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Replaying Life's Tape With Intraclonal Germinal Center Evolution
Tatsuya Araki
Jan 01, 0001
Because high-affinity antibodies produced by germinal centers (GCs) are critical in protecting against the ever-increasing array of pathogens, understanding how GC response allows our immune system to recognize a variety of...
Published by: Rockefeller University
Hand posture affects brain-function measures associated with listening to speech.
A major difficulty in studies of the brain, from the molecular to large-scale network level, is ensuring the accuracy and reliability of results, since repeatability has been a problem in studies utilizing functional magnetic...
Data processing for the sandwiched Rényi divergence
The α-sandwiched Rényi divergence satisfies the data processing inequality, i.e. monotonicity under quantum operations, for α≥ 1 / 2. In this article, we derive a necessary and sufficient algebraic condition for equality in the...
Modification of Service Content for Evolution of Service Platform Ecosystems
In platform ecosystems, the proper modification of goods provided could promote innovation and fulfill the need for diversity among consumers. However, most platforms in the service industry currently serve merely as...
Published by: IGI Global Scientific Publishing
Hand posture affects brain-function measures associated with listening to speech.
A major difficulty in studies of the brain, from the molecular to large-scale network level, is ensuring the accuracy and reliability of results, since repeatability has been a problem in studies utilizing functional magnetic...
Published by: Scientific reports
Cationic Rectifier Based on a Graphene Oxide-Covered Microhole
Cation transport through nanochannels in graphene oxide can be rectified to give ionic diode devices for future applications, for example, in desalination. A film of graphene oxide is applied to a 6 μm thick poly(ethylene...
Cationic Rectifier Based on a Graphene Oxide-Covered Microhole
Cation transport through nanochannels in graphene oxide can be rectified to give ionic diode devices for future applications, for example, in desalination. A film of graphene oxide is applied to a 6 μm thick poly(ethylene...
HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.
Dennis Kappei, Falk Butter, Christian Benda, Marion Scheibe, Irena Draškovič, Michelle Stevense, Clara Lopes Novo, Claire Basquin, Masatake Araki, Kimi Araki, Dragomir Blazhev Krastev, Ralf Kittler, Rolf Jessberger, J Arturo Londoño-Vallejo, Matthias Mann, Frank Buchholz
Jun 28, 2019
Telomeres are repetitive DNA structures that, together with the shelterin and the CST complex, protect the ends of chromosomes. Telomere shortening is mitigated in stem and cancer cells through the de novo addition of telomeric...
Generating polyketide diversity in Dictyostelium
Tamao Saito, Tomoyuki Iijima, Kohei Koyama, Tomonori Shinagawa, Ayaka Yamanaka, Tsuyoshi Araki, Noriyuki Suzuki, Toyonobu Usuki, Robert R. Kay
Oct 24, 2022
Development and physiology RESEARCH ARTICLES Dictyostelium discoideum polyketide synthase dibenzofuran differentiation-inducing factor (DIF) antibacterial compound
Published by: The Royal Society
Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice.
Hiromi Yamazaki, Shuya Kasai, Junsei Mimura, Peng Ye, Atsushi Inose-Maruyama, Kunikazu Tanji, Koichi Wakabayashi, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Douglas R Cavener, Masayuki Yamamoto, Ken Itoh
Apr 23, 2020
Amino acids exert many biological functions, serving as allosteric regulators and neurotransmitters, as constituents in proteins and as nutrients. GCN2-mediated phosphorylation of eukaryotic initiation factor 2 alpha (elF2α)...
Vasohibin-1 is identified as a master-regulator of endothelial cell apoptosis using gene network analysis.
Muna Affara, Debbie Sanders, Hiromitsu Araki, Yoshinori Tamada, Benjamin J Dunmore, Sally Humphreys, Seiya Imoto, Christopher Savoie, Satoru Miyano, Satoru Kuhara, David Jeffries, Cristin Print, D Stephen Charnock-Jones
Apr 06, 2020
BACKGROUND: Apoptosis is a critical process in endothelial cell (EC) biology and pathology, which has been extensively studied at protein level. Numerous gene expression studies of EC apoptosis have also been performed, however...
GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
Chikashi Terao, Yukihide Momozawa, Kazuyoshi Ishigaki, Eiryo Kawakami, Masato Akiyama, Po-Ru Loh, Giulio Genovese, Hiroki Sugishita, Tazro Ohta, Makoto Hirata, John R. B. Perry, Koichi Matsuda, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani
Oct 16, 2020
Abstract: Mosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing men. However, the genetic architecture and biological mechanisms underlying mLOY are not fully understood. In a cohort of 95,380...
GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
Elucidating the genetic architecture of reproductive ageing in the Japanese population.
Momoko Horikoshi, Felix R Day, Masato Akiyama, Makoto Hirata, Yoichiro Kamatani, Koichi Matsuda, Kazuyoshi Ishigaki, Masahiro Kanai, Hollis Wright, Carlos A Toro, Sergio R Ojeda, Alejandro Lomniczi, Michiaki Kubo, Ken K Ong, John RB Perry
Aug 16, 2018
Population studies elucidating the genetic architecture of reproductive ageing have been largely limited to European ancestries, restricting the generalizability of the findings and overlooking possible key genes poorly captured...
Gene network inference and visualization tools for biologists
Daniel Hurley, Hiromitsu Araki, Yoshinori Tamada, Ben Dunmore, Deborah Sanders, Sally Humphreys, Muna Affara, Seiya Imoto, Kaori Yasuda, Yuki Tomiyasu, Kosuke Tashiro, Christopher Savoie, Vicky Cho, Stephen Smith, Satoru Kuhara, Satoru Miyano, D Stephen Charnock-Jones, Edmund J Crampin, Cristin G Print
Jan 23, 2018
Gene regulatory networks inferred from RNA abundance data have generated significant interest, but despite this, gene network approaches are used infrequently and often require input from bioinformaticians. We have assembled a...
Thyroid MALT lymphoma
Fangtian Wu, Natsuko Watanabe, Maria-Myrsini Tzioni, Ayse Akarca, Chunye Zhang, Yan Li, Zi Chen, Francesco Cucco, Natasha Carmell, Jaeduk Yoshimura Noh, Koichi Ito, Rachel Dobson, Sarah Moody, Wenqing Yao, Wenyan Zhang, Weiping Liu, Hongxiang Liu, Jessica Okosun, Andreas Chott, Yingwen Bi, Shih-Sung Chuang, Markus Raderer, Jian-Yong Li, Teresa Marafioti, Ming-Qing Du
Dec 15, 2021
PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.
Joanne I Hsu, Tajhal Dayaram, Ayala Tovy, Etienne De Braekeleer, Mira Jeong, Feng Wang, Jianhua Zhang, Timothy P Heffernan, Sonal Gera, Jeffrey J Kovacs, Joseph R Marszalek, Christopher Bristow, Yuanqing Yan, Guillermo Garcia-Manero, Hagop Kantarjian, George Vassiliou, P Andrew Futreal, Lawrence A Donehower, Koichi Takahashi, Margaret A Goodell
Jan 02, 2019
The Naming of Names
John L Bowman, Takashi Araki, Mario A Arteaga-Vazquez, Frederic Berger, Liam Dolan, Jim Haseloff, Kimitsune Ishizaki, Junko Kyozuka, Shih-Shun Lin, Hideki Nagasaki, Hirofumi Nakagami, Keiji Nakajima, Yasukazu Nakamura, Kyoko Ohashi-Ito, Shinichiro Sawa, Masaki Shimamura, Roberto Solano, Hirokazu Tsukaya, Takashi Ueda, Yuichiro Watanabe, Katsuyuki T Yamato, Sabine Zachgo, Takayuki Kohchi
Sep 15, 2021
While Marchantia polymorpha has been utilized as a model system to investigate fundamental biological questions for over almost two centuries, there is renewed interest in M. polymorpha as a model genetic organism in the...
Mobile PEAR transcription factors integrate positional cues to prime cambial growth.
Shunsuke Miyashima, Pawel Roszak, Iris Sevilem, Koichi Toyokura, Bernhard Blob, Jung-Ok Heo, Nathan Mellor, Hanna Help-Rinta-Rahko, Sofia Otero, Wouter Smet, Mark Boekschoten, Guido Hooiveld, Kayo Hashimoto, Ondřej Smetana, Riccardo Siligato, Eva-Sophie Wallner, Ari Pekka Mähönen, Yuki Kondo, Charles W Melnyk, Thomas Greb, Keiji Nakajima, Rosangela Sozzani, Anthony Bishopp, Bert De Rybel, Ykä Helariutta
Feb 06, 2019
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