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Psychological Study of Cyber-Bullying Against Adolescent Girls in India Using Twitter
Due to the rise in digital activity of students as well as increased social media presence, the lack of regulation of platforms has given rise to another form of bullying, popularly known as cyberbullying. Cyberbullying is one...
Published by: IGI Global Scientific Publishing
Synthesis and Reactivity of a Bis-Strained Alkyne Derived from 1,1'-Biphenyl-2,2',6,6'-tetrol.
The novel "double strained alkyne" 3 has been prepared and evaluated in strain-promoted azide-alkyne cycloaddition reactions with azides. The X-ray crystallographic structure of 3, which was prepared in one step from...
Mathematics Teachers' Self-Reported Practices of Formative Assessments in Teaching Mathematics Online
The current study examined the mathematics teachers' awareness toward and practices of different forms of assessments (of, for, and as learning) in teaching mathematics online during the pandemic. A cross-sectional online survey...
Published by: IGI Global Scientific Publishing
Combining Internally Contracted States and Matrix Product States To Perform Multireference Perturbation Theory.
We present two efficient and intruder-free methods for treating dynamic correlation on top of general multiconfiguration reference wave functions - including such as obtained by the density matrix renormalization group (DMRG)...
Highly reactive bis-cyclooctyne-modified diarylethene for SPAAC-mediated cross-linking.
Alexander V Strizhak, Krishna Sharma, Oleg Babii, Sergii Afonin, Anne S Ulrich, Igor V Komarov, David R Spring
Dec 04, 2018
Photoisomerizable diarylethenes equipped with triple bonds are promising building blocks for constructing bistable photocontrollable systems. Here we report on the design, synthesis and application of a cross-linking reagent...
Changing Antimicrobial Resistance Trends in Kathmandu, Nepal
Raphaël M Zellweger, Buddha Basnyat, Poojan Shrestha, Krishna G Prajapati, Sabina Dongol, Paban K Sharma, Samir Koirala, Thomas C Darton, Christine Boinett, Corinne N Thompson, Guy E Thwaites, Stephen Baker, Abhilasha Karkey
Apr 10, 2019
A comprehensive longitudinal understanding of the changing epidemiology of the agents causing bacteraemia and their AMR profiles in key locations is crucial for assessing the progression and magnitude of the global AMR crisis....
A 23-year retrospective investigation of Salmonella Typhi and Salmonella Paratyphi isolated in a tertiary Kathmandu hospital.
Raphaël M Zellweger, Buddha Basnyat, Poojan Shrestha, Krishna G Prajapati, Sabina Dongol, Paban K Sharma, Samir Koirala, Thomas C Darton, Christiane Dolecek, Corinne N Thompson, Guy E Thwaites, Stephen G Baker, Abhilasha Karkey
Feb 19, 2019
BACKGROUND: Salmonella serovars Typhi (S. Typhi) and Paratyphi A (S. Paratyphi A), the causative agents of enteric fever, have been routinely isolated organisms from the blood of febrile patients in the Kathmandu Valley since...
Interactive Documentary Practices as an Emerging Tool for Development Communication
Interactive documentary is an evolving form of filmmaking which has the potential to become an influential development communication tool to facilitate social change because of its participatory nature. Study explores how can...
Published by: IGI Global Scientific Publishing
Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction
Krishna Sharma, Alexander V. Strizhak, Elaine Fowler, Wenshu Xu, Ben Chappell, Hannah F. Sore, Warren R. J. D. Galloway, Matthew N. Grayson, Yu Heng Lau, Laura S. Itzhaki, David R. Spring
Jan 21, 2020
The Sondheimer dialkyne reagent has previously been employed in strain-promoted double-click cycloadditions with bis-azide peptides to generate stapled peptide inhibitors of protein–protein interactions. The substituted variants...
Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction
Krishna Sharma, Alexander V. Strizhak, Elaine Fowler, Wenshu Xu, Ben Chappell, Hannah F. Sore, Warren R. J. D. Galloway, Matthew N. Grayson, Yu Heng Lau, Laura S. Itzhaki, David R. Spring
Jan 21, 2020
The Sondheimer dialkyne reagent has previously been employed in strain-promoted double-click cycloadditions with bis-azide peptides to generate stapled peptide inhibitors of protein–protein interactions. The substituted variants...
Volunteers and Conscripts
Abstract Philippa Foot, like others of her philosophical generation, was much concerned with the status and authority of morality. How universal are its demands, and how dependent on the...
Nakul Krishna
Aug 11, 2020
Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction.
Krishna Sharma, Alexander V Strizhak, Elaine Fowler, Wenshu Xu, Ben Chappell, Hannah F Sore, Warren RJD Galloway, Matthew N Grayson, Yu Heng Lau, Laura S Itzhaki, David R Spring
Feb 27, 2020
The Sondheimer dialkyne reagent has previously been employed in strain-promoted double-click cycloadditions with bis-azide peptides to generate stapled peptide inhibitors of protein-protein interactions. The substituted variants...
Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry.
Krishna Sharma, Alexander V Strizhak, Elaine Fowler, Xuelu Wang, Wenshu Xu, Claus Hatt Jensen, Yuteng Wu, Hannah F Sore, Yu Heng Lau, Marko Hyvönen, Laura S Itzhaki, David R Spring
Aug 21, 2019
The Sondheimer dialkyne is extensively used in double strain-promoted azide-alkyne cycloadditions. This reagent suffers with poor water-solubility and rapidly decomposes in aqueous solutions. This intrinsically limits its...
Regulation of host and viral promoters during human cytomegalovirus latency via US28 and CTCF.
Viral latency is an active process during which the host cell environment is optimized for latent carriage and reactivation. This requires control of both viral and host gene promoters and enhancers often at the level of...
CTCF Chromatin Cytomegalovirus latency viral gene expression virus-host interactions CCCTC-Binding Factor Calgranulin A Calgranulin B Cytomegalovirus Cytomegalovirus Infections Enhancer Elements Genetic Gene Expression Regulation Genes Immediate-Early Host-Pathogen Interactions Humans Monocytes Promoter Regions Genetic Receptors Chemokine Viral Proteins Virus Latency
Advances in the treatment of cytomegalovirus.
antivirals human cytomegalovirus Infection latency vaccines Antiviral Agents Cytomegalovirus Cytomegalovirus Infections Cytomegalovirus Vaccines Drug development Early Diagnosis Hematopoietic Stem Cell Transplantation Humans Immunity Cellular Immunoglobulins Immunosuppression Therapy Infant Newborn Organ Transplantation Perinatal Care Virus Latency
Multi-Objective Optimization-Oriented Resource Allocation in the Fog Environment
Fog computing is a decentralized computer system where data, processing, storage, as well as applications are located anywhere between the cloud and data source. Fog computing takes the cloud closer to users, decreasing the...
Published by: IGI Global Scientific Publishing
Credit Card Fraud Prediction Using XGBoost
With the development of technology, the internet and eCommerce online payment has become an essential mode of payment. Nowadays, credit card payment is a convenient mode of payment online as well as offline transactions. As...
Published by: IGI Global Scientific Publishing
Sorting Out Fuzzy Transportation Problems via ECCT and Standard Deviation
A well-organized arithmetical procedure entitled standard deviation is employed to find the optimum solution in this paper. This technique has been divided into two parts. The first methodology deals with constructing the entire...
Published by: IGI Global Scientific Publishing
Corrigendum
Scientific Reports 6: Article number: 31205; published online: 05 August 2016; updated: 26 September 2016. The original version of this Article contained an error in the spelling of the author Immaculada Montanuy which...
Betty Lau, Emma Poole, Benjamin Krishna, Immaculada Montanuy, Mark R Wills, Eain Murphy, John Sinclair
Nov 29, 2017
Transient activation of human cytomegalovirus lytic gene expression during latency allows cytotoxic T cell killing of latently infected cells.
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