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Results: 119
Co-delivery of buparvaquone and polymyxin B in a nanostructured lipid carrier for leishmaniasis treatment
L.M Monteiro, Raimar Löbenberg, Nikoletta Fotaki, Gabriel Lima Barros de Araujo, P.C Cotrim, Nádia Araci Bou-Chacra
Sep 01, 2019
Objectives: This study aimed to describe the preparation and in vitro evaluation of a surface-modified nanostructured lipid carrier (NLC) using chitosan and dextran for co-delivery of buparvaquone (BPQ) and polymyxin B (PB)...
Co-delivery of buparvaquone and polymyxin B in a nanostructured lipid carrier for leishmaniasis treatment
L.M Monteiro, Raimar Löbenberg, Nikoletta Fotaki, Gabriel Lima Barros de Araujo, P.C Cotrim, Nádia Araci Bou-Chacra
Sep 01, 2019
Objectives: This study aimed to describe the preparation and in vitro evaluation of a surface-modified nanostructured lipid carrier (NLC) using chitosan and dextran for co-delivery of buparvaquone (BPQ) and polymyxin B (PB)...
Novel imaging method to quantify stratum corneum in dermatopharmacokinetic studies
Purpose: Tape-stripping the stratum corneum (SC) is used in the assessment of dermatopharmacokinetics (DPK). The amount of SC per tape can be determined gravimetrically, but a novel imaging method offers advantages in terms of...
Energetics and kinetics of light-driven oxygen evolution at semiconductor electrodes
L.M. Peter
Feb 01, 2013
Light-driven water-splitting (photoelectrolysis) at semiconductor electrodes continues to excite interest as a potential route to produce hydrogen as a sustainable fuel, but surprisingly little is known about the kinetics and...
Application of the relationship between pharmacokinetics and pharmacodynamics in drug development and therapeutic equivalence:
Ioannis Loisios-Konstantinidis, Rafael L.M. Paraiso, Nikoletta Fotaki, Mark McAllister, Rodrigo Cristofoletti, Jennifer Dressman
Apr 01, 2019
Objectives
The objective of this review was to provide an overview of pharmacokinetic/pharmacodynamic (PK/PD) models, focusing on drug‐specific PK/PD models and highlighting their value added in drug development and...
The objective of this review was to provide an overview of pharmacokinetic/pharmacodynamic (PK/PD) models, focusing on drug‐specific PK/PD models and highlighting their value added in drug development and...
Potential prediction of formulation performance in paediatric patients using biopharmaceutical tools and simulation of clinically relevant administration scenarios of nifedipine and lorazepam
Aims: This study explores the impact of paediatric patient related factors and choice of formulation on the dissolution characteristics of nifedipine and lorazepam, 2 drug substances regularly applied in very young patients...
Energetics and kinetics of light-driven oxygen evolution at semiconductor electrodes
L.M. Peter
Feb 01, 2013
Light-driven water-splitting (photoelectrolysis) at semiconductor electrodes continues to excite interest as a potential route to produce hydrogen as a sustainable fuel, but surprisingly little is known about the kinetics and...
Potential prediction of formulation performance in paediatric patients using biopharmaceutical tools and simulation of clinically relevant administration scenarios of nifedipine and lorazepam
Aims: This study explores the impact of paediatric patient related factors and choice of formulation on the dissolution characteristics of nifedipine and lorazepam, 2 drug substances regularly applied in very young patients...
In situ detection of free and trapped electrons in dye-sensitized solar cells by photo-induced microwave reflectance measurements
In order to study the behavior of photoinjected electrons in dye-sensitized solar cells (DSC), steady-state microwave reflectance measurements (33 GHz, Ka band) have been carried out on a working cell filled with electrolyte....
Novel imaging method to quantify stratum corneum in dermatopharmacokinetic studies
Purpose: Tape-stripping the stratum corneum (SC) is used in the assessment of dermatopharmacokinetics (DPK). The amount of SC per tape can be determined gravimetrically, but a novel imaging method offers advantages in terms of...
Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase
Checkpoints maintain the order of cell cycle events during DNA damage or incomplete replication. How the checkpoint response is tailored to different phases of the cell cycle remains poorly understood. The S-phase checkpoint for...
Structure-Guided Computational Approaches to Unravel Druggable Proteomic Landscape of Mycobacterium leprae
Sundeep Chaitanya Vedithi, Sony Malhotra, Marta Acebrón-García-de-Eulate, Modestas Matusevicius, Pedro Henrique Monteiro Torres, Tom L. Blundell
May 21, 2021
Leprosy, caused by Mycobacterium leprae (M. leprae), is treated with a multidrug regimen comprising Dapsone, Rifampicin, and Clofazimine. These drugs exhibit bacteriostatic, bactericidal and anti-inflammatory properties...
Adipose Tissue Epigenetic Profile in Obesity-Related Dysglycemia - A Systematic Review.
Sara Andrade, Tiago Morais, Ionel Sandovici, Alexandre L Seabra, Miguel Constância, Mariana P Monteiro
Aug 16, 2021
BACKGROUND: Obesity is a major risk factor for dysglycemic disorders, including type 2 diabetes (T2D). However, there is wide phenotypic variation in metabolic profiles. Tissue-specific epigenetic modifications could be...
The use of PBPK/PD to establish clinically relevant dissolution specifications for zolpidem immediate release tablets
Rafael L.M. Paraiso, Rachel H. Rose, Nikoletta Fotaki, Mark McAllister, Jennifer B. Dressman
Dec 01, 2020
Background: Zolpidem is a non-benzodiazepine hypnotic agent which has been shown to be effective in inducing and maintaining sleep in adults and is one of the most frequently prescribed hypnotics in the world. For drugs that...
In situ detection of free and trapped electrons in dye-sensitized solar cells by photo-induced microwave reflectance measurements
In order to study the behavior of photoinjected electrons in dye-sensitized solar cells (DSC), steady-state microwave reflectance measurements (33 GHz, Ka band) have been carried out on a working cell filled with electrolyte....
Psychometric parameters of an abbreviated vengeance scale across two countries
Gabriel L.H. Coelho, Renan P. Monteiro, Paul H.P. Hanel, Valdiney V. Gouveia, Gregory Maio
Jan 01, 2018
We propose a short and ultrashort version of the Vengeance Scale (Stuckless & Goranson, 1992). Across three samples, good psychometric properties and convergent validity for the new scales were found. Study 1 found in a...
The perception of octave pitch affinity and harmonic fusion have a common origin.
Musicians say that the pitches of tones with a frequency ratio of 2:1 (one octave) have a distinctive affinity, even if the tones do not have common spectral components. It has been suggested, however, that this affinity...
Asymptotic Weyl double copy
Abstract
A characteristic value formulation of the Weyl double copy leads to an asymptotic formulation. We find that the Weyl double copy holds...
Aggregation in economies with search frictions
We derive an aggregation result in economies with indivisible labor supply choices and frictional labor markets, obtaining a tractable model of gross worker flows in aggregate labor markets with search frictions. Our result...
Need for affect and attitudes toward drugs
Gabriel Lins de Holanda Coelho, Paul H. P. Hanel, Roosevelt Vilar, Renan P Monteiro, Valdiney V Gouveia, Gregory R Maio
Jan 01, 0001
Human values and affective traits were found to predict attitudes toward the use of different types of drugs (e.g., alcohol, marijuana, and other illegal drugs). In this study (N = 196, M age = 23.09), we aimed to...
Characterizing palliative care needs in people with or at risk of developing diabetic foot ulcers.
Liliane Mendonça, Bárbara Antunes, Joana Rigor, Daniela Martins-Mendes, Matilde Monteiro-Soares
Dec 22, 2022
AIMS: Diabetic foot ulcers (DFUs) have a significant impact on a patient's quality of life and life expectancy, with mortality rates comparable with malignant diseases. However, there is a lack of data regarding palliative care...
Structure-Guided Computational Approaches to Unravel Druggable Proteomic Landscape of Mycobacterium leprae.
Sundeep Chaitanya Vedithi, Sony Malhotra, Marta Acebrón-García-de-Eulate, Modestas Matusevicius, Pedro Henrique Monteiro Torres, Tom L Blundell
Jul 09, 2021
Leprosy, caused by Mycobacterium leprae (M. leprae), is treated with a multidrug regimen comprising Dapsone, Rifampicin, and Clofazimine. These drugs exhibit bacteriostatic, bactericidal and anti-inflammatory properties...
Application of the relationship between pharmacokinetics and pharmacodynamics in drug development and therapeutic equivalence:
Ioannis Loisios-Konstantinidis, Rafael L.M. Paraiso, Nikoletta Fotaki, Mark McAllister, Rodrigo Cristofoletti, Jennifer Dressman
Apr 01, 2019
Objectives
The objective of this review was to provide an overview of pharmacokinetic/pharmacodynamic (PK/PD) models, focusing on drug‐specific PK/PD models and highlighting their value added in drug development and...
The objective of this review was to provide an overview of pharmacokinetic/pharmacodynamic (PK/PD) models, focusing on drug‐specific PK/PD models and highlighting their value added in drug development and...
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