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Sonic Hedgehog Agonist Protects Against Complex Neonatal Cerebellar Injury.
Vien Nguyen, Khalida Sabeur, Emin Maltepe, Kurosh Ameri, Omer Bayraktar, David H Rowitch
Nov 29, 2018
The cerebellum undergoes rapid growth during the third trimester and is vulnerable to injury and deficient growth in infants born prematurely. Factors associated with preterm cerebellar hypoplasia include chronic lung disease...
brain development cerebral palsy Glucocorticoid HIF signaling Hypoxia Shh signaling Amino Acids Dicarboxylic Animals Animals Newborn Anti-Inflammatory Agents Basic Helix-Loop-Helix Transcription Factors Calcium-Binding Proteins Cell Proliferation Cells Cultured cerebellum Cyclohexylamines Developmental Disabilities Disease Models Animal Gene Expression Regulation Developmental Glucocorticoids Hedgehog Proteins Hypoxia Brain Mice Mice Inbred C57BL Mice Transgenic Microfilament Proteins Nerve Tissue Proteins Nervous System Malformations Neuroprotective Agents Prednisolone Purkinje Cells Thiophenes Von Hippel-Lindau Tumor Suppressor Protein Zinc Finger Protein GLI1
One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia.
Timothy Barkham, Ruth N Zadoks, Mohammad Noor Amal Azmai, Stephen Baker, Vu Thi Ngoc Bich, Victoria Chalker, Man Ling Chau, David Dance, Rama Narayana Deepak, H Rogier van Doorn, Ramona A Gutierrez, Mark A Holmes, Lan Nguyen Phu Huong, Tse Hsien Koh, Elisabete Martins, Kurosh Mehershahi, Paul Newton, Lee Ching Ng, Nguyen Ngoc Phuoc, Ornuma Sangwichian, Pongpun Sawatwong, Uraiwan Surin, Thean Yen Tan, Wen Ying Tang, Nguyen Vu Thuy, Paul Turner, Manivanh Vongsouvath, Defeng Zhang, Toni Whistler, Swaine L Chen
Jul 09, 2019
BACKGROUND: In 2015, Singapore had the first and only reported foodborne outbreak of invasive disease caused by the group B Streptococcus (GBS; Streptococcus agalactiae). Disease, predominantly septic arthritis and meningitis...
Adolescent Adult Aged Aged 80 and over Animals Asia Southeastern Child Child Preschool Female Fish Diseases Foodborne Diseases Genotype Humans Infant Infant Newborn Male Middle Aged molecular epidemiology Multilocus Sequence Typing Phylogeny Pregnancy Streptococcal Infections Streptococcus Agalactiae Tilapia whole genome sequencing Young Adult
Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors
Eun Young Kang, Dane Cheasley, Cecile LePage, Matthew J Wakefield, Michelle da Cunha Torres, Simone Rowley, Carolina Salazar, Zhongyue Xing, Prue Allan, David DL Bowtell, Anne-Marie Mes-Masson, Diane M Provencher, Kurosh Rahimi, Linda E Kelemen, Peter A Fasching, Jennifer A Doherty, Marc T Goodman, Ellen L Goode, Suha Deen, Paul DP Pharoah, James D Brenton, Weiva Sieh, Constantina Mateoiu, Karin Sundfeldt, Linda S Cook, Nhu D Le, Michael S Anglesio, C Blake Gilks, David G Huntsman, Catherine J Kennedy, Nadia Traficante, Australian Ovarian Cancer Study, Anna DeFazio, Scott Kaufmann, Michael Churchman, Charlie Gourley, Andrew N Stephens, Nicola S Meagher, Susan J Ramus, Yoland C Antill, Ian Campbell, Clare L Scott, Martin Köbel, Kylie L Gorringe, GAMuT Collaborators
Jul 07, 2020
Adult Australia Biomarkers Tumor DNA Mutational Analysis Female Humans Immunohistochemistry Middle Aged Mutation Neoplasms Cystic Mucinous and Serous North America Observer Variation Ovarian Neoplasms Predictive Value of Tests Prognosis Reproducibility of Results Risk Assessment Risk Factors Tissue Array Analysis Tumor Suppressor Protein p53 United Kingdom
Altered regulation of BRCA1 exon 11 splicing is associated with breast cancer risk in carriers of BRCA1 pathogenic variants.
Gorka Ruiz de Garibay, Ignacio Fernandez-Garcia, Sylvie Mazoyer, Flavia Leme de Calais, Pietro Ameri, Sangeeta Haydeliz Martinez-Ruiz, Francesca Damiola, Laure Barjhoux, Mads Thomassen, Lars VB Andersen, Carmen Herranz, Francesca Mateo, Luis Palomero, Roderic Espin, Antonio Gómez, Nadia García, Daniel Jimenez, Núria Bonifaci, Ana I Extremera, Julio Castaño, Angel Raya, Eduardo Eyras, Xose S Puente, Joan Brunet, Conxi Lázaro, Gemo, CIMBA, Paolo Radice, Daniel R Barnes, Antonis C Antoniou, Amanda B Spurdle, Miguel de la Hoya, Diana Baralle, Mary Helen Barcellos-Hoff, Miquel A Pujana
Sep 01, 2021
Germline pathogenic variants in BRCA1 confer a high risk of developing breast and ovarian cancer. The BRCA1 exon 11 (formally exon 10) is one of the largest exons and codes for the nuclear localization signals of the...