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Modified HEK cells simulate DCT cells in their sensitivity and response to changes in extracellular K.
A potassium (K+ ) rich diet is known to have an antihypertensive effect that has been embodied by the NHLBI in the DASH diet. However, the molecular basis for this blood pressure-lowering effect has been unclear, until a recent...
Sound human, steer clear of jargon, and be prepared.
Kevin McConway and David Spiegelhalter offer tips to statisticians communicating through the media, especially in the time of Covid-19.
ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3Δ403-459 mutation.
Cullin‐3 ROMK WNK kinases hyperkalemia Proteasome ubiquitin‐ligase complex Adaptor Proteins Signal Transducing Animals Biomarkers Cell Line Cullin Proteins Gene Knock-In Techniques Genetic Predisposition to Disease Kidney Membrane Potentials Mice Transgenic Microfilament Proteins Mutation Oocytes Phenotype Potassium Potassium Channels Inwardly Rectifying Protein Processing Post-Translational Protein Serine-Threonine Kinases Pseudohypoaldosteronism Transfection Xenopus laevis
β1-Adrenoreceptor Polymorphisms and Blood Pressure
BACKGROUND: Activation of beta-1 adrenoreceptor (β1-AR) in the kidney releases renin that plays a major role in the maintenance of blood pressure. Genetic variation in β1-AR could therefore alter the physiological and clinical...
WNK signalling pathways in blood pressure regulation.
hyperkalemia Hypertension NCC Proteasome Ubiquitin-E3 ligase complex WNK kinases Animals blood pressure Cullin Proteins Humans Hypertension Neovascularization Physiologic Protein Serine-Threonine Kinases Pseudohypoaldosteronism Receptors Drug Signal Transduction Sodium Chloride Symporters Sodium-Potassium-Chloride Symporters
Targeted disruption of the Kcnj5 gene in the female mouse lowers aldosterone levels.
Aldosterone is released from adrenal zona glomerulosa (ZG) cells and plays an important role in Na and K homoeostasis. Mutations in the human inwardly rectifying K channel CNJ type (KCNJ) 5 (KCNJ5) gene encoding the G-coupled...
GIRK4 K channel KCNJ5 gene RNASeq aldosterone knockout mice aldosterone Angiotensin II Animals Cell Line Tumor Cytochrome P-450 CYP11B2 Female G Protein-Coupled Inwardly-Rectifying Potassium Channels Gene Expression Profiling Humans Male Mice Inbred C57BL Mice Knockout Sex Factors Vasoconstrictor Agents zona glomerulosa
Written in White
Nathan Lyons
Jan 16, 2017
The poem ‘Colloquies’ by Australian poet Kevin Hart can be read as a literary elaboration of Rabbi Isaac the Blind’s theory of divine white writing. ‘Colloquies’ finds white writing in the pages of God s three books—scripture...
Nonadherence to antihypertensive medications amongst patients with uncontrolled hypertension
Spoorthy Kulkarni, Raunak Rao, James Delman Harry Goodman, Kathleen Connolly, Kevin M O'Shaughnessy
Feb 23, 2021
Medication nonadherence represents a modifiable risk factor for patients with hypertension. Identification of nonadherent patients could have significant clinical and economic implications in the management of uncontrolled...
Review of Kevin Decker and Jeffery Ewing, Alien and Philosophy: I Infest, Therefore I Am. Oxford
Jared Call
Jan 07, 2020
The movie Alien first hit the box office in the spring of 1979, and it was met with critical acclaim; in 2008, it ranked seventh best film in the science fiction genre by the American Film Institute. The chestburster scene is...
Published by: Memorial University of Newfoundland
Re-Imagining Data Governance
Kevin Sweeney
May 25, 2018
Contemporary business environments reflect the growing influence of data as a mission-critical resource of relevance across the enterprise, suggesting a need for robust infrastructures to enable good data management practice....
Knowledge Management Business and Management Business and Organizational Research Social Sciences and Humanities
Published by: IGI Global Scientific Publishing
The Human Rights Violation
Ifeanyi Kevin
Jan 04, 2021
The proliferation of ‘violent-oriented' ethnic organizations and agitation groups operating in Nigeria, is a result of the inability of the Nigerian state to resolve the questions of citizenship, resource control, federalism and...
Published by: Department of History, University of Karachi
Review of Kevin Decker and Jeffery Ewing, Alien and Philosophy: I Infest, Therefore I Am. Oxford
Jared Call
Jan 07, 2020
The movie Alien first hit the box office in the spring of 1979, and it was met with critical acclaim; in 2008, it ranked seventh best film in the science fiction genre by the American Film Institute. The chestburster scene is...
Published by: Memorial University of Newfoundland
Agile Model-Driven Engineering
In this article, the authors describe the field of agile model-driven software engineering methods and present the results of a survey of the research and industrial practice in this field over the last 25 years. They evaluate...
Published by: IGI Global Scientific Publishing
Functional characterization of common BCL11B gene desert variants suggests a lymphocyte-mediated association of BCL11B with aortic stiffness.
Raya Al Maskari, Iris Hardege, Sarah Cleary, Nicki Figg, Ye Li, Keith Siew, Ashraf Khir, Yong Yu, Pentao Liu, Ian Wilkinson, Kevin O'Shaughnessy, Yasmin
Sep 05, 2018
Presidents, Prime Ministers and Policy Rhetoric
US President Woodrow Wilson and Australian Prime Minister Kevin Rudd were separated by institutional contexts, relative power positions and decades in time. However, each confronted a similar dilemma — of reconciling...
Winthrop Graduate Student With Social Studies Aspirations Passes Away
Winthrop University
Jan 01, 0001
R. Kevin Carter is described as an engaged student who always engaged in thought-provoking discussions.
Published by: Winthrop University
The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness.
Yasmin, Raya Al Maskari, Carmel M McEniery, Sarah E Cleary, Ye Li, Keith Siew, Nichola L Figg, Ashraf W Khir, John R Cockcroft, Ian B Wilkinson, Kevin M O'Shaughnessy
Jul 18, 2018
Stiffening of the aorta is an important independent risk factor for myocardial infarction and stroke. Yet its genetics is complex and little is known about its molecular drivers. We have identified for the first time, tagSNPs in...
The Ursinus Weekly, February 24, 1972
Candy Silver, William Hafer, Jane Siegel, Lesa Spacek, Nina Camiel, Bob Swarr, Carol Wasserman, Ruthann Connell
Jan 01, 0001
I.R.C. plans Spring semester Kevin Akey elected new USGA President Sorority rushing reaches climax WRUC-FM presents Jaime Brockett concert Walk-a-thon planned for MDA Bloodmobile comes to UC Editorial: Two students Focus...
Ursinus College Collegeville Pennsylvania newspaper International Relations Club Kevin Akey student government sororities Red Cross Muscular Dystrophy Association Jaime Brockett Richard C. Fidler Alumni Association Swimming Basketball Robert M. McAllister cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia.
James S Ware, Louise V Wain, Sarath K Channavajjhala, Victoria E Jackson, Elizabeth Edwards, Run Lu, Keith Siew, Wenjing Jia, Nick Shrine, Sue Kinnear, Mahli Jalland, Amanda P Henry, Jenny Clayton, Kevin M O'Shaughnessy, Martin D Tobin, Victor L Schuster, Stuart Cook, Ian P Hall, Mark Glover
Sep 03, 2019
Aged Aged 80 and over Aquaporin 1 Aquaporin 2 Cohort Studies Dinoprostone Female Genome-Wide Association Study Humans Hyponatremia Male Middle Aged Nephrons Organic Anion Transporters Pharmacogenetics Phenotype Polymorphism Single Nucleotide Prostaglandins Sodium Chloride Symporter Inhibitors Thiazides United Kingdom water
Science Advocacy Group President at Winthrop to Critique U.S. Nuclear Weapons Policy
Winthrop University
Jan 01, 0001
Kevin Knobloch, president of the Union of Concerned Scientists, will speak Oct. 2. The lecture is free and open to the public.
Published by: Winthrop University
Detection of mutations in KLHL3 and CUL3 in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome).
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