Search
Results: 13
Human Papillomaviruses; Epithelial Tropisms, and the Development of Neoplasia.
The Reservoir of Persistent Human Papillomavirus Infection; Strategies for Elimination Using Anti-Viral Therapies.
Ke Zheng, Nagayasu Egawa, Aslam Shiraz, Mayako Katakuse, Maki Okamura, Heather M Griffin, John Doorbar
Jan 28, 2022
Human Papillomaviruses have co-evolved with their human host, with each of the over 200 known HPV types infecting distinct epithelial niches to cause diverse disease pathologies. Despite the success of prophylactic vaccines in...
Dynamics of papillomavirus in vivo disease formation & susceptibility to high-level disinfection-Implications for transmission in clinical settings.
Nagayasu Egawa, Aslam Shiraz, Robin Crawford, Taylor Saunders-Wood, Jeremy Yarwood, Marc Rogers, Ankur Sharma, Gary Eichenbaum, John Doorbar
Feb 19, 2021
BACKGROUND: High-level disinfection protects tens-of-millions of patients from the transmission of viruses on reusable medical devices. The efficacy of high-level disinfectants for preventing human papillomavirus (HPV)...
HPV16 and 18 genome amplification show different E4-dependence, with 16E4 enhancing E1 nuclear accumulation and replicative efficiency via its cell cycle arrest and kinase activation functions
Cell Cycle Checkpoints Cells Cultured Enzyme Activation Fluorescent Antibody Technique Gene Amplification Genome Viral Human papillomavirus 16 Human papillomavirus 18 Humans Immunoblotting Immunohistochemistry In Situ Hybridization Fluorescence Keratinocytes Life Cycle Stages Mutagenesis Site-Directed Oncogene Proteins Viral Real-Time Polymerase Chain Reaction Virus Replication
The Reservoir of Persistent Human Papillomavirus Infection; Strategies for Elimination Using Anti-Viral Therapies.
Ke Zheng, Nagayasu Egawa, Aslam Shiraz, Mayako Katakuse, Maki Okamura, Heather M Griffin, John Doorbar
Mar 29, 2022
Human Papillomaviruses have co-evolved with their human host, with each of the over 200 known HPV types infecting distinct epithelial niches to cause diverse disease pathologies. Despite the success of prophylactic vaccines in...
Roles for E1-independent replication and E6-mediated p53 degradation during low-risk and high-risk human papillomavirus genome maintenance.
Isao Murakami, Nagayasu Egawa, Heather Griffin, Wen Yin, Christian Kranjec, Tomomi Nakahara, Tohru Kiyono, John Doorbar
Jul 25, 2019
Human papillomavirus type 16 causes a defined subset of conjunctival in situ squamous cell carcinomas.
Heather Griffin, Hardeep Singh Mudhar, Paul Rundle, Aslam Shiraz, Radma Mahmood, Nagayasu Egawa, Wim Quint, Ian G Rennie, John Doorbar
Jul 26, 2019
Squamous cell carcinoma of the conjunctiva is associated with a number of risk factors, including HIV infection, iatrogenic immunosuppression and atopy. In addition, several studies have suggested an involvement of HPV, based on...
Cervical cell lift
Aslam Shiraz, Nagayasu Egawa, Daniël M Pelt, Robin Crawford, Adeline K Nicholas, Veronika Romashova, Peter Sasieni, Heather Griffin, John Doorbar
Aug 21, 2022
BACKGROUND: Primary HPV screening, due to its low specificity, requires an additional liquid-based cytology (LBC) triage test. However, even with LBC triage there has been a near doubling in the number of patients referred for...
Biomarker for cervical screening CIN Cervical cancer Cytology HPV Methodology for cervical screening Non-invasive sampling Spatial mapping of lesion Triage test Cervix Uteri Early Detection of Cancer Female Humans Papillomaviridae Papillomavirus Infections Pilot Projects Precancerous Conditions Triage Uterine Cervical Neoplasms Vaginal Smears Uterine Cervical Dysplasia
Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin.
Liang Weng, Atsushi Enomoto, Hiroshi Miyoshi, Kiyofumi Takahashi, Naoya Asai, Nobuhiro Morone, Ping Jiang, Jian An, Takuya Kato, Keisuke Kuroda, Takashi Watanabe, Masato Asai, Maki Ishida-Takagishi, Yoshiki Murakumo, Hideki Nakashima, Kozo Kaibuchi, Masahide Takahashi
May 28, 2019
In clathrin-mediated endocytosis (CME), specificity and selectivity for cargoes are thought to be tightly regulated by cargo-specific adaptors for distinct cellular functions. Here, we show that the actin-binding protein girdin...
Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance.
Ankur Chakravarthy, Ian Reddin, Stephen Henderson, Cindy Dong, Nerissa Kirkwood, Maxmilan Jeyakumar, Daniela Rothschild Rodriguez, Natalia Gonzalez Martinez, Jacqueline McDermott, Xiaoping Su, Nagayasau Egawa, Christina S Fjeldbo, Vilde Eide Skingen, Heidi Lyng, Mari Kyllesø Halle, Camilla Krakstad, Afschin Soleiman, Susanne Sprung, Matt Lechner, Peter JI Ellis, Mark Wass, Martin Michaelis, Heidi Fiegl, Helga Salvesen, Gareth J Thomas, John Doorbar, Kerry Chester, Andrew Feber, Tim R Fenton
Oct 07, 2022
Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance.
Ankur Chakravarthy, Ian Reddin, Stephen Henderson, Cindy Dong, Nerissa Kirkwood, Maxmilan Jeyakumar, Daniela Rothschild Rodriguez, Natalia Gonzalez Martinez, Jacqueline McDermott, Xiaoping Su, Nagayasau Egawa, Christina S Fjeldbo, Vilde Eide Skingen, Heidi Lyng, Mari Kyllesø Halle, Camilla Krakstad, Afschin Soleiman, Susanne Sprung, Matt Lechner, Peter JI Ellis, Mark Wass, Martin Michaelis, Heidi Fiegl, Helga Salvesen, Gareth J Thomas, John Doorbar, Kerry Chester, Andrew Feber, Tim R Fenton
Nov 07, 2022
Human papillomavirus (HPV)-associated cervical cancer is a leading cause of cancer deaths in women. Here we present an integrated multi-omic analysis of 643 cervical squamous cell carcinomas (CSCC, the most common histological...