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Results: 81011
Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells
Bhardwaj, N., Bender, A., Gonzalez, N., Bui, L.K., Garrett, M.C., and Steinman, R.M. Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells. J. Clin. Invest. 94...
Published by: The American Society for Clinical Investigation
Coupling of Dimensionality Reduction and Stacking Ensemble Learning for Smartphone-Based Human Activity Recognition
Human activity recognition (HAR) plays a vital role in the field of ambient assisted living (AAL) for the welfare of the elders who live alone in the home. AAL provides service through ambient sensors, vision systems, smartphone...
Published by: IGI Global Scientific Publishing
A Novel Framework Using Zero Shot Learning Technique for a Non-Factoid Question Answering System
Non-Factoid Question Answering (QA) is the next generation of textual QA systems, which gives passage level summaries for a natural language query, posted by the user. The main issue lies in the appropriateness of the generated...
Published by: IGI Global Scientific Publishing
Capturing the systemic immune signature of a norovirus infection
A J. Cutler, J Oliveira, R C. Ferreira, B Challis, N M. Walker, S Caddy, J Lu, H E. Stevens, D J. Smyth, M L. Pekalski, J Kennet, K M.D. Hunter, I Goodfellow, L S. Wicker, J A. Todd, F Waldron-Lynch
Jun 30, 2017
Co-ingestion of whey protein with a carbohydrate-rich breakfast boes not affect glycemia, insulinemia or subjective appetite following a subsequent meal in healthy males
Dean M. Allerton, Matthew D. Campbell, Javier T. Gonzalez, Penny L. S. Rumbold, Daniel J. West, Emma J. Stevenson
Feb 25, 2016
We aimed to assess postprandial metabolic and appetite responses to a mixed-macronutrient lunch following prior addition of whey protein to a carbohydrate-rich breakfast. Ten healthy males (age: 24 ± 1 y; body mass index (BMI)...
Co-ingestion of whey protein with a carbohydrate-rich breakfast boes not affect glycemia, insulinemia or subjective appetite following a subsequent meal in healthy males
Dean M. Allerton, Matthew D. Campbell, Javier T. Gonzalez, Penny L. S. Rumbold, Daniel J. West, Emma J. Stevenson
Feb 25, 2016
We aimed to assess postprandial metabolic and appetite responses to a mixed-macronutrient lunch following prior addition of whey protein to a carbohydrate-rich breakfast. Ten healthy males (age: 24 ± 1 y; body mass index (BMI)...
S-2-Amino-4-cyanobutanoic acid (β-cyanomethyl-L-Ala) as an atom-efficient solubilising synthon for L-glutamine
Glutamine (Gln) is often a difficult amino acid to incorporate during solution-phase peptide synthesis, owing to poor solubility and unwanted dehydrations as side-reactions. Current approaches to solving these problems are...
S-2-Amino-4-cyanobutanoic acid (β-cyanomethyl-L-Ala) as an atom-efficient solubilising synthon for L-glutamine
Glutamine (Gln) is often a difficult amino acid to incorporate during solution-phase peptide synthesis, owing to poor solubility and unwanted dehydrations as side-reactions. Current approaches to solving these problems are...
A retrospective study of canine idiopathic renal haematuria
A. J. Kortum, J. Bazelle, A. Gomez Selgas, A. C. C. Kent, T. L. Williams, M. E. Herrtage
Jun 04, 2021
Objectives: To characterise and document the progression of idiopathic renal haematuria in a large cohort of medically managed UK dogs. Materials and Methods: Retrospective study of 41 client‐owned dogs with confirmed (n=14), or...
Breakfast and exercise contingently affect postprandial metabolism and energy balance in physically active males
The present study examined the impact of breakfast and exercise on postprandial metabolism, appetite and macronutrient balance. A sample of twelve (blood variables n 11) physically active males completed four trials in a...
Computation Provides Chemical Insight into the Diverse Hydride NMR Chemical Shifts of [Ru(NHC)<sub>4</sub>(L)H]<sup>0/+</sup> Species (NHC = N-heterocyclic carbene; L = vacant, H<sub>2</sub>, N<sub>2</sub>, CO, MeCN, O<sub>2</sub>, P<sub>4</sub>, SO<sub>2</sub>, H<sup>-</sup>, F<sup>-</sup> and Cl<sup>-</sup>) and their [Ru(R<sub>2</sub>PCH<sub>2</sub>CH<sub>2</sub>PR<sub>2</sub>)<sub>2</sub>(L)H]<sup>+</sup> Congeners
L J L Haller, Elena Mas-Marza, Mateusz K Cybulski, Rajashekharayya A Sanguramath, Stuart A Macgregor, Mary F Mahon, Christophe Raynaud, Christopher A Russell, Michael K Whittlesey
Mar 07, 2017
Relativistic density functional theory calculations, both with and without the effects of spin–orbit coupling, have been employed to model hydride NMR chemical shifts for a series of [Ru(NHC)4(L)H]0/+ species (NHC =...
Breakfast and exercise contingently affect postprandial metabolism and energy balance in physically active males
The present study examined the impact of breakfast and exercise on postprandial metabolism, appetite and macronutrient balance. A sample of twelve (blood variables n 11) physically active males completed four trials in a...
Computation Provides Chemical Insight into the Diverse Hydride NMR Chemical Shifts of [Ru(NHC)<sub>4</sub>(L)H]<sup>0/+</sup> Species (NHC = N-heterocyclic carbene; L = vacant, H<sub>2</sub>, N<sub>2</sub>, CO, MeCN, O<sub>2</sub>, P<sub>4</sub>, SO<sub>2</sub>, H<sup>-</sup>, F<sup>-</sup> and Cl<sup>-</sup>) and their [Ru(R<sub>2</sub>PCH<sub>2</sub>CH<sub>2</sub>PR<sub>2</sub>)<sub>2</sub>(L)H]<sup>+</sup> Congeners
L J L Haller, Elena Mas-Marza, Mateusz K Cybulski, Rajashekharayya A Sanguramath, Stuart A Macgregor, Mary F Mahon, Christophe Raynaud, Christopher A Russell, Michael K Whittlesey
Mar 07, 2017
Relativistic density functional theory calculations, both with and without the effects of spin–orbit coupling, have been employed to model hydride NMR chemical shifts for a series of [Ru(NHC)4(L)H]0/+ species (NHC =...
Glucose control upon waking is unaffected by hourly sleep fragmentation during the night, but is impaired by morning caffeinated coffee
Harry A. Smith, Aaron Hengist, Joel Thomas, Jean Philippe Walhin, Philippa Heath, Oliver Perkin, Yung Chih Chen, Javier T. Gonzalez, James A. Betts
Nov 28, 2020
Morning coffee is a common remedy following disrupted sleep, yet each factor can independently impair glucose tolerance and insulin sensitivity in healthy adults. Remarkably, the combined effects of sleep fragmentation and...
Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury
The impact of age and biological sex on outcome in moderate/severe traumatic brain injury (TBI) has been documented in large cohort studies, with advanced age and male sex linked to worse long-term outcomes. However, the...
Hydration and N-acetyl-l-cysteine alter the microstructure of human nail and bovine hoof
This work aimed to (a) characterize the microstructure and porosity of human nail and bovine hoof by mercury intrusion porosimetry and SEM image analysis, (b) study the effects of hydration and of N-acetyl-l-cysteine treatment...
A soil microbial fuel cell-based biosensor for dissolved oxygen monitoring in water
Water pollution can cause significant depletions of dissolved oxygen (DO) in water systems with serious environmental and economic consequences. Online and continuous monitoring of DO can help prevent or minimise the risks...
A soil microbial fuel cell-based biosensor for dissolved oxygen monitoring in water
Water pollution can cause significant depletions of dissolved oxygen (DO) in water systems with serious environmental and economic consequences. Online and continuous monitoring of DO can help prevent or minimise the risks...
Floer Simple Manifolds and L-Space Intervals
An oriented three-manifold with torus boundary admits either no L-space Dehn filling, a unique L-space filling, or an interval of L-space fillings. In the latter case, which we call “Floer simple,” we construct an invariant...
L q -spectra of self-affine measures
Abstract: We study L q -spectra of planar self-affine measures generated by diagonal matrices. We introduce a new technique for constructing and understanding examples based on combinatorial estimates for the exponential growth...
Hydration and N-acetyl-l-cysteine alter the microstructure of human nail and bovine hoof
This work aimed to (a) characterize the microstructure and porosity of human nail and bovine hoof by mercury intrusion porosimetry and SEM image analysis, (b) study the effects of hydration and of N-acetyl-l-cysteine treatment...
A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis.
Pooja Gupta, Sherine E Thomas, Shaymaa A Zaidan, Maria A Pasillas, James Cory-Wright, Víctor Sebastián-Pérez, Ailidh Burgess, Emma Cattermole, Clio Meghir, Chris Abell, Anthony G Coyne, William R Jacobs, Tom L Blundell, Sangeeta Tiwari, Vítor Mendes
Sep 02, 2021
The L-arginine biosynthesis pathway consists of eight enzymes that catalyse the conversion of L-glutamate to L-arginine. Arginine auxotrophs (argB/argF deletion mutants) of Mycobacterium tuberculosis are rapidly sterilised in...
L-carnitine, a friend or foe for cardiovascular disease? A Mendelian randomization study.
BACKGROUND: L-carnitine is emerging as an item of interest for cardiovascular disease (CVD) prevention and treatment, but controversy exists. To examine the effectiveness and safety of L-carnitine, we assessed how genetically...
l-carnitine, a friend or foe for cardiovascular disease? A Mendelian randomization study
Abstract
Background
l -carnitine is emerging as an item of interest for cardiovascular disease (CVD)...
L-dopa responsiveness in early Parkinson's disease is associated with the rate of motor progression.
Naveed Malek, Sofia Kanavou, Michael A Lawton, Vanessa Pitz, Katherine A Grosset, Nin Bajaj, Roger A Barker, Yoav Ben-Shlomo, David J Burn, Tom Foltynie, John Hardy, Nigel M Williams, Nicholas Wood, Huw R Morris, Donald G Grosset, PRoBaND clinical consortium
Jul 25, 2019
BACKGROUND: L-dopa responsiveness in Parkinson's disease (PD) varies, but the clinical correlates and significance of this are ill-defined. METHODS: Patients were assessed before and after their usual morning L-dopa dose, using...
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