Expanding Theranostic Radiopharmaceuticals for Tumor Diagnosis and Therapy.
Cristina Barca, Christoph M Griessinger, Andreas Faust, Dominic Depke, Markus Essler, Albert D Windhorst, Nick Devoogdt, Kevin Brindle, Michael Schäfers, Bastian Zinnhardt, Andreas H Jacobs
Jan 07, 2022
Radioligand theranostics (RT) in oncology use cancer-type specific biomarkers and molecular imaging (MI), including positron emission tomography (PET), single-photon emission computed tomography (SPECT) and planar scintigraphy...
A referenceless Nyquist ghost correction workflow for echo planar imaging of hyperpolarized [1-13 C]pyruvate and [1-13 C]lactate.
Single-shot echo planar imaging (EPI), which allows an image to be acquired using a single excitation pulse, is used widely for imaging the metabolism of hyperpolarized 13 C-labelled metabolites in vivo as the technique is rapid...
EPI [1-13C]lactate [1-13C]pyruvate ghosting hyperpolarized Imaging metabolism tumours Animals Carbon Isotopes echo-planar imaging Female Image Processing Computer-Assisted Lactic Acid Mice Inbred C57BL Phantoms imaging Pyruvic Acid Reference Standards Signal Processing Computer-Assisted Signal-To-Noise Ratio
Metabolic imaging with hyperpolarized [1-13C] pyruvate in patient-derived preclinical mouse models of breast cancer.
13C nuclear spin hyperpolarization can increase the sensitivity of detection in an MRI experiment by more than 10,000-fold. 13C magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized 13C label exchange between...
Eliminating Transition State Calculations for Faster and More Accurate Reactivity Prediction in Sulfa-Michael Additions Relevant to Human Health and the Environment
Fast and accurate computational approaches to predicting reactivity in sulfa-Michael additions are required for high-throughput screening in toxicology (e.g., predicting excess aquatic toxicity and skin sensitization), chemical...
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